TissGDB

Home

	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP2E1

Gene summary

Basic gene information	Gene symbol	CYP2E1
	Gene name	cytochrome P450, family 2, subfamily E, polypeptide 1
	Synonyms	CPE1\|CYP2E\|P450-J\|P450C2E
	Cytomap	UCSC genome browser: 10q26.3
	Type of gene	protein-coding
	RefGenes	NM_000773.3,
	Description	4-nitrophenol 2-hydroxylaseCYPIIE1cytochrome P450 2E1cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1cytochrome P450-Jflavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenase
	Modification date	20141222
dbXrefs	MIM : 124040
	HGNC : HGNC
	Ensembl : ENSG00000130649
	HPRD : 11813
	Vega : OTTHUMG00000019322
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CYP2E1
	BioGPS: 1571
Pathway	NCI Pathway Interaction Database: CYP2E1
	KEGG: CYP2E1
	REACTOME: CYP2E1
	Pathway Commons: CYP2E1
Context	iHOP: CYP2E1
	ligand binding site mutation search in PubMed: CYP2E1
	UCL Cancer Institute: CYP2E1
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of CYP2E1	Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. J Toxicol Environ Health A. 2015;78(1):15-31. doi: 10.1080/15287394.2015.958417. (pmid:25424544) go to article
Description by TissGene annotations	TissgsKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0016098	monoterpenoid metabolic process	16401082
GO:0017144	drug metabolic process	19219744
GO:0046483	heterocycle metabolic process	19651758
GO:0055114	oxidation-reduction process	16401082
GO:0016098	monoterpenoid metabolic process	16401082
GO:0017144	drug metabolic process	19219744
GO:0046483	heterocycle metabolic process	19651758
GO:0055114	oxidation-reduction process	16401082

Top

TissGeneExp for CYP2E1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRP	-1.710098237	0.264461138	-1.974559375	9.00E-06	3.81E-05
LIHC	7.885319513	12.38027951	-4.49496	3.11E-08	2.45E-07
HNSC	-0.622190533	2.129869932	-2.752060465	1.47E-07	1.38E-06
BLCA	-2.345030803	-0.707578171	-1.637452632	0.0018	0.011671137
KICH	-1.613544487	-0.343348487	-1.270196	0.00188	0.003886979
PRAD	-0.865491025	0.243008975	-1.1085	0.000454	0.001612384
KIRC	-2.081793376	-0.889946154	-1.191847222	0.000114	0.000237872

Top

TissGene-miRNA for CYP2E1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

Top

TissGeneMut for CYP2E1

TissGeneSNV for CYP2E1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.M350I	SKCM	2
p.S129F	SKCM	2
p.E328*	UCEC	1
p.D167N	PAAD	1
p.L171F	SKCM	1
p.E346Q	BLCA	1
p.D287N	STAD	1
p.R282H	STAD	1
p.L449I	COAD	1
p.I42M	LUAD	1
p.D470N	COAD	1
p.M200I	ESCA	1
p.E320A	KIRC	1
p.F427L	BLCA	1
p.R359Q	COAD	1
p.G300R	SKCM	1
p.A181V	SKCM	1
p.P384T	SARC	1
p.R126W	COAD	1
p.M22T	LIHC	1
p.L32V	BRCA	1
p.V464I	READ	1
p.R146W	SKCM	1
p.P222S	SKCM	1
p.G386D	ESCA	1
p.R492C	LIHC	1
p.Y227C	STAD	1
p.Q255K	KICH	1
p.R444C	SKCM	1
p.L257V	LUAD	1
p.A240S	LUAD	1
p.M1V	LIHC	1
p.R186L	LUAD	1
p.D124N	SKCM	1
p.G439V	LUAD	1
p.L451S	THYM	1
p.P165L	SKCM	1
p.P339S	SKCM	1
p.V388L	GBM	1
p.D351G	STAD	1
p.G439V	BLCA	1
p.R337Q	STAD	1
p.L382R	UCEC	1
p.L463V	CESC	1
p.R233*	HNSC	1
p.I476V	HNSC	1
p.L184F	SKCM	1
p.A352S	STAD	1
p.I289M	HNSC	1
p.T266S	HNSC	1
p.H254Y	SKCM	1
p.F409L	SKCM	1
p.R337*	SARC	1
p.E322K	SKCM	1
p.R484H	PRAD	1
p.E244V	BLCA	1
p.P339T	READ	1
p.I183M	THCA	1
p.R149S	HNSC	1
p.A352V	SKCM	1
p.A280T	THYM	1
p.R374L	HNSC	1
p.C480F	LUAD	1
p.R492C	STAD	1
p.R374Q	SKCM	1
p.A157T	COAD	1

Top

TissGeneCNV for CYP2E1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

Top

TissGeneFusions for CYP2E1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

Top

TissGeneNet for CYP2E1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

COAD (tumor)	COAD (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

HNSC (tumor)	HNSC (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

KICH (tumor)	KICH (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

KIRC (tumor)	KIRC (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

KIRP (tumor)	KIRP (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

LIHC (tumor)	LIHC (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

LUAD (tumor)	LUAD (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

LUSC (tumor)	LUSC (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

PRAD (tumor)	PRAD (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

STAD (tumor)	STAD (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

THCA (tumor)	THCA (normal)
CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (tumor)	CYP2E1, RPL13A, PTN, AMFR, STUB1, LAMC3, ECHS1, MAFG, FANCG, POR, NFAT5, CLU, NMI, AGXT2, GATM, ABCA5 (normal)

Top

TissGeneProg for CYP2E1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Top

TissGeneClin for CYP2E1

TissGeneDrug for CYP2E1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

TissGeneDisease for CYP2E1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0242379	Malignant neoplasm of lung	50	BeFree,GAD
umls:C0684249	Carcinoma of lung	38	BeFree
umls:C0001973	Alcoholic Intoxication, Chronic	32	BeFree,CTD_human,GAD,LHGDN
umls:C2239176	Liver carcinoma	28	BeFree,CTD_human,GAD,LHGDN
umls:C1527249	Colorectal Cancer	26	BeFree,GAD
umls:C0007137	Squamous cell carcinoma	24	BeFree,GAD,LHGDN
umls:C0024623	Malignant neoplasm of stomach	23	BeFree,GAD
umls:C0699791	Stomach Carcinoma	20	BeFree
umls:C0014859	Esophageal Neoplasms	19	BeFree,GAD
umls:C0546837	Malignant neoplasm of esophagus	19	BeFree,GAD
umls:C0023896	Alcoholic Liver Diseases	18	BeFree,GAD,LHGDN
umls:C0596263	Carcinogenesis	18	BeFree
umls:C0023890	Liver Cirrhosis	16	BeFree,GAD,LHGDN
umls:C0009402	Colorectal Carcinoma	15	BeFree
umls:C0041296	Tuberculosis	15	BeFree,GAD
umls:C0023895	Liver diseases	14	BeFree,GAD,RGD
umls:C0023903	Liver neoplasms	13	BeFree,CTD_human,GAD
umls:C0023891	Liver Cirrhosis, Alcoholic	12	BeFree,CTD_human,GAD,LHGDN
umls:C0038356	Stomach Neoplasms	12	GAD,LHGDN
umls:C0278996	Cancer of Head and Neck	12	BeFree,GAD
umls:C0028754	Obesity	11	BeFree,CTD_human,GAD,RGD
umls:C0152018	Esophageal carcinoma	11	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	10	BeFree,GAD
umls:C0162309	Adrenoleukodystrophy	10	BeFree
umls:C0376670	Pancreatitis, Alcoholic	10	BeFree,GAD
umls:C0860207	Drug-Induced Liver Injury	10	CTD_human,GAD
umls:C0153381	Malignant neoplasm of mouth	9	BeFree,GAD
umls:C1623038	Cirrhosis	9	BeFree,GAD
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	9	BeFree,GAD,LHGDN
umls:C0220641	Lip and Oral Cavity Carcinoma	8	BeFree
umls:C0001418	Adenocarcinoma	7	BeFree,CTD_human,GAD
umls:C0012860	DNA Damage	7	GAD
umls:C0018671	Head and Neck Neoplasms	7	GAD
umls:C1827377	Slow acetylator due to N-acetyltransferase enzyme variant	7	BeFree
umls:C2931822	Nasopharyngeal carcinoma	7	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	6	BeFree,CTD_human
umls:C0015695	Fatty Liver	6	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0019196	Hepatitis C	6	BeFree,LHGDN
umls:C0023467	Leukemia, Myelocytic, Acute	6	BeFree
umls:C0024121	Lung Neoplasms	6	BeFree,CTD_human,GAD,LHGDN
umls:C0024305	Lymphoma, Non-Hodgkin	6	BeFree,CTD_human,GAD
umls:C0030567	Parkinson Disease	6	BeFree,CTD_human,GAD
umls:C0699885	Carcinoma of bladder	6	BeFree
umls:C0006142	Malignant neoplasm of breast	5	BeFree,GAD
umls:C0008626	Congenital chromosomal disease	5	BeFree
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	5	BeFree,GAD
umls:C0026640	Mouth Neoplasms	5	GAD
umls:C0027439	Nasopharyngeal Neoplasms	5	GAD,LHGDN
umls:C0085762	Alcohol abuse	5	BeFree,GAD
umls:C0279626	Squamous cell carcinoma of esophagus	5	BeFree
umls:C0011847	Diabetes	4	BeFree
umls:C0011849	Diabetes Mellitus	4	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	GAD,RGD
umls:C0019158	Hepatitis	4	BeFree,GAD,LHGDN
umls:C0023449	Acute lymphocytic leukemia	4	BeFree
umls:C0024299	Lymphoma	4	BeFree,GAD
umls:C0028797	Occupational Diseases	4	BeFree,GAD
umls:C0041327	Tuberculosis, Pulmonary	4	BeFree,GAD
umls:C0376358	Malignant neoplasm of prostate	4	BeFree,GAD
umls:C0524910	Hepatitis C, Chronic	4	BeFree
umls:C0678222	Breast Carcinoma	4	BeFree
umls:C1168401	Squamous cell carcinoma of the head and neck	4	BeFree,GAD
umls:C1262760	Hepatitis, Drug-Induced	4	BeFree
umls:C1458155	Mammary Neoplasms	4	GAD,LHGDN
umls:C0007113	Rectal Carcinoma	3	BeFree
umls:C0008625	Chromosome Aberrations	3	GAD
umls:C0019829	Hodgkin Disease	3	GAD
umls:C0023418	leukemia	3	GAD
umls:C0023532	Leukoplakia, Oral	3	BeFree,GAD
umls:C0030305	Pancreatitis	3	BeFree,GAD,LHGDN
umls:C0036341	Schizophrenia	3	BeFree,GAD
umls:C0149521	Pancreatitis, Chronic	3	BeFree,GAD
umls:C0152013	Adenocarcinoma of lung (disorder)	3	BeFree
umls:C0302592	Cervix carcinoma	3	BeFree,GAD
umls:C0345904	Malignant neoplasm of liver	3	BeFree,GAD
umls:C0400966	Non-alcoholic Fatty Liver Disease	3	BeFree
umls:C0850666	Helicobacter pylori infection	3	BeFree
umls:C1272641	Systemic arterial pressure	3	GAD
umls:C1442981	Alcoholic liver damage	3	BeFree
umls:C1512409	Hepatocarcinogenesis	3	BeFree
umls:C2711227	Steatohepatitis	3	BeFree
umls:C3241937	Nonalcoholic Steatohepatitis	3	BeFree
umls:C0001956	alcohol use disorder	2	BeFree
umls:C0003469	Anxiety Disorders	2	BeFree
umls:C0004096	Asthma	2	GAD
umls:C0004153	Atherosclerosis	2	BeFree,GAD
umls:C0005695	Bladder Neoplasm	2	GAD,LHGDN
umls:C0009404	Colorectal Neoplasms	2	GAD,LHGDN
umls:C0011581	Depressive disorder	2	BeFree,RGD
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	2	BeFree
umls:C0017152	Gastritis	2	GAD
umls:C0019159	Hepatitis A	2	BeFree
umls:C0019163	Hepatitis B	2	BeFree
umls:C0019193	Hepatitis, Toxic	2	GAD
umls:C0023055	Laryngeal neoplasm	2	GAD
umls:C0023434	Chronic Lymphocytic Leukemia	2	GAD
umls:C0023531	Leukoplakia	2	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	2	BeFree,GAD,LHGDN
umls:C0024141	Lupus Erythematosus, Systemic	2	BeFree
umls:C0025202	melanoma	2	BeFree,GAD
umls:C0027540	Necrosis	2	CTD_human
umls:C0028043	Nicotine Dependence	2	BeFree
umls:C0033054	Prenatal Exposure Delayed Effects	2	GAD
umls:C0206720	Squamous Cell Neoplasms	2	GAD,LHGDN
umls:C0236664	Alcohol-Related Disorders	2	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	2	BeFree
umls:C0341439	Chronic liver disease	2	BeFree
umls:C0600139	Prostate carcinoma	2	BeFree
umls:C1956346	Coronary Artery Disease	2	BeFree,GAD
umls:C0001430	Adenoma	1	BeFree,GAD
umls:C0002874	Aplastic Anemia	1	BeFree
umls:C0002875	Cooley's anemia	1	BeFree
umls:C0002938	Aneuploidy	1	GAD
umls:C0003431	Antisocial Personality Disorder	1	BeFree
umls:C0003850	Arteriosclerosis	1	BeFree
umls:C0003864	Arthritis	1	GAD
umls:C0003944	As If Personality	1	GAD
umls:C0005283	beta Thalassemia	1	LHGDN
umls:C0006277	Bronchitis	1	GAD
umls:C0007107	Malignant neoplasm of larynx	1	BeFree
umls:C0007138	Carcinoma, Transitional Cell	1	BeFree
umls:C0007193	Cardiomyopathy, Dilated	1	BeFree
umls:C0007222	Cardiovascular Diseases	1	BeFree
umls:C0007847	Malignant tumor of cervix	1	BeFree
umls:C0007873	Uterine Cervical Neoplasm	1	GAD
umls:C0008924	Cleft Lip	1	GAD
umls:C0008925	Cleft Palate	1	GAD
umls:C0011570	Mental Depression	1	BeFree
umls:C0011609	Drug Eruptions	1	CTD_human
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0013990	Pathological accumulation of air in tissues	1	GAD
umls:C0014175	Endometriosis	1	GAD
umls:C0014599	Epithelial hyperplasia	1	BeFree
umls:C0015230	Exanthema	1	BeFree
umls:C0015934	Fetal Growth Retardation	1	GAD
umls:C0016059	Fibrosis	1	LHGDN
umls:C0017154	Gastritis, Atrophic	1	BeFree
umls:C0017638	Glioma	1	BeFree
umls:C0018799	Heart Diseases	1	BeFree
umls:C0018800	Cardiomegaly	1	CTD_human
umls:C0018801	Heart failure	1	BeFree
umls:C0018802	Congestive heart failure	1	BeFree
umls:C0019693	HIV Infections	1	GAD
umls:C0020538	Hypertensive disease	1	GAD
umls:C0020627	Hypopharyngeal Neoplasms	1	GAD
umls:C0022116	Ischemia	1	LHGDN
umls:C0022665	Kidney Neoplasm	1	GAD
umls:C0023343	Leprosy	1	BeFree
umls:C0023904	Liver Neoplasms, Experimental	1	CTD_human
umls:C0024301	Lymphoma, Follicular	1	BeFree,GAD
umls:C0025500	Mesothelioma	1	GAD
umls:C0025568	Metaplasia	1	LHGDN
umls:C0027626	Neoplasm Invasiveness	1	CTD_human
umls:C0027663	Neoplasms, Multiple Primary	1	GAD
umls:C0027859	Acoustic Neuroma	1	BeFree
umls:C0029295	Oropharyngeal Neoplasms	1	GAD
umls:C0029408	Degenerative polyarthritis	1	GAD
umls:C0029445	Bone necrosis	1	GAD
umls:C0030920	Peptic Ulcer	1	BeFree
umls:C0031099	Periodontitis	1	GAD
umls:C0031117	Peripheral Neuropathy	1	GAD
umls:C0032229	Pleural Neoplasms	1	GAD
umls:C0032285	Pneumonia	1	BeFree,GAD
umls:C0032914	Pre-Eclampsia	1	GAD
umls:C0032962	Pregnancy Complications	1	GAD
umls:C0033578	Prostatic Neoplasms	1	CTD_human
umls:C0034885	Rectal Neoplasms	1	LHGDN
umls:C0035126	Reperfusion Injury	1	RGD
umls:C0035242	Respiratory Tract Diseases	1	GAD
umls:C0035244	Respiratory Tract Neoplasms	1	GAD
umls:C0035369	Retroviridae Infections	1	BeFree
umls:C0036421	Systemic Scleroderma	1	GAD
umls:C0038354	Stomach Diseases	1	GAD
umls:C0039730	Thalassemia	1	LHGDN
umls:C0040332	Tobacco Dependence	1	BeFree
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0041107	Trisomy	1	GAD
umls:C0041755	Adverse reaction to drug	1	CTD_human
umls:C0041955	Ureteral Neoplasms	1	GAD
umls:C0042963	Vomiting	1	BeFree
umls:C0079487	Helicobacter Infections	1	GAD
umls:C0085084	Motor Neuron Disease	1	GAD
umls:C0085669	Acute leukemia	1	BeFree
umls:C0149782	Squamous cell carcinoma of lung	1	BeFree
umls:C0149925	Small cell carcinoma of lung	1	BeFree
umls:C0151526	Premature Birth	1	GAD
umls:C0153405	Malignant neoplasm of pharynx	1	BeFree
umls:C0153633	Malignant neoplasm of brain	1	BeFree
umls:C0206708	Cervical Intraepithelial Neoplasia	1	GAD
umls:C0220624	adult brain tumor	1	BeFree,GAD
umls:C0233697	Obsessions	1	BeFree
umls:C0236969	Substance-Related Disorders	1	GAD
umls:C0239946	Fibrosis, Liver	1	BeFree
umls:C0241910	Hepatitis, Autoimmune	1	BeFree
umls:C0241913	Halothane Hepatitis	1	BeFree
umls:C0242383	Age related macular degeneration	1	GAD
umls:C0243026	Sepsis	1	RGD
umls:C0262584	Carcinoma, Small Cell	1	BeFree
umls:C0271907	Acquired aplastic anemia	1	BeFree
umls:C0272139	Erythrocytosis due to low atmospheric pressure	1	BeFree
umls:C0278701	Gastric Adenocarcinoma	1	BeFree
umls:C0333873	Squamous intraepithelial lesion	1	BeFree
umls:C0333875	High-Grade Squamous Intraepithelial Lesions	1	BeFree
umls:C0346647	Malignant neoplasm of pancreas	1	GAD
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	1	BeFree
umls:C0400943	Cirrhosis - non-alcoholic	1	BeFree
umls:C0426576	Gastrointestinal symptom	1	BeFree
umls:C0595989	Carcinoma of larynx	1	BeFree
umls:C0677886	Epithelial ovarian cancer	1	GAD
umls:C0745744	End Stage Liver Disease	1	BeFree
umls:C0747548	Pharyngeal Carcinoma	1	BeFree
umls:C0751606	Adult Acute Lymphocytic Leukemia	1	BeFree
umls:C0751688	Malignant Squamous Cell Neoplasm	1	BeFree
umls:C0751865	Alcohol-Induced Disorders, Nervous System	1	GAD
umls:C0851887	Adenoviral infections	1	BeFree
umls:C0860204	Cholestatic liver disease	1	BeFree
umls:C0878544	Cardiomyopathies	1	BeFree
umls:C0919532	Genomic Instability	1	GAD
umls:C1140680	Malignant neoplasm of ovary	1	GAD
umls:C1302401	Adenoma of large intestine	1	BeFree
umls:C1332977	Childhood Leukemia	1	BeFree
umls:C1449861	Micronuclei, Chromosome-Defective	1	CTD_human
umls:C1609538	Latent Tuberculosis	1	BeFree
umls:C2145472	Urothelial Carcinoma	1	BeFree
umls:C2718067	Alcoholic Steatohepatitis	1	BeFree
umls:C3146244	Alcohol Related Birth Defect	1	BeFree