TissGeneSummary for ALS2CR11 |
Gene summary |
Basic gene information | Gene symbol | ALS2CR11 |
Gene name | amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q33.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001168216.1, NM_001168217.1,NM_001168221.1,NM_152525.5, | |
Description | amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000155754 | ||
HPRD : 08687 | ||
Vega : OTTHUMG00000132830 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ALS2CR11 | |
BioGPS: 151254 | ||
Pathway | NCI Pathway Interaction Database: ALS2CR11 | |
KEGG: ALS2CR11 | ||
REACTOME: ALS2CR11 | ||
Pathway Commons: ALS2CR11 | ||
Context | iHOP: ALS2CR11 | |
ligand binding site mutation search in PubMed: ALS2CR11 | ||
UCL Cancer Institute: ALS2CR11 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ALS2CR11 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ALS2CR11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.55593027 | -0.526107463 | -1.029822807 | 7.44E-11 | 2.95E-10 |
KICH | -3.068469849 | -1.420201849 | -1.648268 | 2.09E-09 | 1.23E-08 |
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TissGene-miRNA for ALS2CR11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ALS2CR11 |
TissGeneSNV for ALS2CR11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P481S | SKCM | 2 |
p.P174L | SKCM | 2 |
p.R1411* | UCEC | 2 |
p.V442M | LAML | 1 |
p.D1728V | LUAD | 1 |
p.H1809L | STAD | 1 |
p.D87N | SKCM | 1 |
p.G858D | CESC | 1 |
p.M1524I | BRCA | 1 |
p.N56K | READ | 1 |
p.E876* | UCEC | 1 |
p.Q1541L | LIHC | 1 |
p.C1636Y | UCEC | 1 |
p.S821Y | THYM | 1 |
p.L100F | THYM | 1 |
p.R1558K | UCEC | 1 |
p.T60M | GBM | 1 |
p.E272X | ESCA | 1 |
p.V277A | LUAD | 1 |
p.R1779L | LUSC | 1 |
p.E1291K | ESCA | 1 |
p.R582* | UCEC | 1 |
p.R1389I | UCEC | 1 |
p.D342Y | LGG | 1 |
p.R315X | READ | 1 |
p.G70S | SKCM | 1 |
p.F133L | UCEC | 1 |
p.L555I | LUAD | 1 |
p.S1273Y | UCEC | 1 |
p.S46L | LGG | 1 |
p.K455Q | UCEC | 1 |
p.R181Q | STAD | 1 |
p.S88C | SKCM | 1 |
p.T747I | UCEC | 1 |
p.K1415N | CESC | 1 |
p.F163L | PAAD | 1 |
p.P261S | UCEC | 1 |
p.R465C | COAD | 1 |
p.R176C | BRCA | 1 |
p.M475T | SKCM | 1 |
p.H42Y | STAD | 1 |
p.N528S | UCEC | 1 |
p.T59K | UCS | 1 |
p.F522L | CESC | 1 |
p.L1752I | LUAD | 1 |
p.K331R | COAD | 1 |
p.Q320E | BLCA | 1 |
p.S1051T | BRCA | 1 |
p.L1368V | UCEC | 1 |
p.R593* | UCEC | 1 |
p.D531V | LUAD | 1 |
p.P437L | SKCM | 1 |
p.V503I | LGG | 1 |
p.G1753V | SKCM | 1 |
p.A26T | STAD | 1 |
p.E272Q | ESCA | 1 |
p.G202E | SKCM | 1 |
p.I112V | STAD | 1 |
p.D15H | CESC | 1 |
p.R1004I | UCEC | 1 |
p.L686I | UCEC | 1 |
p.E583X | READ | 1 |
p.N477I | UCEC | 1 |
p.S170F | SKCM | 1 |
p.E826K | UCEC | 1 |
p.K64N | LUSC | 1 |
p.A304V | KIRC | 1 |
p.L631I | UCEC | 1 |
p.S308C | UCEC | 1 |
p.N193S | LUAD | 1 |
p.F1639L | UCEC | 1 |
p.T278I | STAD | 1 |
p.E1468A | UCEC | 1 |
p.E1441K | UCEC | 1 |
p.P884T | ESCA | 1 |
p.R593X | COAD | 1 |
p.G1753R | SKCM | 1 |
p.S46L | UCEC | 1 |
p.R541M | UCEC | 1 |
p.L631I | CHOL | 1 |
p.R9K | SKCM | 1 |
p.D105N | LUAD | 1 |
p.S369C | CESC | 1 |
p.R181Q | SKCM | 1 |
p.I1816N | THYM | 1 |
p.E325K | KIRC | 1 |
p.A290V | HNSC | 1 |
p.I448L | HNSC | 1 |
p.D1732N | SKCM | 1 |
p.N1054H | UCEC | 1 |
p.P289T | OV | 1 |
p.S88I | UCEC | 1 |
p.S1051R | UCEC | 1 |
p.L445F | LUSC | 1 |
p.I930L | UCEC | 1 |
p.F1076L | ESCA | 1 |
p.K253Q | READ | 1 |
p.E727G | SARC | 1 |
p.D535N | SKCM | 1 |
p.P377H | BRCA | 1 |
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TissGeneCNV for ALS2CR11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ALS2CR11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ALS2CR11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ALS2CR11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ALS2CR11 |
TissGeneDrug for ALS2CR11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ALS2CR11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |