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| TissGeneSummary for DDX53 |
 Gene summary |
| Basic gene information | Gene symbol | DDX53 |
| Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 | |
| Synonyms | CAGE|CT26 | |
| Cytomap | UCSC genome browser: Xp22.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_182699.3, | |
| Description | DEAD box protein 53DEAD-box protein CAGEcancer-associated gene proteincancer/testis antigen 26probable ATP-dependent RNA helicase DDX53 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 06466 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DDX53 | |
| BioGPS: 168400 | ||
| Pathway | NCI Pathway Interaction Database: DDX53 | |
| KEGG: DDX53 | ||
| REACTOME: DDX53 | ||
| Pathway Commons: DDX53 | ||
| Context | iHOP: DDX53 | |
| ligand binding site mutation search in PubMed: DDX53 | ||
| UCL Cancer Institute: DDX53 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DDX53 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DDX53 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 0.804642907 | -0.888713093 | 1.693356 | 3.33E-06 | 1.60E-05 |
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| TissGene-miRNA for DDX53 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DDX53 |
| TissGeneSNV for DDX53 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E199K | SKCM | 2 |
| p.S576L | SKCM | 2 |
| p.G45V | LUAD | 1 |
| p.E602K | BLCA | 1 |
| p.K165R | LUSC | 1 |
| p.Q603H | UCEC | 1 |
| p.M426I | GBM | 1 |
| p.R16K | KIRC | 1 |
| p.P41L | LAML | 1 |
| p.L284I | UCEC | 1 |
| p.V312M | OV | 1 |
| p.Y66* | LUAD | 1 |
| p.E100K | SKCM | 1 |
| p.D486N | STAD | 1 |
| p.E122Q | LUSC | 1 |
| p.R529Q | LUAD | 1 |
| p.N86S | LUSC | 1 |
| p.R333K | SKCM | 1 |
| p.P50Q | LUAD | 1 |
| p.I260M | LIHC | 1 |
| p.R398H | LUSC | 1 |
| p.E162K | BRCA | 1 |
| p.N432D | COAD | 1 |
| p.G337E | SKCM | 1 |
| p.P388L | HNSC | 1 |
| p.Q229* | UCEC | 1 |
| p.M101L | SKCM | 1 |
| p.A11V | STAD | 1 |
| p.A107V | UCEC | 1 |
| p.R613I | LUAD | 1 |
| p.N202S | STAD | 1 |
| p.S118N | STAD | 1 |
| p.A252T | UCEC | 1 |
| p.G40R | SKCM | 1 |
| p.A309D | ACC | 1 |
| p.E626K | SKCM | 1 |
| p.T524A | UCEC | 1 |
| p.K605N | STAD | 1 |
| p.E7D | BRCA | 1 |
| p.A11V | UCEC | 1 |
| p.I82M | STAD | 1 |
| p.E313* | HNSC | 1 |
| p.N363K | UCEC | 1 |
| p.F629V | PAAD | 1 |
| p.R47C | SKCM | 1 |
| p.N57S | UCEC | 1 |
| p.A91S | KIRC | 1 |
| p.L300I | BLCA | 1 |
| p.L582M | UCEC | 1 |
| p.L208F | HNSC | 1 |
| p.I349F | BLCA | 1 |
| p.S485G | LIHC | 1 |
| p.G516R | GBM | 1 |
| p.S121* | LUAD | 1 |
| p.M101I | SKCM | 1 |
| p.L533F | UCEC | 1 |
| p.A108G | SKCM | 1 |
| p.S77L | COAD | 1 |
| p.S118N | SKCM | 1 |
| p.N137I | SKCM | 1 |
| p.I375T | BLCA | 1 |
| p.I71M | LUSC | 1 |
| p.P297H | LUAD | 1 |
| p.R401* | SKCM | 1 |
| p.Y330H | CESC | 1 |
| p.Q287X | SKCM | 1 |
| p.E148D | UCEC | 1 |
| p.S286F | UCEC | 1 |
| p.I526T | THCA | 1 |
| p.A226T | ACC | 1 |
| p.Q287* | SKCM | 1 |
| p.G19R | SKCM | 1 |
| p.E450Q | BLCA | 1 |
| p.V240I | SKCM | 1 |
| p.V527G | BRCA | 1 |
| p.Q39H | PRAD | 1 |
| p.V312M | KIRP | 1 |
| p.S528F | SKCM | 1 |
| p.R546K | HNSC | 1 |
| p.T273A | UCEC | 1 |
| p.E450Q | CESC | 1 |
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| TissGeneCNV for DDX53 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DDX53 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for DDX53 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| COAD (tumor) | COAD (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| KICH (tumor) | KICH (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| STAD (tumor) | STAD (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| THCA (tumor) | THCA (normal) |
| DDX53, HDAC2 (tumor) | DDX53, HDAC2 (normal) |
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| TissGeneProg for DDX53 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DDX53 |
| TissGeneDrug for DDX53 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DDX53 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0699790 | Colon Carcinoma | 51 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 17 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 13 | BeFree |
| umls:C1527249 | Colorectal Cancer | 8 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 7 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 7 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 6 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 6 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C0013295 | Duodenal Ulcer | 4 | BeFree |
| umls:C0025202 | melanoma | 4 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 4 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 4 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree,LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0030920 | Peptic Ulcer | 2 | BeFree |
| umls:C0085762 | Alcohol abuse | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1623038 | Cirrhosis | 2 | BeFree |
| umls:C0001956 | alcohol use disorder | 1 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | GAD |
| umls:C0004565 | Melanoma, B16 | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0015625 | Fanconi Anemia | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0035372 | Rett Syndrome | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
| umls:C0279671 | Cervical Squamous Cell Carcinoma | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0549393 | Alcohol problem | 1 | BeFree |
| umls:C0687132 | heavy drinking | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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