TissGeneSummary for C9orf84 |
Gene summary |
Basic gene information | Gene symbol | C9orf84 |
Gene name | chromosome 9 open reading frame 84 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q31.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001080551.2, NM_173521.4,NR_109816.1, | |
Description | uncharacterized protein C9orf84 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165181 | ||
HPRD : 12982 | ||
Vega : OTTHUMG00000020495 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C9orf84 | |
BioGPS: 158401 | ||
Pathway | NCI Pathway Interaction Database: C9orf84 | |
KEGG: C9orf84 | ||
REACTOME: C9orf84 | ||
Pathway Commons: C9orf84 | ||
Context | iHOP: C9orf84 | |
ligand binding site mutation search in PubMed: C9orf84 | ||
UCL Cancer Institute: C9orf84 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C9orf84 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C9orf84 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | 2.776442462 | 0.92379595 | 1.852646512 | 7.45E-09 | 9.42E-08 |
LUAD | 1.813913713 | -0.089886287 | 1.9038 | 2.18E-08 | 9.39E-08 |
KIRC | -0.731101756 | 3.374698244 | -4.1058 | 1.16E-41 | 5.42E-40 |
LUSC | 2.072436397 | 0.040852084 | 2.031584314 | 7.37E-15 | 4.44E-14 |
KIRP | -0.829061826 | 3.625672549 | -4.454734375 | 1.12E-15 | 3.49E-14 |
BLCA | 1.49025972 | -0.051077122 | 1.541336842 | 0.00549 | 0.028263333 |
KICH | 6.120235299 | 3.600887299 | 2.519348 | 0.000385 | 0.00089983 |
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TissGene-miRNA for C9orf84 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C9orf84 |
TissGeneSNV for C9orf84 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E444* | UCEC | 2 |
p.G191E | BLCA | 1 |
p.E1227D | PAAD | 1 |
p.H663R | LIHC | 1 |
p.P987A | HNSC | 1 |
p.S458L | BLCA | 1 |
p.K493N | BLCA | 1 |
p.E320K | SKCM | 1 |
p.E993X | STAD | 1 |
p.N809K | COAD | 1 |
p.F285Y | KIRP | 1 |
p.Q551L | LUAD | 1 |
p.V65A | STAD | 1 |
p.E425K | SKCM | 1 |
p.P1054S | UCEC | 1 |
p.E21D | LGG | 1 |
p.V1143E | KIRC | 1 |
p.D670N | READ | 1 |
p.A301V | COAD | 1 |
p.G1162A | BLCA | 1 |
p.R704S | LIHC | 1 |
p.A935S | BRCA | 1 |
p.S936P | STAD | 1 |
p.K716N | OV | 1 |
p.S462L | HNSC | 1 |
p.S1115X | ESCA | 1 |
p.R528X | COAD | 1 |
p.P615A | KIRP | 1 |
p.K1032E | STAD | 1 |
p.R316I | UCEC | 1 |
p.E386K | SKCM | 1 |
p.T920N | UCEC | 1 |
p.E35K | SKCM | 1 |
p.G675E | SKCM | 1 |
p.E1313K | HNSC | 1 |
p.K716R | THYM | 1 |
p.R1425H | COAD | 1 |
p.M60V | KIRP | 1 |
p.I346R | PAAD | 1 |
p.E993* | STAD | 1 |
p.E181X | KIRC | 1 |
p.E408G | UCEC | 1 |
p.E359K | SKCM | 1 |
p.F182L | READ | 1 |
p.M734L | COAD | 1 |
p.E405* | SKCM | 1 |
p.K997N | READ | 1 |
p.K1276Q | UCEC | 1 |
p.P879S | UCS | 1 |
p.E1357* | UCEC | 1 |
p.F810L | UCEC | 1 |
p.A442T | ESCA | 1 |
p.P147T | LGG | 1 |
p.S139F | LUSC | 1 |
p.R1385Q | SKCM | 1 |
p.L632P | PCPG | 1 |
p.E64K | SKCM | 1 |
p.Y1178C | BLCA | 1 |
p.E1352K | HNSC | 1 |
p.H61Q | SARC | 1 |
p.E745K | LUAD | 1 |
p.A460V | OV | 1 |
p.Q925_splice | GBM | 1 |
p.P1054S | ESCA | 1 |
p.E204K | BLCA | 1 |
p.I1171T | LUAD | 1 |
p.P1141L | HNSC | 1 |
p.E1174G | COAD | 1 |
p.R528Q | UCEC | 1 |
p.S848F | SKCM | 1 |
p.Q590L | LUAD | 1 |
p.L614I | STAD | 1 |
p.L269I | ACC | 1 |
p.E397K | HNSC | 1 |
p.S1232Y | READ | 1 |
p.K1036T | UCEC | 1 |
p.K1173N | STAD | 1 |
p.P840S | UCS | 1 |
p.K537N | UCEC | 1 |
p.E142* | KIRC | 1 |
p.I651M | SKCM | 1 |
p.Q590H | KIRC | 1 |
p.E992K | STAD | 1 |
p.P289T | THYM | 1 |
p.A1132V | LUAD | 1 |
p.L1168V | BLCA | 1 |
p.E1399X | COAD | 1 |
p.I307R | PAAD | 1 |
p.A1093V | LUAD | 1 |
p.S1324Y | PAAD | 1 |
p.E303K | SKCM | 1 |
p.V1182E | KIRC | 1 |
p.L5V | BLCA | 1 |
p.E753Q | GBM | 1 |
p.Q551H | KIRC | 1 |
p.S1240L | HNSC | 1 |
p.E123D | HNSC | 1 |
p.E183G | SKCM | 1 |
p.E307A | UCEC | 1 |
p.G230E | BLCA | 1 |
p.K496T | UCEC | 1 |
p.R708K | SKCM | 1 |
p.S1285Y | PAAD | 1 |
p.S1137* | BLCA | 1 |
p.S1145L | SKCM | 1 |
p.I663N | SARC | 1 |
p.L1207V | BLCA | 1 |
p.I980M | UCEC | 1 |
p.S1066F | SKCM | 1 |
p.S791T | LIHC | 1 |
p.N44H | UCEC | 1 |
p.S563F | SKCM | 1 |
p.I359K | LIHC | 1 |
p.Q274X | THYM | 1 |
p.S276C | CESC | 1 |
p.T973A | STAD | 1 |
p.K321* | SKCM | 1 |
p.D484N | STAD | 1 |
p.D841N | LGG | 1 |
p.E598K | COAD | 1 |
p.T30N | LUAD | 1 |
p.D1225Y | ESCA | 1 |
p.P1242H | LGG | 1 |
p.S752T | LIHC | 1 |
p.E784K | LUAD | 1 |
p.E222G | SKCM | 1 |
p.L593P | PCPG | 1 |
p.E1002Q | BLCA | 1 |
p.R30Q | UCEC | 1 |
p.L632F | COAD | 1 |
p.D453N | LUSC | 1 |
p.R1440W | UCEC | 1 |
p.H1358Q | SARC | 1 |
p.I690M | SKCM | 1 |
p.L230I | ACC | 1 |
p.D445N | SKCM | 1 |
p.S1341F | READ | 1 |
p.E264K | SKCM | 1 |
p.E515D | UCEC | 1 |
p.V914G | BRCA | 1 |
p.T283I | STAD | 1 |
p.A422G | HNSC | 1 |
p.Q1276E | LUAD | 1 |
p.I398K | LIHC | 1 |
p.K620I | SKCM | 1 |
p.A12V | UCS | 1 |
p.E358K | HNSC | 1 |
p.E1301K | BLCA | 1 |
p.L121S | LUSC | 1 |
p.E918D | STAD | 1 |
p.A442V | STAD | 1 |
p.F324Y | KIRP | 1 |
p.K581I | SKCM | 1 |
p.D1365Y | COAD | 1 |
p.T402M | STAD | 1 |
p.P334L | KIRP | 1 |
p.G472D | LUAD | 1 |
p.Q1108* | BLCA | 1 |
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TissGeneCNV for C9orf84 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C9orf84 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C9orf84 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C9orf84 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C9orf84 |
TissGeneDrug for C9orf84 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C9orf84 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |