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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DDC
check button Gene summary
Basic gene informationGene symbolDDC
Gene namedopa decarboxylase (aromatic L-amino acid decarboxylase)
SynonymsAADC
CytomapUCSC genome browser: 7p12.2
Type of geneprotein-coding
RefGenesNM_000790.3,
NM_001082971.1,NM_001242886.1,NM_001242887.1,NM_001242888.1,
NM_001242889.1,NM_001242890.1,
Descriptionaromatic-L-amino-acid decarboxylase
Modification date20141211
dbXrefs MIM : 107930
HGNC : HGNC
Ensembl : ENSG00000132437
HPRD : 00145
Vega : OTTHUMG00000023353
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DDC
BioGPS: 1644
PathwayNCI Pathway Interaction Database: DDC
KEGG: DDC
REACTOME: DDC
Pathway Commons: DDC
ContextiHOP: DDC
ligand binding site mutation search in PubMed: DDC
UCL Cancer Institute: DDC
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of DDC
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for DDC

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-2.6312377990.303662201-2.93491.12E-146.62E-14
KICH-3.591391214.85528479-8.4466761.32E-153.06E-14
KIRP3.686001546.406098415-2.7200968750.0003160.000971841
LIHC3.710978795.60132479-1.8903460.0001440.000478778
LUAD-0.9970775550.574317272-1.5713948285.59E-050.000145795


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TissGene-miRNA for DDC

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DDC
TissGeneSNV for DDC

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G140ESKCM2
p.G203ABLCA2
p.R27HSTAD1
p.V184AGBM1
p.E399*HNSC1
p.A294VUCEC1
p.R160QSKCM1
p.R226ICOAD1
p.H337NLUAD1
p.R160QKICH1
p.R447HSARC1
p.D59NUCEC1
p.H434YSKCM1
p.S452FBLCA1
p.L153MBLCA1
p.E307*UCEC1
p.Q190HLUAD1
p.R319IESCA1
p.H434LLUSC1
p.M125LOV1
p.C311FLUAD1
p.V382ASTAD1
p.Y79FLUAD1
p.G10ESKCM1
p.P31THNSC1
p.G203*PRAD1
p.A131TSKCM1
p.R453CUCEC1
p.R218GPAAD1
p.P43LSKCM1
p.V154ALUAD1
p.E127*LUSC1
p.E127ALUSC1
p.G370RSKCM1
p.D59EOV1
p.A231VBLCA1
p.L325MUCEC1
p.R358CSKCM1
p.S220CBLCA1
p.R356IUCEC1
p.G123RSKCM1
p.I378MBLCA1
p.L413PUCEC1
p.K263MUCEC1
p.S187LCESC1
p.E12DKIRC1
p.P81SSTAD1
p.D473NSKCM1
p.R393CGBM1
p.G96RSARC1
p.R379SBLCA1
p.E127KHNSC1
p.Y37HUCEC1
p.T69MGBM1
p.R453CSKCM1
p.M93VKIRC1
p.H341YSKCM1
p.R254LREAD1
p.E127KSKCM1
p.N19SSKCM1
p.D271YSTAD1
p.D212ELIHC1
p.W105CSTAD1
p.D473ELUSC1
p.E115KSKCM1
p.R476QSKCM1
p.I405TUCEC1
p.P301SSKCM1
p.G373*UCEC1
p.R347WESCA1
p.D339NUCEC1
p.A471VTHCA1
p.L133FHNSC1
p.R379SLUSC1
p.R447HUCEC1
p.A241SLUSC1
p.D32ELUAD1
p.T52MLGG1
p.R166WESCA1
p.P236SSKCM1
p.V404IHNSC1
p.G138*CESC1
p.E469KSKCM1
p.T454MDLBC1
p.E54*HNSC1
p.L122RLUAD1
p.P40LHNSC1
p.A294VESCA1
p.V143MBRCA1


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TissGeneCNV for DDC

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DDC

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanLUADTCGA-55-8094-01AGRB10-DDCIn-Framechr7:50737418chr7:50537869
Chimerdb3.0TopHat-FusionLUADTCGA-55-8094-01AGRB10-DDCIn-Framechr7:50737418chr7:50537868


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TissGeneNet for DDC

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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COAD (tumor)COAD (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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HNSC (tumor)HNSC (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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KICH (tumor)KICH (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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KIRC (tumor)KIRC (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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KIRP (tumor)KIRP (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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LIHC (tumor)LIHC (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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LUAD (tumor)LUAD (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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LUSC (tumor)LUSC (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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PRAD (tumor)PRAD (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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STAD (tumor)STAD (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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THCA (tumor)THCA (normal)
DDC, RELA, AR, POU3F2, ATF6 (tumor)DDC, RELA, AR, POU3F2, ATF6 (normal)
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TissGeneProg for DDC

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DDC
TissGeneDrug for DDC

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00190CarbidopaInhibitorSmall moleculeApproved
DB00968MethyldopaSmall moleculeApproved


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TissGeneDisease for DDC

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0030567Parkinson Disease7BeFree,CTD_human,RGD
umls:C1263846Attention deficit hyperactivity disorder7BeFree,GAD,RGD
umls:C0027819Neuroblastoma5BeFree,LHGDN
umls:C0036341Schizophrenia5BeFree,GAD
umls:C0005586Bipolar Disorder4BeFree,GAD
umls:C0019187Hepatitis, Alcoholic4BeFree
umls:C0028043Nicotine Dependence4BeFree
umls:C0149925Small cell carcinoma of lung4BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C0700095Central neuroblastoma4BeFree
umls:C0001418Adenocarcinoma3BeFree
umls:C0004352Autistic Disorder3BeFree,GAD
umls:C0031511Pheochromocytoma3BeFree,CTD_human
umls:C1291564Deficiency of aromatic-L-amino-acid decarboxylase3BeFree,CLINVAR,MGD,ORPHANET,UNIPROT
umls:C1839839MAJOR AFFECTIVE DISORDER 23BeFree,GAD
umls:C0007095Carcinoid Tumor2BeFree
umls:C0024530Malaria2BeFree,GAD
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0154723Migraine with Aura2BeFree
umls:C0338480Common Migraine2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C1319315Adenocarcinoma of large intestine2BeFree
umls:C1852197MAJOR AFFECTIVE DISORDER 12BeFree,GAD
umls:C1970943MAJOR AFFECTIVE DISORDER 42BeFree,GAD
umls:C1970944MAJOR AFFECTIVE DISORDER 52BeFree,GAD
umls:C1970945MAJOR AFFECTIVE DISORDER 62BeFree,GAD
umls:C2700438MAJOR AFFECTIVE DISORDER 72BeFree,GAD
umls:C2700439MAJOR AFFECTIVE DISORDER 82BeFree,GAD
umls:C2700440MAJOR AFFECTIVE DISORDER 92BeFree,GAD
umls:C0002793Anaplasia1BeFree
umls:C0003469Anxiety Disorders1BeFree
umls:C0003944As If Personality1GAD
umls:C0004936Mental disorders1CTD_human
umls:C0006012Borderline Personality Disorder1BeFree
umls:C0006111Brain Diseases1GAD
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0008313Cholangitis, Sclerosing1BeFree
umls:C0013386Dyskinesia, Drug-Induced1RGD
umls:C0020541Hypertension, Portal1RGD
umls:C0022661Kidney Failure, Chronic1RGD
umls:C0023452Leukemia, Lymphocytic, Acute, L11GWASCAT
umls:C0023893Liver Cirrhosis, Experimental1RGD
umls:C0023895Liver diseases1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0027726Nephrotic Syndrome1RGD
umls:C0027746Nerve Degeneration1CTD_human
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0033975Psychotic Disorders1BeFree
umls:C0036349Paranoid Schizophrenia1BeFree,LHGDN
umls:C0040336Tobacco Use Disorder1GAD
umls:C0040411Tongue Neoplasms1BeFree
umls:C0043094Weight Gain1GAD
umls:C0085633Mood swings1BeFree
umls:C0149931Migraine Disorders1GAD
umls:C0175693Russell-Silver syndrome1BeFree
umls:C0242422Parkinsonian Disorders1CTD_human
umls:C0242596Neoplasm, Residual1LHGDN
umls:C0278694Disseminated neuroblastoma1BeFree
umls:C0393610Dystonia, Diurnal1BeFree
umls:C0566602Primary sclerosing cholangitis1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0936215Vitamin B 6 Deficiency1BeFree
umls:C1135161Stage 4S neuroblastoma1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1851920Dopa-Responsive Dystonia1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2911647Weight Gain Adverse Event1GAD
umls:C3888018Congenital Hyperinsulinism1LHGDN
umls:C0342686Aromatic amino acid decarboxylase deficiency0CTD_human