 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for DCT |
 Gene summary |
| Basic gene information | Gene symbol | DCT |
| Gene name | dopachrome tautomerase | |
| Synonyms | TRP-2|TYRP2 | |
| Cytomap | UCSC genome browser: 13q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001129889.1, NM_001922.3, | |
| Description | DTL-dopachrome Delta-isomeraseL-dopachrome tautomeraseTRP2dopachrome delta-isomerasedopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)tyrosinase-related protein 2tyrosine-related protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 191275 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000080166 | ||
| HPRD : 01864 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCT | |
| BioGPS: 1638 | ||
| Pathway | NCI Pathway Interaction Database: DCT | |
| KEGG: DCT | ||
| REACTOME: DCT | ||
| Pathway Commons: DCT | ||
| Context | iHOP: DCT | |
| ligand binding site mutation search in PubMed: DCT | ||
| UCL Cancer Institute: DCT | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of DCT | Seberg HE, Van Otterloo E, Loftus SK, Liu H, Bonde G, Sompallae R, Gildea DE, Santana JF, Manak JR, Pavan WJ, Williams T, Cornell RA. PLoS Genet. 2017 Mar 1;13(3):e1006636. doi: 10.1371/journal.pgen.1006636. eCollection 2017 Mar. (pmid:28249010) go to article | |
| Description by TissGene annotations | Unique usage of specific isoform TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for DCT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -2.268291577 | 0.433654914 | -2.701946491 | 2.01E-37 | 4.62E-36 |
| KICH | -2.10319863 | -0.52594263 | -1.577256 | 3.21E-06 | 1.10E-05 |
| HNSC | -2.258634723 | -0.168320769 | -2.090313953 | 0.000185 | 0.000765165 |
| STAD | -2.47779388 | -1.18278138 | -1.2950125 | 7.42E-05 | 0.000591758 |
| Top |
| TissGene-miRNA for DCT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for DCT |
| TissGeneSNV for DCT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R532Q | UCEC | 3 |
| p.R78Q | STAD | 2 |
| p.R532* | UCEC | 2 |
| p.C61Y | ESCA | 2 |
| p.T31M | COAD | 2 |
| p.R127W | LUAD | 1 |
| p.Q140K | LUAD | 1 |
| p.A49V | STAD | 1 |
| p.G250W | HNSC | 1 |
| p.N310K | KIRC | 1 |
| p.R398C | UCEC | 1 |
| p.T360A | HNSC | 1 |
| p.W469* | SKCM | 1 |
| p.E438K | CESC | 1 |
| p.R83C | COAD | 1 |
| p.R221W | ESCA | 1 |
| p.F141L | UCS | 1 |
| p.Q450K | SKCM | 1 |
| p.S192F | KIRP | 1 |
| p.A357E | BLCA | 1 |
| p.R532Q | COAD | 1 |
| p.N178K | LUAD | 1 |
| p.G353W | STAD | 1 |
| p.I130M | SARC | 1 |
| p.R78Q | COAD | 1 |
| p.V256M | BLCA | 1 |
| p.P154S | STAD | 1 |
| p.A177V | GBM | 1 |
| p.T218I | SKCM | 1 |
| p.L493V | BLCA | 1 |
| p.R202C | STAD | 1 |
| p.F345I | UCS | 1 |
| p.C106R | UCEC | 1 |
| p.R69G | LIHC | 1 |
| p.E139X | COAD | 1 |
| p.V157M | THCA | 1 |
| p.D208Y | PAAD | 1 |
| p.H396Y | BLCA | 1 |
| p.D230N | READ | 1 |
| p.T31M | CHOL | 1 |
| p.S346I | KIRP | 1 |
| p.R65P | OV | 1 |
| p.D67E | LUSC | 1 |
| p.L480V | KIRC | 1 |
| p.D67N | STAD | 1 |
| p.S330F | SARC | 1 |
| p.D269H | LUAD | 1 |
| p.L145F | OV | 1 |
| p.V496A | DLBC | 1 |
| p.Y430* | PAAD | 1 |
| p.R461W | CESC | 1 |
| p.G501* | LUAD | 1 |
| p.R221W | BRCA | 1 |
| p.L513V | KIRC | 1 |
| p.N37K | LUAD | 1 |
| p.A148T | ESCA | 1 |
| p.R499Q | COAD | 1 |
| p.A148T | READ | 1 |
| p.G213E | SKCM | 1 |
| p.M30I | UCEC | 1 |
| p.G99_splice | LUSC | 1 |
| p.G168V | ACC | 1 |
| p.I126M | BLCA | 1 |
| p.R83C | LIHC | 1 |
| p.A49T | LGG | 1 |
| p.G143A | UCEC | 1 |
| p.G213R | LUAD | 1 |
| p.E517* | PAAD | 1 |
| p.R398H | PAAD | 1 |
| p.A449T | LUSC | 1 |
| p.G112C | OV | 1 |
| p.W282L | LUAD | 1 |
| p.D230Y | UCEC | 1 |
| p.W187R | STAD | 1 |
| p.A144T | LAML | 1 |
| p.E550X | PAAD | 1 |
| p.E84* | LUAD | 1 |
| p.G103C | BLCA | 1 |
| p.R499X | READ | 1 |
| p.S363Y | READ | 1 |
| p.P270L | COAD | 1 |
| p.R151T | LUAD | 1 |
| p.D155Y | LUAD | 1 |
| p.C95F | ESCA | 1 |
| p.R461Q | STAD | 1 |
| p.R428Q | STAD | 1 |
| p.S346G | UCEC | 1 |
| p.W469X | SKCM | 1 |
| p.L322F | SKCM | 1 |
| p.C109W | BLCA | 1 |
| p.A434V | UCEC | 1 |
| p.N406S | BLCA | 1 |
| p.D268G | LUAD | 1 |
| p.T31M | STAD | 1 |
| p.I325M | STAD | 1 |
| p.E476* | LUSC | 1 |
| p.D155N | UCEC | 1 |
| p.H509R | HNSC | 1 |
| p.C40* | SARC | 1 |
| p.R83H | STAD | 1 |
| Top |
| TissGeneCNV for DCT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for DCT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | MESO | TCGA-TS-A7P0-01A | GPC6-DCT | In-Frame | chr13:94680148 | chr13:95121299 |
| Top |
| TissGeneNet for DCT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| DCT, VCL, MITF, LEF1 (tumor) | DCT, VCL, MITF, LEF1 (normal) |
 |  |
| Top |
| TissGeneProg for DCT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for DCT |
| TissGeneDrug for DCT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for DCT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 44 | BeFree,LHGDN |
| umls:C0004565 | Melanoma, B16 | 6 | BeFree |
| umls:C0042900 | Vitiligo | 4 | BeFree |
| umls:C0162835 | Hypopigmentation disorder | 4 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 4 | BeFree |
| umls:C0036396 | Sciatica | 3 | BeFree |
| umls:C0158266 | Intervertebral Disc Degeneration | 3 | BeFree |
| umls:C0221775 | Lumbar disc disease | 3 | BeFree |
| umls:C0017636 | Glioblastoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0019270 | Hernia | 2 | BeFree |
| umls:C0555198 | Malignant Glioma | 2 | BeFree |
| umls:C1519680 | Tumor Immunity | 2 | BeFree |
| umls:C0001916 | Albinism | 1 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0014116 | Endocardial Cushion Defects | 1 | BeFree |
| umls:C0014511 | Epithelial cyst | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0021818 | Intervertebral Disk Displacement | 1 | GAD |
| umls:C0023003 | Langer-Giedion Syndrome | 1 | BeFree |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
| umls:C0342158 | Hypothyroidism, Autoimmune | 1 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
| umls:C1704421 | Skin Pigmentation Disorder | 1 | BeFree |
| umls:C1876214 | ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |