TissGeneSummary for TTC16 |
Gene summary |
Basic gene information | Gene symbol | TTC16 |
Gene name | tetratricopeptide repeat domain 16 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q34.11 | |
Type of gene | protein-coding | |
RefGenes | NM_144965.1, | |
Description | TPR repeat protein 16tetratricopeptide repeat protein 16 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000167094 | ||
HPRD : 15581 | ||
Vega : OTTHUMG00000020711 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTC16 | |
BioGPS: 158248 | ||
Pathway | NCI Pathway Interaction Database: TTC16 | |
KEGG: TTC16 | ||
REACTOME: TTC16 | ||
Pathway Commons: TTC16 | ||
Context | iHOP: TTC16 | |
ligand binding site mutation search in PubMed: TTC16 | ||
UCL Cancer Institute: TTC16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
Reference showing the relevant tissue of TTC16 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TTC16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.156783219 | -2.198058657 | 1.041275439 | 1.23E-11 | 5.16E-11 |
LUSC | -1.673597925 | 0.954047173 | -2.627645098 | 7.95E-13 | 3.70E-12 |
LUAD | -1.06274184 | 0.905147816 | -1.967889655 | 3.94E-08 | 1.63E-07 |
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TissGene-miRNA for TTC16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UVM | hsa-miR-24-3p | MIMAT0000080 | 0.012 | -0.28 | 80 |
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TissGeneMut for TTC16 |
TissGeneSNV for TTC16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E634K | SKCM | 2 |
p.S816R | UCEC | 1 |
p.A664T | SKCM | 1 |
p.R781W | UCEC | 1 |
p.T620A | ACC | 1 |
p.S843* | CESC | 1 |
p.S44I | LUAD | 1 |
p.A262D | KIRP | 1 |
p.R434W | HNSC | 1 |
p.P201L | SKCM | 1 |
p.S707F | BLCA | 1 |
p.Q865K | COAD | 1 |
p.R101W | COAD | 1 |
p.S215C | CESC | 1 |
p.R779C | UCEC | 1 |
p.C171* | UCEC | 1 |
p.T333S | BRCA | 1 |
p.G853R | ACC | 1 |
p.L287F | SKCM | 1 |
p.G366R | HNSC | 1 |
p.G567E | SKCM | 1 |
p.S681G | LIHC | 1 |
p.R800Q | UCEC | 1 |
p.A163V | LIHC | 1 |
p.Q218X | SKCM | 1 |
p.R225Q | UCEC | 1 |
p.R67T | HNSC | 1 |
p.L815H | LGG | 1 |
p.E748K | SKCM | 1 |
p.C46S | LUAD | 1 |
p.E553K | UCEC | 1 |
p.R796K | SKCM | 1 |
p.A182V | UCEC | 1 |
p.T723I | UCEC | 1 |
p.R718W | COAD | 1 |
p.F414V | KICH | 1 |
p.A515V | PRAD | 1 |
p.D462N | SKCM | 1 |
p.Q329X | SKCM | 1 |
p.L394X | THCA | 1 |
p.F209L | BLCA | 1 |
p.E73Q | STAD | 1 |
p.S605G | LIHC | 1 |
p.A537V | KIRC | 1 |
p.A240V | SKCM | 1 |
p.A258V | BRCA | 1 |
p.Q218* | SKCM | 1 |
p.G205V | KIRC | 1 |
p.R173C | SKCM | 1 |
p.S656* | BLCA | 1 |
p.R446Q | SKCM | 1 |
p.P471R | LUAD | 1 |
p.P201S | SKCM | 1 |
p.R210L | LUAD | 1 |
p.E6K | ESCA | 1 |
p.S746C | ESCA | 1 |
p.Y445C | COAD | 1 |
p.G14S | BLCA | 1 |
p.Q144* | HNSC | 1 |
p.Q329* | SKCM | 1 |
p.R276H | ESCA | 1 |
p.E553K | STAD | 1 |
p.L83F | LUSC | 1 |
p.A249V | LIHC | 1 |
p.Q678H | BLCA | 1 |
p.R800Q | LGG | 1 |
p.C145R | LIHC | 1 |
p.R781Q | HNSC | 1 |
p.S648L | UCEC | 1 |
p.Y809C | COAD | 1 |
p.G458A | LUAD | 1 |
p.D226N | UCEC | 1 |
p.Y295C | STAD | 1 |
p.R419H | LUAD | 1 |
p.A501V | LIHC | 1 |
p.S113L | SKCM | 1 |
p.P669H | LUAD | 1 |
p.P562S | SKCM | 1 |
p.R460H | KIRC | 1 |
p.H340Q | LUAD | 1 |
p.A258V | PAAD | 1 |
p.E73* | LUAD | 1 |
p.D302G | STAD | 1 |
p.E196* | BLCA | 1 |
p.T191M | SKCM | 1 |
p.R255C | BLCA | 1 |
p.A163T | COAD | 1 |
p.E589G | ESCA | 1 |
p.P559L | BLCA | 1 |
p.W542* | SKCM | 1 |
p.P50T | PAAD | 1 |
p.V61F | UCEC | 1 |
p.S113L | BLCA | 1 |
p.I456M | SKCM | 1 |
p.I35N | LUAD | 1 |
p.G825R | LIHC | 1 |
p.D257N | SKCM | 1 |
p.V509L | OV | 1 |
p.K246Q | DLBC | 1 |
p.R86H | COAD | 1 |
p.R670K | SKCM | 1 |
p.V599A | UCEC | 1 |
p.T736S | HNSC | 1 |
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TissGeneCNV for TTC16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TTC16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TTC16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TTC16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TTC16 |
TissGeneDrug for TTC16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TTC16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |