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| TissGeneSummary for SLC5A8 |
 Gene summary |
| Basic gene information | Gene symbol | SLC5A8 |
| Gene name | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | |
| Synonyms | AIT|SMCT|SMCT1 | |
| Cytomap | UCSC genome browser: 12q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_145913.3, | |
| Description | apical iodide transporterelectrogenic sodium monocarboxylate cotransportersodium iodide-related cotransportersodium-coupled monocarboxylate transporter 1solute carrier family 5 (iodide transporter), member 8solute carrier family 5 member 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608044 | |
| HGNC : HGNC | ||
| HPRD : 10475 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC5A8 | |
| BioGPS: 160728 | ||
| Pathway | NCI Pathway Interaction Database: SLC5A8 | |
| KEGG: SLC5A8 | ||
| REACTOME: SLC5A8 | ||
| Pathway Commons: SLC5A8 | ||
| Context | iHOP: SLC5A8 | |
| ligand binding site mutation search in PubMed: SLC5A8 | ||
| UCL Cancer Institute: SLC5A8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
| Reference showing the relevant tissue of SLC5A8 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC5A8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.463398792 | 4.375457208 | -6.838856 | 5.68E-24 | 9.63E-22 |
| COAD | -2.011223869 | -0.424027715 | -1.587196154 | 2.01E-05 | 8.57E-05 |
| THCA | 2.791332259 | 7.766269547 | -4.974937288 | 4.28E-16 | 6.87E-15 |
| LUAD | 1.291942311 | 3.418407829 | -2.126465517 | 1.75E-06 | 5.66E-06 |
| LUSC | -0.067884125 | 3.752492345 | -3.820376471 | 4.50E-15 | 2.82E-14 |
| HNSC | -2.117894978 | 1.309121301 | -3.427016279 | 1.23E-09 | 1.90E-08 |
| KIRP | 2.632649208 | 5.088117958 | -2.45546875 | 0.00171 | 0.004437292 |
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| TissGene-miRNA for SLC5A8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC5A8 |
| TissGeneSNV for SLC5A8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q503* | SKCM | 3 |
| p.R128C | SKCM | 3 |
| p.G339R | SKCM | 2 |
| p.E559X | READ | 2 |
| p.S540N | SKCM | 2 |
| p.D309N | SKCM | 2 |
| p.G545E | SKCM | 2 |
| p.P310S | SKCM | 2 |
| p.P467S | SKCM | 2 |
| p.E77K | SKCM | 2 |
| p.P552H | ESCA | 1 |
| p.I537L | READ | 1 |
| p.A89D | LUAD | 1 |
| p.E366D | UCEC | 1 |
| p.K370E | STAD | 1 |
| p.R50C | STAD | 1 |
| p.R266K | STAD | 1 |
| p.C177Y | HNSC | 1 |
| p.Q548H | LUSC | 1 |
| p.E494* | UCEC | 1 |
| p.Q192* | SKCM | 1 |
| p.F18Y | HNSC | 1 |
| p.R374K | SKCM | 1 |
| p.K578T | CESC | 1 |
| p.P4L | SKCM | 1 |
| p.D329N | READ | 1 |
| p.V264L | LUAD | 1 |
| p.G457R | BLCA | 1 |
| p.G607R | SKCM | 1 |
| p.A318T | BLCA | 1 |
| p.D329Y | LGG | 1 |
| p.T543S | LUSC | 1 |
| p.T62N | LUSC | 1 |
| p.D2Y | LGG | 1 |
| p.W187* | SKCM | 1 |
| p.T352A | PAAD | 1 |
| p.P552H | UCEC | 1 |
| p.R5W | COAD | 1 |
| p.D307Y | LUAD | 1 |
| p.G82R | LUAD | 1 |
| p.Q265R | LUSC | 1 |
| p.S25X | ACC | 1 |
| p.P105Q | TGCT | 1 |
| p.T178S | COAD | 1 |
| p.A401V | UCS | 1 |
| p.A313T | SKCM | 1 |
| p.R226I | LUSC | 1 |
| p.W253X | PAAD | 1 |
| p.W230X | SKCM | 1 |
| p.T74N | LUAD | 1 |
| p.S385F | SKCM | 1 |
| p.N515K | LUSC | 1 |
| p.S579L | LUSC | 1 |
| p.F251S | KIRC | 1 |
| p.A165V | STAD | 1 |
| p.M323L | LUAD | 1 |
| p.S380F | SKCM | 1 |
| p.R5W | ESCA | 1 |
| p.S375L | SKCM | 1 |
| p.R374I | UCEC | 1 |
| p.R128C | READ | 1 |
| p.Q192X | SKCM | 1 |
| p.R609C | DLBC | 1 |
| p.R122X | SKCM | 1 |
| p.V416L | SKCM | 1 |
| p.G459* | LUAD | 1 |
| p.G213E | HNSC | 1 |
| p.F502S | ESCA | 1 |
| p.I205M | LUAD | 1 |
| p.A401S | LUAD | 1 |
| p.V391M | SKCM | 1 |
| p.G586R | SKCM | 1 |
| p.A401V | LIHC | 1 |
| p.A442S | PAAD | 1 |
| p.L326M | LGG | 1 |
| p.D560N | SKCM | 1 |
| p.P511L | SKCM | 1 |
| p.F232C | COAD | 1 |
| p.R122* | SKCM | 1 |
| p.W230* | SKCM | 1 |
| p.T312K | ESCA | 1 |
| p.S303F | UCEC | 1 |
| p.G336R | SKCM | 1 |
| p.S356N | UCEC | 1 |
| p.S482N | COAD | 1 |
| p.Y523H | GBM | 1 |
| p.R50H | STAD | 1 |
| p.L340V | LUAD | 1 |
| p.W455R | ESCA | 1 |
| p.S525N | STAD | 1 |
| p.P338S | SKCM | 1 |
| p.W288R | LUAD | 1 |
| p.Q192E | PRAD | 1 |
| p.G249R | HNSC | 1 |
| p.S542L | HNSC | 1 |
| p.V353M | UCEC | 1 |
| p.A184S | UCEC | 1 |
| p.D320G | LIHC | 1 |
| p.P234S | SKCM | 1 |
| p.W253* | PAAD | 1 |
| p.P105Q | COAD | 1 |
| p.C130R | COAD | 1 |
| p.A58V | STAD | 1 |
| p.C396S | LUAD | 1 |
| p.E583K | UCEC | 1 |
| p.T169M | GBM | 1 |
| p.A403V | LGG | 1 |
| p.M513I | LUSC | 1 |
| p.M406I | SKCM | 1 |
| p.S500I | SARC | 1 |
| p.T498S | OV | 1 |
| p.E494K | SKCM | 1 |
| p.I136T | ESCA | 1 |
| p.N155K | BLCA | 1 |
| p.R609C | SKCM | 1 |
| p.D588N | SKCM | 1 |
| p.S602G | HNSC | 1 |
| p.P590S | BLCA | 1 |
| p.S269F | LUAD | 1 |
| p.S25* | ACC | 1 |
| p.I87S | UCEC | 1 |
| p.G603S | SKCM | 1 |
| p.P435L | SKCM | 1 |
| p.I84V | SKCM | 1 |
| p.L376I | THYM | 1 |
| p.S520L | SKCM | 1 |
| p.M425I | SKCM | 1 |
| p.D588H | UCS | 1 |
| p.D367Y | HNSC | 1 |
| p.A151D | ESCA | 1 |
| p.N506Y | LIHC | 1 |
| p.Q478K | LUAD | 1 |
| p.T543P | UCEC | 1 |
| p.G457E | SKCM | 1 |
| p.S215N | THYM | 1 |
| p.A429T | COAD | 1 |
| p.T244A | BLCA | 1 |
| p.A165T | PRAD | 1 |
| p.G459V | LUAD | 1 |
| p.S375L | LUAD | 1 |
| Top |
| TissGeneCNV for SLC5A8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC5A8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC5A8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC5A8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC5A8 |
| TissGeneDrug for SLC5A8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC5A8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007102 | Malignant tumor of colon | 6 | BeFree |
| umls:C0001430 | Adenoma | 5 | BeFree,LHGDN |
| umls:C0699790 | Colon Carcinoma | 5 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 3 | CTD_human,LHGDN |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 2 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0017638 | Glioma | 1 | BeFree,LHGDN |
| umls:C0023418 | leukemia | 1 | LHGDN |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree,LHGDN |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027430 | Nasal Polyps | 1 | BeFree |
| umls:C0028945 | oligodendroglioma | 1 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 1 | LHGDN |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0205696 | Anaplastic carcinoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0740394 | Hyperuricemia | 1 | CTD_human |
| umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
| umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
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