TissGeneSummary for CCDC63 |
Gene summary |
Basic gene information | Gene symbol | CCDC63 |
Gene name | coiled-coil domain containing 63 | |
Synonyms | ODA5 | |
Cytomap | UCSC genome browser: 12q24.11 | |
Type of gene | protein-coding | |
RefGenes | NM_001286243.1, NM_001286244.1,NM_152591.2, | |
Description | coiled-coil domain-containing protein 63outer row dynein assembly 5 homolog | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000173093 | ||
HPRD : 08765 | ||
Vega : OTTHUMG00000169534 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC63 | |
BioGPS: 160762 | ||
Pathway | NCI Pathway Interaction Database: CCDC63 | |
KEGG: CCDC63 | ||
REACTOME: CCDC63 | ||
Pathway Commons: CCDC63 | ||
Context | iHOP: CCDC63 | |
ligand binding site mutation search in PubMed: CCDC63 | ||
UCL Cancer Institute: CCDC63 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTGCT | |
Reference showing the relevant tissue of CCDC63 | ||
Description by TissGene annotations | Cancer gene TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC63 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC63 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC63 |
TissGeneSNV for CCDC63 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E330K | SKCM | 3 |
p.K46T | UCEC | 2 |
p.R356Q | UCEC | 2 |
p.R273H | UCEC | 2 |
p.T338K | LUAD | 2 |
p.R282S | LUAD | 1 |
p.D346N | UCEC | 1 |
p.R148L | ESCA | 1 |
p.N455K | LUSC | 1 |
p.E215D | UCEC | 1 |
p.R32Q | BRCA | 1 |
p.D521E | LIHC | 1 |
p.M205I | ESCA | 1 |
p.L66Q | LUAD | 1 |
p.V268I | BRCA | 1 |
p.G317E | SKCM | 1 |
p.R336W | BLCA | 1 |
p.L370F | LUAD | 1 |
p.E461D | READ | 1 |
p.K290N | THYM | 1 |
p.K427R | LUSC | 1 |
p.E206D | UCEC | 1 |
p.R160C | LUSC | 1 |
p.N175T | PAAD | 1 |
p.Q200K | LUAD | 1 |
p.H167Y | SKCM | 1 |
p.D408Y | LUAD | 1 |
p.S19L | CESC | 1 |
p.F509V | STAD | 1 |
p.K64N | BLCA | 1 |
p.V268I | BLCA | 1 |
p.S243C | CESC | 1 |
p.L255F | SKCM | 1 |
p.R179Q | STAD | 1 |
p.L443P | UCEC | 1 |
p.K287N | KIRP | 1 |
p.E473K | SKCM | 1 |
p.V164A | STAD | 1 |
p.A306P | LUAD | 1 |
p.E188K | SKCM | 1 |
p.L491I | COAD | 1 |
p.D373N | SKCM | 1 |
p.R32W | THYM | 1 |
p.A472P | LUAD | 1 |
p.E253K | SKCM | 1 |
p.P508L | SKCM | 1 |
p.R9G | SKCM | 1 |
p.T390M | LUAD | 1 |
p.S58C | LUAD | 1 |
p.S243C | BLCA | 1 |
p.A472V | LUAD | 1 |
p.P483T | MESO | 1 |
p.N344K | UCEC | 1 |
p.R45W | UCEC | 1 |
p.P444L | SKCM | 1 |
p.E158K | SKCM | 1 |
p.I63L | OV | 1 |
p.P15L | SKCM | 1 |
p.Q355* | SKCM | 1 |
p.R160H | UCEC | 1 |
p.P549S | LUAD | 1 |
p.Q518L | KIRP | 1 |
p.V543M | LIHC | 1 |
p.P508T | LUSC | 1 |
p.G401R | LUSC | 1 |
p.A425T | ESCA | 1 |
p.G545R | LUAD | 1 |
p.K290Q | UCEC | 1 |
p.E275* | UCEC | 1 |
p.L313M | LUAD | 1 |
p.R465C | UCEC | 1 |
p.R273C | SKCM | 1 |
p.E315D | STAD | 1 |
p.A425T | STAD | 1 |
p.M210I | SKCM | 1 |
p.S547G | HNSC | 1 |
p.P477Q | LUAD | 1 |
p.D456N | SKCM | 1 |
p.R250Q | KIRC | 1 |
p.R365Q | UCEC | 1 |
p.L125I | UCEC | 1 |
p.L120R | LUAD | 1 |
p.A213T | STAD | 1 |
p.S2F | BLCA | 1 |
p.R186* | SKCM | 1 |
p.E284K | SKCM | 1 |
p.R512S | LUAD | 1 |
p.G317R | MESO | 1 |
p.Q54H | BLCA | 1 |
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TissGeneCNV for CCDC63 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC63 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1KW-01A | PWP1-CCDC63 | In-Frame | chr12:108098524 | chr12:111330879 |
Chimerdb3.0 | TopHat-Fusion | SARC | TCGA-DX-A1KW-01A | PWP1-CCDC63 | In-Frame | chr12:108098523 | chr12:111330879 |
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TissGeneNet for CCDC63 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC63 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC63 |
TissGeneDrug for CCDC63 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC63 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 1 | CTD_human |