TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP2B6

Gene summary

Basic gene information	Gene symbol	CYP2B6
	Gene name	cytochrome P450, family 2, subfamily B, polypeptide 6
	Synonyms	CPB6\|CYP2B\|CYP2B7\|CYP2B7P\|CYPIIB6\|EFVM\|IIB1\|P450
	Cytomap	UCSC genome browser: 19q13.2
	Type of gene	protein-coding
	RefGenes	NM_000767.4,
	Description	1,4-cineole 2-exo-monooxygenasecytochrome P450 2B6cytochrome P450 IIB1cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
	Modification date	20141222
dbXrefs	MIM : 123930
	HGNC : HGNC
	Ensembl : ENSG00000197408
	HPRD : 00477
	Vega : OTTHUMG00000182714
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CYP2B6
	BioGPS: 1555
Pathway	NCI Pathway Interaction Database: CYP2B6
	KEGG: CYP2B6
	REACTOME: CYP2B6
	Pathway Commons: CYP2B6
Context	iHOP: CYP2B6
	ligand binding site mutation search in PubMed: CYP2B6
	UCL Cancer Institute: CYP2B6
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of CYP2B6	Oxidative metabolism of BDE-99 by human liver microsomes: predominant role of CYP2B6. Erratico CA, Szeitz A, Bandiera SM. Toxicol Sci. 2012 Oct;129(2):280-92. doi: 10.1093/toxsci/kfs215. Epub 2012 Jun 27. (pmid:22738989) go to article
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006805	xenobiotic metabolic process	20061448
GO:0017144	drug metabolic process	19651758
GO:0042180	cellular ketone metabolic process	19651758
GO:0042738	exogenous drug catabolic process	19029318
GO:0055114	oxidation-reduction process	19651758
GO:0006805	xenobiotic metabolic process	20061448
GO:0017144	drug metabolic process	19651758
GO:0042180	cellular ketone metabolic process	19651758
GO:0042738	exogenous drug catabolic process	19029318
GO:0055114	oxidation-reduction process	19651758

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TissGeneExp for CYP2B6

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LUSC	-2.608046933	-0.84903909	-1.759007843	1.18E-16	9.04E-16
KIRP	-1.737626774	4.381923226	-6.11955	1.50E-17	6.86E-16
KIRC	-1.524087538	3.743336073	-5.267423611	2.20E-28	3.63E-27
BRCA	-1.353753693	-2.637508956	1.283755263	9.98E-10	3.57E-09
KICH	-3.102558149	2.886621851	-5.98918	2.44E-12	2.66E-11
LIHC	6.991341851	10.57291385	-3.581572	8.81E-14	2.17E-12
ESCA	3.194959306	-2.559767967	5.754727273	0.00143	0.018490233
STAD	2.736395101	-0.176717399	2.9131125	0.000498	0.003018873

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TissGene-miRNA for CYP2B6

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for CYP2B6

TissGeneSNV for CYP2B6

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E445K	SKCM	2
p.R187Q	SKCM	2
p.A407T	UCEC	2
p.R120C	SKCM	1
p.E93D	LUSC	1
p.R253H	LGG	1
p.F58L	LUAD	1
p.S294L	ESCA	1
p.F169L	BLCA	1
p.E273K	SKCM	1
p.A425D	BLCA	1
p.R85Q	LUAD	1
p.S141N	UCEC	1
p.A444E	LUAD	1
p.L340F	UCEC	1
p.P465S	LUAD	1
p.A279T	UCEC	1
p.Q357H	BLCA	1
p.D192H	BLCA	1
p.M365I	SKCM	1
p.Y203H	GBM	1
p.G71*	HNSC	1
p.R443H	UCEC	1
p.F202L	LUSC	1
p.Q357X	LIHC	1
p.L88P	HNSC	1
p.E355G	LIHC	1
p.T292M	COAD	1
p.R308H	GBM	1
p.G71R	SKCM	1
p.E240K	LUSC	1
p.A260T	UCEC	1
p.G80R	SKCM	1
p.R35H	PRAD	1
p.S96Y	PRAD	1
p.R126*	UCEC	1
p.L470V	HNSC	1
p.R343Q	SKCM	1
p.E282K	SKCM	1
p.F429L	LGG	1
p.D134N	THYM	1
p.F202L	BLCA	1
p.P10L	SKCM	1
p.R253H	UCEC	1
p.S277F	SKCM	1
p.L288I	LUAD	1
p.S284C	GBM	1
p.H252R	STAD	1
p.R120C	UCEC	1
p.A260T	LUAD	1
p.G118E	SKCM	1
p.Q172H	COAD	1
p.P481L	SKCM	1
p.P258S	STAD	1
p.S173F	SKCM	1
p.P383S	SKCM	1
p.Q239*	GBM	1
p.P364L	SKCM	1
p.R35H	COAD	1
p.M165I	SKCM	1
p.K251M	BRCA	1
p.P364S	UCEC	1
p.F108C	SKCM	1
p.V113E	LUAD	1
p.A407S	BLCA	1
p.E350G	BRCA	1
p.R378*	OV	1
p.T67M	BRCA	1
p.V75M	STAD	1
p.R378L	LUAD	1
p.I179V	PRAD	1
p.G118R	SKCM	1
p.G162E	SKCM	1
p.E144K	SKCM	1
p.P410L	BLCA	1
p.V183I	COAD	1
p.I381M	BLCA	1
p.P106A	BRCA	1
p.G136E	SKCM	1
p.M46V	DLBC	1
p.T303I	KIRC	1
p.A176T	HNSC	1
p.I468M	LUSC	1
p.A442T	UCEC	1
p.A444V	STAD	1
p.L392M	UCEC	1
p.R59Q	SKCM	1
p.H341N	ACC	1
p.V81A	ACC	1
p.D266N	STAD	1
p.P32L	LIHC	1
p.G136R	STAD	1
p.M132I	SKCM	1
p.K404E	SKCM	1
p.R358I	UCEC	1
p.E275D	UCEC	1
p.Q286L	HNSC	1
p.E350K	SKCM	1
p.E82D	PAAD	1
p.V212A	UCEC	1

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TissGeneCNV for CYP2B6

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for CYP2B6

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for CYP2B6

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

COAD (tumor)	COAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

HNSC (tumor)	HNSC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

KICH (tumor)	KICH (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

KIRC (tumor)	KIRC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

KIRP (tumor)	KIRP (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

LIHC (tumor)	LIHC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

LUAD (tumor)	LUAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

LUSC (tumor)	LUSC (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

PRAD (tumor)	PRAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

STAD (tumor)	STAD (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

THCA (tumor)	THCA (normal)
CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (tumor)	CYP2B6, HNF4A, RXRA, NR1I2, VDR, NR1I3 (normal)

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TissGeneProg for CYP2B6

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for CYP2B6

TissGeneDrug for CYP2B6

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB04794	Bifonazole		Small molecule	Approved

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TissGeneDisease for CYP2B6

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0019693	HIV Infections	65	BeFree,GAD
umls:C0006142	Malignant neoplasm of breast	36	BeFree,GAD
umls:C0678222	Breast Carcinoma	32	BeFree
umls:C0684249	Carcinoma of lung	25	BeFree
umls:C0242379	Malignant neoplasm of lung	22	BeFree
umls:C2239176	Liver carcinoma	20	BeFree,LHGDN
umls:C0001627	Congenital adrenal hyperplasia	15	BeFree
umls:C0596263	Carcinogenesis	14	BeFree
umls:C0014175	Endometriosis	13	BeFree
umls:C0020538	Hypertensive disease	13	BeFree
umls:C1458155	Mammary Neoplasms	11	BeFree,GAD,LHGDN
umls:C0023903	Liver neoplasms	10	BeFree
umls:C0032460	Polycystic Ovary Syndrome	10	BeFree
umls:C2936791	Antley-Bixler Syndrome, Autosomal Dominant	10	BeFree
umls:C0023895	Liver diseases	9	BeFree,GAD
umls:C0009402	Colorectal Carcinoma	7	BeFree
umls:C0014544	Epilepsy	7	BeFree,GAD
umls:C1527249	Colorectal Cancer	7	BeFree
umls:C1533041	Primary congenital glaucoma	7	BeFree
umls:C0001623	Adrenal gland hypofunction	6	BeFree
umls:C0011570	Mental Depression	6	BeFree
umls:C0011581	Depressive disorder	6	BeFree
umls:C0019196	Hepatitis C	6	BeFree
umls:C0024141	Lupus Erythematosus, Systemic	6	BeFree
umls:C0036341	Schizophrenia	6	BeFree
umls:C0041296	Tuberculosis	6	BeFree,GAD
umls:C0241910	Hepatitis, Autoimmune	6	BeFree
umls:C0376358	Malignant neoplasm of prostate	6	BeFree,GAD
umls:C0520463	Chronic active hepatitis	6	BeFree
umls:C2936858	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	6	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	5	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	5	BeFree
umls:C0023267	Fibroid Tumor	5	BeFree
umls:C0023890	Liver Cirrhosis	5	BeFree
umls:C0024143	Lupus Nephritis	5	BeFree,GAD
umls:C0024530	Malaria	5	BeFree,GAD
umls:C0042133	Uterine Fibroids	5	BeFree
umls:C0405580	Adrenal cortical hypofunction	5	BeFree
umls:C0600139	Prostate carcinoma	5	BeFree
umls:C0699885	Carcinoma of bladder	5	BeFree
umls:C0852654	21-hydroxylase deficiency	5	BeFree
umls:C0007222	Cardiovascular Diseases	4	BeFree,GAD
umls:C0022661	Kidney Failure, Chronic	4	BeFree,CTD_human,GAD
umls:C0023467	Leukemia, Myelocytic, Acute	4	BeFree,GAD
umls:C0024121	Lung Neoplasms	4	BeFree,GAD
umls:C0028043	Nicotine Dependence	4	BeFree
umls:C0029928	Ovarian Diseases	4	BeFree
umls:C0042755	Virilism	4	BeFree
umls:C0085215	Ovarian Failure, Premature	4	BeFree,GAD
umls:C0152115	Lingual-Facial-Buccal Dyskinesia	4	BeFree
umls:C0497169	hiv-infection/aids	4	BeFree
umls:C0686347	Tardive Dyskinesia	4	BeFree
umls:C1623038	Cirrhosis	4	BeFree
umls:C3811653	Experimental Organism Basal Cell Carcinoma	4	BeFree
umls:C0001175	Acquired Immunodeficiency Syndrome	3	GAD
umls:C0001430	Adenoma	3	BeFree
umls:C0003850	Arteriosclerosis	3	BeFree
umls:C0004153	Atherosclerosis	3	BeFree
umls:C0007682	CNS disorder	3	BeFree
umls:C0011849	Diabetes Mellitus	3	BeFree
umls:C0024299	Lymphoma	3	BeFree
umls:C0027051	Myocardial Infarction	3	BeFree,GAD
umls:C0038454	Cerebrovascular accident	3	BeFree,GAD
umls:C0152013	Adenocarcinoma of lung (disorder)	3	BeFree
umls:C0155626	Acute myocardial infarction	3	BeFree
umls:C0206667	Adrenal Cortical Adenoma	3	BeFree
umls:C0235974	Pancreatic carcinoma	3	BeFree
umls:C0269102	Endometrioma	3	BeFree
umls:C0346647	Malignant neoplasm of pancreas	3	BeFree
umls:C0524910	Hepatitis C, Chronic	3	BeFree
umls:C0555198	Malignant Glioma	3	BeFree
umls:C1956346	Coronary Artery Disease	3	BeFree
umls:C0000768	Congenital Abnormality	2	BeFree
umls:C0003469	Anxiety Disorders	2	BeFree
umls:C0003873	Rheumatoid Arthritis	2	BeFree
umls:C0004096	Asthma	2	BeFree
umls:C0004364	Autoimmune Diseases	2	BeFree
umls:C0004936	Mental disorders	2	BeFree
umls:C0007137	Squamous cell carcinoma	2	BeFree
umls:C0008354	Cholera	2	BeFree
umls:C0008370	Cholestasis	2	BeFree,CTD_mouse
umls:C0008626	Congenital chromosomal disease	2	BeFree
umls:C0010054	Coronary Arteriosclerosis	2	BeFree
umls:C0010068	Coronary heart disease	2	BeFree
umls:C0010278	Craniosynostosis	2	BeFree
umls:C0011847	Diabetes	2	BeFree
umls:C0015695	Fatty Liver	2	BeFree
umls:C0017411	Female Genital Diseases	2	BeFree
umls:C0017638	Glioma	2	BeFree
umls:C0019348	Herpes Simplex Infections	2	BeFree
umls:C0020302	Hydrophthalmos	2	BeFree
umls:C0021051	Immunologic Deficiency Syndromes	2	BeFree
umls:C0022116	Ischemia	2	BeFree
umls:C0023418	leukemia	2	BeFree,GAD
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree,GAD
umls:C0023449	Acute lymphocytic leukemia	2	BeFree
umls:C0023473	Myeloid Leukemia, Chronic	2	BeFree
umls:C0024623	Malignant neoplasm of stomach	2	BeFree
umls:C0025202	melanoma	2	BeFree
umls:C0026848	Myopathy	2	BeFree
umls:C0027627	Neoplasm Metastasis	2	BeFree
umls:C0027658	Neoplasms, Germ Cell and Embryonal	2	GAD
umls:C0028754	Obesity	2	BeFree
umls:C0029925	Ovarian Carcinoma	2	BeFree
umls:C0031269	Peutz-Jeghers Syndrome	2	BeFree
umls:C0033975	Psychotic Disorders	2	BeFree
umls:C0038325	Stevens-Johnson Syndrome	2	BeFree
umls:C0040336	Tobacco Use Disorder	2	GAD
umls:C0042769	Virus Diseases	2	BeFree
umls:C0085669	Acute leukemia	2	BeFree
umls:C0085859	Polyglandular Type I Autoimmune Syndrome	2	BeFree
umls:C0153381	Malignant neoplasm of mouth	2	BeFree
umls:C0206062	Lung Diseases, Interstitial	2	BeFree
umls:C0206726	gliosarcoma	2	CTD_human
umls:C0220641	Lip and Oral Cavity Carcinoma	2	BeFree
umls:C0235031	Neurologic Symptoms	2	BeFree
umls:C0241880	Endometriosis of pelvis	2	BeFree
umls:C0266362	Ambiguous Genitalia	2	BeFree
umls:C0278996	Cancer of Head and Neck	2	BeFree
umls:C0280100	Solid tumour	2	BeFree
umls:C0339573	Glaucoma, Primary Open Angle	2	BeFree
umls:C0341858	Endometriosis of uterus	2	BeFree
umls:C0349204	Nonorganic psychosis	2	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0376545	Hematologic Neoplasms	2	BeFree,GAD
umls:C0476089	Endometrial Carcinoma	2	BeFree
umls:C0596321	Chemical Carcinogenesis	2	BeFree
umls:C0600113	Stromal tumor of ovary	2	BeFree
umls:C0699791	Stomach Carcinoma	2	BeFree
umls:C0745744	End Stage Liver Disease	2	BeFree
umls:C0851140	Carcinoma in situ of uterine cervix	2	BeFree
umls:C0860207	Drug-Induced Liver Injury	2	GAD
umls:C0919267	ovarian neoplasm	2	GAD
umls:C0948008	Ischemic stroke	2	BeFree
umls:C0948089	Acute Coronary Syndrome	2	BeFree,GAD
umls:C1140680	Malignant neoplasm of ovary	2	BeFree
umls:C1370419	Granulosa cell tumor of the ovary	2	BeFree
umls:C1384514	Conn Syndrome	2	BeFree
umls:C1858142	ICHTHYOSIS, LAMELLAR, 3	2	BeFree
umls:C1859486	BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY	2	BeFree
umls:C1860042	Antley-Bixler Syndrome with Disordered Steroidogenesis	2	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	GAD
umls:C2987516	Cervix Intraepithelial Neoplasia Grade 3 AJCC v7	2	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	2	BeFree
umls:C0001973	Alcoholic Intoxication, Chronic	1	BeFree
umls:C0002395	Alzheimer's Disease	1	BeFree
umls:C0002874	Aplastic Anemia	1	BeFree
umls:C0003872	Arthritis, Psoriatic	1	BeFree
umls:C0004779	Basal Cell Nevus Syndrome	1	BeFree
umls:C0005411	Biliary Atresia	1	BeFree
umls:C0005695	Bladder Neoplasm	1	BeFree
umls:C0006118	Brain Neoplasms	1	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	1	BeFree
umls:C0008312	Primary biliary cirrhosis	1	BeFree
umls:C0008497	Choriocarcinoma	1	BeFree
umls:C0008677	Bronchitis, Chronic	1	BeFree
umls:C0010414	Infection by Cryptococcus neoformans	1	BeFree
umls:C0011644	Scleroderma	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	CTD_mouse
umls:C0013080	Down Syndrome	1	BeFree
umls:C0013146	Drug abuse	1	BeFree
umls:C0014130	Endocrine System Diseases	1	BeFree
umls:C0014173	Endometrial Hyperplasia	1	BeFree
umls:C0014518	Toxic Epidermal Necrolysis	1	BeFree
umls:C0014869	Peptic Esophagitis	1	BeFree
umls:C0016057	Fibrosarcoma	1	BeFree
umls:C0017601	Glaucoma	1	BeFree
umls:C0017606	Primary angle-closure glaucoma	1	BeFree
umls:C0017636	Glioblastoma	1	BeFree
umls:C0017658	Glomerulonephritis	1	BeFree
umls:C0018133	Graft-vs-Host Disease	1	GAD
umls:C0018524	Hallucinations	1	BeFree
umls:C0018801	Heart failure	1	BeFree
umls:C0018802	Congestive heart failure	1	BeFree
umls:C0019158	Hepatitis	1	BeFree
umls:C0019159	Hepatitis A	1	BeFree
umls:C0019340	Herpes NOS	1	BeFree
umls:C0019569	Hirschsprung Disease	1	BeFree
umls:C0020433	Hyperbilirubinemia	1	BeFree
umls:C0020443	Hypercholesterolemia	1	BeFree
umls:C0021364	Male infertility	1	BeFree
umls:C0021368	Inflammation	1	GAD
umls:C0022658	Kidney Diseases	1	BeFree
umls:C0022680	Polycystic Kidney Diseases	1	BeFree
umls:C0023470	Myeloid Leukemia	1	BeFree
umls:C0023487	Acute Promyelocytic Leukemia	1	BeFree
umls:C0023530	Leukopenia	1	BeFree
umls:C0023601	Leydig Cell Tumor	1	BeFree
umls:C0023976	Long QT Syndrome	1	BeFree
umls:C0025322	Premature Menopause	1	BeFree
umls:C0025517	Metabolic Diseases	1	BeFree
umls:C0026764	Multiple Myeloma	1	BeFree
umls:C0027126	Myotonic Dystrophy	1	BeFree
umls:C0027404	Narcolepsy	1	GAD
umls:C0027765	nervous system disorder	1	BeFree
umls:C0029463	Osteosarcoma	1	BeFree
umls:C0030193	Pain	1	BeFree
umls:C0030297	Pancreatic Neoplasm	1	BeFree
umls:C0032463	Polycythemia Vera	1	BeFree
umls:C0033578	Prostatic Neoplasms	1	LHGDN
umls:C0035078	Kidney Failure	1	BeFree
umls:C0035579	Rickets	1	BeFree
umls:C0036349	Paranoid Schizophrenia	1	BeFree
umls:C0036421	Systemic Scleroderma	1	BeFree
umls:C0037286	Skin Neoplasms	1	BeFree
umls:C0038013	Ankylosing spondylitis	1	BeFree
umls:C0038362	Stomatitis	1	BeFree
umls:C0038644	Sudden infant death syndrome	1	BeFree
umls:C0040053	Thrombosis	1	GAD
umls:C0040136	Thyroid Neoplasm	1	BeFree
umls:C0040479	Torsades de Pointes	1	BeFree
umls:C0042063	Urogenital Abnormalities	1	BeFree
umls:C0085692	Hemorrhagic cystitis	1	BeFree
umls:C0149871	Deep Vein Thrombosis	1	BeFree
umls:C0150055	Chronic pain	1	BeFree
umls:C0151744	Myocardial Ischemia	1	BeFree
umls:C0151971	Primary ulcer of intestine	1	BeFree
umls:C0162533	Porphyrias, Hepatic	1	BeFree
umls:C0175754	Agenesis of corpus callosum	1	BeFree
umls:C0206081	Hyperandrogenism	1	BeFree
umls:C0206139	Lichen Planus, Oral	1	BeFree
umls:C0206624	Hepatoblastoma	1	BeFree
umls:C0206686	Adrenocortical carcinoma	1	BeFree
umls:C0206708	Cervical Intraepithelial Neoplasia	1	BeFree
umls:C0220611	childhood rhabdomyosarcoma	1	BeFree
umls:C0220615	Adult Acute Myeloblastic Leukemia	1	BeFree
umls:C0242785	Food-Drug Interactions	1	BeFree
umls:C0268285	Adrenal hyperplasia, congenital, type 5	1	BeFree
umls:C0268689	Vitamin D-dependent rickets, type 1	1	BeFree
umls:C0271528	Isosexual precocious puberty	1	BeFree
umls:C0276496	Familial Alzheimer Disease (FAD)	1	BeFree
umls:C0278688	Stage IV Ovarian Carcinoma	1	BeFree
umls:C0333516	Tumor necrosis	1	BeFree
umls:C0334287	Fibrolamellar hepatocellular carcinoma	1	BeFree
umls:C0334409	Leydig cell tumor, benign	1	BeFree
umls:C0340708	Deep vein thrombosis of lower limb	1	BeFree
umls:C0345904	Malignant neoplasm of liver	1	BeFree
umls:C0345964	Adenoma of lung	1	BeFree
umls:C0392702	Abnormal involuntary movement	1	BeFree
umls:C0400966	Non-alcoholic Fatty Liver Disease	1	BeFree
umls:C0410226	Congenital Myotonic Dystrophy	1	BeFree
umls:C0410528	Skeletal dysplasia	1	BeFree
umls:C0429468	Anovulatory	1	BeFree
umls:C0452147	Hypospadias, penoscrotal	1	BeFree
umls:C0522055	Electrocardiogram abnormal	1	GAD
umls:C0524851	Neurodegenerative Disorders	1	BeFree
umls:C0585442	Osteosarcoma of bone	1	BeFree
umls:C0600142	Hot flushes	1	BeFree
umls:C0677659	Gastro-esophageal reflux disease with esophagitis	1	BeFree
umls:C0685938	Malignant neoplasm of gastrointestinal tract	1	BeFree
umls:C0740391	Middle Cerebral Artery Occlusion	1	BeFree
umls:C0751075	Cancer of Digestive System	1	BeFree
umls:C0751956	Acute Cerebrovascular Accidents	1	BeFree
umls:C0855197	Testicular malignant germ cell tumor	1	BeFree
umls:C0877008	Enzyme inhibition disorder	1	BeFree
umls:C0917801	Sleeplessness	1	BeFree
umls:C0948380	Colorectal cancer metastatic	1	BeFree
umls:C0948807	Hepatic impairment	1	BeFree
umls:C1262760	Hepatitis, Drug-Induced	1	BeFree
umls:C1263733	Uroporphyrinuria	1	BeFree
umls:C1276127	Sporadic porphyria cutanea tarda	1	BeFree
umls:C1291314	Deficiency of monooxygenase	1	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1302401	Adenoma of large intestine	1	BeFree
umls:C1332977	Childhood Leukemia	1	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	1	BeFree
umls:C1384583	Congenital absence of germinal epithelium of testes	1	BeFree
umls:C1512409	Hepatocarcinogenesis	1	BeFree
umls:C1520166	Xenograft Model	1	BeFree
umls:C1568868	Oral Mucositis	1	BeFree
umls:C1654637	androgen independent prostate cancer	1	BeFree
umls:C1704436	Peripheral Arterial Diseases	1	BeFree
umls:C1861063	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	1	CTD_human
umls:C1955741	Glucocorticoid deficiency	1	BeFree
umls:C1970109	AROMATASE EXCESS SYNDROME	1	BeFree
umls:C2608079	WARFARIN SENSITIVITY (disorder)	1	BeFree
umls:C2711227	Steatohepatitis	1	BeFree
umls:C2745900	Promyelocytic leukemia	1	BeFree
umls:C2931876	Hirschsprung disease 1	1	BeFree
umls:C3241937	Nonalcoholic Steatohepatitis	1	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	GAD
umls:C3825816	Pneumonia in children	1	BeFree
umls:C3281153	EFAVIRENZ, POOR METABOLISM OF	0	ORPHANET