TissGeneSummary for RHOXF1 |
Gene summary |
Basic gene information | Gene symbol | RHOXF1 |
Gene name | Rhox homeobox family, member 1 | |
Synonyms | OTEX|PEPP1 | |
Cytomap | UCSC genome browser: Xq24 | |
Type of gene | protein-coding | |
RefGenes | NM_139282.2, | |
Description | PEPP subfamily gene 1ovary-, testis- and epididymis-expressed gene proteinpaired-like homeobox protein PEPP-1rhox homeobox family member 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300446 | |
HGNC : HGNC | ||
Ensembl : ENSG00000101883 | ||
HPRD : 02345 | ||
HPRD : 15954 | ||
Vega : OTTHUMG00000022290 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RHOXF1 | |
BioGPS: 158800 | ||
Pathway | NCI Pathway Interaction Database: RHOXF1 | |
KEGG: RHOXF1 | ||
REACTOME: RHOXF1 | ||
Pathway Commons: RHOXF1 | ||
Context | iHOP: RHOXF1 | |
ligand binding site mutation search in PubMed: RHOXF1 | ||
UCL Cancer Institute: RHOXF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RHOXF1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RHOXF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.547660616 | 1.755389384 | -2.30305 | 4.22E-34 | 7.32E-33 |
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TissGene-miRNA for RHOXF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RHOXF1 |
TissGeneSNV for RHOXF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L5P | CESC | 1 |
p.H124Q | UCEC | 1 |
p.R133K | SKCM | 1 |
p.E86K | SKCM | 1 |
p.T125S | GBM | 1 |
p.G59D | STAD | 1 |
p.T24P | SKCM | 1 |
p.A92T | MESO | 1 |
p.D8E | UCS | 1 |
p.T108M | COAD | 1 |
p.R148W | COAD | 1 |
p.S22R | ACC | 1 |
p.G65D | LUSC | 1 |
p.V6I | LUAD | 1 |
p.A168T | STAD | 1 |
p.G53S | UCEC | 1 |
p.G141S | LUAD | 1 |
p.P42T | LUAD | 1 |
p.R163* | LUAD | 1 |
p.G53D | SKCM | 1 |
p.R123Q | UCS | 1 |
p.R104Q | HNSC | 1 |
p.G65D | COAD | 1 |
p.D63Y | LUAD | 1 |
p.P42Q | BLCA | 1 |
p.D8N | SKCM | 1 |
p.G141S | SKCM | 1 |
p.Q102R | UCEC | 1 |
p.M93K | BLCA | 1 |
p.R172L | COAD | 1 |
p.R62H | UCEC | 1 |
p.E117* | LUAD | 1 |
p.N169I | LGG | 1 |
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TissGeneCNV for RHOXF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RHOXF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RHOXF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RHOXF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RHOXF1 |
TissGeneDrug for RHOXF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RHOXF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |