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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TIMM8A
check button Gene summary
Basic gene informationGene symbolTIMM8A
Gene nametranslocase of inner mitochondrial membrane 8 homolog A (yeast)
SynonymsDDP|DDP1|DFN1|MTS|TIM8
CytomapUCSC genome browser: Xq22.1
Type of geneprotein-coding
RefGenesNM_001145951.1,
NM_004085.3,NM_032696.1,
DescriptionX-linked deafness dystonia proteindeafness dystonia protein 1deafness/dystonia peptidemitochondrial import inner membrane translocase subunit Tim8 A
Modification date20141219
dbXrefs MIM : 300356
HGNC : HGNC
Ensembl : ENSG00000126953
HPRD : 02287
Vega : OTTHUMG00000022028
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TIMM8A
BioGPS: 1678
PathwayNCI Pathway Interaction Database: TIMM8A
KEGG: TIMM8A
REACTOME: TIMM8A
Pathway Commons: TIMM8A
ContextiHOP: TIMM8A
ligand binding site mutation search in PubMed: TIMM8A
UCL Cancer Institute: TIMM8A
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderBone marrowLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCALAMLLIHC
Reference showing the relevant tissue of TIMM8A
Description by TissGene annotationsTissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for TIMM8A

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD-0.274661349-1.5063544531.2316931032.10E-259.24E-24
LUSC0.071816609-1.3837147641.4555313732.71E-234.84E-22


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TissGene-miRNA for TIMM8A

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TIMM8A
TissGeneSNV for TIMM8A

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S87FSKCM2
p.S6CBLCA1
p.R69HCOAD1
p.V67ILUAD1
p.V64MBRCA1
p.R31CUCEC1
p.P17QSTAD1
p.A59TSTAD1
p.Q75HUCEC1


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TissGeneCNV for TIMM8A

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TIMM8A

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for TIMM8A

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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COAD (tumor)COAD (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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HNSC (tumor)HNSC (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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KICH (tumor)KICH (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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KIRC (tumor)KIRC (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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KIRP (tumor)KIRP (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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LIHC (tumor)LIHC (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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LUAD (tumor)LUAD (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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LUSC (tumor)LUSC (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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PRAD (tumor)PRAD (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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STAD (tumor)STAD (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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THCA (tumor)THCA (normal)
TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (tumor)TIMM8A, UBC, ADRM1, STAM, USP30, TIMM13, JOSD1 (normal)
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TissGeneProg for TIMM8A

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TIMM8A
TissGeneDrug for TIMM8A

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for TIMM8A

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0796074MOHR-TRANEBJAERG SYNDROME16BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0029925Ovarian Carcinoma15BeFree
umls:C1140680Malignant neoplasm of ovary10BeFree
umls:C0024623Malignant neoplasm of stomach8BeFree
umls:C0699791Stomach Carcinoma8BeFree
umls:C0013421Dystonia7BeFree,LHGDN
umls:C0393593Dystonia Disorders6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0677886Epithelial ovarian cancer5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0007131Non-Small Cell Lung Carcinoma4BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0025202melanoma2BeFree
umls:C0029463Osteosarcoma2BeFree
umls:C0152013Adenocarcinoma of lung (disorder)2BeFree
umls:C0155320Blindness, Cortical2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C0585442Osteosarcoma of bone2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0740457Malignant neoplasm of kidney2BeFree
umls:C0917816Mental deficiency2BeFree
umls:C1378703Renal carcinoma2BeFree
umls:C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0000768Congenital Abnormality1BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0005695Bladder Neoplasm1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0018784Sensorineural Hearing Loss (disorder)1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0026838Muscle Spasticity1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0042133Uterine Fibroids1BeFree
umls:C0079588Ichthyosis, X-Linked1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0431399Familial aplasia of the vermis1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0547030Visual disturbance1BeFree
umls:C0558353Tongue Carcinoma1BeFree
umls:C0687120Nephronophthisis1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0743332Focal Dystonia1BeFree
umls:C0751093Dystonia, Limb1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree
umls:C1839564Jensen syndrome1BeFree,CLINVAR,CTD_human
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C3665346Unspecified visual loss1BeFree
umls:C3711374Nonsyndromic Deafness1BeFree