TissGeneSummary for CYP8B1 |
Gene summary |
Basic gene information | Gene symbol | CYP8B1 |
Gene name | cytochrome P450, family 8, subfamily B, polypeptide 1 | |
Synonyms | CP8B|CYP12 | |
Cytomap | UCSC genome browser: 3p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_004391.2, | |
Description | 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseCYPVIIIB1cytochrome P450 8B1cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylas | |
Modification date | 20141207 | |
dbXrefs | MIM : 602172 | |
HGNC : HGNC | ||
Ensembl : ENSG00000180432 | ||
HPRD : 03705 | ||
Vega : OTTHUMG00000133047 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYP8B1 | |
BioGPS: 1582 | ||
Pathway | NCI Pathway Interaction Database: CYP8B1 | |
KEGG: CYP8B1 | ||
REACTOME: CYP8B1 | ||
Pathway Commons: CYP8B1 | ||
Context | iHOP: CYP8B1 | |
ligand binding site mutation search in PubMed: CYP8B1 | ||
UCL Cancer Institute: CYP8B1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CYP8B1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CYP8B1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.364725367 | 4.106658633 | -4.471384 | 1.22E-10 | 9.18E-10 |
BRCA | -0.853749157 | 0.641638563 | -1.495387719 | 1.39E-16 | 7.97E-16 |
COAD | -1.558879521 | -0.531867983 | -1.027011538 | 7.76E-06 | 3.66E-05 |
KIRP | 2.690260383 | 6.128744758 | -3.438484375 | 4.23E-08 | 2.81E-07 |
THCA | -1.479177435 | 0.185210701 | -1.664388136 | 2.91E-23 | 2.15E-21 |
LIHC | 8.588016633 | 12.19337063 | -3.605354 | 1.81E-08 | 1.52E-07 |
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TissGene-miRNA for CYP8B1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CYP8B1 |
TissGeneSNV for CYP8B1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D138N | SKCM | 3 |
p.R26* | OV | 1 |
p.L35M | LIHC | 1 |
p.F419L | ESCA | 1 |
p.L212F | SKCM | 1 |
p.L447H | KIRC | 1 |
p.K425T | STAD | 1 |
p.K238R | DLBC | 1 |
p.S241Y | UCEC | 1 |
p.D191N | BLCA | 1 |
p.L202I | STAD | 1 |
p.V437I | COAD | 1 |
p.S435L | UCEC | 1 |
p.Q194H | LUAD | 1 |
p.R407C | SKCM | 1 |
p.P398H | LUAD | 1 |
p.R28C | COAD | 1 |
p.W281* | SKCM | 1 |
p.R50Q | BLCA | 1 |
p.G285R | SKCM | 1 |
p.E205K | SKCM | 1 |
p.R306Q | LUSC | 1 |
p.P473S | SKCM | 1 |
p.E264K | SKCM | 1 |
p.D195N | BLCA | 1 |
p.M431I | LIHC | 1 |
p.A333V | THYM | 1 |
p.Y374C | LIHC | 1 |
p.R494H | HNSC | 1 |
p.A161V | GBM | 1 |
p.T62S | KIRC | 1 |
p.D160N | SKCM | 1 |
p.P394L | BRCA | 1 |
p.T39I | SKCM | 1 |
p.R224L | HNSC | 1 |
p.D406N | SKCM | 1 |
p.P398L | HNSC | 1 |
p.S369F | GBM | 1 |
p.E322K | SKCM | 1 |
p.L3F | CESC | 1 |
p.S435L | SKCM | 1 |
p.E166K | UCEC | 1 |
p.D476N | SKCM | 1 |
p.W4G | PAAD | 1 |
p.R114C | BLCA | 1 |
p.S283Y | SKCM | 1 |
p.L375Q | PRAD | 1 |
p.R28C | BLCA | 1 |
p.L366M | UCEC | 1 |
p.T401I | COAD | 1 |
p.H378Y | SKCM | 1 |
p.R59S | LUAD | 1 |
p.G266E | SKCM | 1 |
p.H45N | HNSC | 1 |
p.M122I | SKCM | 1 |
p.V360A | KIRC | 1 |
p.W281X | SKCM | 1 |
p.M475I | SARC | 1 |
p.R28C | HNSC | 1 |
p.R207H | LGG | 1 |
p.H130L | LIHC | 1 |
p.W433C | HNSC | 1 |
p.R479C | COAD | 1 |
p.R494C | STAD | 1 |
p.D418N | SKCM | 1 |
p.R95K | SKCM | 1 |
p.L35M | LUAD | 1 |
p.M81R | BRCA | 1 |
p.R306Q | PAAD | 1 |
p.R349W | STAD | 1 |
p.R349Q | READ | 1 |
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TissGeneCNV for CYP8B1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CYP8B1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CYP8B1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CYP8B1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CYP8B1 |
TissGeneDrug for CYP8B1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CYP8B1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008370 | Cholestasis | 1 | CTD_human |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0856727 | Cholesterol gallstones | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
umls:C3887873 | Hearing Loss | 1 | GAD |