TissGeneSummary for CCDC112 |
Gene summary |
Basic gene information | Gene symbol | CCDC112 |
Gene name | coiled-coil domain containing 112 | |
Synonyms | MBC1 | |
Cytomap | UCSC genome browser: 5q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001040440.2, NM_152549.2, | |
Description | coiled-coil domain-containing protein 112mutated in bladder cancer 1mutated in bladder cancer protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164221 | ||
HPRD : 11346 | ||
Vega : OTTHUMG00000128894 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC112 | |
BioGPS: 153733 | ||
Pathway | NCI Pathway Interaction Database: CCDC112 | |
KEGG: CCDC112 | ||
REACTOME: CCDC112 | ||
Pathway Commons: CCDC112 | ||
Context | iHOP: CCDC112 | |
ligand binding site mutation search in PubMed: CCDC112 | ||
UCL Cancer Institute: CCDC112 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC112 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CCDC112 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -2.413609124 | -3.513721124 | 1.100112 | 8.62E-06 | 3.70E-05 |
Top |
TissGene-miRNA for CCDC112 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-330-3p | MIMAT0000751 | 0.022 | -0.26 | 78 |
ACC | hsa-miR-330-3p | MIMAT0000751 | 0.022 | -0.26 | 78 |
Top |
TissGeneMut for CCDC112 |
TissGeneSNV for CCDC112 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q354H | UCEC | 2 |
p.W521C | BRCA | 1 |
p.R72C | BRCA | 1 |
p.E443X | ESCA | 1 |
p.Q465H | PAAD | 1 |
p.K398Q | UCEC | 1 |
p.A357S | LUAD | 1 |
p.E321K | GBM | 1 |
p.E120K | UCEC | 1 |
p.Q173H | CESC | 1 |
p.G248V | LUAD | 1 |
p.L106I | ESCA | 1 |
p.N343K | KIRC | 1 |
p.E359K | THYM | 1 |
p.K318Q | UCEC | 1 |
p.E286G | PRAD | 1 |
p.D87Y | UCEC | 1 |
p.R319G | THYM | 1 |
p.E413X | READ | 1 |
p.Q344K | KIRC | 1 |
p.R393C | KICH | 1 |
p.E497Q | BLCA | 1 |
p.K378E | KIRC | 1 |
p.E302X | COAD | 1 |
p.K385R | HNSC | 1 |
p.S216L | LUSC | 1 |
p.Q465H | UCEC | 1 |
p.T168N | UCEC | 1 |
p.E178D | PRAD | 1 |
p.G165V | LUAD | 1 |
p.R246* | BRCA | 1 |
p.S403I | UCEC | 1 |
p.A274S | LUAD | 1 |
p.S134N | PAAD | 1 |
p.E384D | UCEC | 1 |
p.K383T | UCEC | 1 |
p.D252N | READ | 1 |
p.S217N | PAAD | 1 |
p.Q139* | SKCM | 1 |
p.Q394L | LUAD | 1 |
p.Q382H | PAAD | 1 |
p.Q465E | OV | 1 |
p.I513V | LGG | 1 |
p.E291Q | UCEC | 1 |
p.R393C | ESCA | 1 |
Top |
TissGeneCNV for CCDC112 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CCDC112 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CA418157 | CCDC112-FN1 | chr5:114612742 | chr2:216226054 |
Top |
TissGeneNet for CCDC112 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CCDC112 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CCDC112 |
TissGeneDrug for CCDC112 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CCDC112 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |