 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CYP24A1 |
 Gene summary |
| Basic gene information | Gene symbol | CYP24A1 |
| Gene name | cytochrome P450, family 24, subfamily A, polypeptide 1 | |
| Synonyms | CP24|CYP24|HCAI|P450-CC24 | |
| Cytomap | UCSC genome browser: 20q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000782.4, NM_001128915.1, | |
| Description | 1,25-@dihydroxyvitamin D3 24-hydroxylase1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial24-OHasecytochrome P450 24A1cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)cytochrome P450-CC24exo-mitochondrial proteinvitamin D 24-hydroxyl | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 126065 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000019186 | ||
| HPRD : 00522 | ||
| Vega : OTTHUMG00000032773 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP24A1 | |
| BioGPS: 1591 | ||
| Pathway | NCI Pathway Interaction Database: CYP24A1 | |
| KEGG: CYP24A1 | ||
| REACTOME: CYP24A1 | ||
| Pathway Commons: CYP24A1 | ||
| Context | iHOP: CYP24A1 | |
| ligand binding site mutation search in PubMed: CYP24A1 | ||
| UCL Cancer Institute: CYP24A1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPRAD | |
| Reference showing the relevant tissue of CYP24A1 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0033280 | response to vitamin D | 16720713 | GO:0055114 | oxidation-reduction process | 8506296 | GO:0033280 | response to vitamin D | 16720713 | GO:0055114 | oxidation-reduction process | 8506296 |
| Top |
| TissGeneExp for CYP24A1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.016864854 | 3.340706521 | -3.323841667 | 1.94E-11 | 7.38E-11 |
| KICH | -2.558945423 | 2.750118577 | -5.309064 | 6.52E-12 | 6.47E-11 |
| LUSC | 2.021360851 | -1.204354835 | 3.225715686 | 6.30E-10 | 2.21E-09 |
| LUAD | 4.05284699 | -1.363268527 | 5.416115517 | 6.16E-22 | 1.57E-20 |
| STAD | -1.849584798 | -3.181503548 | 1.33191875 | 0.0145 | 0.04619051 |
| PRAD | -0.657013885 | 0.470543807 | -1.127557692 | 0.0168 | 0.03783799 |
| THCA | 1.670991526 | 0.484172882 | 1.186818644 | 0.00926 | 0.018015501 |
| BRCA | -2.149843844 | -0.979518406 | -1.170325439 | 0.000214 | 0.000454196 |
| Top |
| TissGene-miRNA for CYP24A1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-30a-5p | MIMAT0000087 | 0.049 | -0.27 | 56 |
| UVM | hsa-miR-30b-5p | MIMAT0000420 | 0.009 | -0.29 | 80 |
| Top |
| TissGeneMut for CYP24A1 |
| TissGeneSNV for CYP24A1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N237Y | OV | 1 |
| p.A468E | LUAD | 1 |
| p.M173I | ACC | 1 |
| p.F301L | ESCA | 1 |
| p.T47I | COAD | 1 |
| p.A326D | LUAD | 1 |
| p.A368E | ESCA | 1 |
| p.A327E | HNSC | 1 |
| p.P449H | UCEC | 1 |
| p.E171K | SKCM | 1 |
| p.V457I | COAD | 1 |
| p.D431N | LUAD | 1 |
| p.A235D | ESCA | 1 |
| p.G405S | SKCM | 1 |
| p.S424F | SKCM | 1 |
| p.P449S | SKCM | 1 |
| p.D484G | STAD | 1 |
| p.T248M | UCEC | 1 |
| p.T388M | COAD | 1 |
| p.V236L | LUAD | 1 |
| p.K135* | LIHC | 1 |
| p.K313Q | LUSC | 1 |
| p.K222R | LUSC | 1 |
| p.H473R | KIRP | 1 |
| p.E443D | UCEC | 1 |
| p.K164N | UCEC | 1 |
| p.N180D | COAD | 1 |
| p.E130K | SKCM | 1 |
| p.R514* | BRCA | 1 |
| p.N341Y | SKCM | 1 |
| p.D399H | CESC | 1 |
| p.E443Q | BLCA | 1 |
| p.V457I | STAD | 1 |
| p.R344G | LUAD | 1 |
| p.P454S | SKCM | 1 |
| p.T31M | DLBC | 1 |
| p.Y204C | COAD | 1 |
| p.M416T | BRCA | 1 |
| p.R465H | ESCA | 1 |
| p.G423E | SKCM | 1 |
| p.M99I | BLCA | 1 |
| p.S205R | THYM | 1 |
| p.P508S | LUAD | 1 |
| p.K292T | SKCM | 1 |
| p.R466Q | UCEC | 1 |
| p.W268C | COAD | 1 |
| p.K351N | LUAD | 1 |
| p.R514Q | SKCM | 1 |
| p.C303S | LGG | 1 |
| p.N237K | ESCA | 1 |
| p.P297S | STAD | 1 |
| p.Y220* | LUAD | 1 |
| p.H260R | UCEC | 1 |
| p.V457A | STAD | 1 |
| p.N373K | READ | 1 |
| p.D399N | LUSC | 1 |
| p.P346S | SKCM | 1 |
| p.A235D | UCEC | 1 |
| p.I286L | BLCA | 1 |
| p.E315Q | BLCA | 1 |
| p.M495L | LIHC | 1 |
| p.E506K | SKCM | 1 |
| p.Y204* | LUAD | 1 |
| Top |
| TissGeneCNV for CYP24A1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CYP24A1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AL711186 | KNOP1-CYP24A1 | chr16:19729435 | chr20:52771828 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-MP-A4TJ-01A | CYP24A1-RNF213 | 3'UTR-3'UTR | chr20:52773707 | chr17:78298829 |
| Top |
| TissGeneNet for CYP24A1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| CYP24A1, TP53, VDR, CITED1 (tumor) | CYP24A1, TP53, VDR, CITED1 (normal) |
 |  |
| Top |
| TissGeneProg for CYP24A1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CYP24A1 |
| TissGeneDrug for CYP24A1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for CYP24A1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 18 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 16 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 15 | BeFree |
| umls:C0600139 | Prostate carcinoma | 15 | BeFree |
| umls:C0020437 | Hypercalcemia | 10 | BeFree,GAD |
| umls:C0699790 | Colon Carcinoma | 8 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 7 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree,GAD |
| umls:C0268080 | Hypercalcemia, Idiopathic, of Infancy | 7 | BeFree,CLINVAR |
| umls:C0009402 | Colorectal Carcinoma | 6 | BeFree |
| umls:C0684249 | Carcinoma of lung | 6 | BeFree |
| umls:C1527249 | Colorectal Cancer | 6 | BeFree |
| umls:C0025202 | melanoma | 5 | BeFree |
| umls:C0024121 | Lung Neoplasms | 4 | BeFree,CTD_human,LHGDN |
| umls:C0026769 | Multiple Sclerosis | 4 | BeFree,GAD,GWASCAT |
| umls:C0027709 | Nephrocalcinosis | 4 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 4 | BeFree |
| umls:C0004096 | Asthma | 3 | BeFree,GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 3 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0392525 | Nephrolithiasis | 3 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 2 | GAD |
| umls:C0020438 | Hypercalciuria | 2 | BeFree,GAD |
| umls:C0022650 | Kidney Calculi | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 2 | BeFree |
| umls:C0410445 | Osteomalacia secondary to drug | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0005940 | Bone Diseases | 1 | BeFree |
| umls:C0006663 | Calcinosis | 1 | GAD |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007789 | Cerebral Palsy | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree,LHGDN |
| umls:C0018801 | Heart failure | 1 | GAD |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | BeFree |
| umls:C0027962 | Melanocytic nevus | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029442 | Osteomalacia | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0038013 | Ankylosing spondylitis | 1 | BeFree |
| umls:C0042164 | Uveitis | 1 | BeFree |
| umls:C0042870 | Vitamin D Deficiency | 1 | GAD |
| umls:C0079745 | Lymphoma, Large-Cell, Follicular | 1 | BeFree |
| umls:C0085207 | Gestational Diabetes | 1 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0342208 | Multinodular goiter | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0475732 | Hypercalcemia, Infantile | 1 | ORPHANET,UNIPROT |
| umls:C0475733 | Idiopathic infantile hypercalcemia - mild form | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0701807 | Acute anterior uveitis | 1 | BeFree |
| umls:C0852949 | Arteriopathic disease | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C0948680 | Adenocarcinoma of liver | 1 | BeFree |
| umls:C1291314 | Deficiency of monooxygenase | 1 | BeFree |
| umls:C1527349 | Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1565489 | Renal Insufficiency | 1 | CTD_human |
| umls:C1567741 | Alport Syndrome | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C2363065 | Vitamin D-resistant rickets | 1 | BeFree |
| umls:C3536983 | Familial Hypophosphatemic Rickets | 1 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |