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| TissGeneSummary for ZSWIM2 |
 Gene summary |
| Basic gene information | Gene symbol | ZSWIM2 |
| Gene name | zinc finger, SWIM-type containing 2 | |
| Synonyms | MEX|ZZZ2 | |
| Cytomap | UCSC genome browser: 2q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_182521.2, | |
| Description | E3 ubiquitin-protein ligase ZSWIM2MEKK1-related protein XZZ-type zinc finger-containing protein 2zinc finger SWIM domain-containing protein 2zinc finger, SWIM domain containing 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000163012 | ||
| HPRD : 15902 | ||
| Vega : OTTHUMG00000154259 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZSWIM2 | |
| BioGPS: 151112 | ||
| Pathway | NCI Pathway Interaction Database: ZSWIM2 | |
| KEGG: ZSWIM2 | ||
| REACTOME: ZSWIM2 | ||
| Pathway Commons: ZSWIM2 | ||
| Context | iHOP: ZSWIM2 | |
| ligand binding site mutation search in PubMed: ZSWIM2 | ||
| UCL Cancer Institute: ZSWIM2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZSWIM2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZSWIM2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZSWIM2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZSWIM2 |
| TissGeneSNV for ZSWIM2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R275C | SKCM | 4 |
| p.P494S | SKCM | 3 |
| p.D145N | SKCM | 3 |
| p.R603Q | SKCM | 2 |
| p.P61S | SKCM | 2 |
| p.E463K | SKCM | 2 |
| p.H538Y | SKCM | 2 |
| p.P70S | SKCM | 2 |
| p.E600K | SKCM | 2 |
| p.S504L | SKCM | 1 |
| p.I149N | SKCM | 1 |
| p.N477Y | COAD | 1 |
| p.G630E | SKCM | 1 |
| p.R115X | SKCM | 1 |
| p.E200Q | HNSC | 1 |
| p.C252Y | LIHC | 1 |
| p.A339T | UCEC | 1 |
| p.K333T | COAD | 1 |
| p.E451K | SKCM | 1 |
| p.E140K | SKCM | 1 |
| p.T332I | PAAD | 1 |
| p.P70L | HNSC | 1 |
| p.T250S | LUAD | 1 |
| p.T162I | SKCM | 1 |
| p.L230I | READ | 1 |
| p.S398L | CESC | 1 |
| p.Q632* | UCEC | 1 |
| p.L180V | UCEC | 1 |
| p.P494L | SKCM | 1 |
| p.R564K | SKCM | 1 |
| p.K459Q | STAD | 1 |
| p.T394P | SKCM | 1 |
| p.Y317C | LUSC | 1 |
| p.G386R | LUAD | 1 |
| p.P515H | UCEC | 1 |
| p.L475F | COAD | 1 |
| p.R13S | COAD | 1 |
| p.I242V | UCS | 1 |
| p.E565D | LUAD | 1 |
| p.L483V | STAD | 1 |
| p.P121T | HNSC | 1 |
| p.G169V | LUAD | 1 |
| p.M598I | LUAD | 1 |
| p.G439E | LGG | 1 |
| p.S30R | LIHC | 1 |
| p.Y247H | LUAD | 1 |
| p.L483I | COAD | 1 |
| p.H492Q | UCEC | 1 |
| p.E48* | OV | 1 |
| p.E210K | SKCM | 1 |
| p.E222Q | LUSC | 1 |
| p.L328F | SKCM | 1 |
| p.T454A | READ | 1 |
| p.P442S | BLCA | 1 |
| p.A220E | HNSC | 1 |
| p.D486E | COAD | 1 |
| p.K305N | OV | 1 |
| p.W395* | SKCM | 1 |
| p.V503L | LIHC | 1 |
| p.S214C | STAD | 1 |
| p.I302T | COAD | 1 |
| p.K223E | STAD | 1 |
| p.M544V | COAD | 1 |
| p.I302V | BRCA | 1 |
| p.V316F | LUAD | 1 |
| p.Q315L | LUAD | 1 |
| p.T71P | BRCA | 1 |
| p.D423Y | LGG | 1 |
| p.S595T | GBM | 1 |
| p.G547S | SKCM | 1 |
| p.H114Y | UCEC | 1 |
| p.E126K | SKCM | 1 |
| p.G122E | SKCM | 1 |
| p.T273A | LGG | 1 |
| p.Y295F | LIHC | 1 |
| p.P160L | SKCM | 1 |
| p.T271M | STAD | 1 |
| p.N552T | STAD | 1 |
| p.R275H | LGG | 1 |
| p.D423Y | LUSC | 1 |
| p.L328I | BLCA | 1 |
| p.W395X | SKCM | 1 |
| p.D576Y | LUAD | 1 |
| p.R3S | GBM | 1 |
| p.W583C | BLCA | 1 |
| p.P233L | SKCM | 1 |
| p.G402E | SKCM | 1 |
| p.P119S | SKCM | 1 |
| p.K420N | BRCA | 1 |
| p.S478L | SKCM | 1 |
| p.H62Y | SKCM | 1 |
| p.A404V | BRCA | 1 |
| p.T585A | LUAD | 1 |
| p.F211V | UCS | 1 |
| p.L89I | SARC | 1 |
| p.L58I | UCEC | 1 |
| p.N92I | LUSC | 1 |
| p.S190Y | LUAD | 1 |
| p.L192S | BRCA | 1 |
| p.M177V | LIHC | 1 |
| p.R111W | UCEC | 1 |
| p.H267Y | SKCM | 1 |
| p.E103G | LUAD | 1 |
| p.L483I | PRAD | 1 |
| p.H62Q | LUSC | 1 |
| p.F537Y | COAD | 1 |
| p.R324I | LUAD | 1 |
| p.E132K | SKCM | 1 |
| p.K420I | SKCM | 1 |
| p.P121Q | LUAD | 1 |
| p.R411S | LUAD | 1 |
| p.R358K | SKCM | 1 |
| p.G535X | ESCA | 1 |
| p.R115* | LUAD | 1 |
| p.R411G | LIHC | 1 |
| p.K546R | OV | 1 |
| p.R569K | SKCM | 1 |
| p.L83F | LUAD | 1 |
| p.S409L | SKCM | 1 |
| p.N479I | KIRP | 1 |
| p.C147* | HNSC | 1 |
| p.C176S | PAAD | 1 |
| p.K568N | BLCA | 1 |
| p.P119L | SKCM | 1 |
| p.S214Y | LUAD | 1 |
| p.P70Q | LUAD | 1 |
| p.V518I | LUSC | 1 |
| p.R275H | PAAD | 1 |
| p.P501H | LUAD | 1 |
| p.G231W | LUAD | 1 |
| p.E126K | LUAD | 1 |
| p.T465K | READ | 1 |
| p.L268R | STAD | 1 |
| p.P241S | SKCM | 1 |
| p.E126K | COAD | 1 |
| p.R35P | BLCA | 1 |
| p.K420N | CESC | 1 |
| p.A339D | UCEC | 1 |
| p.S381L | SKCM | 1 |
| p.D125E | LUAD | 1 |
| p.R115* | SKCM | 1 |
| p.S20G | BLCA | 1 |
| p.D24N | SKCM | 1 |
| p.D468N | SKCM | 1 |
| p.P70L | SKCM | 1 |
| p.Q315H | ESCA | 1 |
| p.G169S | SKCM | 1 |
| p.Q446E | CESC | 1 |
| p.S185R | LUAD | 1 |
| p.E251* | BLCA | 1 |
| p.L99M | STAD | 1 |
| p.R368K | SKCM | 1 |
| p.H364Q | LUAD | 1 |
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| TissGeneCNV for ZSWIM2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZSWIM2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ZSWIM2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
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| COAD (tumor) | COAD (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
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| KICH (tumor) | KICH (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ZSWIM2, UBC, MAGEA11, UBE2U (tumor) | ZSWIM2, UBC, MAGEA11, UBE2U (normal) |
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| TissGeneProg for ZSWIM2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZSWIM2 |
| TissGeneDrug for ZSWIM2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZSWIM2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
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