TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP17A1

Gene summary

Basic gene information	Gene symbol	CYP17A1
	Gene name	cytochrome P450, family 17, subfamily A, polypeptide 1
	Synonyms	CPT7\|CYP17\|P450C17\|S17AH
	Cytomap	UCSC genome browser: 10q24.3
	Type of gene	protein-coding
	RefGenes	NM_000102.3,
	Description	17-alpha-hydroxyprogesterone aldolaseCYPXVIIcytochrome P450 17A1cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasiacytochrome P450-C17cytochrome P450c17cytochrome p450 XVIIA1steroid 17-alpha-hydroxylase/17,20 lyases
	Modification date	20141222
dbXrefs	MIM : 609300
	HGNC : HGNC
	Ensembl : ENSG00000148795
	HPRD : 01944
	Vega : OTTHUMG00000018969
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CYP17A1
	BioGPS: 1586
Pathway	NCI Pathway Interaction Database: CYP17A1
	KEGG: CYP17A1
	REACTOME: CYP17A1
	Pathway Commons: CYP17A1
Context	iHOP: CYP17A1
	ligand binding site mutation search in PubMed: CYP17A1
	UCL Cancer Institute: CYP17A1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	HPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	KidneyAdrenal gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	KIRC,KIRP,KICHPCPG,ACC
Reference showing the relevant tissue of CYP17A1
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0008202	steroid metabolic process	22266943
GO:0042446	hormone biosynthetic process	22266943
GO:0042448	progesterone metabolic process	22266943
GO:0008202	steroid metabolic process	22266943
GO:0042446	hormone biosynthetic process	22266943
GO:0042448	progesterone metabolic process	22266943

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TissGeneExp for CYP17A1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRC	0.345713937	4.851676437	-4.5059625	9.73E-18	6.23E-17
THCA	0.440548306	2.839755086	-2.39920678	2.97E-16	4.94E-15
KIRP	1.503563243	5.948450743	-4.4448875	4.50E-09	3.71E-08
LUSC	-2.491556978	0.741972434	-3.233529412	4.06E-32	2.61E-30
LUAD	-1.947732231	0.790231562	-2.737963793	8.48E-22	2.11E-20
LIHC	3.628021493	2.013797493	1.614224	0.00789	0.017129707
KICH	1.746219493	4.081359493	-2.33514	0.000618	0.001388453

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TissGene-miRNA for CYP17A1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for CYP17A1

TissGeneSNV for CYP17A1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E149K	SKCM	2
p.K29M	STAD	1
p.R449C	COAD	1
p.S488Y	BRCA	1
p.K245X	TGCT	1
p.Q323E	LUAD	1
p.R496C	COAD	1
p.L7P	UCEC	1
p.E505D	LIHC	1
p.R362C	SKCM	1
p.P225S	SKCM	1
p.R440H	KIRP	1
p.E415K	SKCM	1
p.R239Q	SKCM	1
p.R125Q	COAD	1
p.D283Y	UCS	1
p.M156I	LUAD	1
p.K492N	LUSC	1
p.Y432_L433delinsSHRQX	ACC	1
p.E330K	SKCM	1
p.R20K	CESC	1
p.E84V	KIRC	1
p.L396V	BLCA	1
p.G436R	PAAD	1
p.R362H	STAD	1
p.S210I	PAAD	1
p.R67C	SKCM	1
p.S94C	BLCA	1
p.D207E	LUAD	1
p.K245*	TGCT	1
p.R347H	UVM	1
p.W17C	STAD	1
p.S65L	UCEC	1
p.A367V	LUAD	1
p.P322S	SKCM	1
p.G69V	STAD	1
p.R462W	LUSC	1
p.L127P	STAD	1
p.Y201H	LUAD	1
p.R449H	ESCA	1
p.E84K	SKCM	1
p.W121X	LIHC	1
p.E451K	SKCM	1
p.V5L	LIHC	1
p.E330K	HNSC	1
p.L315M	KIRP	1
p.W406*	STAD	1
p.I104S	PRAD	1
p.R349H	CESC	1
p.D264N	SKCM	1
p.D387N	BLCA	1
p.P28H	LIHC	1
p.Q334R	STAD	1
p.H120Y	COAD	1

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TissGeneCNV for CYP17A1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for CYP17A1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	AV706830	CYP17A1-LHFP		chr10:104593881	chr13:39917445

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TissGeneNet for CYP17A1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

COAD (tumor)	COAD (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

HNSC (tumor)	HNSC (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

KICH (tumor)	KICH (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

KIRC (tumor)	KIRC (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

KIRP (tumor)	KIRP (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

LIHC (tumor)	LIHC (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

LUAD (tumor)	LUAD (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

LUSC (tumor)	LUSC (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

PRAD (tumor)	PRAD (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

STAD (tumor)	STAD (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

THCA (tumor)	THCA (normal)
CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (tumor)	CYP17A1, SP1, HSP90AB1, PPP2R4, SP3, GATA4, NFIC, POR, ATP5E, NR5A1, CYB5A, CDO1, RPAIN, BARX1, TIGD7 (normal)

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TissGeneProg for CYP17A1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for CYP17A1

TissGeneDrug for CYP17A1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB05812	Abiraterone	Inhibitor	Small molecule	Approved
DB00396	Progesterone	Inhibitor	Small molecule	Approved\|Vet_approved

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TissGeneDisease for CYP17A1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0006142	Malignant neoplasm of breast	75	BeFree,GAD
umls:C0376358	Malignant neoplasm of prostate	71	BeFree,GAD
umls:C0678222	Breast Carcinoma	62	BeFree
umls:C0600139	Prostate carcinoma	58	BeFree
umls:C0268285	Adrenal hyperplasia, congenital, type 5	30	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0032460	Polycystic Ovary Syndrome	27	BeFree,GAD,LHGDN
umls:C0020538	Hypertensive disease	22	BeFree,GAD
umls:C0029928	Ovarian Diseases	15	BeFree,GAD
umls:C0476089	Endometrial Carcinoma	15	BeFree,GAD
umls:C1291557	Deficiency of lyase	14	BeFree
umls:C0014175	Endometriosis	13	BeFree,GAD,LHGDN
umls:C1704272	Benign Prostatic Hyperplasia	13	BeFree
umls:C0007103	Malignant neoplasm of endometrium	12	BeFree
umls:C1883486	Uterine Corpus Cancer	12	BeFree
umls:C0001627	Congenital adrenal hyperplasia	11	BeFree,CTD_human
umls:C0033578	Prostatic Neoplasms	11	BeFree,CTD_human,GAD,LHGDN
umls:C1291314	Deficiency of monooxygenase	9	BeFree
umls:C0014170	Endometrial Neoplasms	8	GAD,LHGDN
umls:C3277849	17,20-Lyase Deficiency, Isolated	8	BeFree,CLINVAR
umls:C1140680	Malignant neoplasm of ovary	7	BeFree,GAD
umls:C1458155	Mammary Neoplasms	7	BeFree,CTD_human,LHGDN
umls:C0029456	Osteoporosis	6	BeFree,GAD,LHGDN
umls:C0029925	Ovarian Carcinoma	6	BeFree
umls:C0206081	Hyperandrogenism	6	BeFree,GAD
umls:C1846502	Mammographic Density	6	BeFree,GAD
umls:C0023267	Fibroid Tumor	5	BeFree,GAD,LHGDN
umls:C0042133	Uterine Fibroids	5	BeFree,GAD
umls:C0242379	Malignant neoplasm of lung	5	BeFree,GAD
umls:C1527249	Colorectal Cancer	5	BeFree,GAD
umls:C0001430	Adenoma	4	BeFree
umls:C0010068	Coronary heart disease	4	BeFree,GAD
umls:C0206667	Adrenal Cortical Adenoma	4	BeFree,LHGDN
umls:C0520463	Chronic active hepatitis	4	BeFree
umls:C0596263	Carcinogenesis	4	BeFree
umls:C1956346	Coronary Artery Disease	4	BeFree
umls:C2937421	Prostatic Hyperplasia	4	BeFree,GAD,LHGDN
umls:C0001624	Adrenal Gland Neoplasms	3	BeFree
umls:C0002395	Alzheimer's Disease	3	BeFree,GAD
umls:C0009402	Colorectal Carcinoma	3	BeFree
umls:C0010054	Coronary Arteriosclerosis	3	BeFree,GAD
umls:C0024305	Lymphoma, Non-Hodgkin	3	BeFree,GAD
umls:C0042138	Uterine Neoplasms	3	GAD
umls:C0232939	Primary physiologic amenorrhea	3	BeFree
umls:C0848558	Hypospadias	3	BeFree
umls:C1691215	Penile hypospadias	3	BeFree
umls:C2239176	Liver carcinoma	3	BeFree,CTD_human
umls:C0001418	Adenocarcinoma	2	BeFree,GAD
umls:C0001623	Adrenal gland hypofunction	2	BeFree
umls:C0002453	Amenorrhea	2	BeFree,CTD_human
umls:C0003873	Rheumatoid Arthritis	2	BeFree,GAD
umls:C0007104	Female Breast Carcinoma	2	BeFree
umls:C0014130	Endocrine System Diseases	2	GAD
umls:C0020619	Hypogonadism	2	BeFree,CTD_human
umls:C0021361	Female infertility	2	CTD_human,GAD
umls:C0021364	Male infertility	2	BeFree,CTD_human
umls:C0023895	Liver diseases	2	BeFree,GAD
umls:C0039590	Testicular Neoplasms	2	BeFree,GAD
umls:C0041408	Turner Syndrome	2	BeFree
umls:C0042755	Virilism	2	BeFree
umls:C0079744	Diffuse Large B-Cell Lymphoma	2	BeFree
umls:C0152115	Lingual-Facial-Buccal Dyskinesia	2	BeFree,GAD
umls:C0153452	Malignant neoplasm of gallbladder	2	BeFree,GAD
umls:C0235653	Malignant neoplasm of female breast	2	BeFree
umls:C0235974	Pancreatic carcinoma	2	BeFree
umls:C0238033	Carcinoma of Male Breast	2	BeFree,GAD
umls:C0242787	Malignant neoplasm of male breast	2	BeFree
umls:C0266362	Ambiguous Genitalia	2	BeFree
umls:C0345904	Malignant neoplasm of liver	2	BeFree,GAD
umls:C0346153	Breast Cancer, Familial	2	BeFree
umls:C0346647	Malignant neoplasm of pancreas	2	BeFree
umls:C0405580	Adrenal cortical hypofunction	2	BeFree
umls:C0432470	46, XY female	2	BeFree
umls:C0567312	Menopause present (finding)	2	GAD
umls:C0600142	Hot flushes	2	BeFree,GAD
umls:C0677886	Epithelial ovarian cancer	2	BeFree,GAD
umls:C0684249	Carcinoma of lung	2	BeFree
umls:C0686347	Tardive Dyskinesia	2	BeFree,GAD
umls:C0741682	Premenopausal breast cancer	2	BeFree
umls:C1271104	Blood pressure finding	2	GAD,GWASCAT
umls:C1272641	Systemic arterial pressure	2	GAD,GWASCAT
umls:C2931456	Prostate cancer, familial	2	BeFree
umls:C0000809	Abortion, Habitual	1	GAD
umls:C0001144	Acne Vulgaris	1	GAD
umls:C0003862	Arthralgia	1	BeFree
umls:C0003944	As If Personality	1	GAD
umls:C0004352	Autistic Disorder	1	GAD
umls:C0005684	Malignant neoplasm of urinary bladder	1	GAD
umls:C0006145	Breast Diseases	1	BeFree
umls:C0007113	Rectal Carcinoma	1	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	1	BeFree
umls:C0007137	Squamous cell carcinoma	1	GAD
umls:C0007222	Cardiovascular Diseases	1	GAD
umls:C0007786	Brain Ischemia	1	GAD
umls:C0008350	Cholelithiasis	1	BeFree,GAD
umls:C0008370	Cholestasis	1	BeFree
umls:C0009375	Colonic Neoplasms	1	LHGDN
umls:C0009405	Hereditary Nonpolyposis Colorectal Neoplasms	1	LHGDN
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	LHGDN
umls:C0013080	Down Syndrome	1	BeFree
umls:C0015934	Fetal Growth Retardation	1	GAD
umls:C0016977	Gall Bladder Diseases	1	BeFree
umls:C0018051	Gonadal Dysgenesis	1	BeFree
umls:C0019196	Hepatitis C	1	BeFree
umls:C0019360	Herpes zoster disease	1	LHGDN
umls:C0020428	Hyperaldosteronism	1	BeFree
umls:C0020459	Hyperinsulinism	1	GAD
umls:C0020461	Hyperkalemia	1	CTD_human
umls:C0020540	Malignant Hypertension	1	CTD_human
umls:C0020595	Hypoaldosteronism	1	BeFree
umls:C0020635	Hypopituitarism	1	CTD_human
umls:C0021359	Infertility	1	LHGDN
umls:C0021655	Insulin Resistance	1	GAD
umls:C0022661	Kidney Failure, Chronic	1	GAD
umls:C0023893	Liver Cirrhosis, Experimental	1	CTD_human
umls:C0023903	Liver neoplasms	1	LHGDN
umls:C0024117	Chronic Obstructive Airway Disease	1	GAD
umls:C0024141	Lupus Erythematosus, Systemic	1	GAD
umls:C0024299	Lymphoma	1	BeFree,GAD
umls:C0024449	Mycetoma	1	GAD
umls:C0024623	Malignant neoplasm of stomach	1	BeFree
umls:C0027051	Myocardial Infarction	1	BeFree
umls:C0027404	Narcolepsy	1	GAD
umls:C0027627	Neoplasm Metastasis	1	BeFree
umls:C0027658	Neoplasms, Germ Cell and Embryonal	1	GAD
umls:C0027663	Neoplasms, Multiple Primary	1	GAD
umls:C0028949	Oligomenorrhea	1	CTD_human
umls:C0029458	Osteoporosis, Postmenopausal	1	GAD
umls:C0029927	Ovarian Cysts	1	CTD_human
umls:C0030297	Pancreatic Neoplasm	1	GAD
umls:C0030567	Parkinson Disease	1	GAD,GWASCAT
umls:C0032914	Pre-Eclampsia	1	GAD
umls:C0033054	Prenatal Exposure Delayed Effects	1	GAD
umls:C0033575	Prostatic Diseases	1	BeFree
umls:C0033804	Pseudohermaphroditism	1	BeFree
umls:C0033953	Psychosexual Disorders	1	CTD_human
umls:C0034013	Precocious Puberty	1	BeFree
umls:C0035369	Retroviridae Infections	1	BeFree
umls:C0036631	Seminoma	1	BeFree
umls:C0038356	Stomach Neoplasms	1	GAD
umls:C0038454	Cerebrovascular accident	1	GAD
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0040765	Transsexualism	1	BeFree,GAD
umls:C0079731	B-Cell Lymphomas	1	BeFree
umls:C0079745	Lymphoma, Large-Cell, Follicular	1	BeFree
umls:C0085215	Ovarian Failure, Premature	1	BeFree
umls:C0085762	Alcohol abuse	1	GAD
umls:C0149940	Sciatic Neuropathy	1	RGD
umls:C0153381	Malignant neoplasm of mouth	1	BeFree,GAD
umls:C0162311	Androgenetic Alopecia	1	BeFree
umls:C0162872	Aortic Aneurysm, Thoracic	1	BeFree
umls:C0206650	Fibroadenoma	1	BeFree
umls:C0206686	Adrenocortical carcinoma	1	BeFree
umls:C0232940	Secondary physiologic amenorrhea	1	BeFree
umls:C0235782	Gallbladder Carcinoma	1	BeFree
umls:C0238339	Hereditary pancreatitis	1	BeFree
umls:C0238395	Male Pseudohermaphroditism	1	BeFree
umls:C0272139	Erythrocytosis due to low atmospheric pressure	1	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	1	BeFree
umls:C0280280	stage, prostate cancer	1	BeFree
umls:C0334524	Mixed Germ Cell Tumor	1	BeFree
umls:C0341858	Endometriosis of uterus	1	BeFree
umls:C0342543	Precocious Puberty, Central	1	BeFree
umls:C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
umls:C0424639	Height / growth measure	1	GAD
umls:C0497406	Overweight	1	GAD
umls:C0524910	Hepatitis C, Chronic	1	BeFree,GAD
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0598935	Tumor Initiation	1	BeFree
umls:C0677932	Progressive Neoplastic Disease	1	BeFree
umls:C0699791	Stomach Carcinoma	1	BeFree
umls:C0740457	Malignant neoplasm of kidney	1	BeFree
umls:C0750952	Biliary Tract Cancer	1	BeFree,GAD
umls:C0852654	21-hydroxylase deficiency	1	BeFree
umls:C0887833	Carcinoma, Pancreatic Ductal	1	GAD
umls:C0947622	Cholecystolithiasis	1	BeFree,GAD
umls:C0949691	Spondylarthropathies	1	BeFree,GAD
umls:C1275126	TNF receptor-associated periodic fever syndrome (TRAPS)	1	BeFree
umls:C1333990	Hereditary Nonpolyposis Colorectal Cancer	1	BeFree
umls:C1336708	Testicular Germ Cell Tumor	1	GAD
umls:C1378703	Renal carcinoma	1	BeFree
umls:C1384514	Conn Syndrome	1	BeFree
umls:C1623038	Cirrhosis	1	GAD
umls:C1853195	Prostate Cancer, Hereditary, 7	1	BeFree
umls:C1868676	GROWTH CONTROL, Y-CHROMOSOME INFLUENCED	1	GAD
umls:C2350619	Maduromycosis	1	GAD
umls:C2936858	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	1	BeFree
umls:C3275124	Biliary System Disorder	1	BeFree
umls:C3539781	Progressive cGVHD	1	BeFree