TissGeneSummary for SLC36A2 |
Gene summary |
Basic gene information | Gene symbol | SLC36A2 |
Gene name | solute carrier family 36 (proton/amino acid symporter), member 2 | |
Synonyms | PAT2|TRAMD1 | |
Cytomap | UCSC genome browser: 5q33.1 | |
Type of gene | protein-coding | |
RefGenes | NM_181776.2, | |
Description | proton-coupled amino acid transporter 2tramdorin-1 | |
Modification date | 20141210 | |
dbXrefs | MIM : 608331 | |
HGNC : HGNC | ||
Ensembl : ENSG00000186335 | ||
HPRD : 12215 | ||
Vega : OTTHUMG00000130129 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC36A2 | |
BioGPS: 153201 | ||
Pathway | NCI Pathway Interaction Database: SLC36A2 | |
KEGG: SLC36A2 | ||
REACTOME: SLC36A2 | ||
Pathway Commons: SLC36A2 | ||
Context | iHOP: SLC36A2 | |
ligand binding site mutation search in PubMed: SLC36A2 | ||
UCL Cancer Institute: SLC36A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC36A2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC36A2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.927048532 | 4.639591468 | -6.56664 | 9.48E-10 | 5.97E-09 |
BRCA | -2.023636918 | -0.845009725 | -1.178627193 | 6.36E-14 | 3.06E-13 |
KIRP | -0.212038782 | 6.728126843 | -6.940165625 | 2.08E-11 | 2.70E-10 |
KIRC | -0.013939477 | 5.470713301 | -5.484652778 | 3.60E-15 | 1.82E-14 |
HNSC | -0.715948811 | 0.996562817 | -1.712511628 | 0.0042 | 0.011595092 |
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TissGene-miRNA for SLC36A2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC36A2 |
TissGeneSNV for SLC36A2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H142Y | SKCM | 2 |
p.A445V | COAD | 2 |
p.E8V | GBM | 1 |
p.E363K | BLCA | 1 |
p.Y265F | LIHC | 1 |
p.A397V | CESC | 1 |
p.N134Y | PCPG | 1 |
p.S371F | SKCM | 1 |
p.M289I | LGG | 1 |
p.L131I | LUAD | 1 |
p.E470K | CESC | 1 |
p.E31D | UCEC | 1 |
p.H62Y | SKCM | 1 |
p.S22X | ESCA | 1 |
p.P210H | LUAD | 1 |
p.P361S | SKCM | 1 |
p.P210L | SKCM | 1 |
p.R320Q | GBM | 1 |
p.S341F | UCEC | 1 |
p.S476F | SKCM | 1 |
p.S300Y | LUAD | 1 |
p.S330N | BRCA | 1 |
p.P401S | SKCM | 1 |
p.F112L | STAD | 1 |
p.G74E | SKCM | 1 |
p.M199I | SKCM | 1 |
p.A314V | READ | 1 |
p.N186S | UCEC | 1 |
p.A462T | SKCM | 1 |
p.Y432C | STAD | 1 |
p.G302V | STAD | 1 |
p.R293C | STAD | 1 |
p.S228F | SKCM | 1 |
p.M121I | HNSC | 1 |
p.G280R | OV | 1 |
p.E465K | SKCM | 1 |
p.A170V | UCEC | 1 |
p.L345P | LUAD | 1 |
p.G66D | SKCM | 1 |
p.S308F | SKCM | 1 |
p.T353S | LIHC | 1 |
p.S35C | KIRP | 1 |
p.E363G | SKCM | 1 |
p.S478F | SKCM | 1 |
p.L173S | SKCM | 1 |
p.A98V | STAD | 1 |
p.A314V | ESCA | 1 |
p.M68R | STAD | 1 |
p.G302V | OV | 1 |
p.V150L | CESC | 1 |
p.L446M | LUAD | 1 |
p.L381Q | KIRP | 1 |
p.A82V | HNSC | 1 |
p.T126M | UCEC | 1 |
p.V413M | BRCA | 1 |
p.S300Y | STAD | 1 |
p.E132Q | LUSC | 1 |
p.S22L | PAAD | 1 |
p.L405R | STAD | 1 |
p.R111H | PRAD | 1 |
p.S189P | LIHC | 1 |
p.A13V | THYM | 1 |
p.V79L | READ | 1 |
p.L316Q | LIHC | 1 |
p.A143T | HNSC | 1 |
p.R483W | UCS | 1 |
p.N185Y | LUSC | 1 |
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TissGeneCNV for SLC36A2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC36A2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK122630 | SLC36A2-RPL24 | chr5:150727123 | chr3:101399942 | |
Chimerdb3.0 | ChiTaRs | NA | AI469343 | OIP5-AS1-SLC36A2 | chr15:41591279 | chr5:150713380 |
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TissGeneNet for SLC36A2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC36A2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC36A2 |
TissGeneDrug for SLC36A2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC36A2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007570 | Celiac Disease | 1 | GAD |
umls:C0268654 | Iminoglycinuria | 1 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0543541 | HYPERGLYCINURIA (disorder) | 1 | CLINVAR,CTD_human,UNIPROT |