TissGeneSummary for MAGEB6 |
Gene summary |
Basic gene information | Gene symbol | MAGEB6 |
Gene name | melanoma antigen family B, 6 | |
Synonyms | CT3.4|MAGE-B6|MAGEB6A | |
Cytomap | UCSC genome browser: Xp21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_173523.2, | |
Description | MAGE-B6 antigencancer/testis antigen 3.4cancer/testis antigen family 3, member 4melanoma-associated antigen B6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300467 | |
HGNC : HGNC | ||
Ensembl : ENSG00000176746 | ||
HPRD : 06628 | ||
Vega : OTTHUMG00000021285 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEB6 | |
BioGPS: 158809 | ||
Pathway | NCI Pathway Interaction Database: MAGEB6 | |
KEGG: MAGEB6 | ||
REACTOME: MAGEB6 | ||
Pathway Commons: MAGEB6 | ||
Context | iHOP: MAGEB6 | |
ligand binding site mutation search in PubMed: MAGEB6 | ||
UCL Cancer Institute: MAGEB6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MAGEB6 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MAGEB6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.612852919 | -0.62939414 | 1.242247059 | 9.10E-08 | 2.56E-07 |
HNSC | 0.76864731 | -0.605489899 | 1.374137209 | 1.88E-05 | 1.00E-04 |
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TissGene-miRNA for MAGEB6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MAGEB6 |
TissGeneSNV for MAGEB6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P61S | SKCM | 3 |
p.D351N | SKCM | 2 |
p.R329W | UCEC | 2 |
p.S120L | SKCM | 2 |
p.R345W | LUAD | 1 |
p.G130C | HNSC | 1 |
p.Q65H | LUAD | 1 |
p.S7G | SARC | 1 |
p.K198T | LUAD | 1 |
p.D141Y | LUAD | 1 |
p.S241F | SKCM | 1 |
p.P115S | SKCM | 1 |
p.H140N | STAD | 1 |
p.G326R | SKCM | 1 |
p.L264I | LUAD | 1 |
p.P352S | SKCM | 1 |
p.V342A | OV | 1 |
p.R46S | LUAD | 1 |
p.S139F | SKCM | 1 |
p.A203V | UCEC | 1 |
p.R46C | STAD | 1 |
p.Q62H | PAAD | 1 |
p.T201M | BRCA | 1 |
p.I396K | BLCA | 1 |
p.S64F | UCEC | 1 |
p.Y355C | LUSC | 1 |
p.R345W | GBM | 1 |
p.S93I | SKCM | 1 |
p.K253Q | COAD | 1 |
p.D318Y | BRCA | 1 |
p.R345P | LIHC | 1 |
p.S290L | SKCM | 1 |
p.S257F | SKCM | 1 |
p.G160S | SKCM | 1 |
p.E273X | ACC | 1 |
p.E171K | BLCA | 1 |
p.V342M | SKCM | 1 |
p.P69S | SKCM | 1 |
p.P94S | SKCM | 1 |
p.E254X | COAD | 1 |
p.L336F | LUAD | 1 |
p.A47T | LGG | 1 |
p.R15H | PRAD | 1 |
p.D57G | UCEC | 1 |
p.G88C | HNSC | 1 |
p.R401T | ESCA | 1 |
p.E273* | ACC | 1 |
p.R226C | COAD | 1 |
p.H389Y | UCEC | 1 |
p.V250I | GBM | 1 |
p.Q338K | LUAD | 1 |
p.R226C | STAD | 1 |
p.N298I | LGG | 1 |
p.T26M | BLCA | 1 |
p.G160D | LUAD | 1 |
p.S350C | SKCM | 1 |
p.C354Y | PAAD | 1 |
p.P61L | SKCM | 1 |
p.S258R | LIHC | 1 |
p.D318N | SKCM | 1 |
p.Y229C | CESC | 1 |
p.H140R | CESC | 1 |
p.A194S | ESCA | 1 |
p.T18I | LGG | 1 |
p.D158N | SKCM | 1 |
p.D397H | PAAD | 1 |
p.S258R | LUSC | 1 |
p.G24D | SKCM | 1 |
p.K213* | SKCM | 1 |
p.K213X | SKCM | 1 |
p.T201K | LUAD | 1 |
p.K165N | DLBC | 1 |
p.P352S | HNSC | 1 |
p.P103S | SKCM | 1 |
p.K230N | ACC | 1 |
p.R98S | HNSC | 1 |
p.A203T | HNSC | 1 |
p.S215Y | LUSC | 1 |
p.S215Y | LUAD | 1 |
p.D279N | SKCM | 1 |
p.R189C | STAD | 1 |
p.A394P | BRCA | 1 |
p.D125N | SKCM | 1 |
p.S143F | SKCM | 1 |
p.Y124S | DLBC | 1 |
p.G71W | LUAD | 1 |
p.V126M | UCS | 1 |
p.A86S | LUAD | 1 |
p.P352L | UCEC | 1 |
p.E63* | UCEC | 1 |
p.A394T | LGG | 1 |
p.G150R | SKCM | 1 |
p.R189C | READ | 1 |
p.L395V | UCEC | 1 |
p.P69L | OV | 1 |
p.A394T | READ | 1 |
p.R98L | THCA | 1 |
p.R10L | LUAD | 1 |
p.H140P | LUAD | 1 |
p.F310L | LUSC | 1 |
p.R189H | STAD | 1 |
p.P73L | SKCM | 1 |
p.S272R | PRAD | 1 |
p.E254K | LUAD | 1 |
p.E254K | UCEC | 1 |
p.G274E | SKCM | 1 |
p.A184S | KIRC | 1 |
p.S137I | HNSC | 1 |
p.C301Y | STAD | 1 |
p.G118D | BLCA | 1 |
p.V102I | THCA | 1 |
p.E91D | UCEC | 1 |
p.S82Y | HNSC | 1 |
p.I324N | GBM | 1 |
p.I320T | COAD | 1 |
p.R3L | LUAD | 1 |
p.G130D | UCEC | 1 |
p.D51N | SKCM | 1 |
p.V195G | BRCA | 1 |
p.A394T | UCEC | 1 |
p.R46H | OV | 1 |
p.D339H | ACC | 1 |
p.P94T | KIRC | 1 |
p.A377D | UCEC | 1 |
p.Y124S | ESCA | 1 |
p.G312S | STAD | 1 |
p.G172V | BLCA | 1 |
p.E228D | UCEC | 1 |
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TissGeneCNV for MAGEB6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MAGEB6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MAGEB6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MAGEB6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MAGEB6 |
TissGeneDrug for MAGEB6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MAGEB6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007113 | Rectal Carcinoma | 2 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |