![]() |
TissGeneSummary for CYP26A1 |
![]() |
Basic gene information | Gene symbol | CYP26A1 |
Gene name | cytochrome P450, family 26, subfamily A, polypeptide 1 | |
Synonyms | CP26|CYP26|P450RAI|P450RAI1 | |
Cytomap | UCSC genome browser: 10q23-q24 | |
Type of gene | protein-coding | |
RefGenes | NM_000783.3, NM_057157.2, | |
Description | P450, retinoic acid-inactivating, 1cytochrome P450 26A1cytochrome P450 retinoic acid-inactivating 1cytochrome P450, subfamily XXVIA, polypeptide 1cytochrome P450RAIhP450RAIretinoic acid 4-hydroxylaseretinoic acid-metabolizing cytochrome | |
Modification date | 20141207 | |
dbXrefs | MIM : 602239 | |
HGNC : HGNC | ||
Ensembl : ENSG00000095596 | ||
HPRD : 03759 | ||
Vega : OTTHUMG00000018765 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYP26A1 | |
BioGPS: 1592 | ||
Pathway | NCI Pathway Interaction Database: CYP26A1 | |
KEGG: CYP26A1 | ||
REACTOME: CYP26A1 | ||
Pathway Commons: CYP26A1 | ||
Context | iHOP: CYP26A1 | |
ligand binding site mutation search in PubMed: CYP26A1 | ||
UCL Cancer Institute: CYP26A1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CYP26A1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID | GO:0034653 | retinoic acid catabolic process | 10823918 | GO:0034653 | retinoic acid catabolic process | 10823918 |
Top |
TissGeneExp for CYP26A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.973479568 | -1.681806707 | 3.655286275 | 3.02E-09 | 9.96E-09 |
LIHC | 0.24174894 | 5.50764094 | -5.265892 | 1.22E-21 | 8.74E-20 |
THCA | -1.261028043 | -2.333970416 | 1.072942373 | 1.07E-05 | 3.46E-05 |
LUAD | -0.671713198 | -1.946559749 | 1.274846552 | 0.000468 | 0.001071147 |
STAD | -1.738185935 | -2.771698435 | 1.0335125 | 0.000138 | 0.001024297 |
Top |
TissGene-miRNA for CYP26A1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CYP26A1 |
TissGeneSNV for CYP26A1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R64W | STAD | 2 |
p.V322I | LAML | 1 |
p.G76S | KIRP | 1 |
p.D134N | HNSC | 1 |
p.Y355C | PAAD | 1 |
p.P424S | UCEC | 1 |
p.R306Q | UCS | 1 |
p.Q255R | HNSC | 1 |
p.H425Y | SKCM | 1 |
p.C12R | LUAD | 1 |
p.G52E | BLCA | 1 |
p.V142L | LUAD | 1 |
p.G232R | UCEC | 1 |
p.L125Q | HNSC | 1 |
p.A24V | STAD | 1 |
p.G204R | STAD | 1 |
p.E296K | CESC | 1 |
p.R375Q | UCS | 1 |
p.W465R | BRCA | 1 |
p.L459P | STAD | 1 |
p.E78K | BLCA | 1 |
p.E193K | LUAD | 1 |
p.G16R | COAD | 1 |
p.R106W | STAD | 1 |
p.R327* | UCEC | 1 |
p.K338N | BRCA | 1 |
p.A460V | UCEC | 1 |
p.E446* | UCEC | 1 |
p.G401R | SKCM | 1 |
p.K331N | UCEC | 1 |
p.R90L | KIRP | 1 |
p.G7S | KIRP | 1 |
p.L194Q | HNSC | 1 |
p.I287L | COAD | 1 |
p.Q324R | HNSC | 1 |
p.T12M | COAD | 1 |
p.A176T | PRAD | 1 |
p.L168R | UCEC | 1 |
p.Y286C | PAAD | 1 |
p.E227K | SKCM | 1 |
p.L164P | LUSC | 1 |
p.T473I | STAD | 1 |
p.R349Q | BLCA | 1 |
p.G135R | STAD | 1 |
p.R418* | UCEC | 1 |
p.R418Q | BLCA | 1 |
p.G123D | STAD | 1 |
p.A460T | STAD | 1 |
p.T387A | LUAD | 1 |
p.R98W | STAD | 1 |
p.E293Q | BLCA | 1 |
p.R191H | STAD | 1 |
p.S441T | OV | 1 |
p.F222L | UCEC | 1 |
p.R219H | STAD | 1 |
p.F153V | COAD | 1 |
p.W279R | UCEC | 1 |
p.A358V | SKCM | 1 |
p.A170E | TGCT | 1 |
p.R365Q | UCEC | 1 |
p.E362Q | BLCA | 1 |
p.I31M | BLCA | 1 |
p.E147K | BLCA | 1 |
Top |
TissGeneCNV for CYP26A1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for CYP26A1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE350062 | CYP26A1-DGCR2 | chr10:94833799 | chr22:19029387 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A97I-01A | EXOC6-CYP26A1 | In-Frame | chr10:94708136 | chr10:94834064 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A576-01A | NRBF2-CYP26A1 | In-frame | Chr10:64893260 | Chr10:94835583 |
Top |
TissGeneNet for CYP26A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CYP26A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for CYP26A1 |
TissGeneDrug for CYP26A1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CYP26A1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023487 | Acute Promyelocytic Leukemia | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0042842 | Vitamin A Deficiency | 3 | BeFree,GAD |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 3 | BeFree |
umls:C0010278 | Craniosynostosis | 2 | BeFree |
umls:C0080178 | Spina Bifida | 2 | BeFree,LHGDN |
umls:C0001418 | Adenocarcinoma | 1 | BeFree,CTD_human |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0004153 | Atherosclerosis | 1 | BeFree |
umls:C0004763 | Barrett Esophagus | 1 | CTD_human |
umls:C0009375 | Colonic Neoplasms | 1 | BeFree,CTD_human |
umls:C0014175 | Endometriosis | 1 | CTD_human |
umls:C0014859 | Esophageal Neoplasms | 1 | CTD_human |
umls:C0017612 | Glaucoma, Open-Angle | 1 | GAD |
umls:C0022658 | Kidney Diseases | 1 | GAD |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024198 | Lyme Disease | 1 | BeFree |
umls:C0027794 | Neural Tube Defects | 1 | GAD |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree,CTD_human |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0038013 | Ankylosing spondylitis | 1 | BeFree |
umls:C0263641 | Epithelial hyperplasia of skin | 1 | BeFree |
umls:C0497327 | Dementia | 1 | GAD |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C1561546 | Alkaline Phosphatase Adverse Event | 1 | GAD |
umls:C1860042 | Antley-Bixler Syndrome with Disordered Steroidogenesis | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |