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| TissGeneSummary for CYP2C8 |
 Gene summary |
| Basic gene information | Gene symbol | CYP2C8 |
| Gene name | cytochrome P450, family 2, subfamily C, polypeptide 8 | |
| Synonyms | CPC8|CYPIIC8|MP-12/MP-20 | |
| Cytomap | UCSC genome browser: 10q23.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000770.3, NM_001198853.1,NM_001198854.1,NM_001198855.1,NM_030878.1, | |
| Description | P450 form 1cytochrome P450 2C8cytochrome P450 IIC2cytochrome P450 MP-12cytochrome P450 MP-20cytochrome P450 form 1cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8flavoprotein-linked monooxygenasemicrosomal monooxygenases- | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 601129 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138115 | ||
| HPRD : 03083 | ||
| Vega : OTTHUMG00000018804 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP2C8 | |
| BioGPS: 1558 | ||
| Pathway | NCI Pathway Interaction Database: CYP2C8 | |
| KEGG: CYP2C8 | ||
| REACTOME: CYP2C8 | ||
| Pathway Commons: CYP2C8 | ||
| Context | iHOP: CYP2C8 | |
| ligand binding site mutation search in PubMed: CYP2C8 | ||
| UCL Cancer Institute: CYP2C8 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CYP2C8 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006082 | organic acid metabolic process | 19651758 | GO:0017144 | drug metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0055114 | oxidation-reduction process | 19651758 | GO:0070989 | oxidative demethylation | 18619574 | GO:0006082 | organic acid metabolic process | 19651758 | GO:0017144 | drug metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0055114 | oxidation-reduction process | 19651758 | GO:0070989 | oxidative demethylation | 18619574 |
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| TissGeneExp for CYP2C8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.686191238 | -0.977215238 | -1.708976 | 2.45E-05 | 7.18E-05 |
| LUSC | -2.61555618 | -1.230093434 | -1.385462745 | 9.77E-10 | 3.34E-09 |
| KIRC | 0.808459262 | -0.54711435 | 1.355573611 | 1.10E-05 | 2.57E-05 |
| LIHC | 7.657578762 | 11.49833276 | -3.840754 | 8.36E-14 | 2.09E-12 |
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| TissGene-miRNA for CYP2C8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP2C8 |
| TissGeneSNV for CYP2C8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S18L | SKCM | 3 |
| p.P402S | SKCM | 3 |
| p.D293N | SKCM | 3 |
| p.A161T | SKCM | 2 |
| p.G117E | SKCM | 2 |
| p.M71I | SKCM | 2 |
| p.S482P | HNSC | 1 |
| p.I269F | DLBC | 1 |
| p.E300D | BLCA | 1 |
| p.W120X | SKCM | 1 |
| p.R124W | SKCM | 1 |
| p.R200I | UCEC | 1 |
| p.L361I | THYM | 1 |
| p.R105I | UCEC | 1 |
| p.R333K | BLCA | 1 |
| p.P317S | PAAD | 1 |
| p.L195F | SKCM | 1 |
| p.E2K | SKCM | 1 |
| p.W20* | BLCA | 1 |
| p.G91R | SKCM | 1 |
| p.P166S | SKCM | 1 |
| p.L294P | SKCM | 1 |
| p.E155K | SKCM | 1 |
| p.E148K | SKCM | 1 |
| p.K59N | PRAD | 1 |
| p.L156F | LIHC | 1 |
| p.A321G | LIHC | 1 |
| p.G91E | SKCM | 1 |
| p.G417D | UVM | 1 |
| p.P402L | SKCM | 1 |
| p.D414Y | UCEC | 1 |
| p.D265H | HNSC | 1 |
| p.R144H | HNSC | 1 |
| p.K4E | BLCA | 1 |
| p.F267L | KIRP | 1 |
| p.R157K | SKCM | 1 |
| p.S359N | UCEC | 1 |
| p.R186Q | COAD | 1 |
| p.K474Q | HNSC | 1 |
| p.A321D | UCEC | 1 |
| p.R342S | PRAD | 1 |
| p.P337S | SKCM | 1 |
| p.M388L | UCEC | 1 |
| p.Y347C | PRAD | 1 |
| p.R333K | SKCM | 1 |
| p.S58* | BLCA | 1 |
| p.D163N | READ | 1 |
| p.H329Y | SKCM | 1 |
| p.R433Q | SKCM | 1 |
| p.R84Q | READ | 1 |
| p.D265N | SKCM | 1 |
| p.N72Y | READ | 1 |
| p.E274K | SKCM | 1 |
| p.R186L | UCEC | 1 |
| p.R342K | SKCM | 1 |
| p.G431R | SKCM | 1 |
| p.E326D | LUSC | 1 |
| p.C13G | STAD | 1 |
| p.R186* | LGG | 1 |
| p.R132Q | GBM | 1 |
| p.E250K | SKCM | 1 |
| p.V352L | BRCA | 1 |
| p.N457I | SKCM | 1 |
| p.K199E | COAD | 1 |
| p.N468S | COAD | 1 |
| p.F168I | SKCM | 1 |
| p.V366L | LUAD | 1 |
| p.E250D | SKCM | 1 |
| p.G475R | SKCM | 1 |
| p.L221V | LUAD | 1 |
| p.G109R | SKCM | 1 |
| p.F165L | KIRP | 1 |
| p.R186X | COAD | 1 |
| p.L464V | READ | 1 |
| p.P346S | SKCM | 1 |
| p.P427H | HNSC | 1 |
| p.C151Y | SKCM | 1 |
| p.K465N | STAD | 1 |
| p.K118N | UCEC | 1 |
| p.S115R | GBM | 1 |
| p.H78Y | SKCM | 1 |
| p.W120* | SKCM | 1 |
| p.E400K | SKCM | 1 |
| p.M1I | SKCM | 1 |
| p.Y358H | DLBC | 1 |
| p.R307K | READ | 1 |
| p.G111X | PRAD | 1 |
| p.F18I | SKCM | 1 |
| p.E325K | SKCM | 1 |
| p.R97K | SKCM | 1 |
| p.D397N | SKCM | 1 |
| p.L3F | LUAD | 1 |
| p.L195V | LUSC | 1 |
| p.K199I | LGG | 1 |
| p.L36F | BRCA | 1 |
| p.E326D | HNSC | 1 |
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| TissGeneCNV for CYP2C8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP2C8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-FC-A5OB-01A | SGMS1-CYP2C8 | 5'UTR-5'UTR | chr10:52193235 | chr10:96827448 |
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| TissGeneNet for CYP2C8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (tumor) | CYP2C8, DNAJB1, HNF4A, APOE, MAST1, A2M, PGRMC1, BLMH, LONP1 (normal) |
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| TissGeneProg for CYP2C8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP2C8 |
| TissGeneDrug for CYP2C8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CYP2C8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree,GAD |
| umls:C0024535 | Malaria, Falciparum | 6 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 5 | BeFree,GAD |
| umls:C0442874 | Neuropathy | 4 | BeFree |
| umls:C0010068 | Coronary heart disease | 3 | BeFree,GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,GAD |
| umls:C0026764 | Multiple Myeloma | 3 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD |
| umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
| umls:C0002871 | Anemia | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0014544 | Epilepsy | 2 | GAD |
| umls:C0014859 | Esophageal Neoplasms | 2 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 2 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 2 | GAD |
| umls:C0024530 | Malaria | 2 | BeFree,GAD |
| umls:C0026640 | Mouth Neoplasms | 2 | GAD |
| umls:C0031347 | Pharyngeal Neoplasms | 2 | GAD |
| umls:C0266807 | Acute gastrointestinal hemorrhage | 2 | BeFree |
| umls:C0948008 | Ischemic stroke | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | GAD |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005779 | Blood Coagulation Disorders | 1 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree,GAD |
| umls:C0013182 | Drug Allergy | 1 | GAD |
| umls:C0017181 | Gastrointestinal Hemorrhage | 1 | GAD |
| umls:C0020473 | Hyperlipidemia | 1 | GAD |
| umls:C0020615 | Hypoglycemia | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0022362 | Jaw Diseases | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | BeFree,CTD_human |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0023904 | Liver Neoplasms, Experimental | 1 | CTD_mouse |
| umls:C0026848 | Myopathy | 1 | GAD |
| umls:C0027765 | nervous system disorder | 1 | CTD_human |
| umls:C0027947 | Neutropenia | 1 | BeFree |
| umls:C0029445 | Bone necrosis | 1 | GAD |
| umls:C0030920 | Peptic Ulcer | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | BeFree |
| umls:C0035410 | Rhabdomyolysis | 1 | CTD_human |
| umls:C0038358 | Gastric ulcer | 1 | GAD |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042065 | Genitourinary Neoplasms | 1 | GAD |
| umls:C0042790 | Vision Disorders | 1 | GAD |
| umls:C0155668 | Old myocardial infarction | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C0270736 | Essential Tremor | 1 | BeFree,GAD,LHGDN |
| umls:C0278996 | Cancer of Head and Neck | 1 | GAD |
| umls:C0403447 | Chronic Kidney Insufficiency | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
| umls:C0595916 | Toxic nephropathy | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 1 | GAD |
| umls:C1832733 | Rhabdomyolysis, Cerivastatin-Induced | 0 | CLINVAR |
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