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| TissGeneSummary for CTSE |
 Gene summary |
| Basic gene information | Gene symbol | CTSE |
| Gene name | cathepsin E | |
| Synonyms | CATE | |
| Cytomap | UCSC genome browser: 1q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001910.3, NM_148964.2, | |
| Description | erythrocyte membrane aspartic proteinaseslow-moving proteinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 116890 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196188 | ||
| HPRD : 00294 | ||
| Vega : OTTHUMG00000036121 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CTSE | |
| BioGPS: 1510 | ||
| Pathway | NCI Pathway Interaction Database: CTSE | |
| KEGG: CTSE | ||
| REACTOME: CTSE | ||
| Pathway Commons: CTSE | ||
| Context | iHOP: CTSE | |
| ligand binding site mutation search in PubMed: CTSE | ||
| UCL Cancer Institute: CTSE | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTAD | |
| Reference showing the relevant tissue of CTSE | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 8765029 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 8765029 |
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| TissGeneExp for CTSE |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 3.832735011 | 7.769154619 | -3.936419608 | 6.97E-10 | 2.43E-09 |
| KICH | -3.421724754 | -1.373860754 | -2.047864 | 6.29E-06 | 2.06E-05 |
| COAD | 3.754407862 | 5.511934785 | -1.757526923 | 0.0102 | 0.022303593 |
| KIRC | 0.475345468 | -0.780967032 | 1.2563125 | 0.000413 | 0.000811871 |
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| TissGene-miRNA for CTSE |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CTSE |
| TissGeneSNV for CTSE |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D372N | SKCM | 1 |
| p.A113T | BRCA | 1 |
| p.C109Y | DLBC | 1 |
| p.V345M | PAAD | 1 |
| p.L370M | UCEC | 1 |
| p.S106Y | PAAD | 1 |
| p.P363S | STAD | 1 |
| p.P284L | DLBC | 1 |
| p.E235K | SARC | 1 |
| p.E279* | LUAD | 1 |
| p.V210L | BRCA | 1 |
| p.W342* | SKCM | 1 |
| p.P177S | SKCM | 1 |
| p.S173C | KIRC | 1 |
| p.N227S | SKCM | 1 |
| p.G288E | SKCM | 1 |
| p.S168C | KIRC | 1 |
| p.D377N | SKCM | 1 |
| p.D343E | STAD | 1 |
| p.A399T | LGG | 1 |
| p.F56L | UCEC | 1 |
| p.G15R | SKCM | 1 |
| p.Q89H | UCEC | 1 |
| p.P310L | SKCM | 1 |
| p.S221P | CESC | 1 |
| p.D348E | STAD | 1 |
| p.S247F | SKCM | 1 |
| p.D151N | READ | 1 |
| p.K33M | KIRP | 1 |
| p.G19E | HNSC | 1 |
| p.R389C | STAD | 1 |
| p.P30L | PRAD | 1 |
| p.G324E | SKCM | 1 |
| p.P30S | SKCM | 1 |
| p.C276R | UCEC | 1 |
| p.S242F | SKCM | 1 |
| p.G352E | SKCM | 1 |
| p.D372G | STAD | 1 |
| p.P112S | SKCM | 1 |
| p.A17T | SKCM | 1 |
| p.R384C | STAD | 1 |
| p.G338E | SKCM | 1 |
| p.S100P | LIHC | 1 |
| p.D312N | SKCM | 1 |
| p.S285F | SKCM | 1 |
| p.A264V | LUAD | 1 |
| p.I237M | SKCM | 1 |
| p.S297L | ESCA | 1 |
| p.D361N | SKCM | 1 |
| p.R39W | UCEC | 1 |
| p.F378L | STAD | 1 |
| p.G283E | SKCM | 1 |
| p.M53I | SKCM | 1 |
| p.R39Q | BLCA | 1 |
| p.V350M | PAAD | 1 |
| p.W103X | SKCM | 1 |
| p.F241L | UCEC | 1 |
| p.F350V | UCEC | 1 |
| p.P368S | STAD | 1 |
| p.N299S | STAD | 1 |
| p.S290F | SKCM | 1 |
| p.Q138X | STAD | 1 |
| p.Q138* | STAD | 1 |
| p.P401S | SKCM | 1 |
| p.L70I | LUAD | 1 |
| p.T116M | PRAD | 1 |
| p.G149E | BLCA | 1 |
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| TissGeneCNV for CTSE |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CTSE |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CTSE |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CTSE, A2M, INS, EDN3, EMG1 (tumor) | CTSE, A2M, INS, EDN3, EMG1 (normal) |
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| TissGeneProg for CTSE |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CTSE |
| TissGeneDrug for CTSE |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CTSE |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1301034 | Pancreatic intraepithelial neoplasia | 2 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree,LHGDN,MGD |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0206696 | Carcinoma, Signet Ring Cell | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0747845 | early pregnancy | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
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