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TissGeneSummary for SLC30A8 |
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Basic gene information | Gene symbol | SLC30A8 |
Gene name | solute carrier family 30 (zinc transporter), member 8 | |
Synonyms | ZNT8|ZnT-8 | |
Cytomap | UCSC genome browser: 8q24.11 | |
Type of gene | protein-coding | |
RefGenes | NM_001172811.1, NM_001172813.1,NM_001172814.1,NM_001172815.1,NM_173851.2, | |
Description | zinc transporter 8zinc transporter ZnT-8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611145 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164756 | ||
HPRD : 15370 | ||
Vega : OTTHUMG00000164962 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC30A8 | |
BioGPS: 169026 | ||
Pathway | NCI Pathway Interaction Database: SLC30A8 | |
KEGG: SLC30A8 | ||
REACTOME: SLC30A8 | ||
Pathway Commons: SLC30A8 | ||
Context | iHOP: SLC30A8 | |
ligand binding site mutation search in PubMed: SLC30A8 | ||
UCL Cancer Institute: SLC30A8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of SLC30A8 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0006829 | zinc ion transport | 15331542 | GO:0032119 | sequestering of zinc ion | 15331542 | GO:0071577 | zinc ion transmembrane transport | 15331542 | GO:0006829 | zinc ion transport | 15331542 | GO:0032119 | sequestering of zinc ion | 15331542 | GO:0071577 | zinc ion transmembrane transport | 15331542 |
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TissGeneExp for SLC30A8 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.56803698 | 1.33163502 | -3.899672 | 1.96E-08 | 9.93E-08 |
KIRP | -1.84485073 | 2.19862427 | -4.043475 | 7.16E-11 | 8.58E-10 |
KIRC | -2.378652813 | 1.510670798 | -3.889323611 | 5.01E-21 | 4.30E-20 |
BRCA | 1.291587757 | -1.173860489 | 2.465448246 | 1.23E-07 | 3.68E-07 |
STAD | -2.634947605 | -0.505628855 | -2.12931875 | 7.17E-09 | 3.66E-07 |
COAD | -2.984368519 | -1.102533903 | -1.881834615 | 1.44E-12 | 3.59E-11 |
ESCA | -2.992093344 | -0.934275162 | -2.057818182 | 0.00207 | 0.023250909 |
BLCA | -2.518399085 | -0.575246454 | -1.943152632 | 0.00361 | 0.02074584 |
LUAD | -2.210100084 | -1.040338015 | -1.169762069 | 0.00428 | 0.00823331 |
LUSC | -2.302527568 | -1.043215804 | -1.259311765 | 0.00198 | 0.00352487 |
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TissGene-miRNA for SLC30A8 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-186-5p | MIMAT0000456 | 0.02 | -0.31 | 56 |
UCS | hsa-miR-543 | MIMAT0004954 | 0.026 | -0.34 | 56 |
UCS | hsa-miR-370-5p | MIMAT0026483 | 0.0094 | -0.36 | 56 |
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TissGeneMut for SLC30A8 |
TissGeneSNV for SLC30A8 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A187V | STAD | 2 |
p.V181I | UCEC | 2 |
p.A187V | LIHC | 1 |
p.S324N | UCEC | 1 |
p.E61K | SKCM | 1 |
p.R131W | PAAD | 1 |
p.G14R | LUAD | 1 |
p.L93F | SKCM | 1 |
p.L260M | STAD | 1 |
p.D356H | HNSC | 1 |
p.V330L | OV | 1 |
p.R282Q | SKCM | 1 |
p.A14T | SKCM | 1 |
p.L45M | BLCA | 1 |
p.P318S | SKCM | 1 |
p.A261T | UCEC | 1 |
p.E164K | ESCA | 1 |
p.W136L | LUAD | 1 |
p.S6R | SKCM | 1 |
p.E207K | SKCM | 1 |
p.A261S | ESCA | 1 |
p.A136V | HNSC | 1 |
p.A70V | UCEC | 1 |
p.D307H | HNSC | 1 |
p.P305S | SKCM | 1 |
p.S76L | SKCM | 1 |
p.G91S | SKCM | 1 |
p.V154L | BRCA | 1 |
p.P354L | SKCM | 1 |
p.M1I | SKCM | 1 |
p.P120A | HNSC | 1 |
p.M129I | SKCM | 1 |
p.A138V | LIHC | 1 |
p.R282W | SKCM | 1 |
p.A15D | SARC | 1 |
p.L260V | SKCM | 1 |
p.V153A | STAD | 1 |
p.M302I | SKCM | 1 |
p.M226I | LIHC | 1 |
p.A19V | LUAD | 1 |
p.W72X | COAD | 1 |
p.E194D | LUAD | 1 |
p.S307F | SKCM | 1 |
p.D224N | UCEC | 1 |
p.L241P | SKCM | 1 |
p.P31T | LUSC | 1 |
p.W23* | SKCM | 1 |
p.S57Y | LUSC | 1 |
p.M275I | LIHC | 1 |
p.L266I | READ | 1 |
p.E243D | LUAD | 1 |
p.V153M | KIRP | 1 |
p.C81F | LUAD | 1 |
p.S125L | SKCM | 1 |
p.L225F | PAAD | 1 |
p.E115K | ESCA | 1 |
p.F221L | HNSC | 1 |
p.R199* | LUSC | 1 |
p.E227* | LIHC | 1 |
p.G247W | HNSC | 1 |
p.A187V | UCEC | 1 |
p.E158K | SKCM | 1 |
p.G48E | SKCM | 1 |
p.M178I | SKCM | 1 |
p.T7M | LUAD | 1 |
p.A136T | LGG | 1 |
p.H318Q | OV | 1 |
p.V281A | SKCM | 1 |
p.L315F | SKCM | 1 |
p.T348I | STAD | 1 |
p.E276X | LIHC | 1 |
p.W87L | LUAD | 1 |
p.T216S | HNSC | 1 |
p.A288V | SKCM | 1 |
p.S258F | SKCM | 1 |
p.H3N | LUAD | 1 |
p.L236R | STAD | 1 |
p.M36I | SKCM | 1 |
p.P305L | SKCM | 1 |
p.P169A | HNSC | 1 |
p.D248N | UCEC | 1 |
p.W72X | SKCM | 1 |
p.S256F | SKCM | 1 |
p.P354S | SKCM | 1 |
p.E333K | UCEC | 1 |
p.H220Y | UCEC | 1 |
p.L315I | UCEC | 1 |
p.G296W | HNSC | 1 |
p.D246N | SKCM | 1 |
p.A268T | SKCM | 1 |
p.L274F | PAAD | 1 |
p.S316L | HNSC | 1 |
p.Q209H | STAD | 1 |
p.A136T | HNSC | 1 |
p.A138V | STAD | 1 |
p.A187G | SKCM | 1 |
p.A261T | HNSC | 1 |
p.T252K | LUSC | 1 |
p.C315F | BLCA | 1 |
p.L211V | SKCM | 1 |
p.G86R | SKCM | 1 |
p.M85I | SKCM | 1 |
p.A320S | STAD | 1 |
p.Y239N | LIHC | 1 |
p.D12N | SKCM | 1 |
p.L266F | SKCM | 1 |
p.F3I | LUAD | 1 |
p.R131Q | READ | 1 |
p.V330A | SKCM | 1 |
p.K22R | BLCA | 1 |
p.D35Y | UCEC | 1 |
p.A104T | LUSC | 1 |
p.S267L | HNSC | 1 |
p.R82W | PAAD | 1 |
p.Q160H | STAD | 1 |
p.A70V | ESCA | 1 |
p.A185T | HNSC | 1 |
p.K13M | SKCM | 1 |
p.Q301E | BLCA | 1 |
p.A138G | SKCM | 1 |
p.C368Y | LUSC | 1 |
p.E44K | SKCM | 1 |
p.S98F | SKCM | 1 |
p.M178I | GBM | 1 |
p.P31Q | LUSC | 1 |
p.E12K | SKCM | 1 |
p.C32F | LUAD | 1 |
p.Q125* | SKCM | 1 |
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TissGeneCNV for SLC30A8 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC30A8 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18L-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806980 | chr8:118165182 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18L-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806980 | chr8:118173976 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18L-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806980 | chr8:118169929 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-C8-A12Z-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806980 | chr8:118165182 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A18L-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806979 | chr8:118165182 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A18L-01A | PVT1-SLC30A8 | 5'UTR-CDS | chr8:128806979 | chr8:118169929 |
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TissGeneNet for SLC30A8 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC30A8 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC30A8 |
TissGeneDrug for SLC30A8 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC30A8 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 128 | BeFree,CTD_human,GAD,GWASCAT |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 40 | BeFree,GAD |
umls:C0011849 | Diabetes Mellitus | 35 | BeFree,GAD,LHGDN |
umls:C0011847 | Diabetes | 29 | BeFree |
umls:C0028754 | Obesity | 6 | BeFree,GAD |
umls:C0004153 | Atherosclerosis | 3 | GAD |
umls:C0271650 | Impaired glucose tolerance | 3 | BeFree |
umls:C0019693 | HIV Infections | 2 | BeFree,GAD |
umls:C0020456 | Hyperglycemia | 2 | BeFree,GAD |
umls:C0205734 | Diabetes, Autoimmune | 2 | BeFree |
umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
umls:C0004096 | Asthma | 1 | GAD,GWASCAT |
umls:C0006663 | Calcinosis | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GAD |
umls:C0015929 | Fetal Diseases | 1 | GAD |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0021655 | Insulin Resistance | 1 | GAD |
umls:C0021670 | insulinoma | 1 | BeFree |
umls:C0032787 | Postoperative Complications | 1 | GAD |
umls:C0038187 | Starvation | 1 | GAD |
umls:C0162429 | Malnutrition | 1 | GAD |
umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
umls:C0242339 | Dyslipidemias | 1 | BeFree |
umls:C0270549 | Generalized Anxiety Disorder | 1 | BeFree |
umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |