TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP3A4

Gene summary

Basic gene information	Gene symbol	CYP3A4
	Gene name	cytochrome P450, family 3, subfamily A, polypeptide 4
	Synonyms	CP33\|CP34\|CYP3A\|CYP3A3\|CYPIIIA3\|CYPIIIA4\|HLP\|NF-25\|P450C3\|P450PCN1
	Cytomap	UCSC genome browser: 7q21.1
	Type of gene	protein-coding
	RefGenes	NM_001202855.2, NM_017460.5,NM_001202856.1,NM_001202857.1,
	Description	1,8-cineole 2-exo-monooxygenaseP450-III, steroid induciblealbendazole monooxygenasealbendazole sulfoxidasecytochrome P450 3A3cytochrome P450 3A4cytochrome P450 HLpcytochrome P450 NF-25cytochrome P450, subfamily IIIA (niphedipine oxidase), polypept
	Modification date	20141207
dbXrefs	MIM : 124010
	HGNC : HGNC
	HPRD : 00484
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CYP3A4
	BioGPS: 1576
Pathway	NCI Pathway Interaction Database: CYP3A4
	KEGG: CYP3A4
	REACTOME: CYP3A4
	Pathway Commons: CYP3A4
Context	iHOP: CYP3A4
	ligand binding site mutation search in PubMed: CYP3A4
	UCL Cancer Institute: CYP3A4
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of CYP3A4
Description by TissGene annotations	TissgsKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0009822	alkaloid catabolic process	15039299
GO:0016098	monoterpenoid metabolic process	16401082
GO:0017144	drug metabolic process	15327587
GO:0036378	calcitriol biosynthetic process from calciol	15546903
GO:0042737	drug catabolic process	15039299
GO:0042738	exogenous drug catabolic process	18619574
GO:0046483	heterocycle metabolic process	15327587
GO:0055114	oxidation-reduction process	16401082
GO:0070989	oxidative demethylation	15039299
GO:0009822	alkaloid catabolic process	15039299
GO:0016098	monoterpenoid metabolic process	16401082
GO:0017144	drug metabolic process	15327587
GO:0036378	calcitriol biosynthetic process from calciol	15546903
GO:0042737	drug catabolic process	15039299
GO:0042738	exogenous drug catabolic process	18619574
GO:0046483	heterocycle metabolic process	15327587
GO:0055114	oxidation-reduction process	16401082
GO:0070989	oxidative demethylation	15039299

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TissGeneExp for CYP3A4

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
HNSC	-1.463078067	1.217335886	-2.680413953	3.13E-09	4.40E-08
LIHC	8.300460165	14.35760817	-6.057148	1.31E-12	2.53E-11
KIRC	0.026997999	1.817417443	-1.790419444	5.22E-07	1.37E-06
BRCA	-1.640620642	0.003701288	-1.64432193	1.34E-24	1.30E-23
COAD	0.603540627	3.080202165	-2.476661538	0.000105	0.00037838
KIRP	0.426789665	2.545895915	-2.11910625	2.91E-05	0.000111908

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TissGene-miRNA for CYP3A4

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for CYP3A4

TissGeneSNV for CYP3A4

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.P218L	SKCM	2
p.M114I	SKCM	2
p.G48E	SKCM	2
p.P68L	SKCM	2
p.K476E	UCEC	1
p.S134Y	STAD	1
p.E122K	SKCM	1
p.G286R	SKCM	1
p.P52S	SKCM	1
p.E10K	SKCM	1
p.K180N	SARC	1
p.G330E	SKCM	1
p.S136F	SKCM	1
p.V204G	BRCA	1
p.N247H	UCEC	1
p.D194N	BLCA	1
p.D142N	SKCM	1
p.S131L	SKCM	1
p.E267Q	BLCA	1
p.E112K	HNSC	1
p.S45Y	SARC	1
p.G37E	SKCM	1
p.P218S	SKCM	1
p.F74L	BLCA	1
p.P488L	SKCM	1
p.E244*	UCEC	1
p.M371I	ESCA	1
p.P169S	BRCA	1
p.K209E	LUAD	1
p.P5L	SKCM	1
p.P284S	SARC	1
p.E63D	BLCA	1
p.E262K	BLCA	1
p.A297T	STAD	1
p.G69E	SKCM	1
p.R268X	LIHC	1
p.L206V	LGG	1
p.P202S	SKCM	1
p.R290K	BLCA	1
p.R130Q	SKCM	1
p.I151T	LUAD	1
p.Q202H	HNSC	1
p.D380Y	READ	1
p.S345*	SARC	1
p.P338L	SKCM	1
p.Y319C	SKCM	1
p.E262K	HNSC	1
p.L299I	HNSC	1
p.T363M	LUAD	1
p.S119F	SKCM	1
p.E262K	LGG	1
p.K390N	COAD	1
p.L325V	BLCA	1
p.F219L	UCEC	1
p.T213M	LUAD	1
p.D174_splice	GBM	1
p.P324L	SKCM	1
p.R212I	UCEC	1
p.E260K	SKCM	1
p.N426S	UCEC	1
p.L449I	HNSC	1
p.S286F	SKCM	1
p.Q334E	BLCA	1
p.E417Q	BLCA	1
p.R440K	BLCA	1
p.E412D	UCEC	1
p.T349I	UCEC	1
p.M452I	UCEC	1
p.G31R	SKCM	1
p.E122K	BLCA	1
p.R403C	STAD	1
p.E112K	BLCA	1
p.E112K	LGG	1
p.V71M	SKCM	1
p.M9V	SKCM	1
p.Y169C	SKCM	1
p.S139N	SKCM	1
p.W258*	SKCM	1
p.P368S	SKCM	1
p.E125K	UCEC	1
p.R403H	GBM	1
p.M452I	SKCM	1
p.M302I	SKCM	1
p.L356V	LGG	1
p.P169L	SKCM	1
p.K59E	LUAD	1
p.E144*	LGG	1
p.P261L	LUAD	1
p.D425E	LUSC	1
p.M89I	SKCM	1

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TissGeneCNV for CYP3A4

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for CYP3A4

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for CYP3A4

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

COAD (tumor)	COAD (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

HNSC (tumor)	HNSC (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

KICH (tumor)	KICH (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

KIRC (tumor)	KIRC (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

KIRP (tumor)	KIRP (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

LIHC (tumor)	LIHC (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

LUAD (tumor)	LUAD (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

LUSC (tumor)	LUSC (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

PRAD (tumor)	PRAD (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

STAD (tumor)	STAD (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

THCA (tumor)	THCA (normal)
CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (tumor)	CYP3A4, HNF4A, SP1, RXRB, CEBPB, GK, RXRA, AMFR, NR1I2, STUB1, CEBPA, USF1, HNF1A, SP3, UGT2B7, VDR, NFIC, NR1I3, PGRMC1, FOXA3 (normal)

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TissGeneProg for CYP3A4

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for CYP3A4

TissGeneDrug for CYP3A4

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB00951	Isoniazid		Small molecule	Approved

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TissGeneDisease for CYP3A4

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0376358	Malignant neoplasm of prostate	39	BeFree,GAD
umls:C0006142	Malignant neoplasm of breast	33	BeFree,GAD
umls:C0600139	Prostate carcinoma	28	BeFree
umls:C0019693	HIV Infections	21	BeFree,GAD
umls:C2239176	Liver carcinoma	18	BeFree,LHGDN
umls:C0678222	Breast Carcinoma	16	BeFree
umls:C0596263	Carcinogenesis	11	BeFree
umls:C0242379	Malignant neoplasm of lung	10	BeFree,GAD
umls:C1458155	Mammary Neoplasms	10	BeFree,CTD_human,GAD,LHGDN
umls:C0023903	Liver neoplasms	9	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	7	BeFree,CTD_rat,GAD,LHGDN
umls:C0020443	Hypercholesterolemia	7	BeFree,GAD
umls:C0023418	leukemia	7	BeFree,GAD
umls:C0020538	Hypertensive disease	6	BeFree,GAD
umls:C0023449	Acute lymphocytic leukemia	6	BeFree
umls:C0023890	Liver Cirrhosis	6	BeFree,LHGDN
umls:C0026848	Myopathy	6	BeFree,GAD
umls:C1527249	Colorectal Cancer	6	BeFree,GAD
umls:C0011849	Diabetes Mellitus	5	BeFree,GAD
umls:C0020479	Hyperlipoproteinemia Type III	5	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	5	BeFree
umls:C0684249	Carcinoma of lung	5	BeFree
umls:C0699790	Colon Carcinoma	5	BeFree
umls:C1704272	Benign Prostatic Hyperplasia	5	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	5	BeFree,GAD
umls:C0005684	Malignant neoplasm of urinary bladder	4	BeFree,GAD
umls:C0010054	Coronary Arteriosclerosis	4	BeFree
umls:C0010068	Coronary heart disease	4	BeFree
umls:C0014544	Epilepsy	4	BeFree,GAD
umls:C0023895	Liver diseases	4	BeFree,GAD,LHGDN
umls:C0027947	Neutropenia	4	BeFree,GAD
umls:C0919267	ovarian neoplasm	4	GAD,LHGDN
umls:C0948089	Acute Coronary Syndrome	4	BeFree,GAD
umls:C1623038	Cirrhosis	4	BeFree
umls:C0008370	Cholestasis	3	BeFree
umls:C0009402	Colorectal Carcinoma	3	BeFree
umls:C0011991	Diarrhea	3	BeFree,GAD
umls:C0018671	Head and Neck Neoplasms	3	GAD
umls:C0019196	Hepatitis C	3	BeFree,CTD_human
umls:C0020473	Hyperlipidemia	3	BeFree,GAD
umls:C0022660	Kidney Failure, Acute	3	BeFree,GAD
umls:C0022661	Kidney Failure, Chronic	3	BeFree,RGD
umls:C0023055	Laryngeal neoplasm	3	GAD
umls:C0023473	Myeloid Leukemia, Chronic	3	BeFree
umls:C0024121	Lung Neoplasms	3	BeFree,GAD,LHGDN
umls:C0033578	Prostatic Neoplasms	3	BeFree,CTD_human,LHGDN
umls:C0036341	Schizophrenia	3	BeFree,GAD
umls:C0149925	Small cell carcinoma of lung	3	BeFree
umls:C0153594	Malignant neoplasm of testis	3	GAD
umls:C0206624	Hepatoblastoma	3	BeFree
umls:C0344307	Absence of pain sensation	3	BeFree
umls:C1140680	Malignant neoplasm of ovary	3	BeFree,GAD
umls:C1956346	Coronary Artery Disease	3	GAD
umls:C0001418	Adenocarcinoma	2	BeFree
umls:C0003850	Arteriosclerosis	2	BeFree
umls:C0004096	Asthma	2	BeFree,GAD
umls:C0004153	Atherosclerosis	2	BeFree
umls:C0007102	Malignant tumor of colon	2	BeFree
umls:C0007103	Malignant neoplasm of endometrium	2	BeFree
umls:C0008312	Primary biliary cirrhosis	2	BeFree
umls:C0009324	Ulcerative Colitis	2	BeFree,GAD
umls:C0009404	Colorectal Neoplasms	2	GAD
umls:C0011847	Diabetes	2	BeFree
umls:C0014859	Esophageal Neoplasms	2	GAD
umls:C0023530	Leukopenia	2	BeFree,GAD
umls:C0026640	Mouth Neoplasms	2	GAD
umls:C0027051	Myocardial Infarction	2	BeFree,GAD
umls:C0027627	Neoplasm Metastasis	2	BeFree,GAD
umls:C0027658	Neoplasms, Germ Cell and Embryonal	2	GAD
umls:C0027726	Nephrotic Syndrome	2	BeFree
umls:C0028754	Obesity	2	BeFree
umls:C0029456	Osteoporosis	2	BeFree,GAD,LHGDN
umls:C0031347	Pharyngeal Neoplasms	2	GAD
umls:C0041296	Tuberculosis	2	BeFree
umls:C0079774	Peripheral T-Cell Lymphoma	2	BeFree,GAD
umls:C0162557	Liver Failure, Acute	2	BeFree,GAD
umls:C0238198	Gastrointestinal Stromal Tumors	2	BeFree,GAD
umls:C0341439	Chronic liver disease	2	BeFree
umls:C0342879	Primary hypercholesterolemia	2	BeFree
umls:C0345904	Malignant neoplasm of liver	2	GAD
umls:C0400966	Non-alcoholic Fatty Liver Disease	2	BeFree
umls:C0476089	Endometrial Carcinoma	2	BeFree
umls:C0524910	Hepatitis C, Chronic	2	BeFree
umls:C0600142	Hot flushes	2	BeFree,GAD
umls:C1319315	Adenocarcinoma of large intestine	2	BeFree
umls:C1883486	Uterine Corpus Cancer	2	BeFree
umls:C2673196	LIPOPROTEIN GLOMERULOPATHY	2	BeFree
umls:C2825306	Treatment related leukaemia	2	BeFree,GAD
umls:C0001175	Acquired Immunodeficiency Syndrome	1	GAD
umls:C0002874	Aplastic Anemia	1	BeFree
umls:C0002875	Cooley's anemia	1	BeFree
umls:C0003469	Anxiety Disorders	1	RGD
umls:C0004509	Azoospermia	1	BeFree
umls:C0005283	beta Thalassemia	1	LHGDN
umls:C0007131	Non-Small Cell Lung Carcinoma	1	GAD
umls:C0007134	Renal Cell Carcinoma	1	GAD
umls:C0007137	Squamous cell carcinoma	1	GAD
umls:C0007621	Neoplastic Cell Transformation	1	GAD
umls:C0007785	Cerebral Infarction	1	BeFree
umls:C0010346	Crohn Disease	1	BeFree
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0011206	Delirium	1	BeFree
umls:C0013182	Drug Allergy	1	GAD
umls:C0014170	Endometrial Neoplasms	1	LHGDN
umls:C0015230	Exanthema	1	GAD
umls:C0015695	Fatty Liver	1	BeFree
umls:C0015814	Femur Head Necrosis	1	GAD
umls:C0017168	Gastroesophageal reflux disease	1	BeFree
umls:C0019163	Hepatitis B	1	BeFree
umls:C0019337	Heroin Dependence	1	GAD
umls:C0020627	Hypopharyngeal Neoplasms	1	GAD
umls:C0021368	Inflammation	1	CTD_rat
umls:C0021390	Inflammatory Bowel Diseases	1	BeFree
umls:C0022658	Kidney Diseases	1	GAD
umls:C0022665	Kidney Neoplasm	1	GAD
umls:C0023448	Lymphoid leukemia	1	GAD
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	1	BeFree
umls:C0024143	Lupus Nephritis	1	GAD
umls:C0024299	Lymphoma	1	BeFree
umls:C0024530	Malaria	1	GAD
umls:C0024620	Primary malignant neoplasm of liver	1	BeFree
umls:C0024667	Animal Mammary Neoplasms	1	GAD
umls:C0025500	Mesothelioma	1	BeFree
umls:C0025517	Metabolic Diseases	1	BeFree
umls:C0027819	Neuroblastoma	1	BeFree
umls:C0029445	Bone necrosis	1	GAD
umls:C0029463	Osteosarcoma	1	CTD_human,LHGDN
umls:C0029925	Ovarian Carcinoma	1	BeFree
umls:C0030201	Pain, Postoperative	1	BeFree
umls:C0031117	Peripheral Neuropathy	1	BeFree
umls:C0037286	Skin Neoplasms	1	GAD
umls:C0038454	Cerebrovascular accident	1	BeFree
umls:C0038525	Subarachnoid Hemorrhage	1	BeFree
umls:C0039590	Testicular Neoplasms	1	GAD
umls:C0039730	Thalassemia	1	LHGDN
umls:C0040038	Thromboembolism	1	BeFree
umls:C0040479	Torsades de Pointes	1	CTD_human
umls:C0042065	Genitourinary Neoplasms	1	GAD
umls:C0042749	Viremia	1	BeFree
umls:C0079773	Lymphoma, T-Cell, Cutaneous	1	GAD
umls:C0085215	Ovarian Failure, Premature	1	GAD
umls:C0085762	Alcohol abuse	1	BeFree
umls:C0086132	Depressive Symptoms	1	BeFree
umls:C0149931	Migraine Disorders	1	GAD
umls:C0151744	Myocardial Ischemia	1	BeFree
umls:C0151798	Hepatic necrosis	1	BeFree
umls:C0152115	Lingual-Facial-Buccal Dyskinesia	1	BeFree,GAD
umls:C0153381	Malignant neoplasm of mouth	1	GAD
umls:C0162872	Aortic Aneurysm, Thoracic	1	BeFree
umls:C0206720	Squamous Cell Neoplasms	1	GAD
umls:C0206726	gliosarcoma	1	BeFree
umls:C0221765	Chronic schizophrenia	1	BeFree
umls:C0238052	Xanthomatosis, Cerebrotendinous	1	BeFree
umls:C0241910	Hepatitis, Autoimmune	1	BeFree
umls:C0242339	Dyslipidemias	1	GAD
umls:C0271561	Somatotropin deficiency	1	BeFree
umls:C0302592	Cervix carcinoma	1	GAD
umls:C0338106	Adenocarcinoma of colon	1	BeFree
umls:C0410445	Osteomalacia secondary to drug	1	BeFree
umls:C0442874	Neuropathy	1	BeFree
umls:C0524620	Metabolic Syndrome X	1	BeFree,GAD
umls:C0546837	Malignant neoplasm of esophagus	1	GAD
umls:C0549473	Thyroid carcinoma	1	GAD
umls:C0574785	Lower Urinary Tract Symptoms	1	BeFree
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0677886	Epithelial ovarian cancer	1	GAD
umls:C0685938	Malignant neoplasm of gastrointestinal tract	1	BeFree
umls:C0686347	Tardive Dyskinesia	1	BeFree,GAD
umls:C0686619	Secondary malignant neoplasm of lymph node	1	BeFree
umls:C0699885	Carcinoma of bladder	1	BeFree
umls:C0700095	Central neuroblastoma	1	BeFree
umls:C0850666	Helicobacter pylori infection	1	GAD
umls:C0852654	21-hydroxylase deficiency	1	BeFree
umls:C0877008	Enzyme inhibition disorder	1	BeFree
umls:C0877373	Advanced cancer	1	BeFree
umls:C0878555	Diffuse panbronchiolitis	1	BeFree
umls:C0948380	Colorectal cancer metastatic	1	BeFree
umls:C0948715	Infusion related reaction	1	BeFree
umls:C1141890	Congenital long QT syndrome	1	BeFree
umls:C1261473	Sarcoma	1	BeFree
umls:C1263666	Advanced cirrhosis	1	BeFree
umls:C1512409	Hepatocarcinogenesis	1	BeFree
umls:C1565489	Renal Insufficiency	1	GAD
umls:C1566590	Delayed Graft Function	1	GAD
umls:C1960870	Transformed migraine	1	BeFree
umls:C2711227	Steatohepatitis	1	BeFree
umls:C2936858	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	1	BeFree
umls:C2937421	Prostatic Hyperplasia	1	GAD
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	GAD