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| TissGeneSummary for DCC |
 Gene summary |
| Basic gene information | Gene symbol | DCC |
| Gene name | DCC netrin 1 receptor | |
| Synonyms | CRC18|CRCR1|IGDCC1|MRMV1|NTN1R1 | |
| Cytomap | UCSC genome browser: 18q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005215.3, | |
| Description | colorectal cancer suppressorcolorectal tumor suppressordeleted in colorectal cancer proteindeleted in colorectal carcinomaimmunoglobulin superfamily DCC subclass member 1immunoglobulin superfamily, DCC subclass, member 1netrin receptor DCCtumor sup | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 120470 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000187323 | ||
| HPRD : 00391 | ||
| Vega : OTTHUMG00000132698 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCC | |
| BioGPS: 1630 | ||
| Pathway | NCI Pathway Interaction Database: DCC | |
| KEGG: DCC | ||
| REACTOME: DCC | ||
| Pathway Commons: DCC | ||
| Context | iHOP: DCC | |
| ligand binding site mutation search in PubMed: DCC | ||
| UCL Cancer Institute: DCC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DCC | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for DCC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -1.795602064 | -0.116598939 | -1.679003125 | 1.88E-06 | 8.93E-06 |
| PRAD | -1.522200141 | 0.339524859 | -1.861725 | 2.17E-10 | 4.23E-09 |
| LUAD | 0.20537035 | 2.784042764 | -2.578672414 | 1.93E-17 | 2.52E-16 |
| LUSC | 0.89695774 | 3.262936171 | -2.365978431 | 7.46E-08 | 2.13E-07 |
| KICH | -2.036888064 | -0.933128064 | -1.10376 | 0.000631 | 0.001414775 |
| Top |
| TissGene-miRNA for DCC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-381-3p | MIMAT0000736 | 0.011 | -0.29 | 78 |
| ACC | hsa-miR-381-3p | MIMAT0000736 | 0.011 | -0.29 | 78 |
| UCS | hsa-miR-499a-5p | MIMAT0002870 | 0.046 | -0.32 | 56 |
| Top |
| TissGeneMut for DCC |
| TissGeneSNV for DCC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R1337* | SKCM | 6 |
| p.R1021* | SKCM | 4 |
| p.R443Q | SKCM | 4 |
| p.G490E | SKCM | 4 |
| p.R501* | SKCM | 3 |
| p.R1337X | SKCM | 3 |
| p.D1147N | SKCM | 2 |
| p.R779Q | SKCM | 2 |
| p.R661* | SKCM | 2 |
| p.P1375S | SKCM | 2 |
| p.R1337X | READ | 2 |
| p.M1162I | SKCM | 2 |
| p.H104Y | SKCM | 2 |
| p.D1071N | SKCM | 2 |
| p.R1329K | SKCM | 2 |
| p.E1358K | SKCM | 2 |
| p.G407X | ESCA | 2 |
| p.S1073L | SARC | 2 |
| p.F598L | UCEC | 2 |
| p.R446H | LUAD | 2 |
| p.R597* | SKCM | 2 |
| p.R661X | READ | 2 |
| p.R501X | SKCM | 2 |
| p.G55E | SKCM | 2 |
| p.E403K | SKCM | 2 |
| p.P330T | UCEC | 1 |
| p.P1092L | SKCM | 1 |
| p.G1088D | ESCA | 1 |
| p.R1133Q | SKCM | 1 |
| p.P204T | HNSC | 1 |
| p.V764I | BLCA | 1 |
| p.D612N | BLCA | 1 |
| p.S636L | SKCM | 1 |
| p.M997L | STAD | 1 |
| p.P1230T | LIHC | 1 |
| p.E586K | SKCM | 1 |
| p.H80N | READ | 1 |
| p.R275* | SKCM | 1 |
| p.P1351L | SKCM | 1 |
| p.T901A | LIHC | 1 |
| p.P429H | KIRC | 1 |
| p.S442C | KIRP | 1 |
| p.P1338T | LUAD | 1 |
| p.L1279F | SKCM | 1 |
| p.I1120M | HNSC | 1 |
| p.T131R | LIHC | 1 |
| p.S789G | ESCA | 1 |
| p.P182L | SKCM | 1 |
| p.L59P | STAD | 1 |
| p.E403K | BLCA | 1 |
| p.T1135A | COAD | 1 |
| p.P870S | SKCM | 1 |
| p.L808H | SKCM | 1 |
| p.Q1308* | HNSC | 1 |
| p.Q486H | SARC | 1 |
| p.A25V | COAD | 1 |
| p.Q1299R | HNSC | 1 |
| p.A1213E | LUAD | 1 |
| p.D256N | SKCM | 1 |
| p.E1077_splice | LUSC | 1 |
| p.R597* | STAD | 1 |
| p.D866G | BLCA | 1 |
| p.A947S | COAD | 1 |
| p.R661X | SKCM | 1 |
| p.T181I | LUAD | 1 |
| p.L5V | LUSC | 1 |
| p.H733Y | SKCM | 1 |
| p.T411A | STAD | 1 |
| p.Q486L | DLBC | 1 |
| p.A431S | LUAD | 1 |
| p.R603C | COAD | 1 |
| p.E225K | SKCM | 1 |
| p.G1294E | SKCM | 1 |
| p.K89T | PRAD | 1 |
| p.G1214E | SKCM | 1 |
| p.V329F | LUAD | 1 |
| p.S24C | UCEC | 1 |
| p.S1344N | SKCM | 1 |
| p.S569F | UCEC | 1 |
| p.P751T | THCA | 1 |
| p.M915V | ESCA | 1 |
| p.R386Q | SKCM | 1 |
| p.L325P | GBM | 1 |
| p.G560S | LIHC | 1 |
| p.D866N | SKCM | 1 |
| p.E147V | LUSC | 1 |
| p.G95A | SKCM | 1 |
| p.R779* | UCEC | 1 |
| p.R41C | STAD | 1 |
| p.R1021X | SKCM | 1 |
| p.V963I | BRCA | 1 |
| p.E586K | HNSC | 1 |
| p.W273C | LIHC | 1 |
| p.R661Q | UCEC | 1 |
| p.E403X | THYM | 1 |
| p.P429S | SKCM | 1 |
| p.R1025G | CESC | 1 |
| p.T923S | LIHC | 1 |
| p.T617R | GBM | 1 |
| p.P1064S | THYM | 1 |
| p.M153R | KIRP | 1 |
| p.E810K | SKCM | 1 |
| p.N363T | KIRP | 1 |
| p.G122E | SKCM | 1 |
| p.A496D | COAD | 1 |
| p.R1021Q | SKCM | 1 |
| p.E549K | SKCM | 1 |
| p.K315E | BLCA | 1 |
| p.E972K | HNSC | 1 |
| p.R661Q | BLCA | 1 |
| p.R597X | SKCM | 1 |
| p.L1148I | BLCA | 1 |
| p.D825Y | BLCA | 1 |
| p.T1122P | GBM | 1 |
| p.S430L | SKCM | 1 |
| p.P1273T | STAD | 1 |
| p.S1096N | SKCM | 1 |
| p.G1388R | SKCM | 1 |
| p.E277K | KIRC | 1 |
| p.F983Y | SKCM | 1 |
| p.P647S | LUAD | 1 |
| p.Q1260* | SKCM | 1 |
| p.R1056C | SKCM | 1 |
| p.D155N | LUAD | 1 |
| p.E957K | SKCM | 1 |
| p.G689R | SKCM | 1 |
| p.S538F | SKCM | 1 |
| p.V489L | LUAD | 1 |
| p.D839N | SKCM | 1 |
| p.V1113L | STAD | 1 |
| p.Q1008* | SKCM | 1 |
| p.W74* | SKCM | 1 |
| p.T301A | READ | 1 |
| p.R879Q | SKCM | 1 |
| p.I576K | SKCM | 1 |
| p.R562I | UCS | 1 |
| p.P622Q | LUSC | 1 |
| p.T875M | COAD | 1 |
| p.G1444S | SKCM | 1 |
| p.G113V | LUSC | 1 |
| p.V754A | READ | 1 |
| p.G571E | SKCM | 1 |
| p.P1179T | UCEC | 1 |
| p.P1230T | KIRC | 1 |
| p.E1161K | SARC | 1 |
| p.R443Q | SARC | 1 |
| p.Q410H | ESCA | 1 |
| p.P551L | LGG | 1 |
| p.A406T | UCEC | 1 |
| p.P204T | PRAD | 1 |
| p.A1346V | UCEC | 1 |
| p.E898Q | BLCA | 1 |
| p.E1414K | SKCM | 1 |
| p.S270R | SARC | 1 |
| p.E507K | SKCM | 1 |
| p.E278K | HNSC | 1 |
| p.T1255M | CESC | 1 |
| p.W74L | STAD | 1 |
| p.S790Y | SKCM | 1 |
| p.P418T | LUAD | 1 |
| p.K1167E | LUSC | 1 |
| p.A455V | SARC | 1 |
| p.D60Y | LUSC | 1 |
| p.T1255M | PRAD | 1 |
| p.D48Y | ESCA | 1 |
| p.I422F | LUAD | 1 |
| p.L236Q | HNSC | 1 |
| p.R468K | SARC | 1 |
| p.G68E | SKCM | 1 |
| p.S789R | HNSC | 1 |
| p.N677S | DLBC | 1 |
| p.M997I | STAD | 1 |
| p.P550S | ESCA | 1 |
| p.G205W | LUAD | 1 |
| p.P528T | COAD | 1 |
| p.C1270Y | LGG | 1 |
| p.S789R | STAD | 1 |
| p.S219N | SKCM | 1 |
| p.P1403S | SKCM | 1 |
| p.L477F | BLCA | 1 |
| p.Q203* | SKCM | 1 |
| p.I387M | LGG | 1 |
| p.S96C | STAD | 1 |
| p.R443Q | UCEC | 1 |
| p.R1025Q | SKCM | 1 |
| p.R473K | SKCM | 1 |
| p.P1375T | HNSC | 1 |
| p.A1225D | UCEC | 1 |
| p.R1227H | READ | 1 |
| p.L796I | SKCM | 1 |
| p.E395K | SKCM | 1 |
| p.P337L | SKCM | 1 |
| p.P726S | SKCM | 1 |
| p.E717D | UCEC | 1 |
| p.H1340Q | LUAD | 1 |
| p.Q203R | UCEC | 1 |
| p.P1179H | BLCA | 1 |
| p.R1133P | ACC | 1 |
| p.S1202N | SKCM | 1 |
| p.F444C | SKCM | 1 |
| p.K493N | UCEC | 1 |
| p.W508L | COAD | 1 |
| p.S1368P | LGG | 1 |
| p.E1414V | STAD | 1 |
| p.P847T | SKCM | 1 |
| p.R1343H | ESCA | 1 |
| p.C740S | LUAD | 1 |
| p.M1235I | SKCM | 1 |
| p.S484F | SKCM | 1 |
| p.Y780* | SKCM | 1 |
| p.A25T | UCEC | 1 |
| p.S929C | LIHC | 1 |
| p.V848L | BRCA | 1 |
| p.P451S | SKCM | 1 |
| p.A409V | COAD | 1 |
| p.A852S | LUAD | 1 |
| p.R1280Q | STAD | 1 |
| p.A1138T | BRCA | 1 |
| p.D434N | UCEC | 1 |
| p.P726L | SKCM | 1 |
| p.E349Q | UCEC | 1 |
| p.R667H | STAD | 1 |
| p.Y881* | LUAD | 1 |
| p.E1161G | STAD | 1 |
| p.E1408D | STAD | 1 |
| p.E87K | HNSC | 1 |
| p.P948S | SKCM | 1 |
| p.D1035N | SKCM | 1 |
| p.P828S | SKCM | 1 |
| p.G1207V | UCEC | 1 |
| p.G975R | SKCM | 1 |
| p.W745X | ESCA | 1 |
| p.V920I | LGG | 1 |
| p.K366N | SKCM | 1 |
| p.T1203N | LUAD | 1 |
| p.R603C | UCEC | 1 |
| p.S412I | SARC | 1 |
| p.A769T | HNSC | 1 |
| p.P182S | LUSC | 1 |
| p.E1408K | SKCM | 1 |
| p.T665M | STAD | 1 |
| p.R1141K | SKCM | 1 |
| p.R1297K | LUAD | 1 |
| p.P1283T | STAD | 1 |
| p.R661* | UCEC | 1 |
| p.T923K | BLCA | 1 |
| p.R443* | CESC | 1 |
| p.V1248M | BLCA | 1 |
| p.P432L | SKCM | 1 |
| p.E253* | BRCA | 1 |
| p.S1178A | ESCA | 1 |
| p.E532X | ESCA | 1 |
| p.R1391K | SKCM | 1 |
| p.T738A | STAD | 1 |
| p.S790P | SKCM | 1 |
| p.S270T | SARC | 1 |
| p.T51I | GBM | 1 |
| p.L27F | CESC | 1 |
| p.R386Q | STAD | 1 |
| p.P970S | SKCM | 1 |
| p.A63T | PAAD | 1 |
| p.N602S | UCEC | 1 |
| p.R603C | THCA | 1 |
| p.R1123* | UCEC | 1 |
| p.P70S | SKCM | 1 |
| p.S213T | PRAD | 1 |
| p.R1124C | HNSC | 1 |
| p.P330L | BRCA | 1 |
| p.T1339P | ESCA | 1 |
| p.E784K | BLCA | 1 |
| p.D66E | LUAD | 1 |
| p.E2D | UCS | 1 |
| p.R879L | CESC | 1 |
| p.G1304* | STAD | 1 |
| p.G113A | LUAD | 1 |
| p.D256Y | UCEC | 1 |
| p.W332C | READ | 1 |
| p.E1221G | STAD | 1 |
| p.L415I | PAAD | 1 |
| p.V1104L | LUSC | 1 |
| p.N1097K | LUSC | 1 |
| p.P1252S | SKCM | 1 |
| p.D899N | ESCA | 1 |
| p.P1393H | UCS | 1 |
| p.V1100A | UCEC | 1 |
| p.N555K | HNSC | 1 |
| p.C400Y | ESCA | 1 |
| p.S897* | LUAD | 1 |
| p.V853L | HNSC | 1 |
| p.G113R | SKCM | 1 |
| p.T566I | SKCM | 1 |
| p.R215Q | COAD | 1 |
| p.D719N | SKCM | 1 |
| p.R53Q | SKCM | 1 |
| p.Q460E | OV | 1 |
| p.R1231Q | PRAD | 1 |
| p.G223E | SKCM | 1 |
| p.V1248L | HNSC | 1 |
| p.L1350I | LUAD | 1 |
| p.G757S | CESC | 1 |
| p.R1133W | SARC | 1 |
| p.P626S | STAD | 1 |
| p.A455V | READ | 1 |
| p.V1248M | ESCA | 1 |
| p.V883I | BRCA | 1 |
| p.V837A | COAD | 1 |
| p.Y594* | LUAD | 1 |
| p.P429H | LGG | 1 |
| p.A431D | OV | 1 |
| p.G653E | SKCM | 1 |
| p.Q399* | SKCM | 1 |
| p.D256G | BLCA | 1 |
| p.F918L | UCS | 1 |
| p.V878M | SKCM | 1 |
| p.D86N | SKCM | 1 |
| p.R773C | COAD | 1 |
| p.V329A | KICH | 1 |
| p.G457R | SKCM | 1 |
| p.E1159K | SKCM | 1 |
| p.L1265P | LUAD | 1 |
| p.L158Q | SKCM | 1 |
| p.Q559K | BRCA | 1 |
| p.V1100L | HNSC | 1 |
| p.T1333I | LIHC | 1 |
| p.R961C | SKCM | 1 |
| p.P1375H | HNSC | 1 |
| p.T30I | DLBC | 1 |
| p.G909D | STAD | 1 |
| p.A1446V | UCEC | 1 |
| p.E253K | SKCM | 1 |
| p.W9L | THYM | 1 |
| p.R446H | HNSC | 1 |
| p.Q851H | LUAD | 1 |
| p.M1354I | BLCA | 1 |
| p.M1436I | SKCM | 1 |
| p.Q627H | THYM | 1 |
| p.D819N | UCS | 1 |
| p.P234T | UCEC | 1 |
| p.S1445* | LUAD | 1 |
| p.P184S | SKCM | 1 |
| p.T353K | STAD | 1 |
| p.R130W | OV | 1 |
| p.R884W | ESCA | 1 |
| p.G1263E | SKCM | 1 |
| p.K896R | LIHC | 1 |
| p.R41H | UCS | 1 |
| p.L231V | UCS | 1 |
| p.N677K | HNSC | 1 |
| p.W680C | LUAD | 1 |
| p.R88K | SKCM | 1 |
| p.L588P | GBM | 1 |
| p.T882I | SKCM | 1 |
| p.S96C | BRCA | 1 |
| p.D256Y | UCS | 1 |
| p.R1231W | THYM | 1 |
| p.G1207_splice | UCEC | 1 |
| p.E405Q | BLCA | 1 |
| p.R773S | HNSC | 1 |
| p.R1133W | BLCA | 1 |
| p.T1339A | STAD | 1 |
| p.S1034F | SKCM | 1 |
| p.D375V | SKCM | 1 |
| p.P970L | SKCM | 1 |
| p.S816F | SKCM | 1 |
| p.E1404K | BRCA | 1 |
| p.E87K | BLCA | 1 |
| p.K73Q | CESC | 1 |
| p.G805E | SKCM | 1 |
| p.K133Q | COAD | 1 |
| p.P1275Q | LUSC | 1 |
| p.G1088C | LUAD | 1 |
| p.P1151H | LUAD | 1 |
| p.R501Q | SKCM | 1 |
| p.H172Q | BLCA | 1 |
| p.R1337X | COAD | 1 |
| p.L27R | LUSC | 1 |
| p.A342V | STAD | 1 |
| p.R756X | READ | 1 |
| p.T700A | UCEC | 1 |
| p.D66N | STAD | 1 |
| p.Y916H | LUSC | 1 |
| p.R668K | PRAD | 1 |
| p.S1027L | SKCM | 1 |
| p.G1304R | SKCM | 1 |
| p.P1266L | BLCA | 1 |
| p.P46S | UCEC | 1 |
| p.R597X | STAD | 1 |
| p.R211* | UCEC | 1 |
| p.D394E | SKCM | 1 |
| p.A1382P | SKCM | 1 |
| p.T1135I | STAD | 1 |
| p.R1130T | BLCA | 1 |
| p.R1021G | UCS | 1 |
| p.M1160I | SARC | 1 |
| p.P767T | STAD | 1 |
| p.R562T | CESC | 1 |
| p.M1050L | HNSC | 1 |
| p.D48H | LUAD | 1 |
| p.P418H | GBM | 1 |
| p.W745* | ESCA | 1 |
| p.A25V | UCEC | 1 |
| p.R215Q | BLCA | 1 |
| p.G235A | BRCA | 1 |
| p.T666P | LUAD | 1 |
| p.C1270Y | UCEC | 1 |
| p.R446H | UCEC | 1 |
| p.P1237S | SKCM | 1 |
| p.V578F | STAD | 1 |
| p.V380L | LUSC | 1 |
| p.R1149* | SKCM | 1 |
| p.G138* | HNSC | 1 |
| p.L599X | LIHC | 1 |
| p.P1396S | SKCM | 1 |
| p.V633A | COAD | 1 |
| p.P606S | SKCM | 1 |
| p.Q515E | LUAD | 1 |
| p.R1025X | ESCA | 1 |
| p.S1328I | KIRP | 1 |
| p.A1246S | LUAD | 1 |
| p.K584E | STAD | 1 |
| p.E532K | BLCA | 1 |
| p.A455V | STAD | 1 |
| p.P1353A | LIHC | 1 |
| p.P110L | HNSC | 1 |
| p.P1266L | HNSC | 1 |
| p.E45A | HNSC | 1 |
| p.N294T | ESCA | 1 |
| p.E1166K | SKCM | 1 |
| p.P807S | SKCM | 1 |
| p.T1016I | UCEC | 1 |
| p.G78S | SKCM | 1 |
| p.S120F | SKCM | 1 |
| p.G382E | SKCM | 1 |
| p.P234S | LIHC | 1 |
| p.K1233N | STAD | 1 |
| p.P217T | LUAD | 1 |
| p.Q526H | ESCA | 1 |
| p.P1252Q | LUAD | 1 |
| p.R661* | OV | 1 |
| p.S264Y | LGG | 1 |
| p.L585P | KICH | 1 |
| p.R450L | LUAD | 1 |
| p.E532D | SKCM | 1 |
| p.M1217V | COAD | 1 |
| p.H1340Q | ESCA | 1 |
| p.E166K | SKCM | 1 |
| p.E351Q | BLCA | 1 |
| p.V1248M | PRAD | 1 |
| p.P1273T | LUAD | 1 |
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| TissGeneCNV for DCC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DCC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF086459 | KCNMA1-DCC | chr10:78799376 | chr18:51031801 | |
| Chimerdb3.0 | ChiTaRs | NA | BE930864 | KCNMA1-DCC | chr10:78799391 | chr18:51031801 | |
| Chimerdb3.0 | ChiTaRs | NA | AA740208 | DCC-DCC | chr18:51058713 | chr18:51058322 | |
| TCGAfusionPortal | PRADA | BLCA | TCGA-G2-A2EL-01A | KIAA1328-DCC | Out-of-frame | Chr18:34664195 | Chr18:50278424 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-5434-01A | ROCK1-DCC | In-frame | Chr18:18586312 | Chr18:50912413 |
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| TissGeneNet for DCC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DCC, CASP3, UBC, MAPK1, PTK2, PTK2B, APPL1, RPL13, RPS6, RPS24, RPL10A, RPL23, MAZ, RPL38, RPL28, RPS13, NTN4, RPS23, EIF2B4, EIF5A2, EIF2B2 (tumor) | DCC, NCK1, CASP3, UBC, MAPK1, PTK2B, MAPK3, RPS4X, RPS24, SIAH2, RPL23, MAZ, RPL38, RPL28, RPS13, PITPNA, RPS23, ADORA2B, EIF2B4, EIF5A2, EIF2B2 (normal) |
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| COAD (tumor) | COAD (normal) |
| DCC, CASP3, EZR, RPS10, AR, PTK2B, MAPK3, SIAH1, RPL13, RPS6, SIAH2, EIF2S3, RPL10A, CASP9, MAZ, NTN1, EIF2S1, RPL28, RPS23, EIF2A, EIF5A2 (tumor) | DCC, NCK1, RPS10, MAPK1, AR, MAPK3, RPL13, EIF3E, RPS6, RPS24, EIF2S2, EIF2S3, RPL23, EIF1AX, NTN1, RPL38, RPS13, NTN4, RPS23, ADORA2B, EIF4E3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DCC, CASP3, UBC, AR, MAPK3, APPL1, SIAH1, RPS24, SIAH2, EIF2S2, EIF4E, CASP9, MAZ, EIF2S1, RPL38, RPL28, NTN4, EIF2B4, EIF5A2, EIF2B2, EIF4E3 (tumor) | DCC, UBC, EZR, RPS10, MAPK1, AR, APPL1, RPL13, RPS24, EIF2S2, RPL5, RPL23, NTN1, EIF2S1, RPL38, RPL28, RPS13, NTN4, RPS23, EIF2B1, EIF2B2 (normal) |
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| KICH (tumor) | KICH (normal) |
| DCC, CASP3, UBC, EZR, MAPK1, AR, PTK2, MAPK3, RPS4X, EIF3E, SIAH2, EIF2S3, CASP9, EIF1AX, NTN4, PITPNA, EIF2A, ADORA2B, EIF5A2, EIF2B2, EIF4E3 (tumor) | DCC, NCK1, CASP3, EZR, MAPK1, AR, PTK2, PTK2B, MAPK3, EIF3E, RPS6, EIF2S3, EIF4E, CASP9, RPL23, EIF2S1, RPS13, NTN4, EIF2B4, EIF5A2, EIF4E3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DCC, NCK1, UBC, EZR, MAPK1, AR, PTK2, MAPK3, SIAH1, SIAH2, EIF2S2, EIF2S3, EIF4E, CASP9, NTN4, PITPNA, EIF2A, EIF2B1, EIF5A2, EIF2B2, EIF4E3 (tumor) | DCC, NCK1, CASP3, EZR, RPS10, AR, PTK2B, RPS4X, SIAH1, RPL13, RPS6, RPS24, RPL5, RPL10A, RPL23, RPL38, RPS13, PITPNA, RPS23, EIF5A2, EIF2B2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DCC, EZR, AR, PTK2, MAPK3, RPS24, EIF2S2, EIF2S3, CASP9, MAZ, RPL38, RPL28, RPS13, NTN4, PITPNA, EIF2A, EIF2B1, ADORA2B, EIF2B4, EIF5A2, EIF4E3 (tumor) | DCC, NCK1, CASP3, EZR, MAPK1, PTK2, PTK2B, RPL13, EIF3E, RPS24, EIF2S2, EIF2S3, RPL23, NTN1, EIF2S1, RPL38, PITPNA, EIF2A, EIF2B1, ADORA2B, EIF2B2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DCC, CASP3, RPS10, AR, PTK2, PTK2B, MAPK3, RPS4X, SIAH1, RPL13, RPS6, RPS24, EIF2S3, RPL23, NTN1, RPL38, RPL28, RPS13, EIF2A, EIF5A2, EIF4E3 (tumor) | DCC, NCK1, CASP3, RPS10, MAPK1, AR, PTK2B, SIAH1, RPL13, RPS24, EIF2S2, RPL10A, RPL23, MAZ, EIF1AX, RPL38, RPL28, RPS13, NTN4, RPS23, EIF5A2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DCC, CASP3, RPS10, AR, PTK2, RPS4X, RPL13, RPS6, RPS24, EIF2S3, RPL5, RPL10A, CASP9, RPL23, EIF1AX, RPL38, RPL28, RPS13, RPS23, EIF2B1, EIF2B4 (tumor) | DCC, UBC, RPS10, AR, PTK2B, APPL1, RPL13, RPS24, EIF2S2, RPL5, RPL23, MAZ, RPL38, RPL28, RPS13, NTN4, PITPNA, EIF2B1, EIF2B4, EIF2B2, EIF4E3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DCC, NCK1, CASP3, RPS10, MAPK1, AR, PTK2, SIAH1, RPL13, RPS6, RPS24, RPL5, RPL10A, CASP9, RPL38, RPL28, RPS13, NTN4, RPS23, EIF2B1, EIF2B4 (tumor) | DCC, EZR, RPS10, MAPK1, PTK2B, MAPK3, APPL1, RPL13, RPS24, SIAH2, EIF2S2, RPL5, CASP9, EIF2S1, RPL28, PITPNA, RPS23, EIF2B1, EIF2B4, EIF5A2, EIF2B2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DCC, RPS10, MAPK1, AR, APPL1, RPS4X, RPL13, RPS6, RPS24, EIF2S3, RPL5, RPL10A, EIF4E, RPL23, MAZ, RPL38, RPL28, RPS13, RPS23, EIF2B1, EIF2B4 (tumor) | DCC, RPS10, MAPK1, AR, RPS4X, RPL13, RPS6, RPS24, EIF2S2, EIF2S3, RPL5, RPL23, MAZ, NTN1, RPL38, RPL28, RPS13, EIF2B1, EIF2B4, EIF5A2, EIF4E3 (normal) |
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| STAD (tumor) | STAD (normal) |
| DCC, NCK1, MAPK1, AR, PTK2B, APPL1, EIF3E, EIF2S3, RPL5, RPL10A, EIF4E, RPL23, MAZ, EIF1AX, NTN1, EIF2S1, NTN4, RPS23, EIF2A, EIF2B1, EIF4E3 (tumor) | DCC, NCK1, RPS10, MAPK1, AR, PTK2B, RPL13, RPS6, RPS24, RPL10A, EIF4E, RPL23, MAZ, NTN1, RPL38, RPL28, NTN4, PITPNA, ADORA2B, EIF5A2, EIF4E3 (normal) |
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| THCA (tumor) | THCA (normal) |
| DCC, NCK1, CASP3, UBC, EZR, MAPK1, PTK2B, MAPK3, APPL1, SIAH1, SIAH2, EIF2S3, RPL5, RPL10A, EIF4E, RPL23, PITPNA, EIF2B1, EIF2B4, EIF2B2, EIF4E3 (tumor) | DCC, NCK1, CASP3, PTK2, MAPK3, RPS4X, SIAH1, EIF3E, RPS6, RPS24, SIAH2, RPL5, RPL10A, EIF4E, CASP9, RPL23, MAZ, EIF1AX, NTN4, ADORA2B, EIF2B2 (normal) |
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| TissGeneProg for DCC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DCC |
| TissGeneDrug for DCC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DCC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 48 | BeFree |
| umls:C1527249 | Colorectal Cancer | 44 | BeFree,GAD |
| umls:C0596263 | Carcinogenesis | 26 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 14 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 13 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 11 | BeFree |
| umls:C0001430 | Adenoma | 10 | BeFree,LHGDN |
| umls:C0009404 | Colorectal Neoplasms | 9 | BeFree,CTD_human,LHGDN |
| umls:C0699790 | Colon Carcinoma | 9 | BeFree,CLINVAR |
| umls:C0001418 | Adenocarcinoma | 8 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 8 | BeFree |
| umls:C0027819 | Neuroblastoma | 8 | BeFree |
| umls:C0700095 | Central neuroblastoma | 8 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 7 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 7 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 6 | BeFree |
| umls:C0178874 | Tumor Progression | 6 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 6 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 5 | BeFree,LHGDN |
| umls:C0023473 | Myeloid Leukemia, Chronic | 5 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 5 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 5 | BeFree |
| umls:C0598766 | Leukemogenesis | 5 | BeFree |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 5 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 4 | BeFree,LHGDN |
| umls:C0023418 | leukemia | 4 | BeFree |
| umls:C0454455 | Mirror movements disorder | 4 | BeFree |
| umls:C0600139 | Prostate carcinoma | 4 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 3 | BeFree |
| umls:C0024299 | Lymphoma | 3 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 3 | BeFree |
| umls:C0153452 | Malignant neoplasm of gallbladder | 3 | BeFree,GWASCAT |
| umls:C0205851 | Germ cell tumor | 3 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 3 | BeFree |
| umls:C0007130 | Mucinous Adenocarcinoma | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 2 | BeFree |
| umls:C0017636 | Glioblastoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0023269 | leiomyosarcoma | 2 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
| umls:C0036341 | Schizophrenia | 2 | BeFree,GAD |
| umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 2 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 2 | BeFree |
| umls:C0349534 | Carcinoma of anal margin | 2 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 2 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 2 | BeFree |
| umls:C0750952 | Biliary Tract Cancer | 2 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 2 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0005699 | Blast Phase | 1 | BeFree |
| umls:C0005911 | Body Weight Changes | 1 | GAD |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0011881 | Diabetic Nephropathy | 1 | GAD |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0016978 | gallbladder neoplasm | 1 | GAD |
| umls:C0017570 | Gingival Neoplasms | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree,GAD |
| umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | CTD_human |
| umls:C0025286 | Meningioma | 1 | BeFree |
| umls:C0026499 | Monosomy | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0027708 | Nephroblastoma | 1 | BeFree,LHGDN |
| umls:C0027814 | Neuritis, Autoimmune, Experimental | 1 | RGD |
| umls:C0028754 | Obesity | 1 | GWASCAT |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042963 | Vomiting | 1 | BeFree |
| umls:C0085695 | Chronic gastritis | 1 | BeFree |
| umls:C0149978 | Adenocarcinoma of rectum | 1 | BeFree |
| umls:C0206674 | Adenoma, Villous | 1 | BeFree |
| umls:C0206687 | Carcinoma, Endometrioid | 1 | BeFree |
| umls:C0238190 | Inclusion Body Myositis (disorder) | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0267446 | Acute gastroenteritis | 1 | BeFree |
| umls:C0275524 | Coinfection | 1 | BeFree |
| umls:C0278694 | Disseminated neuroblastoma | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0279637 | Anal carcinoma | 1 | BeFree |
| umls:C0280793 | Mixed Oligodendroglioma-Astrocytoma | 1 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 1 | GWASCAT |
| umls:C0345893 | Juvenile polyposis syndrome | 1 | BeFree |
| umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
| umls:C0456483 | Simple Endometrial Hyperplasia | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0677948 | Stage II Colorectal Cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0729233 | Dissecting aneurysm of the thoracic aorta | 1 | BeFree |
| umls:C0877373 | Advanced cancer | 1 | BeFree |
| umls:C0948216 | Ovarian adenocarcinoma | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1334811 | Mucinous Neoplasm | 1 | BeFree |
| umls:C1370868 | refractory CML | 1 | BeFree |
| umls:C1561535 | Creatinine finding | 1 | GAD |
| umls:C1561549 | Glomerular filtration rate finding | 1 | GAD |
| umls:C2129214 | Loose stool | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3146252 | Stage II Colorectal Cancer AJCC v7 | 1 | BeFree |
| umls:C1834870 | MIRROR MOVEMENTS 1 | 0 | CLINVAR,CTD_human |
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