TissGeneSummary for CCDC13 |
Gene summary |
Basic gene information | Gene symbol | CCDC13 |
Gene name | coiled-coil domain containing 13 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_144719.3, | |
Description | coiled-coil domain-containing protein 13 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000244607 | ||
HPRD : 08692 | ||
Vega : OTTHUMG00000133046 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC13 | |
BioGPS: 152206 | ||
Pathway | NCI Pathway Interaction Database: CCDC13 | |
KEGG: CCDC13 | ||
REACTOME: CCDC13 | ||
Pathway Commons: CCDC13 | ||
Context | iHOP: CCDC13 | |
ligand binding site mutation search in PubMed: CCDC13 | ||
UCL Cancer Institute: CCDC13 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of CCDC13 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC13 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.637795949 | 1.432534606 | -2.070330556 | 3.18E-28 | 5.16E-27 |
COAD | -1.799701612 | -0.070766996 | -1.728934615 | 2.75E-11 | 4.60E-10 |
THCA | 0.938306993 | 2.124227332 | -1.185920339 | 1.80E-17 | 3.75E-16 |
KICH | 0.117409773 | 1.992193773 | -1.874784 | 6.29E-08 | 2.98E-07 |
LUSC | -1.435348972 | 1.044686322 | -2.480035294 | 1.36E-19 | 1.52E-18 |
LUAD | -0.624775882 | 0.972517221 | -1.597293103 | 2.04E-09 | 1.04E-08 |
STAD | -1.715458102 | -0.304951852 | -1.41050625 | 3.21E-05 | 0.000299556 |
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TissGene-miRNA for CCDC13 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC13 |
TissGeneSNV for CCDC13 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R440L | KIRP | 2 |
p.R592Q | LGG | 2 |
p.R287Q | SKCM | 2 |
p.H82L | OV | 1 |
p.R573W | UCEC | 1 |
p.R84Q | COAD | 1 |
p.M30I | ESCA | 1 |
p.S469C | LIHC | 1 |
p.S613L | LUAD | 1 |
p.R355W | LUAD | 1 |
p.E323K | SKCM | 1 |
p.E603G | LIHC | 1 |
p.D381N | LIHC | 1 |
p.L678M | UCEC | 1 |
p.A187T | STAD | 1 |
p.Q195H | BLCA | 1 |
p.R573W | ESCA | 1 |
p.Q22L | CESC | 1 |
p.E297G | THYM | 1 |
p.G463R | SKCM | 1 |
p.G713V | LIHC | 1 |
p.Q395H | CESC | 1 |
p.E557K | STAD | 1 |
p.D223Y | OV | 1 |
p.D650H | PRAD | 1 |
p.E116K | SKCM | 1 |
p.D249N | ACC | 1 |
p.P65Q | SKCM | 1 |
p.M30I | UCEC | 1 |
p.E343K | HNSC | 1 |
p.K640N | LUAD | 1 |
p.I397S | SKCM | 1 |
p.K73N | LUAD | 1 |
p.A44D | ESCA | 1 |
p.A555D | LGG | 1 |
p.R606H | LUSC | 1 |
p.D46N | HNSC | 1 |
p.N631S | SKCM | 1 |
p.E585D | BRCA | 1 |
p.S70I | HNSC | 1 |
p.T636S | BLCA | 1 |
p.H511N | SARC | 1 |
p.S151T | SKCM | 1 |
p.A181V | HNSC | 1 |
p.R236Q | STAD | 1 |
p.P490L | ESCA | 1 |
p.E72Q | LUSC | 1 |
p.L147V | SKCM | 1 |
p.W262C | COAD | 1 |
p.R119K | UCEC | 1 |
p.E694K | SKCM | 1 |
p.A134T | UCEC | 1 |
p.E694K | UCEC | 1 |
p.V246A | SKCM | 1 |
p.G260R | SKCM | 1 |
p.R460L | SKCM | 1 |
p.V132M | STAD | 1 |
p.E343K | BLCA | 1 |
p.A435V | PAAD | 1 |
p.A332D | READ | 1 |
p.Q195P | KIRP | 1 |
p.Q29K | SARC | 1 |
p.G684V | LIHC | 1 |
p.S613L | BLCA | 1 |
p.L219F | HNSC | 1 |
p.R504G | SKCM | 1 |
p.E93K | COAD | 1 |
p.Q22* | UCEC | 1 |
p.R594C | UCEC | 1 |
p.R25W | COAD | 1 |
p.D45G | LIHC | 1 |
p.P205L | LUAD | 1 |
p.R12W | THCA | 1 |
p.R84Q | READ | 1 |
p.E52D | THYM | 1 |
p.N631Y | LIHC | 1 |
p.I605M | SKCM | 1 |
p.E52D | OV | 1 |
p.R573Q | ACC | 1 |
p.R683W | LGG | 1 |
p.A238T | READ | 1 |
p.A200S | STAD | 1 |
p.E686K | SKCM | 1 |
p.E89K | SKCM | 1 |
p.G63E | BLCA | 1 |
p.T365N | KIRC | 1 |
p.T162N | THYM | 1 |
p.K143N | CESC | 1 |
p.L552F | COAD | 1 |
p.R225Q | UCEC | 1 |
p.R225Q | READ | 1 |
p.S258L | DLBC | 1 |
p.P609Q | LUAD | 1 |
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TissGeneCNV for CCDC13 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC13 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC13 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC13 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC13 |
TissGeneDrug for CCDC13 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC13 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |