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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP2B6
check button Gene summary
Basic gene informationGene symbolCYP2B6
Gene namecytochrome P450, family 2, subfamily B, polypeptide 6
SynonymsCPB6|CYP2B|CYP2B7|CYP2B7P|CYPIIB6|EFVM|IIB1|P450
CytomapUCSC genome browser: 19q13.2
Type of geneprotein-coding
RefGenesNM_000767.4,
Description1,4-cineole 2-exo-monooxygenasecytochrome P450 2B6cytochrome P450 IIB1cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
Modification date20141222
dbXrefs MIM : 123930
HGNC : HGNC
Ensembl : ENSG00000197408
HPRD : 00477
Vega : OTTHUMG00000182714
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP2B6
BioGPS: 1555
PathwayNCI Pathway Interaction Database: CYP2B6
KEGG: CYP2B6
REACTOME: CYP2B6
Pathway Commons: CYP2B6
ContextiHOP: CYP2B6
ligand binding site mutation search in PubMed: CYP2B6
UCL Cancer Institute: CYP2B6
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of CYP2B6Oxidative metabolism of BDE-99 by human liver microsomes: predominant role of CYP2B6. Erratico CA, Szeitz A, Bandiera SM. Toxicol Sci. 2012 Oct;129(2):280-92. doi: 10.1093/toxsci/kfs215. Epub 2012 Jun 27. (pmid:22738989)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006805xenobiotic metabolic process20061448
GO:0017144drug metabolic process19651758
GO:0042180cellular ketone metabolic process19651758
GO:0042738exogenous drug catabolic process19029318
GO:0055114oxidation-reduction process19651758
GO:0006805xenobiotic metabolic process20061448
GO:0017144drug metabolic process19651758
GO:0042180cellular ketone metabolic process19651758
GO:0042738exogenous drug catabolic process19029318
GO:0055114oxidation-reduction process19651758


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TissGeneExp for CYP2B6

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-2.608046933-0.84903909-1.7590078431.18E-169.04E-16
KIRP-1.7376267744.381923226-6.119551.50E-176.86E-16
KIRC-1.5240875383.743336073-5.2674236112.20E-283.63E-27
BRCA-1.353753693-2.6375089561.2837552639.98E-103.57E-09
KICH-3.1025581492.886621851-5.989182.44E-122.66E-11
LIHC6.99134185110.57291385-3.5815728.81E-142.17E-12
ESCA3.194959306-2.5597679675.7547272730.001430.018490233
STAD2.736395101-0.1767173992.91311250.0004980.003018873


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TissGene-miRNA for CYP2B6

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CYP2B6
TissGeneSNV for CYP2B6

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E445KSKCM2
p.R187QSKCM2
p.A407TUCEC2
p.R120CSKCM1
p.E93DLUSC1
p.R253HLGG1
p.F58LLUAD1
p.S294LESCA1
p.F169LBLCA1
p.E273KSKCM1
p.A425DBLCA1
p.R85QLUAD1
p.S141NUCEC1
p.A444ELUAD1
p.L340FUCEC1
p.P465SLUAD1
p.A279TUCEC1
p.Q357HBLCA1
p.D192HBLCA1
p.M365ISKCM1
p.Y203HGBM1
p.G71*HNSC1
p.R443HUCEC1
p.F202LLUSC1
p.Q357XLIHC1
p.L88PHNSC1
p.E355GLIHC1
p.T292MCOAD1
p.R308HGBM1
p.G71RSKCM1
p.E240KLUSC1
p.A260TUCEC1
p.G80RSKCM1
p.R35HPRAD1
p.S96YPRAD1
p.R126*UCEC1
p.L470VHNSC1
p.R343QSKCM1
p.E282KSKCM1
p.F429LLGG1
p.D134NTHYM1
p.F202LBLCA1
p.P10LSKCM1
p.R253HUCEC1
p.S277FSKCM1
p.L288ILUAD1
p.S284CGBM1
p.H252RSTAD1
p.R120CUCEC1
p.A260TLUAD1
p.G118ESKCM1
p.Q172HCOAD1
p.P481LSKCM1
p.P258SSTAD1
p.S173FSKCM1
p.P383SSKCM1
p.Q239*GBM1
p.P364LSKCM1
p.R35HCOAD1
p.M165ISKCM1
p.K251MBRCA1
p.P364SUCEC1
p.F108CSKCM1
p.V113ELUAD1
p.A407SBLCA1
p.E350GBRCA1
p.R378*OV1
p.T67MBRCA1
p.V75MSTAD1
p.R378LLUAD1
p.I179VPRAD1
p.G118RSKCM1
p.G162ESKCM1
p.E144KSKCM1
p.P410LBLCA1
p.V183ICOAD1
p.I381MBLCA1
p.P106ABRCA1
p.G136ESKCM1
p.M46VDLBC1
p.T303IKIRC1
p.A176THNSC1
p.I468MLUSC1
p.A442TUCEC1
p.A444VSTAD1
p.L392MUCEC1
p.R59QSKCM1
p.H341NACC1
p.V81AACC1
p.D266NSTAD1
p.P32LLIHC1
p.G136RSTAD1
p.M132ISKCM1
p.K404ESKCM1
p.R358IUCEC1
p.E275DUCEC1
p.Q286LHNSC1
p.E350KSKCM1
p.E82DPAAD1
p.V212AUCEC1


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TissGeneCNV for CYP2B6

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CYP2B6

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CYP2B6

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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COAD (tumor)COAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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HNSC (tumor)HNSC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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KICH (tumor)KICH (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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KIRC (tumor)KIRC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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KIRP (tumor)KIRP (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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LIHC (tumor)LIHC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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LUAD (tumor)LUAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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LUSC (tumor)LUSC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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PRAD (tumor)PRAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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STAD (tumor)STAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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THCA (tumor)THCA (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)
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TissGeneProg for CYP2B6

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CYP2B6
TissGeneDrug for CYP2B6

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB04794BifonazoleSmall moleculeApproved


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TissGeneDisease for CYP2B6

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019693HIV Infections65BeFree,GAD
umls:C0006142Malignant neoplasm of breast36BeFree,GAD
umls:C0678222Breast Carcinoma32BeFree
umls:C0684249Carcinoma of lung25BeFree
umls:C0242379Malignant neoplasm of lung22BeFree
umls:C2239176Liver carcinoma20BeFree,LHGDN
umls:C0001627Congenital adrenal hyperplasia15BeFree
umls:C0596263Carcinogenesis14BeFree
umls:C0014175Endometriosis13BeFree
umls:C0020538Hypertensive disease13BeFree
umls:C1458155Mammary Neoplasms11BeFree,GAD,LHGDN
umls:C0023903Liver neoplasms10BeFree
umls:C0032460Polycystic Ovary Syndrome10BeFree
umls:C2936791Antley-Bixler Syndrome, Autosomal Dominant10BeFree
umls:C0023895Liver diseases9BeFree,GAD
umls:C0009402Colorectal Carcinoma7BeFree
umls:C0014544Epilepsy7BeFree,GAD
umls:C1527249Colorectal Cancer7BeFree
umls:C1533041Primary congenital glaucoma7BeFree
umls:C0001623Adrenal gland hypofunction6BeFree
umls:C0011570Mental Depression6BeFree
umls:C0011581Depressive disorder6BeFree
umls:C0019196Hepatitis C6BeFree
umls:C0024141Lupus Erythematosus, Systemic6BeFree
umls:C0036341Schizophrenia6BeFree
umls:C0041296Tuberculosis6BeFree,GAD
umls:C0241910Hepatitis, Autoimmune6BeFree
umls:C0376358Malignant neoplasm of prostate6BeFree,GAD
umls:C0520463Chronic active hepatitis6BeFree
umls:C2936858Congenital adrenal hyperplasia due to 21 hydroxylase deficiency6BeFree
umls:C0005684Malignant neoplasm of urinary bladder5BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent5BeFree
umls:C0023267Fibroid Tumor5BeFree
umls:C0023890Liver Cirrhosis5BeFree
umls:C0024143Lupus Nephritis5BeFree,GAD
umls:C0024530Malaria5BeFree,GAD
umls:C0042133Uterine Fibroids5BeFree
umls:C0405580Adrenal cortical hypofunction5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0699885Carcinoma of bladder5BeFree
umls:C085265421-hydroxylase deficiency5BeFree
umls:C0007222Cardiovascular Diseases4BeFree,GAD
umls:C0022661Kidney Failure, Chronic4BeFree,CTD_human,GAD
umls:C0023467Leukemia, Myelocytic, Acute4BeFree,GAD
umls:C0024121Lung Neoplasms4BeFree,GAD
umls:C0028043Nicotine Dependence4BeFree
umls:C0029928Ovarian Diseases4BeFree
umls:C0042755Virilism4BeFree
umls:C0085215Ovarian Failure, Premature4BeFree,GAD
umls:C0152115Lingual-Facial-Buccal Dyskinesia4BeFree
umls:C0497169hiv-infection/aids4BeFree
umls:C0686347Tardive Dyskinesia4BeFree
umls:C1623038Cirrhosis4BeFree
umls:C3811653Experimental Organism Basal Cell Carcinoma4BeFree
umls:C0001175Acquired Immunodeficiency Syndrome3GAD
umls:C0001430Adenoma3BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0004153Atherosclerosis3BeFree
umls:C0007682CNS disorder3BeFree
umls:C0011849Diabetes Mellitus3BeFree
umls:C0024299Lymphoma3BeFree
umls:C0027051Myocardial Infarction3BeFree,GAD
umls:C0038454Cerebrovascular accident3BeFree,GAD
umls:C0152013Adenocarcinoma of lung (disorder)3BeFree
umls:C0155626Acute myocardial infarction3BeFree
umls:C0206667Adrenal Cortical Adenoma3BeFree
umls:C0235974Pancreatic carcinoma3BeFree
umls:C0269102Endometrioma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0524910Hepatitis C, Chronic3BeFree
umls:C0555198Malignant Glioma3BeFree
umls:C1956346Coronary Artery Disease3BeFree
umls:C0000768Congenital Abnormality2BeFree
umls:C0003469Anxiety Disorders2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0004096Asthma2BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0004936Mental disorders2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0008354Cholera2BeFree
umls:C0008370Cholestasis2BeFree,CTD_mouse
umls:C0008626Congenital chromosomal disease2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree
umls:C0010278Craniosynostosis2BeFree
umls:C0011847Diabetes2BeFree
umls:C0015695Fatty Liver2BeFree
umls:C0017411Female Genital Diseases2BeFree
umls:C0017638Glioma2BeFree
umls:C0019348Herpes Simplex Infections2BeFree
umls:C0020302Hydrophthalmos2BeFree
umls:C0021051Immunologic Deficiency Syndromes2BeFree
umls:C0022116Ischemia2BeFree
umls:C0023418leukemia2BeFree,GAD
umls:C0023434Chronic Lymphocytic Leukemia2BeFree,GAD
umls:C0023449Acute lymphocytic leukemia2BeFree
umls:C0023473Myeloid Leukemia, Chronic2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0025202melanoma2BeFree
umls:C0026848Myopathy2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0027658Neoplasms, Germ Cell and Embryonal2GAD
umls:C0028754Obesity2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0031269Peutz-Jeghers Syndrome2BeFree
umls:C0033975Psychotic Disorders2BeFree
umls:C0038325Stevens-Johnson Syndrome2BeFree
umls:C0040336Tobacco Use Disorder2GAD
umls:C0042769Virus Diseases2BeFree
umls:C0085669Acute leukemia2BeFree
umls:C0085859Polyglandular Type I Autoimmune Syndrome2BeFree
umls:C0153381Malignant neoplasm of mouth2BeFree
umls:C0206062Lung Diseases, Interstitial2BeFree
umls:C0206726gliosarcoma2CTD_human
umls:C0220641Lip and Oral Cavity Carcinoma2BeFree
umls:C0235031Neurologic Symptoms2BeFree
umls:C0241880Endometriosis of pelvis2BeFree
umls:C0266362Ambiguous Genitalia2BeFree
umls:C0278996Cancer of Head and Neck2BeFree
umls:C0280100Solid tumour2BeFree
umls:C0339573Glaucoma, Primary Open Angle2BeFree
umls:C0341858Endometriosis of uterus2BeFree
umls:C0349204Nonorganic psychosis2BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site2BeFree
umls:C0376545Hematologic Neoplasms2BeFree,GAD
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0596321Chemical Carcinogenesis2BeFree
umls:C0600113Stromal tumor of ovary2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0745744End Stage Liver Disease2BeFree
umls:C0851140Carcinoma in situ of uterine cervix2BeFree
umls:C0860207Drug-Induced Liver Injury2GAD
umls:C0919267ovarian neoplasm2GAD
umls:C0948008Ischemic stroke2BeFree
umls:C0948089Acute Coronary Syndrome2BeFree,GAD
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1370419Granulosa cell tumor of the ovary2BeFree
umls:C1384514Conn Syndrome2BeFree
umls:C1858142ICHTHYOSIS, LAMELLAR, 32BeFree
umls:C1859486BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY2BeFree
umls:C1860042Antley-Bixler Syndrome with Disordered Steroidogenesis2BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2GAD
umls:C2987516Cervix Intraepithelial Neoplasia Grade 3 AJCC v72BeFree
umls:C3272363Ischemic Cerebrovascular Accident2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0002874Aplastic Anemia1BeFree
umls:C0003872Arthritis, Psoriatic1BeFree
umls:C0004779Basal Cell Nevus Syndrome1BeFree
umls:C0005411Biliary Atresia1BeFree
umls:C0005695Bladder Neoplasm1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0008497Choriocarcinoma1BeFree
umls:C0008677Bronchitis, Chronic1BeFree
umls:C0010414Infection by Cryptococcus neoformans1BeFree
umls:C0011644Scleroderma1BeFree
umls:C0011853Diabetes Mellitus, Experimental1CTD_mouse
umls:C0013080Down Syndrome1BeFree
umls:C0013146Drug abuse1BeFree
umls:C0014130Endocrine System Diseases1BeFree
umls:C0014173Endometrial Hyperplasia1BeFree
umls:C0014518Toxic Epidermal Necrolysis1BeFree
umls:C0014869Peptic Esophagitis1BeFree
umls:C0016057Fibrosarcoma1BeFree
umls:C0017601Glaucoma1BeFree
umls:C0017606Primary angle-closure glaucoma1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0017658Glomerulonephritis1BeFree
umls:C0018133Graft-vs-Host Disease1GAD
umls:C0018524Hallucinations1BeFree
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0019158Hepatitis1BeFree
umls:C0019159Hepatitis A1BeFree
umls:C0019340Herpes NOS1BeFree
umls:C0019569Hirschsprung Disease1BeFree
umls:C0020433Hyperbilirubinemia1BeFree
umls:C0020443Hypercholesterolemia1BeFree
umls:C0021364Male infertility1BeFree
umls:C0021368Inflammation1GAD
umls:C0022658Kidney Diseases1BeFree
umls:C0022680Polycystic Kidney Diseases1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0023530Leukopenia1BeFree
umls:C0023601Leydig Cell Tumor1BeFree
umls:C0023976Long QT Syndrome1BeFree
umls:C0025322Premature Menopause1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0027126Myotonic Dystrophy1BeFree
umls:C0027404Narcolepsy1GAD
umls:C0027765nervous system disorder1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0030193Pain1BeFree
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0032463Polycythemia Vera1BeFree
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0035078Kidney Failure1BeFree
umls:C0035579Rickets1BeFree
umls:C0036349Paranoid Schizophrenia1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0037286Skin Neoplasms1BeFree
umls:C0038013Ankylosing spondylitis1BeFree
umls:C0038362Stomatitis1BeFree
umls:C0038644Sudden infant death syndrome1BeFree
umls:C0040053Thrombosis1GAD
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0040479Torsades de Pointes1BeFree
umls:C0042063Urogenital Abnormalities1BeFree
umls:C0085692Hemorrhagic cystitis1BeFree
umls:C0149871Deep Vein Thrombosis1BeFree
umls:C0150055Chronic pain1BeFree
umls:C0151744Myocardial Ischemia1BeFree
umls:C0151971Primary ulcer of intestine1BeFree
umls:C0162533Porphyrias, Hepatic1BeFree
umls:C0175754Agenesis of corpus callosum1BeFree
umls:C0206081Hyperandrogenism1BeFree
umls:C0206139Lichen Planus, Oral1BeFree
umls:C0206624Hepatoblastoma1BeFree
umls:C0206686Adrenocortical carcinoma1BeFree
umls:C0206708Cervical Intraepithelial Neoplasia1BeFree
umls:C0220611childhood rhabdomyosarcoma1BeFree
umls:C0220615Adult Acute Myeloblastic Leukemia1BeFree
umls:C0242785Food-Drug Interactions1BeFree
umls:C0268285Adrenal hyperplasia, congenital, type 51BeFree
umls:C0268689Vitamin D-dependent rickets, type 11BeFree
umls:C0271528Isosexual precocious puberty1BeFree
umls:C0276496Familial Alzheimer Disease (FAD)1BeFree
umls:C0278688Stage IV Ovarian Carcinoma1BeFree
umls:C0333516Tumor necrosis1BeFree
umls:C0334287Fibrolamellar hepatocellular carcinoma1BeFree
umls:C0334409Leydig cell tumor, benign1BeFree
umls:C0340708Deep vein thrombosis of lower limb1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0345964Adenoma of lung1BeFree
umls:C0392702Abnormal involuntary movement1BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0410226Congenital Myotonic Dystrophy1BeFree
umls:C0410528Skeletal dysplasia1BeFree
umls:C0429468Anovulatory1BeFree
umls:C0452147Hypospadias, penoscrotal1BeFree
umls:C0522055Electrocardiogram abnormal1GAD
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0600142Hot flushes1BeFree
umls:C0677659Gastro-esophageal reflux disease with esophagitis1BeFree
umls:C0685938Malignant neoplasm of gastrointestinal tract1BeFree
umls:C0740391Middle Cerebral Artery Occlusion1BeFree
umls:C0751075Cancer of Digestive System1BeFree
umls:C0751956Acute Cerebrovascular Accidents1BeFree
umls:C0855197Testicular malignant germ cell tumor1BeFree
umls:C0877008Enzyme inhibition disorder1BeFree
umls:C0917801Sleeplessness1BeFree
umls:C0948380Colorectal cancer metastatic1BeFree
umls:C0948807Hepatic impairment1BeFree
umls:C1262760Hepatitis, Drug-Induced1BeFree
umls:C1263733Uroporphyrinuria1BeFree
umls:C1276127Sporadic porphyria cutanea tarda1BeFree
umls:C1291314Deficiency of monooxygenase1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1302401Adenoma of large intestine1BeFree
umls:C1332977Childhood Leukemia1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1384583Congenital absence of germinal epithelium of testes1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1568868Oral Mucositis1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1704436Peripheral Arterial Diseases1BeFree
umls:C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)1CTD_human
umls:C1955741Glucocorticoid deficiency1BeFree
umls:C1970109AROMATASE EXCESS SYNDROME1BeFree
umls:C2608079WARFARIN SENSITIVITY (disorder)1BeFree
umls:C2711227Steatohepatitis1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C2931876Hirschsprung disease 11BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3463824MYELODYSPLASTIC SYNDROME1GAD
umls:C3825816Pneumonia in children1BeFree
umls:C3281153EFAVIRENZ, POOR METABOLISM OF0ORPHANET