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| TissGeneSummary for TDRD5 |
 Gene summary |
| Basic gene information | Gene symbol | TDRD5 |
| Gene name | tudor domain containing 5 | |
| Synonyms | TUDOR3 | |
| Cytomap | UCSC genome browser: 1q25.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199085.1, NM_001199089.1,NM_001199091.1,NM_001199092.1,NM_173533.3, | |
| Description | tudor domain-containing protein 5 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000162782 | ||
| HPRD : 15483 | ||
| Vega : OTTHUMG00000035259 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TDRD5 | |
| BioGPS: 163589 | ||
| Pathway | NCI Pathway Interaction Database: TDRD5 | |
| KEGG: TDRD5 | ||
| REACTOME: TDRD5 | ||
| Pathway Commons: TDRD5 | ||
| Context | iHOP: TDRD5 | |
| ligand binding site mutation search in PubMed: TDRD5 | ||
| UCL Cancer Institute: TDRD5 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
| Reference showing the relevant tissue of TDRD5 | TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95. doi: 10.1083/jcb.201009043. (pmid:21383078) go to article | |
| Description by TissGene annotations | Protective TissGene in OS Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TDRD5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -3.296373244 | 0.811198978 | -4.107572222 | 1.89E-42 | 9.21E-41 |
| KICH | -2.844839633 | 0.842552367 | -3.687392 | 1.95E-07 | 8.48E-07 |
| LUAD | -0.202949633 | -2.911018599 | 2.708068966 | 8.82E-11 | 5.28E-10 |
| LUSC | 0.841390563 | -2.794634927 | 3.63602549 | 6.79E-13 | 3.20E-12 |
| KIRP | -2.257462133 | 0.549228492 | -2.806690625 | 3.36E-08 | 2.29E-07 |
| THCA | -1.323643701 | 0.085671553 | -1.409315254 | 1.81E-10 | 1.17E-09 |
| HNSC | -0.542801959 | -2.160104284 | 1.617302326 | 0.00623 | 0.016394737 |
| ESCA | 0.958191276 | -2.345908724 | 3.3041 | 0.000508 | 0.009337124 |
| STAD | -0.495080883 | -2.323952758 | 1.828871875 | 0.000584 | 0.003429285 |
| BLCA | 1.166984577 | -2.106331212 | 3.273315789 | 0.000278 | 0.002533902 |
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| TissGene-miRNA for TDRD5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TDRD5 |
| TissGeneSNV for TDRD5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G293E | SKCM | 4 |
| p.G806E | SKCM | 2 |
| p.E206K | SKCM | 2 |
| p.S471F | SKCM | 2 |
| p.D792N | SKCM | 2 |
| p.E626K | SKCM | 2 |
| p.R163Q | SKCM | 2 |
| p.R518* | SKCM | 2 |
| p.Q377L | LIHC | 2 |
| p.E643K | SKCM | 2 |
| p.R101Q | SKCM | 2 |
| p.G616S | STAD | 1 |
| p.W846R | BLCA | 1 |
| p.P409S | SKCM | 1 |
| p.S899Y | PAAD | 1 |
| p.G107E | SKCM | 1 |
| p.R108I | LUAD | 1 |
| p.D984Y | LUSC | 1 |
| p.M503I | SKCM | 1 |
| p.E500K | UCEC | 1 |
| p.A213P | LUSC | 1 |
| p.R16K | SKCM | 1 |
| p.S496* | LUAD | 1 |
| p.L801F | HNSC | 1 |
| p.T294A | SKCM | 1 |
| p.Q4H | UCEC | 1 |
| p.M832T | LIHC | 1 |
| p.R880G | LUAD | 1 |
| p.P291T | LUAD | 1 |
| p.P391T | LUAD | 1 |
| p.L48F | SKCM | 1 |
| p.M255V | DLBC | 1 |
| p.E82K | SKCM | 1 |
| p.P950S | ESCA | 1 |
| p.A812T | LUSC | 1 |
| p.R718C | BLCA | 1 |
| p.P590S | SKCM | 1 |
| p.D775N | LIHC | 1 |
| p.R518Q | SKCM | 1 |
| p.R962W | UCEC | 1 |
| p.L740X | LIHC | 1 |
| p.A181V | LGG | 1 |
| p.V659L | KIRC | 1 |
| p.R535K | LUSC | 1 |
| p.L990* | LUSC | 1 |
| p.P424L | SKCM | 1 |
| p.K334T | UCS | 1 |
| p.W794* | SKCM | 1 |
| p.D790N | BRCA | 1 |
| p.E1034K | SKCM | 1 |
| p.Q931H | SARC | 1 |
| p.S712P | LUAD | 1 |
| p.Q882* | LUSC | 1 |
| p.D795N | SKCM | 1 |
| p.R979H | OV | 1 |
| p.P674S | SKCM | 1 |
| p.E55K | SKCM | 1 |
| p.S709I | KIRP | 1 |
| p.R160I | LGG | 1 |
| p.T639A | HNSC | 1 |
| p.R970C | STAD | 1 |
| p.Q872* | UCEC | 1 |
| p.V64F | LUSC | 1 |
| p.I295M | CESC | 1 |
| p.S982C | HNSC | 1 |
| p.H530P | KIRP | 1 |
| p.E600D | LIHC | 1 |
| p.A1013S | LUAD | 1 |
| p.E30K | SKCM | 1 |
| p.R518X | READ | 1 |
| p.S296I | LUAD | 1 |
| p.G567E | SKCM | 1 |
| p.T437K | LUAD | 1 |
| p.S605L | COAD | 1 |
| p.R6G | LIHC | 1 |
| p.R979H | ESCA | 1 |
| p.Q818* | UCEC | 1 |
| p.S928C | HNSC | 1 |
| p.D923E | LUAD | 1 |
| p.F486L | UCEC | 1 |
| p.E256D | SKCM | 1 |
| p.G114* | LUAD | 1 |
| p.E32D | HNSC | 1 |
| p.K106N | LUAD | 1 |
| p.L855F | HNSC | 1 |
| p.E383* | HNSC | 1 |
| p.E919Q | BLCA | 1 |
| p.E777Q | LUAD | 1 |
| p.D791A | ESCA | 1 |
| p.L740* | LIHC | 1 |
| p.Q998H | LUAD | 1 |
| p.G210R | SKCM | 1 |
| p.S495L | SKCM | 1 |
| p.G694V | DLBC | 1 |
| p.S317C | BLCA | 1 |
| p.G474R | STAD | 1 |
| p.E654K | SKCM | 1 |
| p.E692K | LUAD | 1 |
| p.V39I | SKCM | 1 |
| p.P782T | COAD | 1 |
| p.R65C | COAD | 1 |
| p.K260X | LIHC | 1 |
| p.P233L | SKCM | 1 |
| p.S482F | SKCM | 1 |
| p.R518X | SKCM | 1 |
| p.S267* | LIHC | 1 |
| p.R126S | COAD | 1 |
| p.S395L | SKCM | 1 |
| p.P424T | SKCM | 1 |
| p.R120Q | SKCM | 1 |
| p.P147S | SKCM | 1 |
| p.V534I | THCA | 1 |
| p.L855F | SKCM | 1 |
| p.M805T | LIHC | 1 |
| p.P1028H | LUSC | 1 |
| p.S951F | LUAD | 1 |
| p.V341L | LUSC | 1 |
| p.P372L | SKCM | 1 |
| p.K419N | SKCM | 1 |
| p.S827X | COAD | 1 |
| p.G474W | PAAD | 1 |
| p.S953Y | PAAD | 1 |
| p.E343K | SKCM | 1 |
| p.S151Y | COAD | 1 |
| p.G564E | SKCM | 1 |
| p.D494N | SKCM | 1 |
| p.E552Q | LUSC | 1 |
| p.S828A | ESCA | 1 |
| p.D791N | SKCM | 1 |
| p.V57A | LIHC | 1 |
| p.A812S | LUAD | 1 |
| p.R222K | SKCM | 1 |
| p.S573F | SKCM | 1 |
| p.E34K | SKCM | 1 |
| p.E643K | GBM | 1 |
| p.R979H | BLCA | 1 |
| p.D977E | LUAD | 1 |
| p.E600Q | BLCA | 1 |
| p.A588S | HNSC | 1 |
| p.R65S | LUSC | 1 |
| p.S267X | LIHC | 1 |
| p.G49W | LUAD | 1 |
| p.G290R | SKCM | 1 |
| p.R718H | LIHC | 1 |
| p.G858R | SKCM | 1 |
| p.D638H | HNSC | 1 |
| p.L1000F | SKCM | 1 |
| p.D848N | SKCM | 1 |
| p.A959S | LUAD | 1 |
| p.R826M | UCEC | 1 |
| p.R46X | READ | 1 |
| p.S819N | SKCM | 1 |
| p.S1020F | SKCM | 1 |
| p.S605L | UCEC | 1 |
| p.D24N | SKCM | 1 |
| p.R192K | SKCM | 1 |
| p.A1009V | LUAD | 1 |
| p.E555D | LUSC | 1 |
| p.A231V | READ | 1 |
| p.R535S | LUSC | 1 |
| p.E643K | COAD | 1 |
| p.D629N | OV | 1 |
| p.G808R | SKCM | 1 |
| p.S665Y | UCEC | 1 |
| p.E993Q | CESC | 1 |
| p.D184N | CESC | 1 |
| p.S317Y | UCEC | 1 |
| p.I216N | UCS | 1 |
| p.E831K | SKCM | 1 |
| p.P920S | KIRC | 1 |
| p.C615Y | SKCM | 1 |
| p.L142Q | LIHC | 1 |
| p.E813Q | BRCA | 1 |
| p.D791N | COAD | 1 |
| p.N642K | LUAD | 1 |
| p.M104I | LUAD | 1 |
| p.L636* | LUAD | 1 |
| p.E265K | SKCM | 1 |
| p.N180S | UCEC | 1 |
| p.S946F | SKCM | 1 |
| p.D629N | ACC | 1 |
| p.E32D | UCEC | 1 |
| p.D539N | SKCM | 1 |
| p.Q377* | SKCM | 1 |
| p.D350V | COAD | 1 |
| p.P391Q | LUAD | 1 |
| p.G86E | SKCM | 1 |
| p.I7T | LUSC | 1 |
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| TissGeneCNV for TDRD5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TDRD5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-ZR-A9CJ-01B | TDRD5-RABGAP1L | Out-of-Frame | chr1:179563002 | chr1:174652659 |
| TCGAfusionPortal | PRADA | OV | TCGA-13-0799-01A | CEP350-TDRD5 | Out-of-frame | Chr1:180010383 | Chr1:179659831 |
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| TissGeneNet for TDRD5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TDRD5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TDRD5 |
| TissGeneDrug for TDRD5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TDRD5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 2 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
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