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| TissGeneSummary for ZFPM1 |
 Gene summary |
| Basic gene information | Gene symbol | ZFPM1 |
| Gene name | zinc finger protein, FOG family member 1 | |
| Synonyms | FOG|FOG1|ZC2HC11A|ZNF408|ZNF89A | |
| Cytomap | UCSC genome browser: 16q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_153813.2, | |
| Description | FOG-1friend of GATA 1friend of GATA protein 1friend of GATA-1zinc finger protein 89Azinc finger protein ZFPM1zinc finger protein, multitype 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601950 | |
| HGNC : HGNC | ||
| HPRD : 11800 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZFPM1 | |
| BioGPS: 161882 | ||
| Pathway | NCI Pathway Interaction Database: ZFPM1 | |
| KEGG: ZFPM1 | ||
| REACTOME: ZFPM1 | ||
| Pathway Commons: ZFPM1 | ||
| Context | iHOP: ZFPM1 | |
| ligand binding site mutation search in PubMed: ZFPM1 | ||
| UCL Cancer Institute: ZFPM1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
| Reference showing the relevant tissue of ZFPM1 | ||
| Description by TissGene annotations | Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15920471 | GO:0010724 | regulation of definitive erythrocyte differentiation | 15920471 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 21646796 | GO:0045403 | negative regulation of interleukin-4 biosynthetic process | 21646796 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15920471 | GO:0010724 | regulation of definitive erythrocyte differentiation | 15920471 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 21646796 | GO:0045403 | negative regulation of interleukin-4 biosynthetic process | 21646796 |
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| TissGeneExp for ZFPM1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZFPM1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZFPM1 |
| TissGeneSNV for ZFPM1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R974P | HNSC | 1 |
| p.P212L | ESCA | 1 |
| p.S352G | LUAD | 1 |
| p.V321M | CESC | 1 |
| p.A39E | THYM | 1 |
| p.E205* | BLCA | 1 |
| p.T278I | BLCA | 1 |
| p.K431N | COAD | 1 |
| p.E208Q | BLCA | 1 |
| p.A161T | COAD | 1 |
| p.R290C | HNSC | 1 |
| p.A228T | READ | 1 |
| p.S985C | HNSC | 1 |
| p.V341L | SKCM | 1 |
| p.R14C | ACC | 1 |
| p.G388E | SKCM | 1 |
| p.E308K | PRAD | 1 |
| p.A48T | HNSC | 1 |
| p.A1002T | COAD | 1 |
| p.R803C | STAD | 1 |
| p.N370S | STAD | 1 |
| p.S15F | SKCM | 1 |
| p.W173L | SARC | 1 |
| p.A207V | COAD | 1 |
| p.K431N | LGG | 1 |
| p.D344N | SKCM | 1 |
| p.E160K | COAD | 1 |
| p.Q528H | THCA | 1 |
| p.E81K | BLCA | 1 |
| p.L684Q | THCA | 1 |
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| TissGeneCNV for ZFPM1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZFPM1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG995293 | MAOA-ZFPM1 | chrX:43579695 | chr16:88578237 | |
| Chimerdb3.0 | ChiTaRs | NA | CT004488 | ZFPM1-KLF6 | chr16:88580928 | chr10:3823839 |
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| TissGeneNet for ZFPM1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| COAD (tumor) | COAD (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| KICH (tumor) | KICH (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| STAD (tumor) | STAD (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| THCA (tumor) | THCA (normal) |
| ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (tumor) | ZFPM1, GIPC1, GATA2, MTA1, GSK3B, RBBP4, GATA1, CTBP2, TOP3B (normal) |
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| TissGeneProg for ZFPM1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZFPM1 |
| TissGeneDrug for ZFPM1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZFPM1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002871 | Anemia | 2 | BeFree |
| umls:C0339539 | Familial Exudative Vitreoretinopathy | 2 | BeFree |
| umls:C1839163 | THROMBOCYTOPENIA 1 (disorder) | 2 | BeFree |
| umls:C0001815 | Primary Myelofibrosis | 1 | LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0039730 | Thalassemia | 1 | LHGDN |
| umls:C0040034 | Thrombocytopenia | 1 | LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C0494463 | Alzheimer Disease, Late Onset | 1 | BeFree |
| umls:C1845837 | Dyserythropoietic Anemia with Thrombocytopenia | 1 | BeFree |
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