TissGeneSummary for C6orf118 |
Gene summary |
Basic gene information | Gene symbol | C6orf118 |
Gene name | chromosome 6 open reading frame 118 | |
Synonyms | bA85G2.1|dJ416F21.2 | |
Cytomap | UCSC genome browser: 6q27 | |
Type of gene | protein-coding | |
RefGenes | NM_144980.3, | |
Description | dJ416F21.2 (novel protein)uncharacterized protein C6orf118 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000112539 | ||
HPRD : 12844 | ||
Vega : OTTHUMG00000015984 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C6orf118 | |
BioGPS: 168090 | ||
Pathway | NCI Pathway Interaction Database: C6orf118 | |
KEGG: C6orf118 | ||
REACTOME: C6orf118 | ||
Pathway Commons: C6orf118 | ||
Context | iHOP: C6orf118 | |
ligand binding site mutation search in PubMed: C6orf118 | ||
UCL Cancer Institute: C6orf118 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C6orf118 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C6orf118 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.132375036 | 2.383417121 | -3.515792157 | 1.12E-12 | 5.11E-12 |
KICH | -2.518457153 | -1.276077153 | -1.24238 | 7.45E-09 | 4.08E-08 |
LUAD | -0.262201912 | 2.523761881 | -2.785963793 | 3.31E-09 | 1.60E-08 |
THCA | -2.082089492 | -0.21534373 | -1.866745763 | 3.85E-19 | 1.18E-17 |
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TissGene-miRNA for C6orf118 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C6orf118 |
TissGeneSNV for C6orf118 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E53K | SKCM | 3 |
p.E157K | SKCM | 2 |
p.N40I | LUSC | 1 |
p.A212T | COAD | 1 |
p.D235G | COAD | 1 |
p.D382N | ACC | 1 |
p.Q262P | STAD | 1 |
p.D109N | SKCM | 1 |
p.V293L | HNSC | 1 |
p.E142Q | LUAD | 1 |
p.R53Q | LAML | 1 |
p.E371K | SKCM | 1 |
p.Q135X | SKCM | 1 |
p.P16H | SKCM | 1 |
p.I381L | CESC | 1 |
p.R68L | PRAD | 1 |
p.A138S | LUAD | 1 |
p.N65S | HNSC | 1 |
p.I380L | COAD | 1 |
p.K129N | HNSC | 1 |
p.S35P | LGG | 1 |
p.T258M | STAD | 1 |
p.E3* | LUAD | 1 |
p.P66T | BRCA | 1 |
p.I256M | COAD | 1 |
p.R85P | LUAD | 1 |
p.E50D | ESCA | 1 |
p.R172H | COAD | 1 |
p.K50I | SKCM | 1 |
p.A139V | LIHC | 1 |
p.K79N | HNSC | 1 |
p.E3K | SKCM | 1 |
p.C272G | ACC | 1 |
p.W13* | BRCA | 1 |
p.R116C | ESCA | 1 |
p.E267K | SKCM | 1 |
p.N67D | STAD | 1 |
p.V15G | ESCA | 1 |
p.D213N | SKCM | 1 |
p.F160L | ESCA | 1 |
p.A212V | PRAD | 1 |
p.R372Q | COAD | 1 |
p.S139P | LGG | 1 |
p.Q188L | LIHC | 1 |
p.K449N | COAD | 1 |
p.L44R | STAD | 1 |
p.R94W | SKCM | 1 |
p.S375L | SKCM | 1 |
p.A329V | BRCA | 1 |
p.R216S | UCEC | 1 |
p.A243T | STAD | 1 |
p.A212T | STAD | 1 |
p.K233R | HNSC | 1 |
p.E154D | ESCA | 1 |
p.V392A | SKCM | 1 |
p.L179Q | LUSC | 1 |
p.K448N | COAD | 1 |
p.Q31* | SKCM | 1 |
p.R85W | STAD | 1 |
p.A136T | DLBC | 1 |
p.P148S | SKCM | 1 |
p.G104A | HNSC | 1 |
p.L277I | LGG | 1 |
p.L78S | SKCM | 1 |
p.P60S | LUAD | 1 |
p.K292M | LUAD | 1 |
p.E405Q | BLCA | 1 |
p.L287V | COAD | 1 |
p.P168T | HNSC | 1 |
p.E358K | SKCM | 1 |
p.S280R | READ | 1 |
p.G104R | LUAD | 1 |
p.R220H | COAD | 1 |
p.H141Q | LUAD | 1 |
p.T18M | STAD | 1 |
p.P44S | SKCM | 1 |
p.I399M | BLCA | 1 |
p.P19L | STAD | 1 |
p.S368F | HNSC | 1 |
p.G453R | SKCM | 1 |
p.V119G | ESCA | 1 |
p.K233N | HNSC | 1 |
p.L128P | STAD | 1 |
p.T18M | PAAD | 1 |
p.R173S | LIHC | 1 |
p.H11L | LUAD | 1 |
p.D21N | HNSC | 1 |
p.E17K | COAD | 1 |
p.Y194* | LUAD | 1 |
p.K370N | UCS | 1 |
p.R68S | HNSC | 1 |
p.R90H | KIRC | 1 |
p.L48P | PAAD | 1 |
p.A103E | HNSC | 1 |
p.P16T | LUAD | 1 |
p.F264L | ESCA | 1 |
p.K255N | READ | 1 |
p.A240V | SKCM | 1 |
p.P64T | HNSC | 1 |
p.P164A | LUSC | 1 |
p.T116M | BRCA | 1 |
p.H15Q | CESC | 1 |
p.S264F | SKCM | 1 |
p.A83G | LUSC | 1 |
p.A243T | PAAD | 1 |
p.S61C | CESC | 1 |
p.H245Q | LUAD | 1 |
p.L9V | STAD | 1 |
p.N175S | BLCA | 1 |
p.T18M | ESCA | 1 |
p.S368F | SKCM | 1 |
p.V80M | LUAD | 1 |
p.A243V | LIHC | 1 |
p.T75M | LIHC | 1 |
p.R469T | STAD | 1 |
p.H115L | LUAD | 1 |
p.L182S | SKCM | 1 |
p.K12T | STAD | 1 |
p.A4V | LUAD | 1 |
p.F236L | COAD | 1 |
p.H84N | LUAD | 1 |
p.R268Q | SKCM | 1 |
p.G208R | LUAD | 1 |
p.T116K | LUAD | 1 |
p.E434D | UCEC | 1 |
p.F146C | STAD | 1 |
p.P325L | STAD | 1 |
p.L44P | STAD | 1 |
p.D181N | UCEC | 1 |
p.E377K | BLCA | 1 |
p.R85Q | LUAD | 1 |
p.S264F | HNSC | 1 |
p.E254K | SKCM | 1 |
p.L138I | LUAD | 1 |
p.Y298* | LUAD | 1 |
p.A2V | UCEC | 1 |
p.V21M | ESCA | 1 |
p.D276Y | LUAD | 1 |
p.R468I | STAD | 1 |
p.L5M | LUAD | 1 |
p.A364E | BRCA | 1 |
p.Q202H | BLCA | 1 |
p.Y279* | LUAD | 1 |
p.A139T | PAAD | 1 |
p.V149M | GBM | 1 |
p.R69S | LIHC | 1 |
p.Q254P | LIHC | 1 |
p.G167D | STAD | 1 |
p.R465T | HNSC | 1 |
p.L34I | LUAD | 1 |
p.T12K | LUAD | 1 |
p.E405* | UCEC | 1 |
p.Y279F | LUAD | 1 |
p.C462F | KIRC | 1 |
p.E390K | ESCA | 1 |
p.F42C | STAD | 1 |
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TissGeneCNV for C6orf118 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C6orf118 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-QC-A6FX-01A | MRPL18-C6orf118 | Out-of-Frame | chr6:160212158 | chr6:165703556 |
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TissGeneNet for C6orf118 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C6orf118 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C6orf118 |
TissGeneDrug for C6orf118 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C6orf118 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |