TissGeneSummary for FMR1NB |
Gene summary |
Basic gene information | Gene symbol | FMR1NB |
Gene name | fragile X mental retardation 1 neighbor | |
Synonyms | CT37|NY-SAR-35|NYSAR35 | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_152578.2, | |
Description | cancer/testis antigen 37fragile X mental retardation 1 neighbor proteinsarcoma antigen NY-SAR-35 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000176988 | ||
HPRD : 06546 | ||
Vega : OTTHUMG00000022608 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FMR1NB | |
BioGPS: 158521 | ||
Pathway | NCI Pathway Interaction Database: FMR1NB | |
KEGG: FMR1NB | ||
REACTOME: FMR1NB | ||
Pathway Commons: FMR1NB | ||
Context | iHOP: FMR1NB | |
ligand binding site mutation search in PubMed: FMR1NB | ||
UCL Cancer Institute: FMR1NB | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FMR1NB | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FMR1NB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FMR1NB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FMR1NB |
TissGeneSNV for FMR1NB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.C173W | STAD | 1 |
p.R58W | PAAD | 1 |
p.C173F | COAD | 1 |
p.Q140X | KIRC | 1 |
p.E212K | SKCM | 1 |
p.K229R | LGG | 1 |
p.Y96H | READ | 1 |
p.T169M | GBM | 1 |
p.R205H | COAD | 1 |
p.Q114* | LUAD | 1 |
p.F174V | STAD | 1 |
p.H103N | STAD | 1 |
p.R223I | LUAD | 1 |
p.A214T | HNSC | 1 |
p.K238N | UCEC | 1 |
p.E118D | LUAD | 1 |
p.L26M | LUAD | 1 |
p.V198L | OV | 1 |
p.E46Q | LUAD | 1 |
p.D119V | HNSC | 1 |
p.Y96* | LGG | 1 |
p.A27T | COAD | 1 |
p.Q140* | BLCA | 1 |
p.F208L | READ | 1 |
p.D215N | BLCA | 1 |
p.V225A | LUSC | 1 |
p.A100T | UCEC | 1 |
p.I193M | CESC | 1 |
p.K236R | STAD | 1 |
p.P55T | UCEC | 1 |
p.A48T | COAD | 1 |
p.G113A | LUAD | 1 |
p.D119N | ESCA | 1 |
p.G227V | LUAD | 1 |
p.G56R | HNSC | 1 |
p.R235Q | STAD | 1 |
p.A18D | LUAD | 1 |
p.G10E | SKCM | 1 |
p.L151F | SKCM | 1 |
p.R235Q | UCEC | 1 |
p.R58Q | UCEC | 1 |
p.S165L | BRCA | 1 |
p.R205H | UCEC | 1 |
p.S36L | UCEC | 1 |
p.I76V | LUSC | 1 |
p.S115F | COAD | 1 |
p.Q114* | BRCA | 1 |
p.V82M | GBM | 1 |
p.M187I | ACC | 1 |
p.N127S | LGG | 1 |
p.F174L | ESCA | 1 |
p.S115T | HNSC | 1 |
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TissGeneCNV for FMR1NB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FMR1NB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | KIRC | TCGA-B0-4699-01A | NCOR2-FMR1NB | In-frame | Chr12:124882665 | ChrX:147084721 |
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TissGeneNet for FMR1NB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FMR1NB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FMR1NB |
TissGeneDrug for FMR1NB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FMR1NB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |