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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP3A5
check button Gene summary
Basic gene informationGene symbolCYP3A5
Gene namecytochrome P450, family 3, subfamily A, polypeptide 5
SynonymsCP35|CYPIIIA5|P450PCN3|PCN3
CytomapUCSC genome browser: 7q21.1
Type of geneprotein-coding
RefGenesNM_000777.4,
NM_001190484.2,NM_001291829.1,NM_001291830.1,NR_033807.2,
NR_033808.1,NR_033809.1,NR_033810.1,NR_033811.1,
NR_033812.1,
Descriptionaryl hydrocarbon hydroxylasecytochrome P450 3A5cytochrome P450 HLp2cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5cytochrome P450-PCN3flavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenase
Modification date20141222
dbXrefs MIM : 605325
HGNC : HGNC
Ensembl : ENSG00000106258
HPRD : 05617
Vega : OTTHUMG00000156724
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP3A5
BioGPS: 1577
PathwayNCI Pathway Interaction Database: CYP3A5
KEGG: CYP3A5
REACTOME: CYP3A5
Pathway Commons: CYP3A5
ContextiHOP: CYP3A5
ligand binding site mutation search in PubMed: CYP3A5
UCL Cancer Institute: CYP3A5
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of CYP3A5
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0009822alkaloid catabolic process15039299
GO:0042737drug catabolic process15039299
GO:0070989oxidative demethylation15039299
GO:0009822alkaloid catabolic process15039299
GO:0042737drug catabolic process15039299
GO:0070989oxidative demethylation15039299


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TissGeneExp for CYP3A5

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC-2.4704412270.569989006-3.0404302338.68E-088.68E-07
KIRC1.566596823-0.7142309552.2808277781.81E-138.18E-13
PRAD-0.9567495451.372706224-2.3294557693.64E-106.69E-09
LUSC-2.597573602-0.159685367-2.4378882351.02E-146.06E-14
BRCA-4.161478762-2.637317359-1.5241614046.67E-194.38E-18
LUAD-1.962348484-0.238432967-1.7239155179.13E-073.09E-06
KICH-2.500778622-1.111430622-1.3893480.01570.027139451
KIRP1.961524253-0.1987226222.1602468758.70E-050.000302409


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TissGene-miRNA for CYP3A5

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-136-5pMIMAT00004480.011-0.3456


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TissGeneMut for CYP3A5
TissGeneSNV for CYP3A5

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.N262DUCEC1
p.D326NSKCM1
p.V384MBLCA1
p.G153ESKCM1
p.M246ISKCM1
p.P39SSKCM1
p.E63KSKCM1
p.C88SSKCM1
p.R118KSKCM1
p.P29SSKCM1
p.P473TTHYM1
p.M256ISKCM1
p.E53KSKCM1
p.E76KSKCM1
p.R152WHNSC1
p.R28HUCEC1
p.L249XDLBC1
p.N331SPAAD1
p.M439TSTAD1
p.F60CLIHC1
p.E53KBLCA1
p.I28VSKCM1
p.Q133KTHYM1
p.D336NSKCM1
p.N159HUCEC1
p.I446MBLCA1
p.H30YDLBC1
p.E112VLUAD1
p.K34RLIHC1
p.I193VUCEC1
p.V147MSKCM1
p.K24RLIHC1
p.H314NLUAD1
p.S42FSKCM1
p.M449TSTAD1
p.I38VSKCM1
p.R28HESCA1
p.P218ACESC1
p.G143ESKCM1
p.E125KUCEC1
p.N341SPAAD1
p.S100YTHYM1
p.M434IBLCA1
p.E66KSKCM1
p.E273KSKCM1
p.L24ITHYM1
p.R128KSKCM1
p.F50CLIHC1
p.I430MLIHC1
p.E402KLUAD1
p.E122VLUAD1
p.R162WHNSC1
p.L304ILUAD1
p.L14IUCEC1
p.D244YCOAD1
p.W48*SKCM1
p.G491RSKCM1
p.A150TCESC1
p.E324GLUAD1


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TissGeneCNV for CYP3A5

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CYP3A5

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanESCATCGA-L5-A4OS-01AFAM200A-CYP3A55'UTR-CDSchr7:99149476chr7:99264688
TCGAfusionPortalPRADAPRADTCGA-KK-A8IA-01AMYH3-CYP3A5In-frameChr17:10532914Chr7:99264688


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TissGeneNet for CYP3A5

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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COAD (tumor)COAD (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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HNSC (tumor)HNSC (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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KICH (tumor)KICH (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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KIRC (tumor)KIRC (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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KIRP (tumor)KIRP (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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LIHC (tumor)LIHC (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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LUAD (tumor)LUAD (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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LUSC (tumor)LUSC (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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PRAD (tumor)PRAD (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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STAD (tumor)STAD (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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THCA (tumor)THCA (normal)
CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (tumor)CYP3A5, HNF4A, RDH13, ETV5, ATOH8 (normal)
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TissGeneProg for CYP3A5

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CYP3A5
TissGeneDrug for CYP3A5

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB01267PaliperidoneSmall moleculeApproved


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TissGeneDisease for CYP3A5

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast20BeFree,GAD
umls:C0019693HIV Infections16BeFree,GAD
umls:C0020538Hypertensive disease15BeFree,GAD,LHGDN
umls:C0376358Malignant neoplasm of prostate15BeFree,GAD
umls:C0242379Malignant neoplasm of lung14BeFree,GAD
umls:C0023418leukemia7GAD,LHGDN
umls:C0023473Myeloid Leukemia, Chronic7BeFree,GAD
umls:C0600139Prostate carcinoma7BeFree
umls:C0684249Carcinoma of lung7BeFree
umls:C0020443Hypercholesterolemia6BeFree,GAD
umls:C0023449Acute lymphocytic leukemia6BeFree
umls:C0023530Leukopenia6BeFree,GAD
umls:C0027947Neutropenia6BeFree,GAD
umls:C0678222Breast Carcinoma6BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma6BeFree,GAD
umls:C0022658Kidney Diseases5BeFree,CTD_human,GAD
umls:C0948089Acute Coronary Syndrome5GAD
umls:C0033578Prostatic Neoplasms4CTD_human,GAD,LHGDN
umls:C0153594Malignant neoplasm of testis4BeFree,GAD
umls:C0546837Malignant neoplasm of esophagus4BeFree,GAD
umls:C1527249Colorectal Cancer4BeFree,GAD
umls:C2239176Liver carcinoma4BeFree
umls:C0007137Squamous cell carcinoma3BeFree,GAD
umls:C0009324Ulcerative Colitis3BeFree,GAD
umls:C0014544Epilepsy3BeFree,GAD
umls:C0023452Leukemia, Lymphocytic, Acute, L13BeFree
umls:C0027051Myocardial Infarction3GAD
umls:C0036341Schizophrenia3BeFree,GAD,LHGDN
umls:C0153381Malignant neoplasm of mouth3GAD
umls:C0302592Cervix carcinoma3GAD
umls:C0345904Malignant neoplasm of liver3GAD
umls:C0549473Thyroid carcinoma3GAD
umls:C0919267ovarian neoplasm3GAD
umls:C1272641Systemic arterial pressure3GAD
umls:C1956346Coronary Artery Disease3BeFree,GAD
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree,GAD
umls:C0007134Renal Cell Carcinoma2BeFree,GAD
umls:C0007222Cardiovascular Diseases2GAD
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree
umls:C0011849Diabetes Mellitus2BeFree,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree,GAD
umls:C0011991Diarrhea2BeFree,GAD
umls:C0018671Head and Neck Neoplasms2GAD
umls:C0023470Myeloid Leukemia2BeFree,GAD,LHGDN
umls:C0023903Liver neoplasms2BeFree
umls:C0024117Chronic Obstructive Airway Disease2BeFree,GAD
umls:C0024143Lupus Nephritis2GAD
umls:C0026848Myopathy2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0027658Neoplasms, Germ Cell and Embryonal2GAD
umls:C0031117Peripheral Neuropathy2BeFree
umls:C0038454Cerebrovascular accident2GAD
umls:C0040053Thrombosis2CTD_human,GAD
umls:C0085215Ovarian Failure, Premature2GAD
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0403447Chronic Kidney Insufficiency2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C1458155Mammary Neoplasms2GAD
umls:C1561643Chronic Kidney Diseases2BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004153Atherosclerosis1GAD
umls:C0005684Malignant neoplasm of urinary bladder1GAD
umls:C0008370Cholestasis1CTD_mouse
umls:C0009404Colorectal Neoplasms1GAD
umls:C0011206Delirium1BeFree
umls:C0011853Diabetes Mellitus, Experimental1CTD_mouse
umls:C0012860DNA Damage1GAD
umls:C0013182Drug Allergy1GAD
umls:C0015230Exanthema1GAD
umls:C0018133Graft-vs-Host Disease1GAD
umls:C0019193Hepatitis, Toxic1GAD
umls:C0020473Hyperlipidemia1GAD
umls:C0022660Kidney Failure, Acute1BeFree
umls:C0022661Kidney Failure, Chronic1GAD
umls:C0022665Kidney Neoplasm1GAD
umls:C0023467Leukemia, Myelocytic, Acute1GAD
umls:C0023474Leukemia, Myeloid, Chronic-Phase1BeFree,GAD
umls:C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1GAD
umls:C0023893Liver Cirrhosis, Experimental1CTD_mouse
umls:C0023895Liver diseases1GAD
umls:C0023904Liver Neoplasms, Experimental1CTD_mouse
umls:C0024121Lung Neoplasms1GAD
umls:C0024530Malaria1GAD
umls:C0024620Primary malignant neoplasm of liver1BeFree
umls:C0027686Pathologic Neovascularization1GAD
umls:C0027720Nephrosis1CTD_rat
umls:C0027819Neuroblastoma1BeFree
umls:C0029172Oral Submucous Fibrosis1BeFree
umls:C0032787Postoperative Complications1GAD
umls:C0035126Reperfusion Injury1CTD_rat
umls:C0035220Respiratory Distress Syndrome, Newborn1BeFree
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree
umls:C0037286Skin Neoplasms1GAD
umls:C0040038Thromboembolism1BeFree
umls:C0042065Genitourinary Neoplasms1GAD
umls:C0042076Urologic Neoplasms1GAD
umls:C0042749Viremia1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1GAD
umls:C0079774Peripheral T-Cell Lymphoma1GAD
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0151650Renal fibrosis1BeFree
umls:C0152115Lingual-Facial-Buccal Dyskinesia1GAD
umls:C0206720Squamous Cell Neoplasms1GAD
umls:C0235032Neurotoxicity Syndromes1CTD_human,GAD
umls:C0238198Gastrointestinal Stromal Tumors1GAD
umls:C0240035Interstitial fibrosis1BeFree
umls:C0242383Age related macular degeneration1GAD
umls:C0242992Multiple Chemical Sensitivity1GAD
umls:C0280100Solid tumour1BeFree
umls:C0280280stage, prostate cancer1BeFree
umls:C0344307Absence of pain sensation1BeFree
umls:C0392525Nephrolithiasis1BeFree
umls:C0442833Arteriolar hyalinosis1BeFree
umls:C0442874Neuropathy1BeFree
umls:C0524909Hepatitis B, Chronic1GAD
umls:C0677886Epithelial ovarian cancer1GAD
umls:C0685938Malignant neoplasm of gastrointestinal tract1BeFree
umls:C0686347Tardive Dyskinesia1GAD
umls:C0700095Central neuroblastoma1BeFree
umls:C0746883Febrile Neutropenia1BeFree
umls:C0809983Schizophrenia and related disorders1BeFree
umls:C0855197Testicular malignant germ cell tumor1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C0948380Colorectal cancer metastatic1BeFree
umls:C1140680Malignant neoplasm of ovary1GAD
umls:C1279296Chronic leukemia (category)1BeFree
umls:C1565489Renal Insufficiency1GAD
umls:C1566590Delayed Graft Function1GAD
umls:C1841972Glucocorticoid Receptor Deficiency1BeFree
umls:C1861172Venous Thromboembolism1GAD
umls:C2937421Prostatic Hyperplasia1GAD
umls:C0085580Essential Hypertension0CTD_human