TissGeneSummary for TBC1D21 |
Gene summary |
Basic gene information | Gene symbol | TBC1D21 |
Gene name | TBC1 domain family, member 21 | |
Synonyms | MgcRabGAP | |
Cytomap | UCSC genome browser: 15q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001286434.1, NM_153356.2, | |
Description | TBC1 domain family member 21male germ cell-specific expressed, containing a RabGAP domain | |
Modification date | 20141217 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000167139 | ||
HPRD : 15473 | ||
Vega : OTTHUMG00000137594 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TBC1D21 | |
BioGPS: 161514 | ||
Pathway | NCI Pathway Interaction Database: TBC1D21 | |
KEGG: TBC1D21 | ||
REACTOME: TBC1D21 | ||
Pathway Commons: TBC1D21 | ||
Context | iHOP: TBC1D21 | |
ligand binding site mutation search in PubMed: TBC1D21 | ||
UCL Cancer Institute: TBC1D21 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TBC1D21 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TBC1D21 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TBC1D21 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TBC1D21 |
TissGeneSNV for TBC1D21 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R113Q | COAD | 2 |
p.P134S | SKCM | 2 |
p.P238L | SKCM | 1 |
p.W239* | SKCM | 1 |
p.W184C | LUAD | 1 |
p.F74L | UCS | 1 |
p.G136D | UCEC | 1 |
p.G229S | SKCM | 1 |
p.R119L | LUAD | 1 |
p.G293R | SKCM | 1 |
p.A222D | UCEC | 1 |
p.Q329* | SKCM | 1 |
p.Q80* | SKCM | 1 |
p.D253N | LUAD | 1 |
p.F18L | CESC | 1 |
p.I129L | LIHC | 1 |
p.L185F | UCEC | 1 |
p.E321Q | BLCA | 1 |
p.T71M | STAD | 1 |
p.E181Q | LAML | 1 |
p.R246C | UCEC | 1 |
p.V138F | BRCA | 1 |
p.A232V | UCEC | 1 |
p.G202V | LUAD | 1 |
p.L70F | SKCM | 1 |
p.M1I | LUSC | 1 |
p.R246L | HNSC | 1 |
p.S45X | ESCA | 1 |
p.R13K | CESC | 1 |
p.L331I | BRCA | 1 |
p.R83W | ESCA | 1 |
p.Q329X | SKCM | 1 |
p.E167* | BRCA | 1 |
p.G293E | SKCM | 1 |
p.V154I | COAD | 1 |
p.P60L | SKCM | 1 |
p.K103N | LUSC | 1 |
p.M281T | ACC | 1 |
p.A314S | STAD | 1 |
p.D326N | SKCM | 1 |
p.L210I | LUAD | 1 |
p.E55K | SKCM | 1 |
p.D37Y | LUAD | 1 |
p.G292V | THYM | 1 |
p.K29N | LUSC | 1 |
p.R124C | BRCA | 1 |
p.M169T | UCEC | 1 |
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TissGeneCNV for TBC1D21 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TBC1D21 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AN-A0AR-01A | OLFM2-TBC1D21 | In-Frame | chr19:10046979 | chr15:74173984 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0AR-01A | OLFM2-TBC1D21 | In-frame | Chr19:10046980 | Chr15:74173985 |
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TissGeneNet for TBC1D21 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TBC1D21 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TBC1D21 |
TissGeneDrug for TBC1D21 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TBC1D21 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0206368 | Exfoliation Syndrome | 1 | BeFree,GWASCAT |