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| TissGeneSummary for IDO2 |
 Gene summary |
| Basic gene information | Gene symbol | IDO2 |
| Gene name | indoleamine 2,3-dioxygenase 2 | |
| Synonyms | INDOL1 | |
| Cytomap | UCSC genome browser: 8p11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_194294.2, | |
| Description | IDO-2indoleamine 2,3-dioxygenase-like 1 proteinindoleamine 2,3-dioxygenase-like protein 1indoleamine-pyrrole 2,3 dioxygenase-like 1indoleamine-pyrrole 2,3-dioxygenase-like protein 1 | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 612129 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000188676 | ||
| HPRD : 14113 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IDO2 | |
| BioGPS: 169355 | ||
| Pathway | NCI Pathway Interaction Database: IDO2 | |
| KEGG: IDO2 | ||
| REACTOME: IDO2 | ||
| Pathway Commons: IDO2 | ||
| Context | iHOP: IDO2 | |
| ligand binding site mutation search in PubMed: IDO2 | ||
| UCL Cancer Institute: IDO2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of IDO2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019441 | tryptophan catabolic process to kynurenine | 17671174 | GO:0019441 | tryptophan catabolic process to kynurenine | 17671174 |
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| TissGeneExp for IDO2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 0.377740538 | 4.114840538 | -3.7371 | 1.58E-14 | 4.44E-13 |
| KIRP | -1.700586337 | -0.280767587 | -1.41981875 | 7.76E-06 | 3.31E-05 |
| THCA | -0.405458106 | 1.556118166 | -1.961576271 | 1.26E-15 | 1.80E-14 |
| STAD | -0.376976962 | -1.388742587 | 1.011765625 | 0.00119 | 0.006082523 |
| KICH | -1.788403462 | -0.519119462 | -1.269284 | 0.00022 | 0.000538756 |
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| TissGene-miRNA for IDO2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IDO2 |
| TissGeneSNV for IDO2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q225* | SKCM | 2 |
| p.P315S | SKCM | 2 |
| p.D311N | SKCM | 2 |
| p.H5Y | SKCM | 2 |
| p.E161K | SKCM | 1 |
| p.G397R | SKCM | 1 |
| p.H417Y | SKCM | 1 |
| p.H288R | ESCA | 1 |
| p.G174E | LUSC | 1 |
| p.G295C | COAD | 1 |
| p.D145E | LUAD | 1 |
| p.Y276* | UCEC | 1 |
| p.E58K | SKCM | 1 |
| p.P315H | BRCA | 1 |
| p.G278S | STAD | 1 |
| p.R297C | COAD | 1 |
| p.R219X | THYM | 1 |
| p.K88* | GBM | 1 |
| p.I140V | COAD | 1 |
| p.L390V | UCEC | 1 |
| p.P418S | SKCM | 1 |
| p.R219* | STAD | 1 |
| p.D409N | SARC | 1 |
| p.S45C | LUSC | 1 |
| p.G106A | LIHC | 1 |
| p.R297P | SARC | 1 |
| p.P43S | SKCM | 1 |
| p.A185D | SKCM | 1 |
| p.Q283H | LUAD | 1 |
| p.H33D | CESC | 1 |
| p.L63R | UCEC | 1 |
| p.P172S | COAD | 1 |
| p.Q115L | LUAD | 1 |
| p.L399S | PAAD | 1 |
| p.R297C | UCEC | 1 |
| p.N347K | STAD | 1 |
| p.T365N | LUAD | 1 |
| p.E355K | SKCM | 1 |
| p.P64S | SKCM | 1 |
| p.H288R | COAD | 1 |
| p.V119I | ESCA | 1 |
| p.Q225* | CESC | 1 |
| p.A262V | ESCA | 1 |
| p.R94H | UCEC | 1 |
| p.P273L | SKCM | 1 |
| p.A185V | SKCM | 1 |
| p.V199L | LGG | 1 |
| p.L412S | PAAD | 1 |
| p.N134K | OV | 1 |
| p.E37D | OV | 1 |
| p.E267K | SKCM | 1 |
| p.P386L | UCEC | 1 |
| p.D409N | SKCM | 1 |
| p.G295S | SKCM | 1 |
| p.F180I | SKCM | 1 |
| p.I169V | STAD | 1 |
| p.L42F | SKCM | 1 |
| p.H143Y | SKCM | 1 |
| p.E36K | SKCM | 1 |
| p.P208L | SKCM | 1 |
| p.Y359X | COAD | 1 |
| p.R219* | THYM | 1 |
| p.R248W | COAD | 1 |
| p.W56* | SKCM | 1 |
| p.L41V | BLCA | 1 |
| p.G106A | KIRC | 1 |
| p.F320L | BLCA | 1 |
| p.F102L | HNSC | 1 |
| p.D340N | SKCM | 1 |
| p.Y307C | UCEC | 1 |
| p.G338V | LUAD | 1 |
| p.L416F | SKCM | 1 |
| p.D323N | SKCM | 1 |
| p.S176N | SKCM | 1 |
| p.H360L | DLBC | 1 |
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| TissGeneCNV for IDO2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IDO2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG007180 | AQPEP-IDO2 | chr5:115314720 | chr8:39810708 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SR-01B | RBM47-IDO2 | 5'UTR-CDS | chr4:40546438 | chr8:39821126 |
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| TissGeneNet for IDO2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for IDO2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IDO2 |
| TissGeneDrug for IDO2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IDO2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0030297 | Pancreatic Neoplasm | 2 | BeFree,GAD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0349459 | Cervical intraepithelial neoplasia grade 2 | 1 | BeFree |
| umls:C0887833 | Carcinoma, Pancreatic Ductal | 1 | GAD |
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