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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DECR1
check button Gene summary
Basic gene informationGene symbolDECR1
Gene name2,4-dienoyl CoA reductase 1, mitochondrial
SynonymsDECR|NADPH|SDR18C1
CytomapUCSC genome browser: 8q21.3
Type of geneprotein-coding
RefGenesNM_001359.1,
Description2,4-dienoyl-CoA reductase, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C, member 1
Modification date20141207
dbXrefs MIM : 222745
HGNC : HGNC
Ensembl : ENSG00000104325
HPRD : 01959
Vega : OTTHUMG00000163829
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DECR1
BioGPS: 1666
PathwayNCI Pathway Interaction Database: DECR1
KEGG: DECR1
REACTOME: DECR1
Pathway Commons: DECR1
ContextiHOP: DECR1
ligand binding site mutation search in PubMed: DECR1
UCL Cancer Institute: DECR1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCALIHC
Reference showing the relevant tissue of DECR1
Description by TissGene annotationsFused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006635fatty acid beta-oxidation15531764
GO:0051289protein homotetramerization15531764
GO:0006635fatty acid beta-oxidation15531764
GO:0051289protein homotetramerization15531764


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TissGeneExp for DECR1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for DECR1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DECR1
TissGeneSNV for DECR1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P267SSKCM1
p.K298TUCEC1
p.P46HSTAD1
p.A50VKICH1
p.T165SSTAD1
p.L280ROV1
p.F8LLUAD1
p.A226SUCEC1
p.P112LSKCM1
p.P112SSKCM1
p.V118MGBM1
p.M233TSTAD1
p.E304KESCA1
p.G59DHNSC1
p.N126KSKCM1
p.A50VTHYM1
p.R315IREAD1
p.V87LLUSC1
p.F43LUCEC1
p.G59VTHYM1
p.E259ACOAD1
p.T69ACOAD1
p.R91PBRCA1
p.A269TSTAD1
p.Q230*BLCA1
p.F43LBLCA1
p.N117KSKCM1
p.K246TKIRP1
p.Q239*BLCA1
p.P242HUCEC1
p.E327*UCEC1
p.V166MPAAD1
p.L11PSTAD1
p.D313YESCA1
p.P258SSKCM1
p.L11RSTAD1
p.N270DLUAD1
p.V175MPAAD1
p.A278TSTAD1
p.W152*LGG1
p.A190TREAD1


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TissGeneCNV for DECR1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DECR1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABQ306273ATP6V0B-DECR1chr1:44443958chr8:91063913
Chimerdb3.0FusionScanLGGTCGA-DB-A64X-01AKHDRBS3-DECR1In-Framechr8:136533598chr8:91029351
Chimerdb3.0FusionScanESCATCGA-2H-A9GG-01ADECR1-STAU2Out-of-Framechr8:91013789chr8:74464554
TCGAfusionPortalPRADALGGTCGA-HW-A5KJ-01AGNB2L1-DECR13UTR-5UTRChr5:180663934Chr8:91017676


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TissGeneNet for DECR1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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COAD (tumor)COAD (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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HNSC (tumor)HNSC (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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KICH (tumor)KICH (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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KIRC (tumor)KIRC (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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KIRP (tumor)KIRP (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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LIHC (tumor)LIHC (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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LUAD (tumor)LUAD (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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LUSC (tumor)LUSC (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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PRAD (tumor)PRAD (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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STAD (tumor)STAD (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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THCA (tumor)THCA (normal)
DECR1, HGS, PTTG1 (tumor)DECR1, HGS, PTTG1 (normal)
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TissGeneProg for DECR1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DECR1
TissGeneDrug for DECR1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DECR1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0018203Chronic granulomatous disease118BeFree,LHGDN
umls:C0020538Hypertensive disease16BeFree
umls:C0003850Arteriosclerosis14BeFree
umls:C0004153Atherosclerosis14BeFree
umls:C1956346Coronary Artery Disease14BeFree
umls:C0011849Diabetes Mellitus9BeFree
umls:C0398686Primary immune deficiency disorder9BeFree
umls:C0856169Endothelial dysfunction9BeFree
umls:C0010054Coronary Arteriosclerosis8BeFree
umls:C0011847Diabetes8BeFree
umls:C0007222Cardiovascular Diseases7BeFree
umls:C0010068Coronary heart disease7BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent6BeFree
umls:C0279628Adenocarcinoma Of Esophagus6BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0017636Glioblastoma5BeFree
umls:C0018802Congestive heart failure5BeFree
umls:C0020456Hyperglycemia5BeFree
umls:C0026946Mycoses5BeFree
umls:C0042373Vascular Diseases5BeFree
umls:C0235974Pancreatic carcinoma5BeFree
umls:C0346647Malignant neoplasm of pancreas5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C1291312Deficiency of oxidase5BeFree
umls:C0002736Amyotrophic Lateral Sclerosis4BeFree
umls:C0011881Diabetic Nephropathy4BeFree
umls:C0017152Gastritis4BeFree
umls:C0017638Glioma4BeFree
umls:C0018801Heart failure4BeFree
umls:C0022116Ischemia4BeFree
umls:C0027051Myocardial Infarction4BeFree
umls:C0038454Cerebrovascular accident4BeFree,LHGDN
umls:C0242379Malignant neoplasm of lung4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0684249Carcinoma of lung4BeFree
umls:C0004096Asthma3BeFree
umls:C0024141Lupus Erythematosus, Systemic3BeFree
umls:C0024530Malaria3BeFree
umls:C0027819Neuroblastoma3BeFree
umls:C0032285Pneumonia3BeFree
umls:C0700095Central neuroblastoma3BeFree
umls:C0740394Hyperuricemia3BeFree
umls:C1846064Recurrent infections (sinusitis and bacterial pneumonia and meningitis)3BeFree
umls:C2939465Deficiency of glucose-6-phosphate dehydrogenase3BeFree
umls:C3495426Homocysteinemia3BeFree
umls:C0000833Abscess2BeFree
umls:C0002895Anemia, Sickle Cell2BeFree
umls:C0003864Arthritis2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0011884Diabetic Retinopathy2BeFree
umls:C0020443Hypercholesterolemia2BeFree
umls:C0020542Pulmonary Hypertension2BeFree
umls:C0021051Immunologic Deficiency Syndromes2BeFree
umls:C0021390Inflammatory Bowel Diseases2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0025202melanoma2BeFree
umls:C0027430Nasal Polyps2BeFree
umls:C0035243Respiratory Tract Infections2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0036690Septicemia2BeFree
umls:C0042900Vitiligo2BeFree
umls:C0043346Xeroderma Pigmentosum2BeFree
umls:C0151650Renal fibrosis2BeFree
umls:C0152013Adenocarcinoma of lung (disorder)2BeFree
umls:C0175702Williams Syndrome2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0238013invasive aspergillosis2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0243026Sepsis2BeFree
umls:C0338656Impaired cognition2BeFree
umls:C0520679Sleep Apnea, Obstructive2BeFree
umls:C0598608Hyperhomocysteinemia2BeFree
umls:C0598894Monocytic leukemia2BeFree
umls:C0850666Helicobacter pylori infection2BeFree
umls:C0858906Infection pyogenic2BeFree
umls:C1318544M5b Acute differentiated monocytic leukemia2BeFree
umls:C1561643Chronic Kidney Diseases2BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis2BeFree
umls:C1847835VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)2BeFree
umls:C2931822Nasopharyngeal carcinoma2BeFree
umls:C2936791Antley-Bixler Syndrome, Autosomal Dominant2BeFree
umls:C3661525Autosomal Recessive Chronic Granulomatous Disease2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0001824Agranulocytosis1BeFree
umls:C0001925Albuminuria1GAD
umls:C0002395Alzheimer's Disease1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0004763Barrett Esophagus1BeFree
umls:C0006840Candidiasis1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0007684Central Nervous System Infection1BeFree
umls:C0007766Intracranial Aneurysm1BeFree
umls:C0007785Cerebral Infarction1BeFree
umls:C0009319Colitis1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0010073Coronary Artery Vasospasm1BeFree
umls:C0010308Congenital Hypothyroidism1BeFree
umls:C0011644Scleroderma1BeFree
umls:C0017168Gastroesophageal reflux disease1BeFree
umls:C0018813Myocardial rupture1BeFree
umls:C0018818Ventricular Septal Defects1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0020676Hypothyroidism1BeFree
umls:C0021831Intestinal Diseases1BeFree
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0022660Kidney Failure, Acute1BeFree
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0023772Lipid Metabolism, Inborn Errors1CTD_human
umls:C0023885Liver Abscess1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0024115Lung diseases1BeFree
umls:C0025295Meningitis, Pneumococcal1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0026985Myelodysplasia1BeFree
umls:C0030567Parkinson Disease1GAD
umls:C0031106Periodontitis, Juvenile1BeFree
umls:C0031485Phenylketonurias1BeFree
umls:C0033027Preleukemia1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0035309Retinal Diseases1BeFree
umls:C0036572Seizures1BeFree
umls:C0037315Sleep Apnea Syndromes1BeFree
umls:C0039231Tachycardia1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0041234Chagas Disease1BeFree
umls:C0041948Uremia1BeFree
umls:C0041956Ureteral obstruction1BeFree
umls:C0079731B-Cell Lymphomas1BeFree
umls:C0085084Motor Neuron Disease1BeFree
umls:C0085096Peripheral Vascular Diseases1BeFree
umls:C0085278Antiphospholipid Syndrome1BeFree
umls:C0085580Essential Hypertension1BeFree
umls:C0152115Lingual-Facial-Buccal Dyskinesia1BeFree
umls:C0155765Disease of capillaries1BeFree
umls:C0162534Prion Diseases1BeFree
umls:C0242350Erectile dysfunction1BeFree
umls:C0266362Ambiguous Genitalia1BeFree
umls:C0268548Hyperargininemia1BeFree
umls:C0272087Congenital Methemoglobinemia1BeFree
umls:C0276447Rhinovirus infection1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0333186Restenosis1BeFree
umls:C0340970Congenital neutropenia1BeFree
umls:C0342200Endemic Cretinism1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0349476Congenital goiter1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0398738Leukocyte adhesion deficiency type 11BeFree
umls:C0428908Sinus Node Dysfunction (disorder)1BeFree
umls:C0483368Human anaplasmosis due to Anaplasma phagocytophilum1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0595916Toxic nephropathy1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0686347Tardive Dyskinesia1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0740391Middle Cerebral Artery Occlusion1BeFree
umls:C0751956Acute Cerebrovascular Accidents1BeFree
umls:C0876973Infectious disease of lung1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0920646Renal ischaemia1BeFree
umls:C1333064Classical Hodgkin's Lymphoma1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1397307Cardiac fibrosis1BeFree
umls:C1442837Myocardial necrosis1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree
umls:C1516170Cancer Cell Growth1BeFree
umls:C1621958Glioblastoma Multiforme1BeFree
umls:C1704436Peripheral Arterial Diseases1BeFree
umls:C1853118Severe congenital neutropenia1BeFree
umls:C18572522,4-Dienoyl-CoA Reductase Deficiency1CTD_human
umls:C2145472Urothelial Carcinoma1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3665425Hemoglobin M Disease1BeFree