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| TissGeneSummary for CYP1A2 |
 Gene summary |
| Basic gene information | Gene symbol | CYP1A2 |
| Gene name | cytochrome P450, family 1, subfamily A, polypeptide 2 | |
| Synonyms | CP12|P3-450|P450(PA) | |
| Cytomap | UCSC genome browser: 15q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000761.4, | |
| Description | CYPIA2P450 form 4aryl hydrocarbon hydroxylasecytochrome P(3)450cytochrome P450 1A2cytochrome P450 4cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2cytochrome P450-P3dioxin-inducible P3-450flavoprotein-linked monooxygenase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 124060 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140505 | ||
| HPRD : 00489 | ||
| Vega : OTTHUMG00000172901 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP1A2 | |
| BioGPS: 1544 | ||
| Pathway | NCI Pathway Interaction Database: CYP1A2 | |
| KEGG: CYP1A2 | ||
| REACTOME: CYP1A2 | ||
| Pathway Commons: CYP1A2 | ||
| Context | iHOP: CYP1A2 | |
| ligand binding site mutation search in PubMed: CYP1A2 | ||
| UCL Cancer Institute: CYP1A2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CYP1A2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009403 | toxin biosynthetic process | 11511187 | GO:0009820 | alkaloid metabolic process | 11511187 | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 15327587 | GO:0032787 | monocarboxylic acid metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0046483 | heterocycle metabolic process | 15327587 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 18619574 | GO:0071615 | oxidative deethylation | 19029318 | GO:0009403 | toxin biosynthetic process | 11511187 | GO:0009820 | alkaloid metabolic process | 11511187 | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 15327587 | GO:0032787 | monocarboxylic acid metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0046483 | heterocycle metabolic process | 15327587 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 18619574 | GO:0071615 | oxidative deethylation | 19029318 |
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| TissGeneExp for CYP1A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -2.197167903 | -0.129351236 | -2.067816667 | 5.92E-23 | 5.87E-22 |
| LUAD | -1.642483612 | 2.250914664 | -3.893398276 | 2.46E-26 | 1.31E-24 |
| LUSC | -1.868263328 | 1.994371966 | -3.862635294 | 4.47E-27 | 1.27E-25 |
| LIHC | 4.355332319 | 11.73810632 | -7.382774 | 3.18E-16 | 1.22E-14 |
| KICH | 2.469854319 | 0.383442319 | 2.086412 | 0.00389 | 0.00752727 |
| HNSC | -2.103185216 | -1.054448006 | -1.048737209 | 5.09E-05 | 0.000245236 |
| KIRP | -1.815098806 | -0.190223806 | -1.624875 | 3.86E-05 | 0.000144235 |
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| TissGene-miRNA for CYP1A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP1A2 |
| TissGeneSNV for CYP1A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V483M | UCEC | 2 |
| p.V483M | BRCA | 2 |
| p.D393N | SKCM | 2 |
| p.G30D | BLCA | 1 |
| p.M448I | CESC | 1 |
| p.S155F | SKCM | 1 |
| p.W466X | SKCM | 1 |
| p.H378N | LUAD | 1 |
| p.R358W | PAAD | 1 |
| p.T284M | COAD | 1 |
| p.R503L | HNSC | 1 |
| p.D490N | SKCM | 1 |
| p.R510W | UCEC | 1 |
| p.R296T | BLCA | 1 |
| p.R457L | HNSC | 1 |
| p.G486V | UCEC | 1 |
| p.L51V | BRCA | 1 |
| p.P295L | COAD | 1 |
| p.D104N | LUSC | 1 |
| p.P337L | SKCM | 1 |
| p.S156L | SKCM | 1 |
| p.R79C | LGG | 1 |
| p.P8S | SKCM | 1 |
| p.R512C | STAD | 1 |
| p.R90H | COAD | 1 |
| p.A97T | KIRC | 1 |
| p.E211K | HNSC | 1 |
| p.V409A | LUAD | 1 |
| p.I302M | THCA | 1 |
| p.R355L | STAD | 1 |
| p.Q77H | BLCA | 1 |
| p.P8L | SKCM | 1 |
| p.P246S | UCS | 1 |
| p.A502T | COAD | 1 |
| p.G30C | SKCM | 1 |
| p.Q101R | UCEC | 1 |
| p.R356W | PRAD | 1 |
| p.R243C | SKCM | 1 |
| p.D282N | SKCM | 1 |
| p.R137W | SKCM | 1 |
| p.E162K | SKCM | 1 |
| p.G460R | UCEC | 1 |
| p.E346Q | HNSC | 1 |
| p.R136H | STAD | 1 |
| p.W466* | SKCM | 1 |
| p.K59N | ESCA | 1 |
| p.R90C | COAD | 1 |
| p.E211K | LUAD | 1 |
| p.R137W | UCEC | 1 |
| p.A150T | UCS | 1 |
| p.D104N | SKCM | 1 |
| p.T83M | KICH | 1 |
| p.A435S | THYM | 1 |
| p.S298R | DLBC | 1 |
| p.D103N | SKCM | 1 |
| p.G294E | UCEC | 1 |
| p.A140S | UCEC | 1 |
| p.P84L | SKCM | 1 |
| p.K442N | SARC | 1 |
| p.P484T | OV | 1 |
| p.A19T | GBM | 1 |
| p.Q177P | KIRP | 1 |
| p.S327F | SKCM | 1 |
| p.A286D | UCEC | 1 |
| p.K500E | STAD | 1 |
| p.R243G | BLCA | 1 |
| p.R100Q | COAD | 1 |
| p.V192M | KIRP | 1 |
| p.V85M | LGG | 1 |
| p.D490G | STAD | 1 |
| p.R108Q | OV | 1 |
| p.K488I | COAD | 1 |
| p.H224Q | SARC | 1 |
| p.D214N | SARC | 1 |
| p.Y400H | UCEC | 1 |
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| TissGeneCNV for CYP1A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP1A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CYP1A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP1A2, POR (tumor) | CYP1A2, POR (normal) |
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| TissGeneProg for CYP1A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP1A2 |
| TissGeneDrug for CYP1A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CYP1A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 28 | BeFree,GAD |
| umls:C1527249 | Colorectal Cancer | 28 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 24 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 23 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 20 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 19 | BeFree |
| umls:C0684249 | Carcinoma of lung | 17 | BeFree |
| umls:C2239176 | Liver carcinoma | 15 | BeFree,GAD,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 13 | BeFree,GAD |
| umls:C0152115 | Lingual-Facial-Buccal Dyskinesia | 13 | BeFree,GAD |
| umls:C0686347 | Tardive Dyskinesia | 13 | BeFree,GAD |
| umls:C0023903 | Liver neoplasms | 8 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 8 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 7 | BeFree,GAD |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 5 | BeFree,GAD,LHGDN |
| umls:C0009404 | Colorectal Neoplasms | 5 | CTD_human,GAD,LHGDN |
| umls:C0023895 | Liver diseases | 4 | BeFree,CTD_human,GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 4 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 4 | GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree,GAD |
| umls:C0162566 | Porphyria Cutanea Tarda | 4 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0476089 | Endometrial Carcinoma | 4 | BeFree,GAD |
| umls:C1140680 | Malignant neoplasm of ovary | 4 | BeFree,GAD |
| umls:C1302401 | Adenoma of large intestine | 4 | BeFree |
| umls:C0001418 | Adenocarcinoma | 3 | BeFree |
| umls:C0004096 | Asthma | 3 | BeFree,GAD |
| umls:C0005695 | Bladder Neoplasm | 3 | BeFree,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 3 | GAD |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD,LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
| umls:C0241910 | Hepatitis, Autoimmune | 3 | BeFree |
| umls:C0243026 | Sepsis | 3 | BeFree,RGD |
| umls:C0345904 | Malignant neoplasm of liver | 3 | GAD |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree,GAD |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C1263733 | Uroporphyrinuria | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | BeFree,GAD |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0007113 | Rectal Carcinoma | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,CTD_human |
| umls:C0014170 | Endometrial Neoplasms | 2 | GAD |
| umls:C0014859 | Esophageal Neoplasms | 2 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 2 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 2 | GAD |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree |
| umls:C0023904 | Liver Neoplasms, Experimental | 2 | CTD_human |
| umls:C0024121 | Lung Neoplasms | 2 | CTD_human,LHGDN |
| umls:C0026640 | Mouth Neoplasms | 2 | GAD |
| umls:C0030297 | Pancreatic Neoplasm | 2 | GAD,LHGDN |
| umls:C0030567 | Parkinson Disease | 2 | GAD |
| umls:C0031347 | Pharyngeal Neoplasms | 2 | GAD |
| umls:C0032708 | Disorders of Porphyrin Metabolism | 2 | GAD |
| umls:C0085859 | Polyglandular Type I Autoimmune Syndrome | 2 | BeFree |
| umls:C0149782 | Squamous cell carcinoma of lung | 2 | BeFree |
| umls:C0149931 | Migraine Disorders | 2 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0221765 | Chronic schizophrenia | 2 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0949059 | Polyp of large intestine | 2 | BeFree |
| umls:C1276127 | Sporadic porphyria cutanea tarda | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | LHGDN |
| umls:C1512409 | Hepatocarcinogenesis | 2 | BeFree |
| umls:C1623038 | Cirrhosis | 2 | BeFree |
| umls:C1846502 | Mammographic Density | 2 | BeFree,GAD |
| umls:C1960870 | Transformed migraine | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0001627 | Congenital adrenal hyperplasia | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree,GAD |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005411 | Biliary Atresia | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0008925 | Cleft Palate | 1 | BeFree |
| umls:C0009376 | Colonic Polyps | 1 | GAD |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0011581 | Depressive disorder | 1 | RGD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| umls:C0011991 | Diarrhea | 1 | GAD |
| umls:C0013386 | Dyskinesia, Drug-Induced | 1 | GAD |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0014544 | Epilepsy | 1 | GAD |
| umls:C0018273 | Growth Disorders | 1 | CTD_human |
| umls:C0019209 | Hepatomegaly | 1 | CTD_human |
| umls:C0022346 | Icterus | 1 | RGD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | LHGDN |
| umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| umls:C0024301 | Lymphoma, Follicular | 1 | GAD |
| umls:C0025500 | Mesothelioma | 1 | GAD |
| umls:C0025637 | Methemoglobinemia | 1 | CTD_human |
| umls:C0027497 | Nausea | 1 | GAD |
| umls:C0027794 | Neural Tube Defects | 1 | CTD_human,GAD |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0032229 | Pleural Neoplasms | 1 | GAD |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0033774 | Pruritus | 1 | GAD |
| umls:C0035220 | Respiratory Distress Syndrome, Newborn | 1 | BeFree |
| umls:C0036349 | Paranoid Schizophrenia | 1 | LHGDN |
| umls:C0037997 | Splenic Diseases | 1 | CTD_human |
| umls:C0038002 | Splenomegaly | 1 | CTD_human |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0039590 | Testicular Neoplasms | 1 | LHGDN |
| umls:C0040053 | Thrombosis | 1 | GAD |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0042963 | Vomiting | 1 | GAD |
| umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | GAD |
| umls:C0085096 | Peripheral Vascular Diseases | 1 | BeFree |
| umls:C0085602 | Polydipsia | 1 | BeFree,GAD |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153500 | Malignant neoplasm of heart | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | GAD |
| umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
| umls:C0206139 | Lichen Planus, Oral | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | GAD |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0220810 | Congenital defects | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | GAD |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0241880 | Endometriosis of pelvis | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | GAD |
| umls:C0273115 | Lung Injury | 1 | CTD_human |
| umls:C0279680 | Transitional cell carcinoma of bladder | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0333641 | Atrophic | 1 | CTD_human |
| umls:C0341439 | Chronic liver disease | 1 | BeFree |
| umls:C0392702 | Abnormal involuntary movement | 1 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0476273 | Respiratory distress | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
| umls:C0596321 | Chemical Carcinogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0600142 | Hot flushes | 1 | BeFree,GAD |
| umls:C0795878 | Monosomy 22 | 1 | BeFree |
| umls:C0809983 | Schizophrenia and related disorders | 1 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
| umls:C0887833 | Carcinoma, Pancreatic Ductal | 1 | GAD |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
| umls:C0919532 | Genomic Instability | 1 | GAD |
| umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree,GAD |
| umls:C1269683 | Major Depressive Disorder | 1 | GAD |
| umls:C1336708 | Testicular Germ Cell Tumor | 1 | GAD |
| umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C1959584 | Cardiac Carcinoma | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| umls:C2919093 | caffeine stimulant related disorder | 1 | GAD |
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