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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AKR1C1
check button Gene summary
Basic gene informationGene symbolAKR1C1
Gene namealdo-keto reductase family 1, member C1
Synonyms2-ALPHA-HSD|20-ALPHA-HSD|C9|DD1|DD1/DD2|DDH|DDH1|H-37|HAKRC|HBAB|MBAB
CytomapUCSC genome browser: 10p15-p14
Type of geneprotein-coding
RefGenesNM_001353.5,
Description20 alpha-hydroxysteroid dehydrogenase20-alpha-hydroxysteroid dehydrogenasealdo-keto reductase Caldo-keto reductase family 1 member C1chlordecone reductase homolog HAKRCdihydrodiol dehydrogenase 1dihydrodiol dehydrogenase 1/2dihydrodiol dehydrogenas
Modification date20141207
dbXrefs MIM : 600449
HGNC : HGNC
HPRD : 07194
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR1C1
BioGPS: 1645
PathwayNCI Pathway Interaction Database: AKR1C1
KEGG: AKR1C1
REACTOME: AKR1C1
Pathway Commons: AKR1C1
ContextiHOP: AKR1C1
ligand binding site mutation search in PubMed: AKR1C1
UCL Cancer Institute: AKR1C1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCALIHC
Reference showing the relevant tissue of AKR1C1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007586digestion8486699
GO:0008206bile acid metabolic process8486699
GO:0030855epithelial cell differentiation21492153
GO:0042448progesterone metabolic process21232532
GO:0042574retinal metabolic process21851338
GO:0051260protein homooligomerization8486699
GO:0055114oxidation-reduction process19442656
GO:0071395cellular response to jasmonic acid stimulus19487289
GO:0007586digestion8486699
GO:0008206bile acid metabolic process8486699
GO:0030855epithelial cell differentiation21492153
GO:0042448progesterone metabolic process21232532
GO:0042574retinal metabolic process21851338
GO:0051260protein homooligomerization8486699
GO:0055114oxidation-reduction process19442656
GO:0071395cellular response to jasmonic acid stimulus19487289


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TissGeneExp for AKR1C1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-1.1829036751.408506494-2.5914101693.27E-188.21E-17
KIRC2.1317697953.35248785-1.2207180562.43E-076.56E-07
PRAD-1.1095409960.135253235-1.2447942313.21E-083.48E-07
COAD-0.7616275341.253553235-2.0151807693.53E-082.75E-07
BRCA-0.2499261853.880597499-4.1305236844.75E-371.05E-35
STAD1.6427097254.0135566-2.3708468755.42E-071.00E-05
KICH3.020999854.18405185-1.1630520.02320.03873697
LUSC4.2873015762.6081172621.6791843140.001270.002325236
KIRP4.785875352.9837534751.8021218753.22E-050.000122776


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TissGene-miRNA for AKR1C1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for AKR1C1
TissGeneSNV for AKR1C1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R263CUCEC1
p.D78HBLCA1
p.L94VSKCM1
p.V228MSTAD1
p.G25ESKCM1
p.V128MBRCA1
p.R258HBLCA1
p.R250QUCEC1
p.R223QHNSC1
p.I14TUCS1
p.L182RUCEC1
p.G264VPRAD1
p.K68NLUAD1
p.R47HLGG1
p.K39TUCEC1
p.R250*UCEC1
p.G22AOV1
p.H248YPAAD1
p.V151MCESC1
p.L19RLIHC1
p.E36QCESC1
p.I49VSTAD1
p.E274KBRCA1
p.D156YKIRC1
p.K33TSTAD1
p.I10TACC1
p.H14QUCEC1
p.E274QCESC1
p.K4ELIHC1
p.R250QSKCM1
p.C154YDLBC1
p.L40FKIRP1
p.Y216CLUAD1
p.S89FSKCM1
p.E174QBRCA1


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TissGeneCNV for AKR1C1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for AKR1C1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADALUSCTCGA-66-2758-01ACCDC88B-AKR1C1CDS-5UTRChr11:64110797Chr10:4950543


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TissGeneNet for AKR1C1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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COAD (tumor)COAD (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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HNSC (tumor)HNSC (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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KICH (tumor)KICH (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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KIRC (tumor)KIRC (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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KIRP (tumor)KIRP (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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LIHC (tumor)LIHC (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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LUAD (tumor)LUAD (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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LUSC (tumor)LUSC (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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PRAD (tumor)PRAD (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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STAD (tumor)STAD (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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THCA (tumor)THCA (normal)
AKR1C1, MAPK3, COMMD8 (tumor)AKR1C1, MAPK3, COMMD8 (normal)
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TissGeneProg for AKR1C1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for AKR1C1
TissGeneDrug for AKR1C1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00936Salicylic acidInhibitorSmall moleculeApproved|Vet_approved
DB00945Acetylsalicylic acidInhibitorSmall moleculeApproved|Vet_approved


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TissGeneDisease for AKR1C1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0242379Malignant neoplasm of lung4BeFree,GAD
umls:C0684249Carcinoma of lung3BeFree
umls:C0006142Malignant neoplasm of breast2BeFree,GAD
umls:C0014175Endometriosis2BeFree,CTD_human
umls:C0024121Lung Neoplasms2BeFree,LHGDN
umls:C0024305Lymphoma, Non-Hodgkin2GAD
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0029928Ovarian Diseases2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C2239176Liver carcinoma2BeFree,LHGDN
umls:C0000768Congenital Abnormality1BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0003469Anxiety Disorders1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1CTD_human
umls:C0007137Squamous cell carcinoma1LHGDN
umls:C0007621Neoplastic Cell Transformation1CTD_human
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0014170Endometrial Neoplasms1CTD_human,LHGDN
umls:C0027661Neoplasms, Hormone-Dependent1CTD_human
umls:C0029408Degenerative polyarthritis1CTD_human
umls:C0030319Panic Disorder1BeFree
umls:C0032460Polycystic Ovary Syndrome1CTD_human
umls:C0036875Disorders of Sex Development1CTD_human
umls:C0156344Endometriosis of ovary1BeFree
umls:C0205851Germ cell tumor1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0598894Monocytic leukemia1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C1318544M5b Acute differentiated monocytic leukemia1BeFree
umls:C1458155Mammary Neoplasms1BeFree,LHGDN
umls:C1527249Colorectal Cancer1BeFree
umls:C1868649PANIC DISORDER 11BeFree
umls:C1883486Uterine Corpus Cancer1BeFree