TissGeneSummary for CYB5A |
Gene summary |
Basic gene information | Gene symbol | CYB5A |
Gene name | cytochrome b5 type A (microsomal) | |
Synonyms | CYB5|MCB5 | |
Cytomap | UCSC genome browser: 18q23 | |
Type of gene | protein-coding | |
RefGenes | NM_001190807.2, NM_001914.3,NM_148923.3, | |
Description | cytochrome b5type 1 cyt-b5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 613218 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166347 | ||
HPRD : 08941 | ||
Vega : OTTHUMG00000132843 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYB5A | |
BioGPS: 1528 | ||
Pathway | NCI Pathway Interaction Database: CYB5A | |
KEGG: CYB5A | ||
REACTOME: CYB5A | ||
Pathway Commons: CYB5A | ||
Context | iHOP: CYB5A | |
ligand binding site mutation search in PubMed: CYB5A | ||
UCL Cancer Institute: CYB5A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CYB5A | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CYB5A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.91116958 | -0.741134696 | -1.170034884 | 1.18E-05 | 6.64E-05 |
LIHC | 2.868429536 | 4.073571536 | -1.205142 | 4.49E-09 | 4.30E-08 |
KICH | 0.487311536 | 2.240535536 | -1.753224 | 5.26E-10 | 3.52E-09 |
KIRP | 0.354489286 | 2.250411161 | -1.895921875 | 1.17E-11 | 1.63E-10 |
LUAD | 0.792697261 | 2.312947261 | -1.52025 | 1.34E-14 | 1.34E-13 |
LUSC | -0.294410346 | 2.086991615 | -2.381401961 | 4.89E-26 | 1.21E-24 |
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TissGene-miRNA for CYB5A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CYB5A |
TissGeneSNV for CYB5A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P86S | SKCM | 1 |
p.R128H | STAD | 1 |
p.I80L | STAD | 1 |
p.R128C | SKCM | 1 |
p.V123L | STAD | 1 |
p.A124T | STAD | 1 |
p.S76F | SKCM | 1 |
p.L125F | BLCA | 1 |
p.A8T | STAD | 1 |
p.X135L | ESCA | 1 |
p.N93K | BLCA | 1 |
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TissGeneCNV for CYB5A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CYB5A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChimerDB 2.0 | NA | NA | CYB5A-CAPRIN1 | chr18:70110077 | chr11:34075372 | |
Chimerdb3.0 | ChiTaRs | NA | AI110592 | SLC20A2-CYB5A | chr8:42274318 | chr18:71920536 | |
Chimerdb3.0 | ChiTaRs | NA | AI207656 | SLC20A2-CYB5A | chr8:42274318 | chr18:71920531 | |
Chimerdb3.0 | ChiTaRs | NA | BF155251 | CYB5A-ST14 | chr18:71959190 | chr11:130069994 | |
Chimerdb3.0 | ChiTaRs | NA | CB162793 | CYB5A-RPL10 | chr18:71928412 | chrX:153630508 | |
Chimerdb3.0 | ChiTaRs | NA | CB164490 | CYB5A-RPL10 | chr18:71928412 | chrX:153630471 | |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A48N-01A | ZNF407-CYB5A | Out-of-Frame | chr18:72353078 | chr18:71923010 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-67-4679-01B | GOLGA4-CYB5A | In-Frame | chr3:37343823 | chr18:71928179 |
TCGAfusionPortal | PRADA | SKCM | TCGA-D9-A4Z5-01A | CYB5A-DCC | Out-of-frame | Chr18:71958982 | Chr18:50848417 |
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TissGeneNet for CYB5A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CYB5A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CYB5A |
TissGeneDrug for CYB5A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CYB5A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C3277849 | 17,20-Lyase Deficiency, Isolated | 3 | BeFree |
umls:C0272087 | Congenital Methemoglobinemia | 2 | BeFree |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0014175 | Endometriosis | 1 | CTD_human |
umls:C0028754 | Obesity | 1 | CTD_human |
umls:C0034186 | Pyelonephritis | 1 | RGD |
umls:C0085215 | Ovarian Failure, Premature | 1 | BeFree |
umls:C0206667 | Adrenal Cortical Adenoma | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C2749559 | Methemoglobinemia, Type I | 1 | BeFree |
umls:C2751824 | 46, XY Disorders of Sex Development | 1 | BeFree |
umls:C3665425 | Hemoglobin M Disease | 1 | BeFree |
umls:C0268285 | Adrenal hyperplasia, congenital, type 5 | 0 | ORPHANET |
umls:C2673427 | METHEMOGLOBINEMIA TYPE IV | 0 | CLINVAR,CTD_human |