 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SLC7A13 |
 Gene summary |
| Basic gene information | Gene symbol | SLC7A13 |
| Gene name | solute carrier family 7 (anionic amino acid transporter), member 13 | |
| Synonyms | AGT-1|AGT1|XAT2 | |
| Cytomap | UCSC genome browser: 8q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_138817.2, | |
| Description | X-amino acid transporter 2amino acid transporter XAT2sodium-independent aspartate/glutamate transporter 1solute carrier family 7 member 13solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000164893 | ||
| HPRD : 15397 | ||
| Vega : OTTHUMG00000163663 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC7A13 | |
| BioGPS: 157724 | ||
| Pathway | NCI Pathway Interaction Database: SLC7A13 | |
| KEGG: SLC7A13 | ||
| REACTOME: SLC7A13 | ||
| Pathway Commons: SLC7A13 | ||
| Context | iHOP: SLC7A13 | |
| ligand binding site mutation search in PubMed: SLC7A13 | ||
| UCL Cancer Institute: SLC7A13 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of SLC7A13 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SLC7A13 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.242926138 | -0.762034388 | 1.004960526 | 2.58E-09 | 9.00E-09 |
| KIRC | -0.697687605 | 4.072788784 | -4.770476389 | 7.09E-20 | 5.54E-19 |
| KICH | -0.86001116 | 3.57505284 | -4.435064 | 4.59E-08 | 2.23E-07 |
| KIRP | -0.82903691 | 5.19814434 | -6.02718125 | 6.60E-15 | 1.72E-13 |
| Top |
| TissGene-miRNA for SLC7A13 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SLC7A13 |
| TissGeneSNV for SLC7A13 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S175F | SKCM | 4 |
| p.E268K | SKCM | 3 |
| p.G214E | SKCM | 3 |
| p.P125S | SKCM | 2 |
| p.G214R | SKCM | 2 |
| p.G30E | SKCM | 2 |
| p.D2N | SKCM | 2 |
| p.R381Q | SKCM | 2 |
| p.S310L | SKCM | 1 |
| p.A274V | STAD | 1 |
| p.E230Q | UCEC | 1 |
| p.V145I | COAD | 1 |
| p.G146E | SKCM | 1 |
| p.P465S | SKCM | 1 |
| p.I314M | SKCM | 1 |
| p.G347E | SKCM | 1 |
| p.N25D | STAD | 1 |
| p.Q80* | SKCM | 1 |
| p.L22S | LUAD | 1 |
| p.D273Y | DLBC | 1 |
| p.T225A | UCEC | 1 |
| p.F124Y | SKCM | 1 |
| p.Q80H | LUAD | 1 |
| p.N461I | SKCM | 1 |
| p.L359F | LUAD | 1 |
| p.R380K | COAD | 1 |
| p.I238V | COAD | 1 |
| p.Q319L | LIHC | 1 |
| p.R445X | KIRP | 1 |
| p.S172T | OV | 1 |
| p.M375I | ESCA | 1 |
| p.K167E | LUAD | 1 |
| p.P35S | SKCM | 1 |
| p.A68P | LUAD | 1 |
| p.L359* | LIHC | 1 |
| p.D406N | UCEC | 1 |
| p.S286L | HNSC | 1 |
| p.S306Y | UCEC | 1 |
| p.V52I | BRCA | 1 |
| p.L359X | LIHC | 1 |
| p.P239L | LIHC | 1 |
| p.P130S | SKCM | 1 |
| p.E188G | SKCM | 1 |
| p.I372T | KIRC | 1 |
| p.L148M | ESCA | 1 |
| p.V168A | HNSC | 1 |
| p.T265R | LUSC | 1 |
| p.V52I | ESCA | 1 |
| p.M291I | STAD | 1 |
| p.P75T | UCEC | 1 |
| p.R235K | SKCM | 1 |
| p.L270F | SKCM | 1 |
| p.A294S | LUAD | 1 |
| p.R380S | LUSC | 1 |
| p.E470K | SKCM | 1 |
| p.R192Q | SKCM | 1 |
| p.A245V | UCEC | 1 |
| p.G4R | PAAD | 1 |
| p.T366M | STAD | 1 |
| p.L139F | STAD | 1 |
| p.E268G | SKCM | 1 |
| p.R445* | KIRP | 1 |
| p.A447D | LUAD | 1 |
| p.I372L | LGG | 1 |
| p.I440T | LUSC | 1 |
| p.L299F | LUAD | 1 |
| p.I7T | UCEC | 1 |
| p.T62A | PRAD | 1 |
| p.G78V | HNSC | 1 |
| p.S311L | SKCM | 1 |
| p.S368L | SKCM | 1 |
| p.S163N | STAD | 1 |
| p.G78* | LUAD | 1 |
| p.L342P | LUAD | 1 |
| p.A29E | LUAD | 1 |
| p.A68L | LUAD | 1 |
| p.A68V | LUAD | 1 |
| p.E385K | SKCM | 1 |
| p.S20R | LUAD | 1 |
| p.L464P | STAD | 1 |
| p.V52I | LGG | 1 |
| p.A60V | LGG | 1 |
| p.R151H | LAML | 1 |
| p.G221W | LUAD | 1 |
| p.P391S | SKCM | 1 |
| p.I307V | LGG | 1 |
| p.V129I | UCEC | 1 |
| p.S348Y | LUSC | 1 |
| p.G221V | LUAD | 1 |
| p.I183V | LGG | 1 |
| p.E320* | SKCM | 1 |
| p.E69K | SKCM | 1 |
| p.R282Q | LUSC | 1 |
| p.R3I | LUAD | 1 |
| p.N195I | SKCM | 1 |
| p.A245V | LUSC | 1 |
| Top |
| TissGeneCNV for SLC7A13 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SLC7A13 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for SLC7A13 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for SLC7A13 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SLC7A13 |
| TissGeneDrug for SLC7A13 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SLC7A13 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0730345 | Microalbuminuria | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |