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| TissGeneSummary for DAO |
 Gene summary |
| Basic gene information | Gene symbol | DAO |
| Gene name | D-amino-acid oxidase | |
| Synonyms | DAAO|DAMOX|OXDA | |
| Cytomap | UCSC genome browser: 12q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001917.4, | |
| Description | D-amino acid oxidase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 124050 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110887 | ||
| HPRD : 15917 | ||
| Vega : OTTHUMG00000169360 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DAO | |
| BioGPS: 1610 | ||
| Pathway | NCI Pathway Interaction Database: DAO | |
| KEGG: DAO | ||
| REACTOME: DAO | ||
| Pathway Commons: DAO | ||
| Context | iHOP: DAO | |
| ligand binding site mutation search in PubMed: DAO | ||
| UCL Cancer Institute: DAO | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of DAO | ||
| Description by TissGene annotations | Cancer gene TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006562 | proline catabolic process | 16616139 | GO:0036088 | D-serine catabolic process | 18544534 | GO:0042416 | dopamine biosynthetic process | 17303072 | GO:0055130 | D-alanine catabolic process | 16616139 | GO:0070178 | D-serine metabolic process | 21679769 | GO:0006562 | proline catabolic process | 16616139 | GO:0036088 | D-serine catabolic process | 18544534 | GO:0042416 | dopamine biosynthetic process | 17303072 | GO:0055130 | D-alanine catabolic process | 16616139 | GO:0070178 | D-serine metabolic process | 21679769 |
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| TissGeneExp for DAO |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 2.777392892 | 4.915776225 | -2.138383333 | 3.51E-05 | 7.81E-05 |
| LIHC | 6.533147225 | 8.445593225 | -1.912446 | 1.67E-05 | 6.71E-05 |
| KICH | -2.330706775 | 4.447233225 | -6.77794 | 7.49E-11 | 5.98E-10 |
| LUSC | -2.578108579 | -1.2385125 | -1.339596078 | 7.84E-12 | 3.31E-11 |
| KIRP | 2.2378981 | 6.254613725 | -4.016715625 | 5.20E-07 | 2.82E-06 |
| LUAD | -2.43058843 | -1.167178085 | -1.263410345 | 3.38E-11 | 2.18E-10 |
| COAD | -2.136671852 | 2.286497379 | -4.423169231 | 2.95E-15 | 2.07E-13 |
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| TissGene-miRNA for DAO |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DAO |
| TissGeneSNV for DAO |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G12R | COAD | 2 |
| p.R297C | SKCM | 2 |
| p.H307R | LUAD | 1 |
| p.K337T | STAD | 1 |
| p.P105L | LUSC | 1 |
| p.R332K | SKCM | 1 |
| p.W260* | SKCM | 1 |
| p.G315E | SKCM | 1 |
| p.E154V | LIHC | 1 |
| p.R279* | ACC | 1 |
| p.R191* | BRCA | 1 |
| p.R22H | DLBC | 1 |
| p.Q28K | UCEC | 1 |
| p.R279X | STAD | 1 |
| p.R286H | STAD | 1 |
| p.E121* | STAD | 1 |
| p.R22H | COAD | 1 |
| p.G239* | LUSC | 1 |
| p.D46N | READ | 1 |
| p.A36T | STAD | 1 |
| p.H80N | PRAD | 1 |
| p.T258A | STAD | 1 |
| p.R199W | READ | 1 |
| p.Q201H | LIHC | 1 |
| p.K337N | UCEC | 1 |
| p.L56F | SKCM | 1 |
| p.R286C | SKCM | 1 |
| p.Y144H | STAD | 1 |
| p.R2H | GBM | 1 |
| p.I19L | SKCM | 1 |
| p.R297C | CESC | 1 |
| p.R155M | COAD | 1 |
| p.R290W | UCEC | 1 |
| p.N302H | UCEC | 1 |
| p.G113E | SKCM | 1 |
| p.E173K | SKCM | 1 |
| p.E121X | STAD | 1 |
| p.H256R | LUAD | 1 |
| p.F39V | COAD | 1 |
| p.G245R | SKCM | 1 |
| p.R286C | GBM | 1 |
| p.F125L | LUAD | 1 |
| p.F282V | DLBC | 1 |
| p.P219T | UCEC | 1 |
| p.E335K | READ | 1 |
| p.R115W | LIHC | 1 |
| p.D192N | SKCM | 1 |
| p.M203V | LIHC | 1 |
| p.R279* | STAD | 1 |
| p.D46E | LUAD | 1 |
| p.V26A | UCEC | 1 |
| p.I138L | READ | 1 |
| p.G50S | PAAD | 1 |
| p.F125L | LIHC | 1 |
| p.G12R | STAD | 1 |
| p.M210V | KIRC | 1 |
| p.Y314H | STAD | 1 |
| p.E173K | GBM | 1 |
| p.D192G | LIHC | 1 |
| p.R199Q | SKCM | 1 |
| p.I138L | HNSC | 1 |
| p.D37N | SKCM | 1 |
| p.R290Q | PAAD | 1 |
| p.R162W | STAD | 1 |
| p.E261K | SKCM | 1 |
| p.G12W | LIHC | 1 |
| p.A207T | UCEC | 1 |
| p.A327T | SKCM | 1 |
| p.R162Q | PRAD | 1 |
| p.R286C | ESCA | 1 |
| p.R162Q | COAD | 1 |
| p.G141E | SKCM | 1 |
| p.G312V | THYM | 1 |
| p.R332I | UCEC | 1 |
| p.F159L | UCEC | 1 |
| p.F159Y | SKCM | 1 |
| p.G50D | STAD | 1 |
| p.R199W | LUAD | 1 |
| p.R38C | ACC | 1 |
| p.V236A | SKCM | 1 |
| p.R283W | GBM | 1 |
| p.E21K | SKCM | 1 |
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| TissGeneCNV for DAO |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DAO |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-BG-A3PP-01A | SART3-DAO | CDS-5'UTR | chr12:108938914 | chr12:109278773 |
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| TissGeneNet for DAO |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| COAD (tumor) | COAD (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| KICH (tumor) | KICH (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| STAD (tumor) | STAD (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| THCA (tumor) | THCA (normal) |
| DAO, EP300, PRKAB2, DAOA (tumor) | DAO, EP300, PRKAB2, DAOA (normal) |
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| TissGeneProg for DAO |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DAO |
| TissGeneDrug for DAO |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DAO |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 41 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0005586 | Bipolar Disorder | 7 | BeFree,GAD,LHGDN |
| umls:C0033975 | Psychotic Disorders | 3 | BeFree |
| umls:C0349204 | Nonorganic psychosis | 3 | BeFree |
| umls:C0003469 | Anxiety Disorders | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C1839839 | MAJOR AFFECTIVE DISORDER 2 | 2 | BeFree,GAD |
| umls:C1852197 | MAJOR AFFECTIVE DISORDER 1 | 2 | BeFree,GAD |
| umls:C1970943 | MAJOR AFFECTIVE DISORDER 4 | 2 | BeFree,GAD |
| umls:C1970944 | MAJOR AFFECTIVE DISORDER 5 | 2 | BeFree,GAD |
| umls:C1970945 | MAJOR AFFECTIVE DISORDER 6 | 2 | BeFree,GAD |
| umls:C2700438 | MAJOR AFFECTIVE DISORDER 7 | 2 | BeFree,GAD |
| umls:C2700439 | MAJOR AFFECTIVE DISORDER 8 | 2 | BeFree,GAD |
| umls:C2700440 | MAJOR AFFECTIVE DISORDER 9 | 2 | BeFree,GAD |
| umls:C0004352 | Autistic Disorder | 1 | CTD_human,GAD |
| umls:C0010346 | Crohn Disease | 1 | GAD |
| umls:C0036337 | Schizoaffective Disorder | 1 | GAD |
| umls:C0041671 | Attention Deficit Disorder | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0853193 | Bipolar I disorder | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C3494358 | Prodromal Symptoms | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 0 | ORPHANET |
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