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| TissGeneSummary for DYX1C1 |
 Gene summary |
| Basic gene information | Gene symbol | DYX1C1 |
| Gene name | dyslexia susceptibility 1 candidate 1 | |
| Synonyms | CILD25|DNAAF4|DYX1|DYXC1|EKN1|RD | |
| Cytomap | UCSC genome browser: 15q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001033559.2, NM_001033560.1,NM_130810.3, | |
| Description | dynein, axonemal, assembly factor 4dyslexia susceptibility 1 candidate gene 1 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608706 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000256061 | ||
| HPRD : 10568 | ||
| Vega : OTTHUMG00000132008 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DYX1C1 | |
| BioGPS: 161582 | ||
| Pathway | NCI Pathway Interaction Database: DYX1C1 | |
| KEGG: DYX1C1 | ||
| REACTOME: DYX1C1 | ||
| Pathway Commons: DYX1C1 | ||
| Context | iHOP: DYX1C1 | |
| ligand binding site mutation search in PubMed: DYX1C1 | ||
| UCL Cancer Institute: DYX1C1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTTHCA | |
| Reference showing the relevant tissue of DYX1C1 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 19423554 | GO:0061136 | regulation of proteasomal protein catabolic process | 19423554 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 19423554 | GO:0061136 | regulation of proteasomal protein catabolic process | 19423554 |
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| TissGeneExp for DYX1C1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.219422516 | 0.239449484 | -2.458872 | 3.95E-12 | 4.09E-11 |
| LUSC | -1.343020241 | 0.177991523 | -1.521011765 | 4.74E-13 | 2.28E-12 |
| COAD | -1.664860362 | -3.219356516 | 1.554496154 | 3.96E-06 | 1.98E-05 |
| ESCA | -0.67695197 | -2.310979243 | 1.634027273 | 0.000398 | 0.008168145 |
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| TissGene-miRNA for DYX1C1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DYX1C1 |
| TissGeneSNV for DYX1C1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I310M | THCA | 1 |
| p.R373K | SKCM | 1 |
| p.V91I | DLBC | 1 |
| p.T359A | STAD | 1 |
| p.D295N | SKCM | 1 |
| p.D7N | HNSC | 1 |
| p.A210D | ESCA | 1 |
| p.A392T | UCEC | 1 |
| p.P397L | SKCM | 1 |
| p.R29K | STAD | 1 |
| p.D282N | UCEC | 1 |
| p.N43S | DLBC | 1 |
| p.A51T | HNSC | 1 |
| p.E138D | UCEC | 1 |
| p.Q4* | BLCA | 1 |
| p.P244T | PRAD | 1 |
| p.E124D | HNSC | 1 |
| p.S20F | BLCA | 1 |
| p.K288N | UCEC | 1 |
| p.E84D | COAD | 1 |
| p.E363Q | BLCA | 1 |
| p.R252H | STAD | 1 |
| p.R123Q | STAD | 1 |
| p.P324S | PRAD | 1 |
| p.N38K | DLBC | 1 |
| p.D295G | UCEC | 1 |
| p.A392V | DLBC | 1 |
| p.E101K | SKCM | 1 |
| p.T36K | PRAD | 1 |
| p.N150D | UCEC | 1 |
| p.E417D | KIRC | 1 |
| p.R372H | STAD | 1 |
| p.I357M | STAD | 1 |
| p.E94Q | HNSC | 1 |
| p.T303M | BRCA | 1 |
| p.I153K | KIRC | 1 |
| p.A350V | STAD | 1 |
| p.S420Y | COAD | 1 |
| p.L209I | STAD | 1 |
| p.E222D | UCEC | 1 |
| p.S420C | COAD | 1 |
| p.R98I | LUAD | 1 |
| p.D276Y | KICH | 1 |
| p.R233H | LGG | 1 |
| p.R207X | LIHC | 1 |
| p.P2S | THYM | 1 |
| p.A375P | HNSC | 1 |
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| TissGeneCNV for DYX1C1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DYX1C1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1NA-01A | DYX1C1-RFX7 | In-frame | Chr15:55783321 | Chr15:56436681 |
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| TissGeneNet for DYX1C1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| COAD (tumor) | COAD (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| KICH (tumor) | KICH (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| STAD (tumor) | STAD (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| THCA (tumor) | THCA (normal) |
| DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (tumor) | DYX1C1, GABARAPL1, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3C, STUB1, HSPA1A (normal) |
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| TissGeneProg for DYX1C1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DYX1C1 |
| TissGeneDrug for DYX1C1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DYX1C1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0476254 | Dyslexia | 29 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0920296 | Developmental reading disorder | 13 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 2 | BeFree,CTD_human |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0871215 | Reading Disabilities | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | BeFree,CTD_human |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C3809641 | CILIARY DYSKINESIA, PRIMARY, 25 | 0 | CLINVAR,MGD |
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