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| TissGeneSummary for CYP2C18 |
 Gene summary |
| Basic gene information | Gene symbol | CYP2C18 |
| Gene name | cytochrome P450, family 2, subfamily C, polypeptide 18 | |
| Synonyms | CPCI|CYP2C|CYP2C17|P450-6B/29C|P450IIC17 | |
| Cytomap | UCSC genome browser: 10q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000772.2, NM_001128925.1, | |
| Description | (S)-mephenytoin hydroxylase associated cytochrome P450CYPIIC18cytochrome P450 2C18cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18cytochrome P450-6B/2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601131 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000108242 | ||
| HPRD : 03085 | ||
| Vega : OTTHUMG00000018796 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP2C18 | |
| BioGPS: 1562 | ||
| Pathway | NCI Pathway Interaction Database: CYP2C18 | |
| KEGG: CYP2C18 | ||
| REACTOME: CYP2C18 | ||
| Pathway Commons: CYP2C18 | ||
| Context | iHOP: CYP2C18 | |
| ligand binding site mutation search in PubMed: CYP2C18 | ||
| UCL Cancer Institute: CYP2C18 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CYP2C18 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CYP2C18 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.573446224 | -1.030290224 | -2.543156 | 3.45E-16 | 9.39E-15 |
| COAD | 1.246737007 | 3.375348545 | -2.128611538 | 1.33E-05 | 5.95E-05 |
| LIHC | 5.755601776 | 7.733493776 | -1.977892 | 5.02E-07 | 2.89E-06 |
| KIRC | -2.860723891 | -1.202203057 | -1.658520833 | 5.49E-12 | 2.19E-11 |
| Top |
| TissGene-miRNA for CYP2C18 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP2C18 |
| TissGeneSNV for CYP2C18 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E199K | SKCM | 4 |
| p.D293N | SKCM | 3 |
| p.E438K | SKCM | 2 |
| p.G98E | SKCM | 2 |
| p.G25E | SKCM | 2 |
| p.G79E | SKCM | 2 |
| p.R478S | HNSC | 1 |
| p.P30S | SKCM | 1 |
| p.G91E | SKCM | 1 |
| p.I467N | ESCA | 1 |
| p.G137W | PAAD | 1 |
| p.S95F | SKCM | 1 |
| p.L77F | LUAD | 1 |
| p.E122D | BLCA | 1 |
| p.I327T | BLCA | 1 |
| p.R333K | SKCM | 1 |
| p.R478H | STAD | 1 |
| p.G384D | UCEC | 1 |
| p.W212* | HNSC | 1 |
| p.P489L | LGG | 1 |
| p.P101S | SKCM | 1 |
| p.R119T | CESC | 1 |
| p.G79V | OV | 1 |
| p.Q146* | BRCA | 1 |
| p.L366M | STAD | 1 |
| p.T371N | SARC | 1 |
| p.E199* | HNSC | 1 |
| p.W120X | LIHC | 1 |
| p.R206K | SKCM | 1 |
| p.R261W | UCEC | 1 |
| p.D463N | LUAD | 1 |
| p.D414N | SKCM | 1 |
| p.E93K | SKCM | 1 |
| p.L380F | SKCM | 1 |
| p.A350V | SKCM | 1 |
| p.S303G | LGG | 1 |
| p.C127R | ESCA | 1 |
| p.N457T | SKCM | 1 |
| p.E325* | SKCM | 1 |
| p.P481L | SKCM | 1 |
| p.R97K | SKCM | 1 |
| p.R119K | STAD | 1 |
| p.D46N | CESC | 1 |
| p.Q454K | COAD | 1 |
| p.E155K | SKCM | 1 |
| p.D191N | SKCM | 1 |
| p.S242N | UCEC | 1 |
| p.S242I | ESCA | 1 |
| p.D224G | READ | 1 |
| p.F487V | SARC | 1 |
| p.E328Q | LUAD | 1 |
| p.E203K | SKCM | 1 |
| p.P166L | SKCM | 1 |
| p.S18L | SKCM | 1 |
| p.R261W | SKCM | 1 |
| p.L156W | SKCM | 1 |
| p.G298* | SKCM | 1 |
| p.W120* | LIHC | 1 |
| p.E272K | SKCM | 1 |
| p.E400X | READ | 1 |
| p.E400* | UCEC | 1 |
| p.D256V | BLCA | 1 |
| p.G410D | SKCM | 1 |
| p.D224N | SKCM | 1 |
| p.Q278K | SKCM | 1 |
| p.D466N | SKCM | 1 |
| p.R132Q | UCEC | 1 |
| p.L9F | LGG | 1 |
| p.E246V | LUAD | 1 |
| p.R357S | LUAD | 1 |
| p.E354K | SKCM | 1 |
| p.G111E | SKCM | 1 |
| p.E104K | SKCM | 1 |
| p.A350D | PAAD | 1 |
| p.L195F | BLCA | 1 |
| p.T364I | SKCM | 1 |
| p.R433W | PRAD | 1 |
| p.W20* | BRCA | 1 |
| p.E405K | CESC | 1 |
| p.H184Y | SKCM | 1 |
| p.T302M | LGG | 1 |
| p.G117E | SKCM | 1 |
| p.T159P | PRAD | 1 |
| p.A430T | SKCM | 1 |
| p.E122D | HNSC | 1 |
| p.D468N | SKCM | 1 |
| p.G62D | STAD | 1 |
| p.V394A | STAD | 1 |
| p.M443I | STAD | 1 |
| p.P163L | LUAD | 1 |
| p.G431E | SKCM | 1 |
| p.R132Q | SKCM | 1 |
| p.K200N | BLCA | 1 |
| Top |
| TissGeneCNV for CYP2C18 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP2C18 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A88Y-01A | PLEKHA1-CYP2C18 | In-Frame | chr10:124159904 | chr10:96484102 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L7-A6VZ-01A | TBC1D12-CYP2C18 | Out-of-Frame | chr10:96256929 | chr10:96447526 |
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| TissGeneNet for CYP2C18 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP2C18, SDC2, A2M, ECSIT (tumor) | CYP2C18, SDC2, A2M, ECSIT (normal) |
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| TissGeneProg for CYP2C18 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP2C18 |
| TissGeneDrug for CYP2C18 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CYP2C18 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014544 | Epilepsy | 4 | BeFree |
| umls:C0020538 | Hypertensive disease | 2 | BeFree,RGD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | RGD |
| umls:C0038644 | Sudden infant death syndrome | 2 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | RGD |
| umls:C0013146 | Drug abuse | 1 | BeFree |
| umls:C0013336 | Dwarfism | 1 | BeFree |
| umls:C0018800 | Cardiomegaly | 1 | CTD_rat |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0025500 | Mesothelioma | 1 | GAD |
| umls:C0030920 | Peptic Ulcer | 1 | BeFree |
| umls:C0032229 | Pleural Neoplasms | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0206726 | gliosarcoma | 1 | CTD_human |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0270736 | Essential Tremor | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
| umls:C0919532 | Genomic Instability | 1 | GAD |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 1 | GAD |
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