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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC5A8
check button Gene summary
Basic gene informationGene symbolSLC5A8
Gene namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SynonymsAIT|SMCT|SMCT1
CytomapUCSC genome browser: 12q23.1
Type of geneprotein-coding
RefGenesNM_145913.3,
Descriptionapical iodide transporterelectrogenic sodium monocarboxylate cotransportersodium iodide-related cotransportersodium-coupled monocarboxylate transporter 1solute carrier family 5 (iodide transporter), member 8solute carrier family 5 member 8
Modification date20141207
dbXrefs MIM : 608044
HGNC : HGNC
HPRD : 10475
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC5A8
BioGPS: 160728
PathwayNCI Pathway Interaction Database: SLC5A8
KEGG: SLC5A8
REACTOME: SLC5A8
Pathway Commons: SLC5A8
ContextiHOP: SLC5A8
ligand binding site mutation search in PubMed: SLC5A8
UCL Cancer Institute: SLC5A8
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHTHCA
Reference showing the relevant tissue of SLC5A8
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SLC5A8

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-2.4633987924.375457208-6.8388565.68E-249.63E-22
COAD-2.011223869-0.424027715-1.5871961542.01E-058.57E-05
THCA2.7913322597.766269547-4.9749372884.28E-166.87E-15
LUAD1.2919423113.418407829-2.1264655171.75E-065.66E-06
LUSC-0.0678841253.752492345-3.8203764714.50E-152.82E-14
HNSC-2.1178949781.309121301-3.4270162791.23E-091.90E-08
KIRP2.6326492085.088117958-2.455468750.001710.004437292


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TissGene-miRNA for SLC5A8

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SLC5A8
TissGeneSNV for SLC5A8

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q503*SKCM3
p.R128CSKCM3
p.G339RSKCM2
p.E559XREAD2
p.S540NSKCM2
p.D309NSKCM2
p.G545ESKCM2
p.P310SSKCM2
p.P467SSKCM2
p.E77KSKCM2
p.P552HESCA1
p.I537LREAD1
p.A89DLUAD1
p.E366DUCEC1
p.K370ESTAD1
p.R50CSTAD1
p.R266KSTAD1
p.C177YHNSC1
p.Q548HLUSC1
p.E494*UCEC1
p.Q192*SKCM1
p.F18YHNSC1
p.R374KSKCM1
p.K578TCESC1
p.P4LSKCM1
p.D329NREAD1
p.V264LLUAD1
p.G457RBLCA1
p.G607RSKCM1
p.A318TBLCA1
p.D329YLGG1
p.T543SLUSC1
p.T62NLUSC1
p.D2YLGG1
p.W187*SKCM1
p.T352APAAD1
p.P552HUCEC1
p.R5WCOAD1
p.D307YLUAD1
p.G82RLUAD1
p.Q265RLUSC1
p.S25XACC1
p.P105QTGCT1
p.T178SCOAD1
p.A401VUCS1
p.A313TSKCM1
p.R226ILUSC1
p.W253XPAAD1
p.W230XSKCM1
p.T74NLUAD1
p.S385FSKCM1
p.N515KLUSC1
p.S579LLUSC1
p.F251SKIRC1
p.A165VSTAD1
p.M323LLUAD1
p.S380FSKCM1
p.R5WESCA1
p.S375LSKCM1
p.R374IUCEC1
p.R128CREAD1
p.Q192XSKCM1
p.R609CDLBC1
p.R122XSKCM1
p.V416LSKCM1
p.G459*LUAD1
p.G213EHNSC1
p.F502SESCA1
p.I205MLUAD1
p.A401SLUAD1
p.V391MSKCM1
p.G586RSKCM1
p.A401VLIHC1
p.A442SPAAD1
p.L326MLGG1
p.D560NSKCM1
p.P511LSKCM1
p.F232CCOAD1
p.R122*SKCM1
p.W230*SKCM1
p.T312KESCA1
p.S303FUCEC1
p.G336RSKCM1
p.S356NUCEC1
p.S482NCOAD1
p.Y523HGBM1
p.R50HSTAD1
p.L340VLUAD1
p.W455RESCA1
p.S525NSTAD1
p.P338SSKCM1
p.W288RLUAD1
p.Q192EPRAD1
p.G249RHNSC1
p.S542LHNSC1
p.V353MUCEC1
p.A184SUCEC1
p.D320GLIHC1
p.P234SSKCM1
p.W253*PAAD1
p.P105QCOAD1
p.C130RCOAD1
p.A58VSTAD1
p.C396SLUAD1
p.E583KUCEC1
p.T169MGBM1
p.A403VLGG1
p.M513ILUSC1
p.M406ISKCM1
p.S500ISARC1
p.T498SOV1
p.E494KSKCM1
p.I136TESCA1
p.N155KBLCA1
p.R609CSKCM1
p.D588NSKCM1
p.S602GHNSC1
p.P590SBLCA1
p.S269FLUAD1
p.S25*ACC1
p.I87SUCEC1
p.G603SSKCM1
p.P435LSKCM1
p.I84VSKCM1
p.L376ITHYM1
p.S520LSKCM1
p.M425ISKCM1
p.D588HUCS1
p.D367YHNSC1
p.A151DESCA1
p.N506YLIHC1
p.Q478KLUAD1
p.T543PUCEC1
p.G457ESKCM1
p.S215NTHYM1
p.A429TCOAD1
p.T244ABLCA1
p.A165TPRAD1
p.G459VLUAD1
p.S375LLUAD1


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TissGeneCNV for SLC5A8

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC5A8

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for SLC5A8

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for SLC5A8

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC5A8
TissGeneDrug for SLC5A8

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC5A8

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007102Malignant tumor of colon6BeFree
umls:C0001430Adenoma5BeFree,LHGDN
umls:C0699790Colon Carcinoma5BeFree
umls:C0009375Colonic Neoplasms3CTD_human,LHGDN
umls:C0596263Carcinogenesis3BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0033578Prostatic Neoplasms2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0549473Thyroid carcinoma2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C1709246Non-Neoplastic Disorder2BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0007133Carcinoma, Papillary1BeFree
umls:C0007137Squamous cell carcinoma1LHGDN
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1LHGDN
umls:C0017638Glioma1BeFree,LHGDN
umls:C0023418leukemia1LHGDN
umls:C0023467Leukemia, Myelocytic, Acute1BeFree,LHGDN
umls:C0024121Lung Neoplasms1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0027430Nasal Polyps1BeFree
umls:C0028945oligodendroglioma1BeFree
umls:C0030297Pancreatic Neoplasm1LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0205696Anaplastic carcinoma1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0740394Hyperuricemia1CTD_human
umls:C0751396Well Differentiated Oligodendroglioma1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree