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| TissGeneSummary for CYP2D6 |
 Gene summary |
| Basic gene information | Gene symbol | CYP2D6 |
| Gene name | cytochrome P450, family 2, subfamily D, polypeptide 6 | |
| Synonyms | CPD6|CYP2D|CYP2D7AP|CYP2D7BP|CYP2D7P2|CYP2D8P2|CYP2DL1|CYPIID6|P450-DB1|P450C2D|P450DB1 | |
| Cytomap | UCSC genome browser: 22q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000106.5, NM_001025161.2, | |
| Description | cytochrome P450 2D6cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogen | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 124030 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100197 | ||
| HPRD : 00487 | ||
| Vega : OTTHUMG00000150918 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP2D6 | |
| BioGPS: 1565 | ||
| Pathway | NCI Pathway Interaction Database: CYP2D6 | |
| KEGG: CYP2D6 | ||
| REACTOME: CYP2D6 | ||
| Pathway Commons: CYP2D6 | ||
| Context | iHOP: CYP2D6 | |
| ligand binding site mutation search in PubMed: CYP2D6 | ||
| UCL Cancer Institute: CYP2D6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CYP2D6 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009804 | coumarin metabolic process | 19438707 | GO:0009820 | alkaloid metabolic process | 19651758 | GO:0009822 | alkaloid catabolic process | 15039299 | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 19219744 | GO:0033076 | isoquinoline alkaloid metabolic process | 19448135 | GO:0042737 | drug catabolic process | 15039299 | GO:0046483 | heterocycle metabolic process | 15327587 | GO:0051100 | negative regulation of binding | 19448135 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 15039299 | GO:0090350 | negative regulation of cellular organofluorine metabolic process | 19448135 | GO:0009804 | coumarin metabolic process | 19438707 | GO:0009820 | alkaloid metabolic process | 19651758 | GO:0009822 | alkaloid catabolic process | 15039299 | GO:0016098 | monoterpenoid metabolic process | 16401082 | GO:0017144 | drug metabolic process | 19219744 | GO:0033076 | isoquinoline alkaloid metabolic process | 19448135 | GO:0042737 | drug catabolic process | 15039299 | GO:0046483 | heterocycle metabolic process | 15327587 | GO:0051100 | negative regulation of binding | 19448135 | GO:0055114 | oxidation-reduction process | 16401082 | GO:0070989 | oxidative demethylation | 15039299 | GO:0090350 | negative regulation of cellular organofluorine metabolic process | 19448135 |
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| TissGeneExp for CYP2D6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| ESCA | -0.728404549 | -2.628486368 | 1.900081818 | 0.00221 | 0.023959034 |
| LIHC | 6.756958178 | 8.318082178 | -1.561124 | 0.000501 | 0.001462183 |
| LUAD | -0.945533546 | -1.999178374 | 1.053644828 | 0.00065 | 0.001453589 |
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| TissGene-miRNA for CYP2D6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP2D6 |
| TissGeneSNV for CYP2D6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.H352R | THYM | 3 |
| p.H352R | GBM | 2 |
| p.R329L | UVM | 2 |
| p.H352R | MESO | 2 |
| p.R329L | PCPG | 2 |
| p.H352R | LGG | 2 |
| p.R380H | BLCA | 1 |
| p.H352R | PAAD | 1 |
| p.S137F | LUAD | 1 |
| p.Y124C | HNSC | 1 |
| p.R474W | LIHC | 1 |
| p.R388C | COAD | 1 |
| p.R365H | BRCA | 1 |
| p.L318I | STAD | 1 |
| p.R329L | READ | 1 |
| p.E211* | STAD | 1 |
| p.Q151E | DLBC | 1 |
| p.A246T | SKCM | 1 |
| p.H352R | BLCA | 1 |
| p.R388H | THYM | 1 |
| p.D292N | LUSC | 1 |
| p.R170H | COAD | 1 |
| p.F464V | STAD | 1 |
| p.V408I | STAD | 1 |
| p.G238D | ESCA | 1 |
| p.G42R | THYM | 1 |
| p.R329C | STAD | 1 |
| p.R123H | STAD | 1 |
| p.S379F | SKCM | 1 |
| p.G36C | CHOL | 1 |
| p.G284E | SKCM | 1 |
| p.T393M | COAD | 1 |
| p.R242H | UCEC | 1 |
| p.R365C | SARC | 1 |
| p.A90V | PAAD | 1 |
| p.E383K | SKCM | 1 |
| p.R497C | STAD | 1 |
| p.V359M | STAD | 1 |
| p.R129H | GBM | 1 |
| p.I233F | READ | 1 |
| p.M377I | BLCA | 1 |
| p.G373S | COAD | 1 |
| p.R242H | GBM | 1 |
| p.A209S | LIHC | 1 |
| p.Q27H | SKCM | 1 |
| p.H352R | THCA | 1 |
| p.D349N | COAD | 1 |
| p.L220M | BLCA | 1 |
| p.V7M | DLBC | 1 |
| p.E89K | BLCA | 1 |
| p.M347I | UCEC | 1 |
| p.R28C | STAD | 1 |
| p.R88H | COAD | 1 |
| p.A305V | HNSC | 1 |
| p.G471V | HNSC | 1 |
| p.C296R | COAD | 1 |
| p.R414H | STAD | 1 |
| p.A163T | KICH | 1 |
| p.S400L | ESCA | 1 |
| p.L213P | LUSC | 1 |
| p.T486S | COAD | 1 |
| p.S311L | SKCM | 1 |
| p.P102S | HNSC | 1 |
| p.S217L | OV | 1 |
| p.P489T | ESCA | 1 |
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| TissGeneCNV for CYP2D6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP2D6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CYP2D6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP2D6, HNF4A, NR2F1 (tumor) | CYP2D6, HNF4A, NR2F1 (normal) |
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| TissGeneProg for CYP2D6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP2D6 |
| TissGeneDrug for CYP2D6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00003 | Dornase alfa | Biotech | Approved | |
| DB00023 | Asparaginase | Other/unknown | Biotech | Approved |
| DB00053 | Imiglucerase | Other/unknown | Biotech | Approved |
| DB00061 | Pegademase bovine | Metabolizer | Biotech | Approved |
| DB00076 | Digoxin Immune Fab (Ovine) | Other/unknown | Biotech | Approved |
| DB00085 | Pancrelipase | Cleavage | Biotech | Approved |
| DB00088 | Alglucerase | Other/unknown | Biotech | Approved |
| DB00090 | Laronidase | Other/unknown | Biotech | Approved |
| DB00194 | Vidarabine | Incorporation into and destabilization | Small molecule | Approved |
| DB00207 | Azithromycin | Inhibitor | Small molecule | Approved |
| DB00236 | Pipobroman | Cross-linking/alkylation | Small molecule | Approved |
| DB00248 | Cabergoline | Agonist | Small molecule | Approved |
| DB00249 | Idoxuridine | Other | Small molecule | Approved |
| DB00258 | Calcium Acetate | Binder | Small molecule | Approved |
| DB00262 | Carmustine | Other/unknown | Small molecule | Approved |
| DB00276 | Amsacrine | Intercalation | Small molecule | Approved |
| DB00282 | Pamidronate | Antagonist | Small molecule | Approved |
| DB00291 | Chlorambucil | Cross-linking/alkylation | Small molecule | Approved |
| DB00305 | Mitomycin | Antagonist|Cross-linking/alkylation | Small molecule | Approved |
| DB00314 | Capreomycin | Inhibitor | Small molecule | Approved |
| DB00316 | Acetaminophen | Inhibitor | Small molecule | Approved |
| DB00339 | Pyrazinamide | Inhibitor | Small molecule | Approved |
| DB00352 | Tioguanine | Intercalation | Small molecule | Approved |
| DB00358 | Mefloquine | Antagonist | Small molecule | Approved |
| DB00375 | Colestipol | Binder | Small molecule | Approved |
| DB00385 | Valrubicin | Intercalation | Small molecule | Approved |
| DB00399 | Zoledronic acid | Antagonist | Small molecule | Approved |
| DB00406 | Gentian Violet | Intercalation | Small molecule | Approved |
| DB00421 | Spironolactone | Small molecule | Approved | |
| DB00432 | Trifluridine | Other/unknown | Small molecule | Approved |
| DB00441 | Gemcitabine | Cross-linking/alkylation | Small molecule | Approved |
| DB00445 | Epirubicin | Intercalation | Small molecule | Approved |
| DB00452 | Framycetin | Inhibitor | Small molecule | Approved |
| DB00453 | Clomocycline | Inhibitor | Small molecule | Approved |
| DB00468 | Quinine | Antagonist | Small molecule | Approved |
| DB00488 | Altretamine | Other/unknown | Small molecule | Approved |
| DB00512 | Vancomycin | Inhibitor | Small molecule | Approved |
| DB00515 | Cisplatin | Cross-linking/alkylation | Small molecule | Approved |
| DB00536 | Guanidine | Small molecule | Approved | |
| DB00544 | Fluorouracil | Incorporation into and destabilization | Small molecule | Approved |
| DB00553 | Methoxsalen | Intercalation | Small molecule | Approved |
| DB00560 | Tigecycline | Adduct | Small molecule | Approved |
| DB00566 | Succimer | Chelator | Small molecule | Approved |
| DB00578 | Carbenicillin | Inhibitor | Small molecule | Approved |
| DB00613 | Amodiaquine | Adduct | Small molecule | Approved |
| DB00630 | Alendronic acid | Antagonist | Small molecule | Approved |
| DB00639 | Butoconazole | Other | Small molecule | Approved |
| DB00658 | Sevelamer | Binder | Small molecule | Approved |
| DB00693 | Fluorescein | Other | Small molecule | Approved |
| DB00694 | Daunorubicin | Intercalation | Small molecule | Approved |
| DB00738 | Pentamidine | Intercalation | Small molecule | Approved |
| DB00779 | Nalidixic Acid | Other | Small molecule | Approved |
| DB00791 | Uracil mustard | Intercalation | Small molecule | Approved |
| DB00803 | Colistin | Incorporation into and destabilization | Small molecule | Approved |
| DB00811 | Ribavirin | Incorporation into and destabilization | Small molecule | Approved |
| DB00826 | Natamycin | Binder | Small molecule | Approved |
| DB00852 | Pseudoephedrine | Small molecule | Approved | |
| DB00859 | Penicillamine | Chelator | Small molecule | Approved |
| DB00888 | Mechlorethamine | Intercalation | Small molecule | Approved |
| DB00930 | Colesevelam | Binder | Small molecule | Approved |
| DB00931 | Methacycline | Inhibitor | Small molecule | Approved |
| DB00954 | Dirithromycin | Inhibitor | Small molecule | Approved |
| DB00955 | Netilmicin | Inhibitor | Small molecule | Approved |
| DB00958 | Carboplatin | Cross-linking/alkylation | Small molecule | Approved |
| DB00970 | Dactinomycin | Adduct | Small molecule | Approved |
| DB00976 | Telithromycin | Inhibitor | Small molecule | Approved |
| DB01040 | Hydroxystilbamidine Isethionate | Other/unknown | Small molecule | Approved |
| DB01042 | Melphalan | Cross-linking/alkylation | Small molecule | Approved |
| DB01073 | Fludarabine | Incorporation into and destabilization | Small molecule | Approved |
| DB01077 | Etidronic acid | Antagonist | Small molecule | Approved |
| DB01087 | Primaquine | Antagonist | Small molecule | Approved |
| DB01096 | Oxamniquine | Other/unknown | Small molecule | Approved |
| DB01099 | Flucytosine | Cross-linking/alkylation | Small molecule | Approved |
| DB01103 | Quinacrine | Intercalation | Small molecule | Approved |
| DB01168 | Procarbazine | Cross-linking/alkylation | Small molecule | Approved |
| DB01177 | Idarubicin | Intercalation | Small molecule | Approved |
| DB01181 | Ifosfamide | Other/unknown | Small molecule | Approved |
| DB01218 | Halofantrine | Antagonist | Small molecule | Approved |
| DB01271 | Idursulfase | Biotech | Approved | |
| DB01272 | Alglucosidase alfa | Cleavage | Biotech | Approved |
| DB01301 | Rolitetracycline | Inhibitor | Small molecule | Approved |
| DB01344 | Polystyrene sulfonate | Binder | Small molecule | Approved |
| DB01369 | Quinupristin | Inhibitor | Small molecule | Approved |
| DB01390 | Sodium bicarbonate | Neutralizer | Small molecule | Approved |
| DB01422 | Nitroxoline | Chelator | Small molecule | Approved |
| DB01427 | Amrinone | Small molecule | Approved | |
| DB01432 | Cholestyramine | Binder | Small molecule | Approved |
| DB01611 | Hydroxychloroquine | Cross-linking/alkylation | Small molecule | Approved |
| DB04571 | Trioxsalen | Cross-linking/alkylation | Small molecule | Approved |
| DB04572 | Thiotepa | Cross-linking/alkylation | Small molecule | Approved |
| DB05528 | Mipomersen | Binder | Small molecule | Approved |
| DB06014 | Eteplirsen | Binding | Biotech | Approved |
| DB06149 | Teicoplanin | Inhibitor | Biotech | Approved |
| DB06205 | Hyaluronidase (Human Recombinant) | Biotech | Approved | |
| DB06715 | Potassium Iodide | Binder | Small molecule | Approved |
| DB06782 | Dimercaprol | Chelator | Small molecule | Approved |
| DB06792 | Lanthanum carbonate | Binder | Small molecule | Approved |
| DB06827 | Viomycin | Small molecule | Approved | |
| DB08876 | Taliglucerase Alfa | Biotech | Approved | |
| DB08898 | Glucarpidase | Metabolizer | Biotech | Approved |
| DB09054 | Idelalisib | Inhibitor | Small molecule | Approved |
| DB09065 | Cobicistat | Inhibitor | Small molecule | Approved |
| DB09068 | Vortioxetine | Blocker | Small molecule | Approved |
| DB09077 | Dinutuximab | Inhibitor | Biotech | Approved |
| DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
| DB09102 | Daclatasvir | Inhibitor | Small molecule | Approved |
| DB09208 | Pegloticase | Metabolizer | Biotech | Approved |
| DB09263 | Patiromer | Binder | Small molecule | Approved |
| DB09264 | Idarucizumab | Antibody | Biotech | Approved |
| DB09291 | Rolapitant | Antagonist | Small molecule | Approved |
| DB09345 | Pramocaine | Antagonist|Inhibitor | Small molecule | Approved |
| DB11574 | Elbasvir | Inhibitor | Small molecule | Approved |
| DB00497 | Oxycodone | Agonist | Small molecule | Approved|Illicit|Investigational |
| DB00049 | Rasburicase | Metabolizer | Biotech | Approved|Investigational |
| DB00059 | Pegaspargase | Other/unknown | Biotech | Approved|Investigational |
| DB00070 | Hyaluronidase | Other | Biotech | Approved|Investigational |
| DB00080 | Daptomycin | Inhibitor | Biotech | Approved|Investigational |
| DB00103 | Agalsidase beta | Ligand | Biotech | Approved|Investigational |
| DB00242 | Cladribine | Other/unknown | Small molecule | Approved|Investigational |
| DB00334 | Olanzapine | Small molecule | Approved|Investigational | |
| DB00442 | Entecavir | Other | Small molecule | Approved|Investigational |
| DB00526 | Oxaliplatin | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB00531 | Cyclophosphamide | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB00601 | Linezolid | Inhibitor | Small molecule | Approved|Investigational |
| DB00631 | Clofarabine | Other/unknown | Small molecule | Approved|Investigational |
| DB00681 | Amphotericin B | Binder | Small molecule | Approved|Investigational |
| DB00684 | Tobramycin | Inhibitor | Small molecule | Approved|Investigational |
| DB00709 | Lamivudine | Adduct | Small molecule | Approved|Investigational |
| DB00710 | Ibandronate | Antagonist | Small molecule | Approved|Investigational |
| DB00746 | Deferoxamine | Chelator | Small molecule | Approved|Investigational |
| DB00851 | Dacarbazine | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB00853 | Temozolomide | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB00884 | Risedronate | Antagonist | Small molecule | Approved|Investigational |
| DB00911 | Tinidazole | Binder | Small molecule | Approved|Investigational |
| DB00928 | Azacitidine | Other | Small molecule | Approved|Investigational |
| DB00987 | Cytarabine | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB00997 | Doxorubicin | Intercalation | Small molecule | Approved|Investigational |
| DB01004 | Ganciclovir | Incorporation into and destabilization | Small molecule | Approved|Investigational |
| DB01008 | Busulfan | Cross-linking/alkylation | Small molecule | Approved|Investigational |
| DB01026 | Ketoconazole | Small molecule | Approved|Investigational | |
| DB01030 | Topotecan | Intercalation | Small molecule | Approved|Investigational |
| DB01101 | Capecitabine | Incorporation into and destabilization | Small molecule | Approved|Investigational |
| DB01204 | Mitoxantrone | Intercalation | Small molecule | Approved|Investigational |
| DB01262 | Decitabine | Other/unknown | Small molecule | Approved|Investigational |
| DB01265 | Telbivudine | Small molecule | Approved|Investigational | |
| DB01279 | Galsulfase | Biotech | Approved|Investigational | |
| DB01280 | Nelarabine | Incorporation into and destabilization | Small molecule | Approved|Investigational |
| DB01421 | Paromomycin | Inhibitor | Small molecule | Approved|Investigational |
| DB01609 | Deferasirox | Chelator | Small molecule | Approved|Investigational |
| DB01610 | Valganciclovir | Adduct | Small molecule | Approved|Investigational |
| DB04967 | Lucanthone | Intercalation | Small molecule | Approved|Investigational |
| DB05109 | Trabectedin | Binder | Small molecule | Approved|Investigational |
| DB06263 | Amrubicin | Small molecule | Approved|Investigational | |
| DB09105 | Asfotase Alfa | Ligand | Biotech | Approved|Investigational |
| DB00254 | Doxycycline | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
| DB00720 | Clodronate | Antagonist | Small molecule | Approved|Investigational|Vet_approved |
| DB00721 | Procaine | Small molecule | Approved|Investigational|Vet_approved | |
| DB01041 | Thalidomide | Small molecule | Approved|Investigational|Withdrawn | |
| DB00127 | Spermine | Binder | Small molecule | Approved|Nutraceutical |
| DB00131 | Adenosine monophosphate | Component of | Small molecule | Approved|Nutraceutical |
| DB00173 | Adenine | Small molecule | Approved|Nutraceutical | |
| DB00199 | Erythromycin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB00479 | Amikacin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB00595 | Oxytetracycline | Inhibitor | Small molecule | Approved|Vet_approved |
| DB00614 | Furazolidone | Cross-linking/alkylation | Small molecule | Approved|Vet_approved |
| DB00626 | Bacitracin | Antagonist | Small molecule | Approved|Vet_approved |
| DB00646 | Nystatin | Binder | Small molecule | Approved|Vet_approved |
| DB00759 | Tetracycline | Inhibitor | Small molecule | Approved|Vet_approved |
| DB00781 | Polymyxin B Sulfate | Incorporation into and destabilization | Small molecule | Approved|Vet_approved |
| DB00878 | Chlorhexidine | Incorporation into and destabilization | Small molecule | Approved|Vet_approved |
| DB00974 | Edetic Acid | Chelator | Small molecule | Approved|Vet_approved |
| DB00994 | Neomycin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB01058 | Praziquantel | Other/unknown | Small molecule | Approved|Vet_approved |
| DB01082 | Streptomycin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB01111 | Colistimethate | Incorporation into and destabilization | Small molecule | Approved|Vet_approved |
| DB01133 | Tiludronic acid | Antagonist | Small molecule | Approved|Vet_approved |
| DB01172 | Kanamycin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB01190 | Clindamycin | Inhibitor | Small molecule | Approved|Vet_approved |
| DB05245 | Silver sulfadiazine | Binder | Small molecule | Approved|Vet_approved |
| DB06718 | Stanozolol | Negative modulator | Small molecule | Approved|Vet_approved |
| DB06803 | Niclosamide | Antagonist | Small molecule | Approved|Vet_approved |
| DB09085 | Tetracaine | Antagonist | Small molecule | Approved|Vet_approved |
| DB00057 | Satumomab Pendetide | Other/unknown | Biotech | Approved|Withdrawn |
| DB00827 | Cinoxacin | Intercalation | Small molecule | Approved|Withdrawn |
| DB06810 | Plicamycin | Antagonist | Small molecule | Approved|Withdrawn |
| DB04626 | Apramycin | Small molecule | Experimental|Vet_approved |
| Top |
| TissGeneDisease for CYP2D6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 99 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 88 | BeFree |
| umls:C0036341 | Schizophrenia | 40 | BeFree,GAD,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 36 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 29 | BeFree |
| umls:C0030567 | Parkinson Disease | 24 | BeFree,CTD_human,GAD |
| umls:C0152115 | Lingual-Facial-Buccal Dyskinesia | 20 | BeFree,GAD |
| umls:C0686347 | Tardive Dyskinesia | 20 | BeFree,GAD |
| umls:C0241910 | Hepatitis, Autoimmune | 18 | BeFree,LHGDN |
| umls:C0011570 | Mental Depression | 16 | BeFree,GAD |
| umls:C1458155 | Mammary Neoplasms | 14 | CTD_human,GAD,LHGDN |
| umls:C0011581 | Depressive disorder | 13 | BeFree |
| umls:C0344307 | Absence of pain sensation | 12 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 11 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 11 | BeFree,GAD |
| umls:C0600142 | Hot flushes | 11 | BeFree,GAD |
| umls:C1269683 | Major Depressive Disorder | 11 | BeFree,GAD,GWASCAT |
| umls:C0007137 | Squamous cell carcinoma | 10 | BeFree,GAD |
| umls:C0027849 | Neuroleptic Malignant Syndrome | 10 | BeFree,GAD,LHGDN |
| umls:C0524910 | Hepatitis C, Chronic | 10 | BeFree,GAD,LHGDN |
| umls:C0234133 | Extrapyramidal sign | 9 | BeFree |
| umls:C0020538 | Hypertensive disease | 8 | BeFree,GAD |
| umls:C0041696 | Unipolar Depression | 8 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 8 | BeFree,GAD |
| umls:C0278996 | Cancer of Head and Neck | 8 | BeFree,GAD |
| umls:C0004782 | Basal Ganglia Diseases | 7 | CTD_human,GAD |
| umls:C0013386 | Dyskinesia, Drug-Induced | 7 | GAD |
| umls:C0023895 | Liver diseases | 7 | BeFree,GAD |
| umls:C0699885 | Carcinoma of bladder | 7 | BeFree |
| umls:C1527249 | Colorectal Cancer | 7 | GAD |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 7 | BeFree,GAD |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 7 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 6 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 6 | BeFree,GAD |
| umls:C0019196 | Hepatitis C | 6 | BeFree,LHGDN |
| umls:C0497327 | Dementia | 6 | BeFree,LHGDN |
| umls:C0752347 | Lewy Body Disease | 6 | BeFree |
| umls:C0003469 | Anxiety Disorders | 5 | BeFree |
| umls:C0011265 | Presenile dementia | 5 | BeFree |
| umls:C0018801 | Heart failure | 5 | BeFree,GAD |
| umls:C0019693 | HIV Infections | 5 | BeFree,GAD |
| umls:C0023449 | Acute lymphocytic leukemia | 5 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 5 | GAD |
| umls:C0030201 | Pain, Postoperative | 5 | BeFree,GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree,GAD |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 5 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 4 | BeFree,GAD |
| umls:C0014544 | Epilepsy | 4 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 4 | BeFree,GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 4 | BeFree,GAD |
| umls:C0023890 | Liver Cirrhosis | 4 | BeFree,GAD |
| umls:C0026650 | Movement Disorders | 4 | BeFree |
| umls:C0027497 | Nausea | 4 | BeFree,GAD |
| umls:C0030193 | Pain | 4 | BeFree,GAD |
| umls:C0038013 | Ankylosing spondylitis | 4 | BeFree,GAD |
| umls:C0085669 | Acute leukemia | 4 | BeFree |
| umls:C0206139 | Lichen Planus, Oral | 4 | BeFree,GAD |
| umls:C0520909 | Postoperative Nausea and Vomiting | 4 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 4 | BeFree |
| umls:C1623038 | Cirrhosis | 4 | BeFree |
| umls:C0001418 | Adenocarcinoma | 3 | BeFree |
| umls:C0002895 | Anemia, Sickle Cell | 3 | BeFree,GAD |
| umls:C0003864 | Arthritis | 3 | GAD |
| umls:C0004238 | Atrial Fibrillation | 3 | GAD |
| umls:C0004936 | Mental disorders | 3 | BeFree,GAD |
| umls:C0007682 | CNS disorder | 3 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 3 | BeFree |
| umls:C0013146 | Drug abuse | 3 | BeFree |
| umls:C0013384 | Dyskinetic syndrome | 3 | BeFree,LHGDN |
| umls:C0018802 | Congestive heart failure | 3 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 3 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 3 | BeFree,GAD |
| umls:C0026769 | Multiple Sclerosis | 3 | BeFree,GAD |
| umls:C0026848 | Myopathy | 3 | BeFree,GAD |
| umls:C0029408 | Degenerative polyarthritis | 3 | GAD |
| umls:C0033975 | Psychotic Disorders | 3 | BeFree |
| umls:C0035078 | Kidney Failure | 3 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 3 | BeFree,GAD |
| umls:C0042963 | Vomiting | 3 | BeFree,GAD |
| umls:C0085580 | Essential Hypertension | 3 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 3 | BeFree |
| umls:C0151526 | Premature Birth | 3 | GAD |
| umls:C0151744 | Myocardial Ischemia | 3 | BeFree |
| umls:C0242992 | Multiple Chemical Sensitivity | 3 | BeFree,GAD |
| umls:C0278488 | Carcinoma breast stage IV | 3 | BeFree |
| umls:C0302592 | Cervix carcinoma | 3 | BeFree,GAD |
| umls:C0345904 | Malignant neoplasm of liver | 3 | BeFree,GAD |
| umls:C0349204 | Nonorganic psychosis | 3 | BeFree |
| umls:C0392702 | Abnormal involuntary movement | 3 | BeFree |
| umls:C0393571 | Multiple System Atrophy | 3 | BeFree,GAD |
| umls:C0520679 | Sleep Apnea, Obstructive | 3 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 3 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 3 | BeFree |
| umls:C1512433 | Cervical high grade squamous intraepithelial lesion | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C2986665 | Early-Stage Breast Carcinoma | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | GAD |
| umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
| umls:C0004096 | Asthma | 2 | GAD |
| umls:C0004352 | Autistic Disorder | 2 | BeFree,GAD |
| umls:C0005779 | Blood Coagulation Disorders | 2 | GAD |
| umls:C0006118 | Brain Neoplasms | 2 | BeFree |
| umls:C0007107 | Malignant neoplasm of larynx | 2 | BeFree |
| umls:C0007121 | Bronchogenic Carcinoma | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0008625 | Chromosome Aberrations | 2 | GAD |
| umls:C0009080 | Clubbed Fingers | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0018799 | Heart Diseases | 2 | BeFree |
| umls:C0020473 | Hyperlipidemia | 2 | BeFree,GAD |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree,GAD |
| umls:C0023418 | leukemia | 2 | BeFree,GAD,LHGDN |
| umls:C0023470 | Myeloid Leukemia | 2 | GAD |
| umls:C0023473 | Myeloid Leukemia, Chronic | 2 | BeFree,GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 2 | GAD |
| umls:C0024586 | Malignant Carcinoid Syndrome | 2 | BeFree |
| umls:C0027066 | Myoclonus | 2 | BeFree |
| umls:C0027412 | Opioid-Related Disorders | 2 | GAD |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0031212 | Personality Disorders | 2 | BeFree,GAD |
| umls:C0032019 | Pituitary Neoplasms | 2 | BeFree,GAD |
| umls:C0033953 | Psychosexual Disorders | 2 | CTD_human |
| umls:C0035455 | Rhinitis | 2 | GAD,LHGDN |
| umls:C0036337 | Schizoaffective Disorder | 2 | BeFree |
| umls:C0036572 | Seizures | 2 | BeFree,GAD |
| umls:C0038356 | Stomach Neoplasms | 2 | GAD |
| umls:C0040479 | Torsades de Pointes | 2 | BeFree,LHGDN |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C0086132 | Depressive Symptoms | 2 | BeFree |
| umls:C0149651 | Clubbing | 2 | BeFree |
| umls:C0151559 | Central nervous system depression (disorder) | 2 | BeFree |
| umls:C0236733 | Amphetamine-Related Disorders | 2 | CTD_human,GAD |
| umls:C0236969 | Substance-Related Disorders | 2 | CTD_human,GAD |
| umls:C0339573 | Glaucoma, Primary Open Angle | 2 | BeFree |
| umls:C0428977 | Bradycardia | 2 | CTD_human,GAD |
| umls:C0524662 | Opiate Addiction | 2 | BeFree |
| umls:C0595921 | Intraocular pressure disorder | 2 | BeFree |
| umls:C0596321 | Chemical Carcinogenesis | 2 | BeFree |
| umls:C0677050 | Manganese Poisoning | 2 | CTD_human,GAD |
| umls:C0850666 | Helicobacter pylori infection | 2 | GAD |
| umls:C0871189 | Psychotic symptom | 2 | BeFree |
| umls:C0877008 | Enzyme inhibition disorder | 2 | BeFree |
| umls:C0878544 | Cardiomyopathies | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C1565489 | Renal Insufficiency | 2 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C3714514 | Infection | 2 | GAD,LHGDN |
| umls:C0000786 | Spontaneous abortion | 1 | GAD |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | BeFree |
| umls:C0001420 | Papillary adenocarcinoma | 1 | GAD |
| umls:C0001824 | Agranulocytosis | 1 | GAD |
| umls:C0002874 | Aplastic Anemia | 1 | BeFree |
| umls:C0003578 | Apnea | 1 | GAD |
| umls:C0003811 | Cardiac Arrhythmia | 1 | GAD |
| umls:C0003944 | As If Personality | 1 | GAD |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0004779 | Basal Cell Nevus Syndrome | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | LHGDN |
| umls:C0006112 | Brain Diseases, Metabolic | 1 | GAD |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 1 | GAD |
| umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
| umls:C0008370 | Cholestasis | 1 | BeFree |
| umls:C0009241 | Cognition Disorders | 1 | CTD_rat |
| umls:C0009373 | Colonic Diseases | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
| umls:C0009421 | Comatose | 1 | CTD_human |
| umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
| umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
| umls:C0011065 | Cessation of life | 1 | LHGDN |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | LHGDN |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0012734 | Disruptive Behavior Disorder | 1 | BeFree |
| umls:C0013182 | Drug Allergy | 1 | GAD |
| umls:C0013274 | Patent ductus arteriosus | 1 | GAD |
| umls:C0013390 | Dysmenorrhea | 1 | GAD |
| umls:C0013421 | Dystonia | 1 | CTD_human |
| umls:C0013473 | Eating Disorders | 1 | BeFree |
| umls:C0014549 | Tonic-Clonic Epilepsy | 1 | CTD_human,GAD |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0015672 | Fatigue | 1 | GAD |
| umls:C0015929 | Fetal Diseases | 1 | GAD |
| umls:C0015934 | Fetal Growth Retardation | 1 | GAD |
| umls:C0017178 | Gastrointestinal Diseases | 1 | GAD |
| umls:C0017181 | Gastrointestinal Hemorrhage | 1 | GAD |
| umls:C0017601 | Glaucoma | 1 | GAD |
| umls:C0017612 | Glaucoma, Open-Angle | 1 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0019189 | Hepatitis, Chronic | 1 | LHGDN |
| umls:C0019337 | Heroin Dependence | 1 | GAD |
| umls:C0020524 | Disorders of Excessive Somnolence | 1 | GAD |
| umls:C0020615 | Hypoglycemia | 1 | GAD |
| umls:C0020625 | Hyponatremia | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
| umls:C0024031 | Low Back Pain | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0024517 | Single major depressive episode | 1 | BeFree |
| umls:C0024620 | Primary malignant neoplasm of liver | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree,GAD |
| umls:C0025286 | Meningioma | 1 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 1 | GAD |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree,GAD |
| umls:C0026837 | Muscle Rigidity | 1 | CTD_human |
| umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0027707 | Nephritis, Interstitial | 1 | CTD_human |
| umls:C0028768 | Obsessive-Compulsive Disorder | 1 | BeFree |
| umls:C0028797 | Occupational Diseases | 1 | CTD_human |
| umls:C0028840 | Ocular Hypertension | 1 | GAD |
| umls:C0028960 | Oligospermia | 1 | BeFree |
| umls:C0029421 | Osteochondritis Dissecans | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | GAD |
| umls:C0032708 | Disorders of Porphyrin Metabolism | 1 | BeFree,GAD |
| umls:C0032787 | Postoperative Complications | 1 | GAD |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0032962 | Pregnancy Complications | 1 | GAD |
| umls:C0032963 | Pregnancy Complications, Cardiovascular | 1 | GAD |
| umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
| umls:C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
| umls:C0033931 | Psychophysiologic Disorders | 1 | BeFree,GAD |
| umls:C0035243 | Respiratory Tract Infections | 1 | GAD |
| umls:C0037019 | Shy-Drager Syndrome | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | GAD |
| umls:C0037286 | Skin Neoplasms | 1 | GAD |
| umls:C0038358 | Gastric ulcer | 1 | GAD |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | GAD |
| umls:C0039231 | Tachycardia | 1 | GAD |
| umls:C0040136 | Thyroid Neoplasm | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0040822 | Tremor | 1 | CTD_human |
| umls:C0041327 | Tuberculosis, Pulmonary | 1 | GAD |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0042109 | Urticaria | 1 | GAD |
| umls:C0042693 | Violence | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | CTD_human |
| umls:C0043352 | Xerostomia | 1 | GAD |
| umls:C0079772 | T-Cell Lymphoma | 1 | GAD |
| umls:C0085179 | Eosinophilia-Myalgia Syndrome | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
| umls:C0085602 | Polydipsia | 1 | BeFree |
| umls:C0085631 | Agitation | 1 | GAD |
| umls:C0149871 | Deep Vein Thrombosis | 1 | GAD |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0151636 | Premature ventricular contractions | 1 | GAD |
| umls:C0152020 | Gastroparesis | 1 | GAD |
| umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
| umls:C0184567 | Acute onset pain | 1 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0221074 | Depression, Postpartum | 1 | GAD |
| umls:C0221765 | Chronic schizophrenia | 1 | BeFree |
| umls:C0236664 | Alcohol-Related Disorders | 1 | GAD |
| umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | GAD |
| umls:C0262584 | Carcinoma, Small Cell | 1 | BeFree |
| umls:C0264716 | Chronic heart failure | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0346153 | Breast Cancer, Familial | 1 | BeFree |
| umls:C0375071 | Malignant neoplasm of vulva | 1 | BeFree |
| umls:C0399368 | Amelogenesis Imperfecta, Type IB | 1 | BeFree |
| umls:C0400936 | Autoimmune liver disease | 1 | BeFree |
| umls:C0424166 | Social fear | 1 | BeFree |
| umls:C0494475 | Tonic - clonic seizures | 1 | BeFree |
| umls:C0520463 | Chronic active hepatitis | 1 | BeFree |
| umls:C0520905 | Vomiting, Postoperative | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree |
| umls:C0542165 | Pseudoparkinsonism | 1 | BeFree |
| umls:C0596240 | Cancer pain | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0677055 | CARCINOMA OF VULVA | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0748061 | psychiatric hospitalization | 1 | BeFree |
| umls:C0748540 | Scleroderma, Limited | 1 | GAD |
| umls:C0809983 | Schizophrenia and related disorders | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C0850741 | Smoker's lung | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
| umls:C0877373 | Advanced cancer | 1 | BeFree |
| umls:C0917799 | Hypersomnia | 1 | BeFree |
| umls:C0948807 | Hepatic impairment | 1 | BeFree |
| umls:C1135191 | Heart Failure, Systolic | 1 | BeFree |
| umls:C1141890 | Congenital long QT syndrome | 1 | BeFree |
| umls:C1258104 | Diffuse Scleroderma | 1 | GAD |
| umls:C1260922 | Abnormal breathing | 1 | BeFree |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C1518005 | Low Grade Cervical Squamous Intraepithelial Neoplasia | 1 | BeFree |
| umls:C1562928 | Progesterone receptor positive tumor | 1 | BeFree |
| umls:C1563119 | Hormone receptor positive tumor | 1 | BeFree |
| umls:C1762616 | Meningioma, benign, no ICD-O subtype | 1 | BeFree |
| umls:C1827377 | Slow acetylator due to N-acetyltransferase enzyme variant | 1 | BeFree |
| umls:C1832426 | Wilms Tumor 4 | 1 | BeFree |
| umls:C1846502 | Mammographic Density | 1 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C2609414 | Acute kidney injury | 1 | CTD_human |
| umls:C3827868 | Tachycardia by ECG Finding | 1 | GAD |
| umls:C3887612 | Psychomotor Agitation | 1 | GAD |
| umls:C1837154 | Drug Metabolism, Poor, CYP2D6-Related | 0 | CTD_human |
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