TissGeneSummary for CYP4B1 |
Gene summary |
Basic gene information | Gene symbol | CYP4B1 |
Gene name | cytochrome P450, family 4, subfamily B, polypeptide 1 | |
Synonyms | CYPIVB1|P-450HP | |
Cytomap | UCSC genome browser: 1p33 | |
Type of gene | protein-coding | |
RefGenes | NM_000779.3, NM_001099772.1, | |
Description | cytochrome P450 4B1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 124075 | |
HGNC : HGNC | ||
Ensembl : ENSG00000142973 | ||
HPRD : 00491 | ||
Vega : OTTHUMG00000007984 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYP4B1 | |
BioGPS: 1580 | ||
Pathway | NCI Pathway Interaction Database: CYP4B1 | |
KEGG: CYP4B1 | ||
REACTOME: CYP4B1 | ||
Pathway Commons: CYP4B1 | ||
Context | iHOP: CYP4B1 | |
ligand binding site mutation search in PubMed: CYP4B1 | ||
UCL Cancer Institute: CYP4B1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
Reference showing the relevant tissue of CYP4B1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CYP4B1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.418056482 | 3.639587704 | -5.057644186 | 1.07E-14 | 6.69E-13 |
LUAD | 2.534003422 | 7.337018939 | -4.803015517 | 3.16E-18 | 4.43E-17 |
COAD | -4.276706392 | -1.185710238 | -3.090996154 | 4.40E-09 | 4.32E-08 |
LUSC | 0.31539044 | 7.164359068 | -6.848968627 | 1.51E-22 | 2.41E-21 |
PRAD | 1.006758992 | 3.350030146 | -2.343271154 | 8.21E-11 | 1.90E-09 |
KIRC | -2.972593465 | -1.14938652 | -1.823206944 | 4.16E-11 | 1.54E-10 |
KIRP | -4.752657354 | -1.415457354 | -3.3372 | 3.90E-15 | 1.05E-13 |
STAD | -2.187110479 | 0.346102021 | -2.5332125 | 0.000445 | 0.002778543 |
ESCA | -1.932444854 | 1.257055146 | -3.1895 | 2.31E-05 | 0.001351958 |
KICH | -3.587036854 | -1.020456854 | -2.56658 | 9.68E-05 | 0.000253081 |
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TissGene-miRNA for CYP4B1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CYP4B1 |
TissGeneSNV for CYP4B1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D270N | SKCM | 3 |
p.R347C | STAD | 2 |
p.D271N | SKCM | 2 |
p.M193I | SKCM | 2 |
p.D217N | UCS | 1 |
p.D183N | LUAD | 1 |
p.Y232S | BRCA | 1 |
p.W53* | LIHC | 1 |
p.F117V | STAD | 1 |
p.P78S | SKCM | 1 |
p.W327L | READ | 1 |
p.R386C | GBM | 1 |
p.F235L | LUAD | 1 |
p.D354N | SKCM | 1 |
p.V128I | UCEC | 1 |
p.R346C | STAD | 1 |
p.H440R | LUSC | 1 |
p.R162H | HNSC | 1 |
p.G497D | STAD | 1 |
p.S428F | BRCA | 1 |
p.E434D | READ | 1 |
p.A188V | KIRC | 1 |
p.L226F | SKCM | 1 |
p.D359N | SKCM | 1 |
p.A292V | HNSC | 1 |
p.L329F | SKCM | 1 |
p.D360N | SKCM | 1 |
p.P78L | THYM | 1 |
p.M164T | LUAD | 1 |
p.R474C | PAAD | 1 |
p.K362N | LUAD | 1 |
p.V491A | STAD | 1 |
p.F181L | BLCA | 1 |
p.P390L | SKCM | 1 |
p.R429H | STAD | 1 |
p.A188V | STAD | 1 |
p.Q352* | STAD | 1 |
p.V391D | LUAD | 1 |
p.V465L | UCS | 1 |
p.G56E | SKCM | 1 |
p.R281W | LUAD | 1 |
p.G123_splice | LUSC | 1 |
p.G243C | LUAD | 1 |
p.W16* | SKCM | 1 |
p.E344* | ESCA | 1 |
p.R398W | GBM | 1 |
p.R244L | LUAD | 1 |
p.Y377H | SKCM | 1 |
p.H75Y | SKCM | 1 |
p.S374N | KIRC | 1 |
p.S12F | SKCM | 1 |
p.R430H | STAD | 1 |
p.A172T | SKCM | 1 |
p.Q353X | STAD | 1 |
p.E372D | SKCM | 1 |
p.M461T | COAD | 1 |
p.H502P | BRCA | 1 |
p.L227F | SKCM | 1 |
p.R265Q | SKCM | 1 |
p.H137P | SKCM | 1 |
p.R162C | GBM | 1 |
p.E372K | SKCM | 1 |
p.R162S | LUAD | 1 |
p.V227L | LUAD | 1 |
p.P507S | SKCM | 1 |
p.G203C | COAD | 1 |
p.V392I | UCEC | 1 |
p.G86R | UCEC | 1 |
p.R474H | COAD | 1 |
p.S427C | BLCA | 1 |
p.G361C | LUAD | 1 |
p.W121* | SKCM | 1 |
p.G90C | TGCT | 1 |
p.W121X | SKCM | 1 |
p.P480L | SKCM | 1 |
p.L429V | LUSC | 1 |
p.W53X | LIHC | 1 |
p.D217N | BLCA | 1 |
p.R375L | SKCM | 1 |
p.E343K | SKCM | 1 |
p.R245C | GBM | 1 |
p.F5Y | SKCM | 1 |
p.V466L | UCS | 1 |
p.P422S | STAD | 1 |
p.W16X | SKCM | 1 |
p.A188T | SKCM | 1 |
p.R245H | STAD | 1 |
p.M43V | COAD | 1 |
p.P143T | SKCM | 1 |
p.G131E | SKCM | 1 |
p.E169K | SKCM | 1 |
p.R225C | STAD | 1 |
p.R274Q | PRAD | 1 |
p.W73C | LIHC | 1 |
p.A40V | UCEC | 1 |
p.D353N | SKCM | 1 |
p.Y153N | LIHC | 1 |
p.G203D | SKCM | 1 |
p.R138H | KIRC | 1 |
p.S11F | SKCM | 1 |
p.V492A | STAD | 1 |
p.S301L | SARC | 1 |
p.G403E | SKCM | 1 |
p.H232R | LGG | 1 |
p.L328F | SKCM | 1 |
p.P481L | SKCM | 1 |
p.R244H | STAD | 1 |
p.R264Q | SKCM | 1 |
p.R473C | PAAD | 1 |
p.L490F | BLCA | 1 |
p.D218N | UCS | 1 |
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TissGeneCNV for CYP4B1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CYP4B1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BM968720 | CYP4B1-CYP4B1 | chr1:47285019 | chr1:47284751 | |
Chimerdb3.0 | ChiTaRs | NA | BG990991 | CYP4B1-NEDD4L | chr1:47283841 | chr18:55959332 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8ER-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47276856 | chr1:47495661 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A88Z-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47276856 | chr1:47495661 |
Chimerdb3.0 | FusionScan | UCEC | TCGA-KJ-A3U4-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47276856 | chr1:47495661 |
Chimerdb3.0 | FusionScan | OV | TCGA-OY-A56Q-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47280936 | chr1:47495661 |
Chimerdb3.0 | FusionScan | OV | TCGA-3P-A9WA-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47280936 | chr1:47495661 |
Chimerdb3.0 | FusionScan | OV | TCGA-3P-A9WA-01A | CYP4B1-CYP4X1 | Out-of-Frame | chr1:47276856 | chr1:47495661 |
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TissGeneNet for CYP4B1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CYP4B1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CYP4B1 |
TissGeneDrug for CYP4B1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CYP4B1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
umls:C0005695 | Bladder Neoplasm | 2 | BeFree,CTD_human,LHGDN |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 2 | BeFree |
umls:C0020538 | Hypertensive disease | 2 | GAD |
umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3887873 | Hearing Loss | 1 | GAD |