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| TissGeneSummary for CYP2C9 |
 Gene summary |
| Basic gene information | Gene symbol | CYP2C9 |
| Gene name | cytochrome P450, family 2, subfamily C, polypeptide 9 | |
| Synonyms | CPC9|CYP2C|CYP2C10|CYPIIC9|P450IIC9 | |
| Cytomap | UCSC genome browser: 10q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000771.3, | |
| Description | cytochrome P-450 S-mephenytoin 4-hydroxylasecytochrome P-450MPcytochrome P450 2C9cytochrome P450 PB-1flavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenase | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 601130 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138109 | ||
| HPRD : 03084 | ||
| Vega : OTTHUMG00000018805 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP2C9 | |
| BioGPS: 1559 | ||
| Pathway | NCI Pathway Interaction Database: CYP2C9 | |
| KEGG: CYP2C9 | ||
| REACTOME: CYP2C9 | ||
| Pathway Commons: CYP2C9 | ||
| Context | iHOP: CYP2C9 | |
| ligand binding site mutation search in PubMed: CYP2C9 | ||
| UCL Cancer Institute: CYP2C9 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CYP2C9 | High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle. Darwish WS, Ikenaka Y, El-Ghareeb WR, Ishizuka M. Animal. 2010 Dec;4(12):2023-9. doi: 10.1017/S1751731110001394. (pmid:22445377) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 19219744 | GO:0019627 | urea metabolic process | 19029318 | GO:0032787 | monocarboxylic acid metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0043603 | cellular amide metabolic process | 19651758 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 18619574 | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 19219744 | GO:0019627 | urea metabolic process | 19029318 | GO:0032787 | monocarboxylic acid metabolic process | 19651758 | GO:0042738 | exogenous drug catabolic process | 18619574 | GO:0043603 | cellular amide metabolic process | 19651758 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 18619574 |
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| TissGeneExp for CYP2C9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.215863368 | 0.822528632 | -3.038392 | 4.94E-12 | 4.99E-11 |
| LIHC | 9.526788632 | 12.85690263 | -3.330114 | 2.30E-12 | 4.19E-11 |
| HNSC | -0.322870066 | 1.087225283 | -1.410095349 | 0.000427 | 0.00162839 |
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| TissGene-miRNA for CYP2C9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP2C9 |
| TissGeneSNV for CYP2C9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E199K | SKCM | 3 |
| p.E85K | SKCM | 2 |
| p.P363S | SKCM | 2 |
| p.E250K | SKCM | 2 |
| p.S390F | SKCM | 2 |
| p.M269I | SKCM | 2 |
| p.R357T | CESC | 1 |
| p.R329H | LGG | 1 |
| p.I88T | THCA | 1 |
| p.G437E | SKCM | 1 |
| p.R335Q | UCEC | 1 |
| p.M129I | CESC | 1 |
| p.S220F | SKCM | 1 |
| p.R186C | BLCA | 1 |
| p.E246K | SKCM | 1 |
| p.M255I | SKCM | 1 |
| p.T301M | PRAD | 1 |
| p.L362F | CESC | 1 |
| p.L152F | SKCM | 1 |
| p.L19I | LGG | 1 |
| p.P37S | SKCM | 1 |
| p.P279S | SKCM | 1 |
| p.D188H | BLCA | 1 |
| p.Q454H | READ | 1 |
| p.Q484X | KICH | 1 |
| p.G135R | SKCM | 1 |
| p.R335W | DLBC | 1 |
| p.Y243H | SKCM | 1 |
| p.S286I | SARC | 1 |
| p.I331F | LUAD | 1 |
| p.G417S | SKCM | 1 |
| p.G109R | LUAD | 1 |
| p.R26S | SKCM | 1 |
| p.P404T | LUSC | 1 |
| p.A103V | LUAD | 1 |
| p.W212* | SKCM | 1 |
| p.E93K | HNSC | 1 |
| p.Q252P | UCS | 1 |
| p.D256N | SKCM | 1 |
| p.Y61H | PRAD | 1 |
| p.R108T | SKCM | 1 |
| p.S460Y | UCEC | 1 |
| p.M198I | SKCM | 1 |
| p.I389T | LUSC | 1 |
| p.P367S | SKCM | 1 |
| p.E354K | SKCM | 1 |
| p.S336I | ESCA | 1 |
| p.P174T | ESCA | 1 |
| p.P402S | LUAD | 1 |
| p.R139K | SKCM | 1 |
| p.M1I | SKCM | 1 |
| p.K383* | SKCM | 1 |
| p.G109R | SKCM | 1 |
| p.P166L | SKCM | 1 |
| p.P279L | SKCM | 1 |
| p.L458V | BRCA | 1 |
| p.D468H | ESCA | 1 |
| p.P35L | SKCM | 1 |
| p.G117E | SKCM | 1 |
| p.T364I | SKCM | 1 |
| p.A309S | SKCM | 1 |
| p.T130M | BLCA | 1 |
| p.E122K | SKCM | 1 |
| p.S127F | SKCM | 1 |
| p.Q252* | SKCM | 1 |
| p.W212X | SKCM | 1 |
| p.K138N | HNSC | 1 |
| p.D414N | SKCM | 1 |
| p.G442D | PAAD | 1 |
| p.M443I | SKCM | 1 |
| p.D188N | SKCM | 1 |
| p.R335Q | SKCM | 1 |
| p.L413M | LIHC | 1 |
| p.S12L | SKCM | 1 |
| p.R124Q | LUAD | 1 |
| p.A149T | HNSC | 1 |
| p.L195F | SKCM | 1 |
| p.R335Q | SARC | 1 |
| p.P30S | HNSC | 1 |
| p.Q252H | LUAD | 1 |
| p.E285K | SKCM | 1 |
| p.Q324* | SKCM | 1 |
| p.R125C | PRAD | 1 |
| p.V237I | STAD | 1 |
| p.G135V | ESCA | 1 |
| p.E199D | READ | 1 |
| p.I264V | LIHC | 1 |
| p.D463Y | LUAD | 1 |
| p.L19F | SKCM | 1 |
| p.I47V | ESCA | 1 |
| p.G27E | SKCM | 1 |
| p.R186H | PAAD | 1 |
| p.R433W | READ | 1 |
| p.K185T | READ | 1 |
| p.G79E | LGG | 1 |
| p.V38A | SKCM | 1 |
| p.P489L | SKCM | 1 |
| p.C164R | LIHC | 1 |
| p.E253K | HNSC | 1 |
| p.E328K | BRCA | 1 |
| p.D341Y | READ | 1 |
| p.G431E | SKCM | 1 |
| p.L90V | LUSC | 1 |
| p.L14S | COAD | 1 |
| p.P402S | SKCM | 1 |
| p.L467I | UCEC | 1 |
| p.L11F | SKCM | 1 |
| p.G27E | UCEC | 1 |
| p.G117R | SKCM | 1 |
| p.P404S | SKCM | 1 |
| p.V323F | LUAD | 1 |
| p.E444D | OV | 1 |
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| TissGeneCNV for CYP2C9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP2C9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AV652799 | SMG1-CYP2C9 | chr16:18856881 | chr10:96740952 |
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| TissGeneNet for CYP2C9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (tumor) | CYP2C9, NR3C1, HNF4A, RXRA, MAST1, CDC37, NR1I2, RNF32, STAMBP, STAT5A, POR, NR1I3, RAB3D (normal) |
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| TissGeneProg for CYP2C9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP2C9 |
| TissGeneDrug for CYP2C9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CYP2C9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 33 | BeFree,GAD |
| umls:C0014544 | Epilepsy | 22 | BeFree,GAD |
| umls:C1527249 | Colorectal Cancer | 22 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 14 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 13 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 13 | BeFree,GAD |
| umls:C0019080 | Hemorrhage | 13 | CTD_human,GAD,LHGDN |
| umls:C0040038 | Thromboembolism | 9 | BeFree,GAD |
| umls:C0040053 | Thrombosis | 9 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 8 | GAD |
| umls:C0020615 | Hypoglycemia | 8 | BeFree,GAD |
| umls:C0017181 | Gastrointestinal Hemorrhage | 7 | GAD |
| umls:C0020538 | Hypertensive disease | 7 | BeFree,GAD,LHGDN |
| umls:C0027051 | Myocardial Infarction | 7 | BeFree,GAD,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree,GAD |
| umls:C0005779 | Blood Coagulation Disorders | 5 | GAD |
| umls:C0009404 | Colorectal Neoplasms | 5 | GAD,LHGDN |
| umls:C0023895 | Liver diseases | 5 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 5 | CTD_human,GAD |
| umls:C1302401 | Adenoma of large intestine | 5 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 5 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 5 | BeFree |
| umls:C0001430 | Adenoma | 4 | BeFree,GAD |
| umls:C0011570 | Mental Depression | 4 | BeFree,GAD |
| umls:C0018799 | Heart Diseases | 4 | BeFree,GAD |
| umls:C0030920 | Peptic Ulcer | 4 | BeFree,GAD |
| umls:C0034065 | Pulmonary Embolism | 4 | BeFree,GAD |
| umls:C0149871 | Deep Vein Thrombosis | 4 | BeFree,GAD |
| umls:C1458155 | Mammary Neoplasms | 4 | BeFree,GAD |
| umls:C0004153 | Atherosclerosis | 3 | BeFree,GAD,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree,LHGDN |
| umls:C0013182 | Drug Allergy | 3 | CTD_human,GAD |
| umls:C0014859 | Esophageal Neoplasms | 3 | BeFree,GAD |
| umls:C0020473 | Hyperlipidemia | 3 | BeFree,GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 3 | BeFree,GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 3 | BeFree,GAD |
| umls:C0036572 | Seizures | 3 | BeFree,GAD |
| umls:C0041696 | Unipolar Depression | 3 | BeFree |
| umls:C0042487 | Venous Thrombosis | 3 | GAD |
| umls:C0085580 | Essential Hypertension | 3 | BeFree |
| umls:C0232197 | Fibrillation | 3 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 3 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 3 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 3 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 3 | GAD |
| umls:C1269683 | Major Depressive Disorder | 3 | BeFree,GAD |
| umls:C1272641 | Systemic arterial pressure | 3 | GAD |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 3 | BeFree |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 2 | GAD |
| umls:C0004238 | Atrial Fibrillation | 2 | GAD |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 2 | GAD |
| umls:C0019693 | HIV Infections | 2 | BeFree,GAD |
| umls:C0020443 | Hypercholesterolemia | 2 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 2 | GAD |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 2 | GAD |
| umls:C0028754 | Obesity | 2 | BeFree,GAD |
| umls:C0030193 | Pain | 2 | BeFree |
| umls:C0031347 | Pharyngeal Neoplasms | 2 | GAD |
| umls:C0038354 | Stomach Diseases | 2 | BeFree |
| umls:C0038358 | Gastric ulcer | 2 | BeFree,GAD |
| umls:C0038454 | Cerebrovascular accident | 2 | BeFree,GAD |
| umls:C0038644 | Sudden infant death syndrome | 2 | BeFree |
| umls:C0041755 | Adverse reaction to drug | 2 | CTD_human |
| umls:C0042373 | Vascular Diseases | 2 | BeFree |
| umls:C0266807 | Acute gastrointestinal hemorrhage | 2 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 2 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0750384 | Coumarin Resistance | 2 | BeFree,CTD_human |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 2 | GAD |
| umls:C2675747 | Coumarin Sensitivity | 2 | BeFree,GAD |
| umls:C0002895 | Anemia, Sickle Cell | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | GAD |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree,CTD_human |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009181 | Cocarcinogenesis | 1 | GAD |
| umls:C0009375 | Colonic Neoplasms | 1 | GAD |
| umls:C0009952 | Febrile Convulsions | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0011991 | Diarrhea | 1 | GAD |
| umls:C0013146 | Drug abuse | 1 | BeFree |
| umls:C0013336 | Dwarfism | 1 | BeFree |
| umls:C0014547 | Epilepsies, Partial | 1 | GAD |
| umls:C0017178 | Gastrointestinal Diseases | 1 | GAD |
| umls:C0017566 | Gingival Hyperplasia | 1 | GAD |
| umls:C0018801 | Heart failure | 1 | GAD |
| umls:C0018939 | Hematological Disease | 1 | GAD |
| umls:C0019193 | Hepatitis, Toxic | 1 | GAD |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree,GAD |
| umls:C0020544 | Renal hypertension | 1 | GAD |
| umls:C0022116 | Ischemia | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0024301 | Lymphoma, Follicular | 1 | GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | GAD |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree,GAD |
| umls:C0026848 | Myopathy | 1 | GAD |
| umls:C0027497 | Nausea | 1 | GAD |
| umls:C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | GAD |
| umls:C0027707 | Nephritis, Interstitial | 1 | CTD_human |
| umls:C0027765 | nervous system disorder | 1 | CTD_human |
| umls:C0027947 | Neutropenia | 1 | GAD |
| umls:C0029408 | Degenerative polyarthritis | 1 | GAD |
| umls:C0030922 | Peptic Ulcer Hemorrhage | 1 | CTD_human,GAD |
| umls:C0031099 | Periodontitis | 1 | GAD |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | GAD |
| umls:C0033687 | Proteinuria | 1 | GAD |
| umls:C0033774 | Pruritus | 1 | GAD |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0035457 | Rhinitis, Allergic, Perennial | 1 | GAD |
| umls:C0036421 | Systemic Scleroderma | 1 | GAD |
| umls:C0040034 | Thrombocytopenia | 1 | GAD |
| umls:C0040156 | Thyrotoxicosis | 1 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 1 | GAD |
| umls:C0042963 | Vomiting | 1 | GAD |
| umls:C0079487 | Helicobacter Infections | 1 | GAD |
| umls:C0079772 | T-Cell Lymphoma | 1 | GAD |
| umls:C0085215 | Ovarian Failure, Premature | 1 | GAD |
| umls:C0085278 | Antiphospholipid Syndrome | 1 | GAD |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
| umls:C0151945 | Thrombosis of cerebral veins | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0152097 | Disease of diaphragm | 1 | BeFree |
| umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
| umls:C0155668 | Old myocardial infarction | 1 | BeFree |
| umls:C0162429 | Malnutrition | 1 | BeFree,GAD |
| umls:C0206139 | Lichen Planus, Oral | 1 | BeFree,GAD |
| umls:C0235032 | Neurotoxicity Syndromes | 1 | GAD |
| umls:C0241910 | Hepatitis, Autoimmune | 1 | BeFree |
| umls:C0242510 | Drug usage | 1 | BeFree |
| umls:C0242992 | Multiple Chemical Sensitivity | 1 | GAD |
| umls:C0270736 | Essential Tremor | 1 | BeFree,GAD,LHGDN |
| umls:C0333641 | Atrophic | 1 | GAD |
| umls:C0340708 | Deep vein thrombosis of lower limb | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | GAD |
| umls:C0376634 | Craniofacial Abnormalities | 1 | BeFree |
| umls:C0391957 | idiopathic epilepsy | 1 | BeFree |
| umls:C0398623 | Thrombophilia | 1 | GAD |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0751956 | Acute Cerebrovascular Accidents | 1 | BeFree |
| umls:C0850572 | Adenomatous polyp of colon | 1 | BeFree |
| umls:C0852077 | Blood Coagulation Disorders, Inherited | 1 | GAD |
| umls:C0856761 | Budd-Chiari Syndrome | 1 | GAD |
| umls:C0878544 | Cardiomyopathies | 1 | CTD_human |
| umls:C0919267 | ovarian neoplasm | 1 | GAD |
| umls:C0920269 | Microsatellite Instability | 1 | GAD |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1319853 | Asthma, Aspirin-Induced | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1565489 | Renal Insufficiency | 1 | GAD |
| umls:C1962972 | Proteinuria Adverse Event | 1 | GAD |
| umls:C2609414 | Acute kidney injury | 1 | CTD_human |
| umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
| umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |
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