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| TissGeneSummary for CTSG |
 Gene summary |
| Basic gene information | Gene symbol | CTSG |
| Gene name | cathepsin G | |
| Synonyms | CATG|CG | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001911.2, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 116830 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100448 | ||
| HPRD : 00289 | ||
| Vega : OTTHUMG00000140182 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CTSG | |
| BioGPS: 1511 | ||
| Pathway | NCI Pathway Interaction Database: CTSG | |
| KEGG: CTSG | ||
| REACTOME: CTSG | ||
| Pathway Commons: CTSG | ||
| Context | iHOP: CTSG | |
| ligand binding site mutation search in PubMed: CTSG | ||
| UCL Cancer Institute: CTSG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLPRAD | |
| Reference showing the relevant tissue of CTSG | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006508 | proteolysis | 11907569 | GO:0006508 | proteolysis | 11907569 |
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| TissGeneExp for CTSG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.537856266 | 3.652169991 | -3.114313725 | 1.46E-15 | 9.79E-15 |
| COAD | 1.058102495 | 4.812914033 | -3.754811538 | 6.04E-11 | 9.06E-10 |
| BRCA | 1.29013738 | 3.982992643 | -2.692855263 | 9.00E-21 | 6.83E-20 |
| BLCA | 0.707012819 | 5.088991766 | -4.381978947 | 8.96E-08 | 5.39E-06 |
| LUAD | 1.425692946 | 3.323567084 | -1.897874138 | 3.46E-07 | 1.24E-06 |
| ESCA | -0.139230722 | 2.957578369 | -3.096809091 | 0.00133 | 0.017712096 |
| LIHC | -0.030359813 | 1.316804187 | -1.347164 | 0.00249 | 0.006192934 |
| STAD | 0.958722687 | 3.028603937 | -2.06988125 | 0.000137 | 0.001020242 |
| HNSC | 1.758943908 | 3.380862513 | -1.621918605 | 0.000109 | 0.000481827 |
| KICH | -1.507915813 | 0.222280187 | -1.730196 | 4.74E-05 | 0.000132744 |
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| TissGene-miRNA for CTSG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CTSG |
| TissGeneSNV for CTSG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R122Q | SKCM | 2 |
| p.Y37H | UCEC | 1 |
| p.L248M | LUAD | 1 |
| p.R96C | SARC | 1 |
| p.P254R | LUAD | 1 |
| p.W66R | PAAD | 1 |
| p.E56K | LUAD | 1 |
| p.R25W | CESC | 1 |
| p.E83K | SKCM | 1 |
| p.R160L | LUAD | 1 |
| p.V215I | UCEC | 1 |
| p.Q87K | LAML | 1 |
| p.R190W | LGG | 1 |
| p.R193Q | SARC | 1 |
| p.D200N | SKCM | 1 |
| p.R82W | PAAD | 1 |
| p.R92C | GBM | 1 |
| p.R81T | LGG | 1 |
| p.R183K | SKCM | 1 |
| p.I70M | STAD | 1 |
| p.R137K | LUSC | 1 |
| p.V210M | THYM | 1 |
| p.R48T | BLCA | 1 |
| p.K246I | OV | 1 |
| p.R122X | COAD | 1 |
| p.G15A | DLBC | 1 |
| p.A94V | LUAD | 1 |
| p.C172Y | PRAD | 1 |
| p.G23A | BLCA | 1 |
| p.V54L | OV | 1 |
| p.D157N | SKCM | 1 |
| p.P33H | LUAD | 1 |
| p.D157N | HNSC | 1 |
| p.T241R | LUAD | 1 |
| p.E17* | BLCA | 1 |
| p.G146S | SKCM | 1 |
| p.Y217H | LUAD | 1 |
| p.P254T | LUAD | 1 |
| p.S115R | KICH | 1 |
| p.L206Q | LUAD | 1 |
| p.M152I | SKCM | 1 |
| p.A36V | UCEC | 1 |
| p.G23R | READ | 1 |
| p.G202R | PRAD | 1 |
| p.G213A | STAD | 1 |
| p.R96H | COAD | 1 |
| p.A94V | THYM | 1 |
| p.R32L | LUAD | 1 |
| p.F52C | COAD | 1 |
| p.R160* | GBM | 1 |
| p.P98T | LUAD | 1 |
| p.D200N | LUSC | 1 |
| p.A211T | LUSC | 1 |
| p.G51R | SKCM | 1 |
| p.R96S | GBM | 1 |
| p.P254S | LUAD | 1 |
| p.L248P | BLCA | 1 |
| p.V118F | BRCA | 1 |
| p.D57N | STAD | 1 |
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| TissGeneCNV for CTSG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CTSG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CTSG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CTSG, SELPLG, GP1BA, CXCR4, THBS1, RAD21, F2RL1, PARP1, LRP1, ERBB2IP, AGT, IGFBP3, CASP7, SDC1, F2R, SERPIND1, C3, VCAM1, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, F5, LRP1, ERBB2IP, IGFBP3, CASP7, F2R, SERPIND1, C3, VCAM1, F2RL2, CXCL12 (normal) |
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| COAD (tumor) | COAD (normal) |
| CTSG, SELPLG, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F5, LRP1, KNG1, ERBB2IP, CASP7, SDC1, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, PARP1, F5, LRP1, ERBB2IP, IGFBP3, SDC1, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, RAD21, F2RL1, LRP1, KNG1, ERBB2IP, AGT, CASP7, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12 (tumor) | CTSG, SELPLG, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, F5, LRP1, AGT, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (normal) |
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| KICH (tumor) | KICH (normal) |
| CTSG, SELPLG, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, PARP1, F5, LRP1, KNG1, ERBB2IP, AGT, CASP7, F2R, SERPIND1, C3, VCAM1, F2RL2, CXCL12 (tumor) | CTSG, SELPLG, CAMP, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, LRP1, KNG1, IGFBP3, SDC1, F2R, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CTSG, SELPLG, CAMP, CXCR4, THBS1, SERPINA3, RAD21, PARP1, F5, LRP1, KNG1, AGT, CASP7, SDC1, F2R, SERPIND1, C3, VCAM1, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, SERPINA1, THBS1, SERPINA3, RAD21, F2RL1, F5, LRP1, ERBB2IP, AGT, IGFBP3, CASP7, F2R, SERPIND1, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CTSG, SELPLG, CAMP, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, LRP1, KNG1, AGT, CASP7, SDC1, F2R, C3, VCAM1, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, SERPINA3, RAD21, F2RL1, PARP1, F5, LRP1, KNG1, ERBB2IP, IGFBP3, CASP7, SDC1, F2R, C3, F2RL2, PPBP (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CTSG, SELPLG, CAMP, GP1BA, CXCR4, THBS1, RAD21, F2RL1, PARP1, LRP1, KNG1, ERBB2IP, AGT, IGFBP3, SDC1, F2R, C3, VCAM1, F2RL2, PPBP, CXCL12 (tumor) | CTSG, SELPLG, CAMP, GP1BA, CXCR4, THBS1, RAD21, F2RL1, F5, LRP1, KNG1, ERBB2IP, IGFBP3, CASP7, SDC1, F2R, SERPIND1, C3, VCAM1, PPBP, CXCL12 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CTSG, SELPLG, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, F5, KNG1, ERBB2IP, IGFBP3, CASP7, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, LRP1, IGFBP3, SDC1, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, F5, LRP1, ERBB2IP, AGT, SDC1, SERPIND1, C3, VCAM1, F2RL2, CXCL12 (tumor) | CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, PARP1, F5, LRP1, AGT, CASP7, F2R, SERPIND1, C3, VCAM1, PPBP, CXCL12, SERPINB13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CTSG, SELPLG, CAMP, GP1BA, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, LRP1, AGT, IGFBP3, CASP7, SDC1, F2R, C3, VCAM1, F2RL2, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, PARP1, F5, LRP1, KNG1, ERBB2IP, IGFBP3, CASP7, SDC1, C3, VCAM1, CXCL12, SERPINB13 (normal) |
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| STAD (tumor) | STAD (normal) |
| CTSG, CAMP, SERPINA1, CXCR4, THBS1, SERPINA3, F2RL1, PARP1, LRP1, ERBB2IP, IGFBP3, CASP7, SDC1, F2R, SERPIND1, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, CAMP, GP1BA, CXCR4, THBS1, SERPINA3, RAD21, F2RL1, PARP1, LRP1, ERBB2IP, AGT, IGFBP3, CASP7, SDC1, F2R, C3, VCAM1, F2RL2, CXCL12 (normal) |
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| THCA (tumor) | THCA (normal) |
| CTSG, SELPLG, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, PARP1, F5, LRP1, AGT, IGFBP3, CASP7, SDC1, F2R, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (tumor) | CTSG, SELPLG, GP1BA, SERPINA1, CXCR4, THBS1, SERPINA3, RAD21, F5, LRP1, ERBB2IP, AGT, IGFBP3, CASP7, F2R, C3, VCAM1, F2RL2, PPBP, CXCL12, SERPINB13 (normal) |
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| TissGeneProg for CTSG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CTSG |
| TissGeneDrug for CTSG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CTSG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023487 | Acute Promyelocytic Leukemia | 5 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree,LHGDN |
| umls:C0004096 | Asthma | 2 | BeFree |
| umls:C0006287 | Bronchopulmonary Dysplasia | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree,LHGDN |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0007820 | Cerebrovascular Disorders | 1 | GAD |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | GAD |
| umls:C0020429 | Hyperalgesia | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0022578 | Keratoconus | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0030193 | Pain | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | LHGDN |
| umls:C0032285 | Pneumonia | 1 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 1 | LHGDN |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | LHGDN |
| umls:C0042111 | Urticaria Pigmentosa | 1 | BeFree |
| umls:C0085669 | Acute leukemia | 1 | BeFree |
| umls:C0150055 | Chronic pain | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | GAD |
| umls:C0280141 | Acute Undifferentiated Leukemia | 1 | BeFree |
| umls:C0333209 | Platelet thrombus | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0475801 | Leukemia, Prolymphocytic, B-Cell | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0751955 | Brain Infarction | 1 | BeFree |
| umls:C0879615 | Stromal Neoplasm | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C1378511 | Undifferentiated leukemia | 1 | BeFree |
| umls:C1565489 | Renal Insufficiency | 1 | LHGDN |
| umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
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