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| TissGeneSummary for BTNL9 |
 Gene summary |
| Basic gene information | Gene symbol | BTNL9 |
| Gene name | butyrophilin-like 9 | |
| Synonyms | BTN3|BTN8|VDLS1900 | |
| Cytomap | UCSC genome browser: 5q35.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152547.4, | |
| Description | butyrophilin 3butyrophilin-like protein 9 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000165810 | ||
| HPRD : 12550 | ||
| Vega : OTTHUMG00000133152 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BTNL9 | |
| BioGPS: 153579 | ||
| Pathway | NCI Pathway Interaction Database: BTNL9 | |
| KEGG: BTNL9 | ||
| REACTOME: BTNL9 | ||
| Pathway Commons: BTNL9 | ||
| Context | iHOP: BTNL9 | |
| ligand binding site mutation search in PubMed: BTNL9 | ||
| UCL Cancer Institute: BTNL9 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASARC | |
| Reference showing the relevant tissue of BTNL9 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for BTNL9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -1.483187612 | 0.869771763 | -2.352959375 | 8.33E-11 | 9.73E-10 |
| BRCA | -0.698931362 | 3.617166884 | -4.316098246 | 2.45E-60 | 7.89E-58 |
| LUAD | -1.341129638 | 3.068268638 | -4.409398276 | 3.45E-33 | 6.45E-31 |
| KIRC | 2.407833916 | 0.921770027 | 1.486063889 | 6.19E-12 | 2.46E-11 |
| LUSC | -1.781456852 | 3.211194129 | -4.99265098 | 6.10E-23 | 1.03E-21 |
| HNSC | -2.332475548 | -1.205633687 | -1.12684186 | 0.00356 | 0.010139241 |
| BLCA | -1.839989256 | 0.499610744 | -2.3396 | 8.04E-05 | 0.000926475 |
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| TissGene-miRNA for BTNL9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for BTNL9 |
| TissGeneSNV for BTNL9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.H384Y | ACC | 4 |
| p.A314S | KIRC | 1 |
| p.F75S | SKCM | 1 |
| p.A219G | HNSC | 1 |
| p.L173F | STAD | 1 |
| p.E166K | SKCM | 1 |
| p.W146* | SKCM | 1 |
| p.R392L | ACC | 1 |
| p.R76W | SKCM | 1 |
| p.S122N | LGG | 1 |
| p.G114V | COAD | 1 |
| p.W186R | STAD | 1 |
| p.E56G | COAD | 1 |
| p.R313W | UCEC | 1 |
| p.R443H | BRCA | 1 |
| p.R313L | LUSC | 1 |
| p.G168D | HNSC | 1 |
| p.G132V | UCEC | 1 |
| p.G458R | HNSC | 1 |
| p.N81S | SKCM | 1 |
| p.A261P | CHOL | 1 |
| p.N231K | LUAD | 1 |
| p.H121Y | BLCA | 1 |
| p.A481S | PRAD | 1 |
| p.A314G | KIRC | 1 |
| p.E199* | ACC | 1 |
| p.W146* | LUSC | 1 |
| p.L232F | HNSC | 1 |
| p.D467N | BLCA | 1 |
| p.A439T | COAD | 1 |
| p.K12M | COAD | 1 |
| p.A439S | LUSC | 1 |
| p.L26P | LIHC | 1 |
| p.L106M | LIHC | 1 |
| p.F140L | UCEC | 1 |
| p.A481T | LIHC | 1 |
| p.V55M | LUSC | 1 |
| p.A481V | COAD | 1 |
| p.A434V | BLCA | 1 |
| p.E71K | SKCM | 1 |
| p.R447Q | STAD | 1 |
| p.S10F | SKCM | 1 |
| p.S349R | LUAD | 1 |
| p.V202I | UCEC | 1 |
| p.V82M | PAAD | 1 |
| p.L106F | ESCA | 1 |
| p.R187T | BRCA | 1 |
| p.C59Y | COAD | 1 |
| p.S223R | OV | 1 |
| p.F140L | BLCA | 1 |
| p.L522I | PAAD | 1 |
| p.A457V | OV | 1 |
| p.R489M | LUAD | 1 |
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| TissGeneCNV for BTNL9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for BTNL9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF919146 | BTNL9-LSM14B | chr5:180469231 | chr20:60709217 |
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| TissGeneNet for BTNL9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for BTNL9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for BTNL9 |
| TissGeneDrug for BTNL9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for BTNL9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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