TissGeneSummary for ANKAR |
Gene summary |
Basic gene information | Gene symbol | ANKAR |
Gene name | ankyrin and armadillo repeat containing | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q32.2 | |
Type of gene | protein-coding | |
RefGenes | NM_144708.3, | |
Description | ankyrin and armadillo repeat-containing protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 609803 | |
HGNC : HGNC | ||
Ensembl : ENSG00000151687 | ||
Vega : OTTHUMG00000154398 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ANKAR | |
BioGPS: 150709 | ||
Pathway | NCI Pathway Interaction Database: ANKAR | |
KEGG: ANKAR | ||
REACTOME: ANKAR | ||
Pathway Commons: ANKAR | ||
Context | iHOP: ANKAR | |
ligand binding site mutation search in PubMed: ANKAR | ||
UCL Cancer Institute: ANKAR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ANKAR | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ANKAR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.859691876 | 0.176754616 | -1.036446491 | 1.95E-24 | 1.86E-23 |
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TissGene-miRNA for ANKAR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ANKAR |
TissGeneSNV for ANKAR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.I43V | LUAD | 1 |
p.V7I | UCEC | 1 |
p.I150M | SKCM | 1 |
p.S787F | SKCM | 1 |
p.R1219C | STAD | 1 |
p.E391K | BLCA | 1 |
p.N842S | SKCM | 1 |
p.Y275X | PRAD | 1 |
p.D964N | PAAD | 1 |
p.R1040C | SKCM | 1 |
p.D39Y | THYM | 1 |
p.H684Y | LUAD | 1 |
p.Q1365R | LUAD | 1 |
p.N790H | SKCM | 1 |
p.N695Y | SKCM | 1 |
p.I143M | BLCA | 1 |
p.I143L | STAD | 1 |
p.I676L | GBM | 1 |
p.N1394S | THYM | 1 |
p.Y275* | PRAD | 1 |
p.K1351E | STAD | 1 |
p.Q1365* | HNSC | 1 |
p.L788V | HNSC | 1 |
p.V29I | STAD | 1 |
p.Q849H | UCEC | 1 |
p.P868L | LUAD | 1 |
p.Y542C | LUAD | 1 |
p.H371Y | SKCM | 1 |
p.P627L | SKCM | 1 |
p.Q128* | LUAD | 1 |
p.K331E | LUAD | 1 |
p.L1109V | OV | 1 |
p.I1099T | STAD | 1 |
p.A1048T | BLCA | 1 |
p.R1021I | UCEC | 1 |
p.A873T | STAD | 1 |
p.R1290C | KIRC | 1 |
p.I369L | UCEC | 1 |
p.F254L | STAD | 1 |
p.I1064V | BLCA | 1 |
p.E1284K | LUAD | 1 |
p.R862I | LGG | 1 |
p.R29I | UCEC | 1 |
p.I1074F | SKCM | 1 |
p.P428S | SKCM | 1 |
p.S1224L | BLCA | 1 |
p.R731H | UCEC | 1 |
p.E1355K | LUAD | 1 |
p.I993V | BLCA | 1 |
p.P135R | LGG | 1 |
p.L255I | UCEC | 1 |
p.I214L | STAD | 1 |
p.R562M | PRAD | 1 |
p.F873C | STAD | 1 |
p.Q478E | HNSC | 1 |
p.W158X | STAD | 1 |
p.F171L | SKCM | 1 |
p.M359I | STAD | 1 |
p.S1266X | ESCA | 1 |
p.L574V | UVM | 1 |
p.F370L | KIRP | 1 |
p.S1243C | LUAD | 1 |
p.E1295K | STAD | 1 |
p.E1106K | STAD | 1 |
p.A1238P | UCS | 1 |
p.A240V | HNSC | 1 |
p.R1357Q | BLCA | 1 |
p.K1340N | COAD | 1 |
p.P324S | SKCM | 1 |
p.Y613C | LUAD | 1 |
p.L174X | KIRC | 1 |
p.E1049K | CESC | 1 |
p.I323F | LGG | 1 |
p.L867P | LIHC | 1 |
p.L870F | BLCA | 1 |
p.T1069S | HNSC | 1 |
p.K301N | COAD | 1 |
p.I1170T | STAD | 1 |
p.K917X | COAD | 1 |
p.D1220V | BLCA | 1 |
p.E891K | BLCA | 1 |
p.S1266L | UCS | 1 |
p.Y424H | STAD | 1 |
p.E462K | BLCA | 1 |
p.E1177K | STAD | 1 |
p.F126C | UCEC | 1 |
p.D139Y | LUAD | 1 |
p.D237Y | UCEC | 1 |
p.A647S | THYM | 1 |
p.S56F | BLCA | 1 |
p.W175R | UCEC | 1 |
p.K1388N | CESC | 1 |
p.Y613C | LUSC | 1 |
p.F1312L | BRCA | 1 |
p.A66S | UCEC | 1 |
p.D308Y | UCS | 1 |
p.D210Y | LUAD | 1 |
p.L1091V | THCA | 1 |
p.Q407E | HNSC | 1 |
p.R1286Q | UCEC | 1 |
p.G1032R | SKCM | 1 |
p.C623Y | DLBC | 1 |
p.E633K | BLCA | 1 |
p.S951T | UCEC | 1 |
p.D127Y | PRAD | 1 |
p.Q64E | BLCA | 1 |
p.R1290C | STAD | 1 |
p.E314* | UCEC | 1 |
p.I214M | BLCA | 1 |
p.K1422E | STAD | 1 |
p.C794Y | PRAD | 1 |
p.K1317N | UCEC | 1 |
p.H1136P | UCEC | 1 |
p.A137S | UCEC | 1 |
p.S1174Y | ESCA | 1 |
p.V435L | BRCA | 1 |
p.T48A | BLCA | 1 |
p.W158* | STAD | 1 |
p.F370S | PRAD | 1 |
p.G992E | SKCM | 1 |
p.M244T | COAD | 1 |
p.A532V | STAD | 1 |
p.V965A | READ | 1 |
p.E99Q | SKCM | 1 |
p.K1317N | BRCA | 1 |
p.A577D | UVM | 1 |
p.N1394T | PRAD | 1 |
p.K1387Q | SKCM | 1 |
p.V1132I | ESCA | 1 |
p.F249V | STAD | 1 |
p.R220I | UCEC | 1 |
p.L1198P | COAD | 1 |
p.S592C | UVM | 1 |
p.A944T | STAD | 1 |
p.N830H | LGG | 1 |
p.P336S | SKCM | 1 |
p.S1103C | BRCA | 1 |
p.W104R | UCEC | 1 |
p.A977T | BLCA | 1 |
p.L583V | LUSC | 1 |
p.S885C | CESC | 1 |
p.A663S | LUSC | 1 |
p.R848W | LIHC | 1 |
p.Q1302E | HNSC | 1 |
p.Q1231E | HNSC | 1 |
p.Y613H | LUAD | 1 |
p.D654N | HNSC | 1 |
p.Y353H | STAD | 1 |
p.S511* | BRCA | 1 |
p.F802C | STAD | 1 |
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TissGeneCNV for ANKAR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ANKAR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ANKAR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ANKAR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ANKAR |
TissGeneDrug for ANKAR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ANKAR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |