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| TissGeneSummary for NKAIN2 |
 Gene summary |
| Basic gene information | Gene symbol | NKAIN2 |
| Gene name | Na+/K+ transporting ATPase interacting 2 | |
| Synonyms | FAM77B|NKAIP2|TCBA|TCBA1 | |
| Cytomap | UCSC genome browser: 6q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001040214.2, NM_001300737.1,NM_001300738.1,NM_001300740.1,NM_153355.4, | |
| Description | Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2T-cell lymphoma breakpoint-associated target protein 1sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 | |
| Modification date | 20141217 | |
| dbXrefs | MIM : 609758 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000188580 | ||
| HPRD : 18168 | ||
| Vega : OTTHUMG00000015500 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NKAIN2 | |
| BioGPS: 154215 | ||
| Pathway | NCI Pathway Interaction Database: NKAIN2 | |
| KEGG: NKAIN2 | ||
| REACTOME: NKAIN2 | ||
| Pathway Commons: NKAIN2 | ||
| Context | iHOP: NKAIN2 | |
| ligand binding site mutation search in PubMed: NKAIN2 | ||
| UCL Cancer Institute: NKAIN2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of NKAIN2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NKAIN2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.646041148 | -0.809519273 | -1.836521875 | 1.68E-05 | 6.73E-05 |
| LUSC | 1.439315163 | -2.330988758 | 3.770303922 | 8.68E-16 | 6.05E-15 |
| KIRC | -3.004772745 | -0.957143578 | -2.047629167 | 8.04E-17 | 4.67E-16 |
| KICH | -3.228868523 | -0.710892523 | -2.517976 | 5.21E-09 | 2.91E-08 |
| BRCA | -1.591213681 | -0.102810172 | -1.488403509 | 2.67E-21 | 2.10E-20 |
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| TissGene-miRNA for NKAIN2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-369-3p | MIMAT0000721 | 0.03 | -0.29 | 56 |
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| TissGeneMut for NKAIN2 |
| TissGeneSNV for NKAIN2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q191H | BLCA | 1 |
| p.G87A | DLBC | 1 |
| p.S187C | LUAD | 1 |
| p.V73I | BRCA | 1 |
| p.E107K | SKCM | 1 |
| p.I44N | BRCA | 1 |
| p.V117L | LUAD | 1 |
| p.I96T | SKCM | 1 |
| p.G112R | SKCM | 1 |
| p.Q202* | BLCA | 1 |
| p.W108C | BLCA | 1 |
| p.M204I | SKCM | 1 |
| p.M137I | SKCM | 1 |
| p.Y65H | BRCA | 1 |
| p.L89P | STAD | 1 |
| p.A149V | LGG | 1 |
| p.E174K | SKCM | 1 |
| p.R132C | SKCM | 1 |
| p.K91R | STAD | 1 |
| p.D180N | SKCM | 1 |
| p.P124L | ACC | 1 |
| p.R60C | BLCA | 1 |
| p.I13M | LUAD | 1 |
| p.V21E | LUAD | 1 |
| p.N100K | STAD | 1 |
| p.V168F | UCEC | 1 |
| p.C177* | LUAD | 1 |
| p.S90* | LUAD | 1 |
| p.Q194* | LUSC | 1 |
| p.Y143* | LUAD | 1 |
| p.Q17X | STAD | 1 |
| p.Q17* | STAD | 1 |
| p.F41V | UCEC | 1 |
| p.R105Q | HNSC | 1 |
| p.W108C | BRCA | 1 |
| p.G185R | SKCM | 1 |
| p.A127T | SKCM | 1 |
| p.R60C | CESC | 1 |
| p.R58I | LUSC | 1 |
| p.W108C | ESCA | 1 |
| p.A158T | STAD | 1 |
| p.F29L | LUSC | 1 |
| p.M204T | LUAD | 1 |
| p.G53R | SKCM | 1 |
| p.A165S | ESCA | 1 |
| p.E92Q | BLCA | 1 |
| p.S152F | SKCM | 1 |
| p.S102L | SARC | 1 |
| p.Q25H | SKCM | 1 |
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| TissGeneCNV for NKAIN2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NKAIN2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW813844 | NKAIN2-NEK1 | chr6:124812714 | chr4:170407936 | |
| Chimerdb3.0 | ChiTaRs | NA | R15394 | NKAIN2-MYOT | chr6:124303917 | chr5:137088370 | |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-33-6737-01A | NKAIN2-MS4A12 | CDS-5'UTR | chr6:124979532 | chr11:60264785 |
| Chimerdb3.0 | TopHat-Fusion | UVM | TCGA-VD-A8KJ-01A | SERINC1-NKAIN2 | In-Frame | chr6:122792843 | chr6:124242778 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A1IX-01A | SNX14-NKAIN2 | Out-of-frame | Chr6:86303297 | Chr6:124604151 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-33-6737-01A | NKAIN2-MS4A12 | CDS-5UTR | Chr6:124979532 | Chr11:60264786 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-66-2759-01A | MAP3K5-NKAIN2 | In-frame | Chr6:137041588 | Chr6:125112485 |
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| TissGeneNet for NKAIN2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for NKAIN2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NKAIN2 |
| TissGeneDrug for NKAIN2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NKAIN2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0079772 | T-Cell Lymphoma | 2 | BeFree,LHGDN |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
| umls:C0007570 | Celiac Disease | 1 | GWASCAT |
| umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0027932 | Neurotic Disorders | 1 | GAD |
| umls:C0031099 | Periodontitis | 1 | GWASCAT |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0424605 | Developmental delay (disorder) | 1 | BeFree |
| umls:C0518014 | Hematocrit level | 1 | GAD |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1842981 | NEUROTICISM | 1 | BeFree,GAD,GWASCAT |
| umls:C1846064 | Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 1 | BeFree |
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