TissGeneSummary for ODF3L1 |
Gene summary |
Basic gene information | Gene symbol | ODF3L1 |
Gene name | outer dense fiber of sperm tails 3-like 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 15q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_175881.3, | |
Description | outer dense fiber protein 3-like protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000182950 | ||
HPRD : 11360 | ||
Vega : OTTHUMG00000142837 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ODF3L1 | |
BioGPS: 161753 | ||
Pathway | NCI Pathway Interaction Database: ODF3L1 | |
KEGG: ODF3L1 | ||
REACTOME: ODF3L1 | ||
Pathway Commons: ODF3L1 | ||
Context | iHOP: ODF3L1 | |
ligand binding site mutation search in PubMed: ODF3L1 | ||
UCL Cancer Institute: ODF3L1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ODF3L1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ODF3L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.528715408 | 2.341950702 | -1.813235294 | 2.48E-11 | 9.94E-11 |
BLCA | -1.238256935 | 1.953895697 | -3.192152632 | 5.01E-09 | 5.86E-07 |
BRCA | -1.54229904 | 0.871214118 | -2.413513158 | 8.35E-39 | 2.27E-37 |
LIHC | -0.760538513 | 0.955361487 | -1.7159 | 2.50E-07 | 1.57E-06 |
THCA | -0.55385292 | 1.533145385 | -2.086998305 | 2.78E-09 | 1.51E-08 |
LUAD | -0.486541962 | 1.918559762 | -2.405101724 | 6.25E-20 | 1.24E-18 |
STAD | 0.174877112 | 1.274236487 | -1.099359375 | 0.0105 | 0.035833839 |
PRAD | -1.54661159 | -0.478853898 | -1.067757692 | 0.000245 | 0.000935341 |
HNSC | 0.706802184 | -0.452069909 | 1.158872093 | 8.02E-05 | 0.000367515 |
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TissGene-miRNA for ODF3L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ODF3L1 |
TissGeneSNV for ODF3L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L69M | STAD | 1 |
p.G197R | HNSC | 1 |
p.V151A | STAD | 1 |
p.V11A | LUAD | 1 |
p.R206* | ESCA | 1 |
p.I259M | LUAD | 1 |
p.P207T | HNSC | 1 |
p.R273H | KIRC | 1 |
p.P172H | STAD | 1 |
p.P103L | SKCM | 1 |
p.T256A | SKCM | 1 |
p.R147H | STAD | 1 |
p.P201H | STAD | 1 |
p.A226T | READ | 1 |
p.R206X | ESCA | 1 |
p.M35I | SKCM | 1 |
p.N155S | BLCA | 1 |
p.P103S | SKCM | 1 |
p.D153N | BLCA | 1 |
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TissGeneCNV for ODF3L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ODF3L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JK-01A | UBE2Q2-ODF3L1 | Out-of-frame | Chr15:76136187 | Chr15:76017449 |
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TissGeneNet for ODF3L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ODF3L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ODF3L1 |
TissGeneDrug for ODF3L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ODF3L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |