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| TissGeneSummary for ZNF645 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF645 |
| Gene name | zinc finger protein 645 | |
| Synonyms | CT138|HAKAIL | |
| Cytomap | UCSC genome browser: Xp22.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152577.3, | |
| Description | E3 ubiquitin ligaseE3 ubiquitin-protein ligase ZNF645 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000175809 | ||
| HPRD : 06545 | ||
| Vega : OTTHUMG00000021242 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF645 | |
| BioGPS: 158506 | ||
| Pathway | NCI Pathway Interaction Database: ZNF645 | |
| KEGG: ZNF645 | ||
| REACTOME: ZNF645 | ||
| Pathway Commons: ZNF645 | ||
| Context | iHOP: ZNF645 | |
| ligand binding site mutation search in PubMed: ZNF645 | ||
| UCL Cancer Institute: ZNF645 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZNF645 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF645 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZNF645 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF645 |
| TissGeneSNV for ZNF645 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R154C | UCEC | 3 |
| p.S308L | SKCM | 2 |
| p.R154C | SKCM | 2 |
| p.A148T | LGG | 1 |
| p.N14S | LIHC | 1 |
| p.R395X | READ | 1 |
| p.R170K | PRAD | 1 |
| p.R69Q | HNSC | 1 |
| p.A283V | OV | 1 |
| p.R137H | STAD | 1 |
| p.E370K | SKCM | 1 |
| p.K42R | STAD | 1 |
| p.R97C | READ | 1 |
| p.R108Q | CESC | 1 |
| p.R69P | OV | 1 |
| p.Q172H | COAD | 1 |
| p.P181A | CESC | 1 |
| p.S147R | LUSC | 1 |
| p.R97C | STAD | 1 |
| p.K139M | READ | 1 |
| p.A268E | LUAD | 1 |
| p.G89R | UCEC | 1 |
| p.S290L | SKCM | 1 |
| p.G89R | STAD | 1 |
| p.R310C | SKCM | 1 |
| p.N44T | STAD | 1 |
| p.L177I | LUAD | 1 |
| p.R142* | SKCM | 1 |
| p.W393* | SKCM | 1 |
| p.Q131L | LUAD | 1 |
| p.R97C | THYM | 1 |
| p.G89R | SARC | 1 |
| p.Y90N | UCEC | 1 |
| p.S414* | LUAD | 1 |
| p.P257H | LUAD | 1 |
| p.D40Y | BLCA | 1 |
| p.P277L | COAD | 1 |
| p.R69Q | LGG | 1 |
| p.R154C | COAD | 1 |
| p.P99H | LUSC | 1 |
| p.P291S | SKCM | 1 |
| p.D166E | COAD | 1 |
| p.P277L | SKCM | 1 |
| p.R122I | UCEC | 1 |
| p.S308L | PAAD | 1 |
| p.D61N | SKCM | 1 |
| p.P261S | SKCM | 1 |
| p.T402K | LUSC | 1 |
| p.I328F | GBM | 1 |
| p.P94T | UCEC | 1 |
| p.R403L | READ | 1 |
| p.E226K | SKCM | 1 |
| p.S351F | UCEC | 1 |
| p.S270L | SKCM | 1 |
| p.R136C | BLCA | 1 |
| p.P257S | SKCM | 1 |
| p.S345Y | LUAD | 1 |
| p.P159L | UCEC | 1 |
| p.R423T | LUSC | 1 |
| p.H195R | HNSC | 1 |
| p.E10* | UCEC | 1 |
| p.P256H | UCEC | 1 |
| p.R136C | UCEC | 1 |
| p.W38L | LIHC | 1 |
| p.W393X | SKCM | 1 |
| p.E370K | PAAD | 1 |
| p.Q301R | UCEC | 1 |
| p.R341C | LUSC | 1 |
| p.P159L | CESC | 1 |
| p.K65T | UCEC | 1 |
| p.A283V | LUAD | 1 |
| p.R310C | PAAD | 1 |
| p.C263Y | BLCA | 1 |
| p.Q346* | BRCA | 1 |
| p.S216F | SKCM | 1 |
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| TissGeneCNV for ZNF645 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF645 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ZNF645 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ZNF645 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF645 |
| TissGeneDrug for ZNF645 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF645 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
| umls:C0015625 | Fanconi Anemia | 7 | BeFree |
| umls:C0030567 | Parkinson Disease | 7 | BeFree |
| umls:C0678222 | Breast Carcinoma | 7 | BeFree |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 7 | BeFree |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0019562 | Von Hippel-Lindau Syndrome | 5 | BeFree |
| umls:C1868675 | PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE | 5 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0026846 | Muscular Atrophy | 4 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 4 | BeFree |
| umls:C0751783 | Lafora Disease | 4 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
| umls:C0004352 | Autistic Disorder | 3 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree |
| umls:C0024299 | Lymphoma | 3 | BeFree |
| umls:C0042769 | Virus Diseases | 3 | BeFree |
| umls:C0162635 | Angelman Syndrome | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 3 | BeFree |
| umls:C0007959 | Charcot-Marie-Tooth Disease | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0019163 | Hepatitis B | 2 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0032461 | Polycythemia | 2 | BeFree |
| umls:C0036572 | Seizures | 2 | BeFree |
| umls:C0162534 | Prion Diseases | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 2 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C1449844 | Pseudohypoaldosteronism, Type II | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C2745900 | Promyelocytic leukemia | 2 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0006625 | Cachexia | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007112 | Adenocarcinoma of prostate | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0012546 | Diphtheria | 1 | BeFree |
| umls:C0013371 | Shigella Infections | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0022336 | Creutzfeldt-Jakob disease | 1 | BeFree |
| umls:C0022408 | Arthropathy | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023480 | Leukemia, Myelomonocytic, Chronic | 1 | BeFree |
| umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
| umls:C0023524 | Leukoencephalopathy, Progressive Multifocal | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025362 | Mental Retardation | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027809 | Neurilemmoma | 1 | BeFree |
| umls:C0028326 | Noonan Syndrome | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0030354 | Papilloma | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0035690 | RNA Virus Infections | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0036690 | Septicemia | 1 | BeFree |
| umls:C0041341 | Tuberous Sclerosis | 1 | BeFree |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0175699 | Saethre-Chotzen Syndrome | 1 | BeFree |
| umls:C0175702 | Williams Syndrome | 1 | BeFree |
| umls:C0221043 | Liddle Syndrome | 1 | BeFree |
| umls:C0242350 | Erectile dysfunction | 1 | GAD |
| umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | BeFree |
| umls:C0270968 | Limb-girdle muscular dystrophy type 2H | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0279583 | T-cell childhood acute lymphoblastic leukemia | 1 | BeFree |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
| umls:C0349639 | Juvenile Myelomonocytic Leukemia | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0524582 | Mulibrey Nanism | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0751778 | Myoclonic Epilepsies, Progressive | 1 | BeFree |
| umls:C0752105 | Parkinsonism, Juvenile | 1 | BeFree |
| umls:C0752166 | Bardet-Biedl Syndrome | 1 | BeFree |
| umls:C0752347 | Lewy Body Disease | 1 | BeFree |
| umls:C1136249 | Mental Retardation, X-Linked | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1275808 | Congenital central hypoventilation | 1 | BeFree |
| umls:C1290884 | Inflammatory disorder | 1 | BeFree |
| umls:C1334978 | Non-Hereditary Clear Cell Renal Cell Carcinoma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |
| umls:C1527405 | Erythrocytosis | 1 | BeFree |
| umls:C1561546 | Alkaline Phosphatase Adverse Event | 1 | GAD |
| umls:C1852467 | Creutzfeldt-Jakob Disease, Sporadic | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2608055 | Hereditary Renal Cell Carcinoma | 1 | BeFree |
| umls:C2986703 | Overgrowth Syndrome | 1 | BeFree |
| umls:C3150649 | AUTOIMMUNE DISEASE, MULTISYSTEM, WITH FACIAL DYSMORPHISM | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | BeFree |
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